RU2534890C2 - Антитела против mst1r и их применение - Google Patents

Антитела против mst1r и их применение Download PDF

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Publication number
RU2534890C2
RU2534890C2 RU2011137405/10A RU2011137405A RU2534890C2 RU 2534890 C2 RU2534890 C2 RU 2534890C2 RU 2011137405/10 A RU2011137405/10 A RU 2011137405/10A RU 2011137405 A RU2011137405 A RU 2011137405A RU 2534890 C2 RU2534890 C2 RU 2534890C2
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RU
Russia
Prior art keywords
seq
amino acid
acid sequence
antibody
region
Prior art date
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RU2011137405/10A
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English (en)
Russian (ru)
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RU2011137405A (ru
Inventor
Рейми КАВАИДА
Тосиаки ОХЦУКА
Тосинори АГАЦУМА
Филип РОДЛИ
Сандра МИЛЛЕР
Ульрике ШУБЕРТ
Original Assignee
Дайити Санкио Компани, Лимитед
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Publication of RU2011137405A publication Critical patent/RU2011137405A/ru
Application granted granted Critical
Publication of RU2534890C2 publication Critical patent/RU2534890C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2011137405/10A 2009-02-10 2010-02-10 Антитела против mst1r и их применение RU2534890C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15141109P 2009-02-10 2009-02-10
US61/151,411 2009-02-10
PCT/JP2010/052479 WO2010093055A1 (en) 2009-02-10 2010-02-10 Anti-mst1r antibodies and uses thereof

Publications (2)

Publication Number Publication Date
RU2011137405A RU2011137405A (ru) 2013-03-20
RU2534890C2 true RU2534890C2 (ru) 2014-12-10

Family

ID=42227811

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2011137405/10A RU2534890C2 (ru) 2009-02-10 2010-02-10 Антитела против mst1r и их применение

Country Status (18)

Country Link
US (1) US9403909B2 (https=)
EP (1) EP2396084B1 (https=)
JP (1) JP5714511B2 (https=)
KR (1) KR101745025B1 (https=)
CN (1) CN102438702B (https=)
AU (1) AU2010214301B2 (https=)
BR (1) BRPI1007979A2 (https=)
CA (1) CA2752136C (https=)
CO (1) CO6420322A2 (https=)
ES (1) ES2583281T3 (https=)
IL (1) IL214527A0 (https=)
MX (1) MX2011008456A (https=)
NZ (1) NZ594452A (https=)
RU (1) RU2534890C2 (https=)
SG (2) SG2014009195A (https=)
TW (1) TWI480050B (https=)
WO (1) WO2010093055A1 (https=)
ZA (1) ZA201105725B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX356749B (es) * 2012-04-27 2018-06-12 Daiichi Sankyo Co Ltd Anticuerpo anti-homologo 4 de roundabout (robo4).
TWI909341B (zh) 2015-09-24 2025-12-21 日商第一三共股份有限公司 抗garp抗體及其製造方法及用途
EP3504244A4 (en) 2016-08-26 2020-08-19 Agency for Science, Technology and Research MACROPHAGE-STIMULATING PROTEIN RECEPTOR ANTIBODIES (OR OF NANTAIS ORIGINAL RON-RECEPTOR) AND THEIR USES
MX2022001812A (es) 2019-08-12 2022-03-11 Regeneron Pharma Variantes del receptor estimulante de macrofagos 1 (mst1r) y sus usos.
WO2021066751A1 (en) * 2019-10-02 2021-04-08 Aslan Pharmaceuticals Pte. Ltd. Antigen specific binding domains and antibody molecules
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU725609C (en) 1995-08-18 2002-01-03 Morphosys Ag Protein/(poly)peptide libraries
ES2327382T3 (es) 1999-07-20 2009-10-29 Morphosys Ag Metodos para presentar (poli)peptidos/proteinas en particulas de bacteriofagos a traves de enlaces disulfuro.
CA2566647A1 (en) * 2004-05-13 2005-12-22 Imclone Systems Incorporated Inhibition of macrophage-stimulating protein receptor (ron)
US20060073256A1 (en) * 2004-06-15 2006-04-06 Frederic Destaillats Self-foaming liquid creamers and processes
JP2008512352A (ja) * 2004-07-17 2008-04-24 イムクローン システムズ インコーポレイティド 新規な四価の二重特異性抗体
UY31478A1 (es) * 2007-11-21 2009-07-17 Inhibicion del receptor para la proteina estimulante del macrofago (ron) y métodos para el tratamiento de lo mismo
MX2010008025A (es) * 2008-01-22 2010-08-04 Biogen Idec Inc Anticuerpos ron y usos de los mismos.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
РЫБАЛЬСКИЙ Н.Г., СЕРОВА М. А., ИГНАТЬЕВА Г.А., СТАРЧЕУС А.П., Моноклональные антитела и гибридомы, Москва: ВАСХНИЛ, 1989 *

Also Published As

Publication number Publication date
EP2396084B1 (en) 2016-05-11
AU2010214301A1 (en) 2011-09-01
US9403909B2 (en) 2016-08-02
KR20110117677A (ko) 2011-10-27
WO2010093055A1 (en) 2010-08-19
TW201036635A (en) 2010-10-16
SG173196A1 (en) 2011-08-29
IL214527A0 (en) 2011-09-27
KR101745025B1 (ko) 2017-06-20
US20120034215A1 (en) 2012-02-09
HK1164193A1 (zh) 2012-09-21
CO6420322A2 (es) 2012-04-16
RU2011137405A (ru) 2013-03-20
TWI480050B (zh) 2015-04-11
JP5714511B2 (ja) 2015-05-07
EP2396084A1 (en) 2011-12-21
ZA201105725B (en) 2012-04-25
MX2011008456A (es) 2011-09-26
AU2010214301B2 (en) 2016-11-10
SG2014009195A (en) 2014-04-28
BRPI1007979A2 (pt) 2017-10-03
ES2583281T3 (es) 2016-09-20
CN102438702A (zh) 2012-05-02
JP2012517223A (ja) 2012-08-02
CA2752136A1 (en) 2010-08-19
CN102438702B (zh) 2016-03-02
CA2752136C (en) 2016-03-15
NZ594452A (en) 2013-01-25

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Effective date: 20190211