JP2012516890A5 - - Google Patents
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- Publication number
- JP2012516890A5 JP2012516890A5 JP2011549157A JP2011549157A JP2012516890A5 JP 2012516890 A5 JP2012516890 A5 JP 2012516890A5 JP 2011549157 A JP2011549157 A JP 2011549157A JP 2011549157 A JP2011549157 A JP 2011549157A JP 2012516890 A5 JP2012516890 A5 JP 2012516890A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- ring
- phenyl
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20220709P | 2009-02-05 | 2009-02-05 | |
| US61/202,207 | 2009-02-05 | ||
| US21392709P | 2009-07-30 | 2009-07-30 | |
| US61/213,927 | 2009-07-30 | ||
| PCT/US2010/000307 WO2010090737A1 (en) | 2009-02-05 | 2010-02-04 | Pyridazinone compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012516890A JP2012516890A (ja) | 2012-07-26 |
| JP2012516890A5 true JP2012516890A5 (enExample) | 2013-03-14 |
| JP5659166B2 JP5659166B2 (ja) | 2015-01-28 |
Family
ID=42398214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011549157A Active JP5659166B2 (ja) | 2009-02-05 | 2010-02-04 | ピリダジノン化合物 |
Country Status (37)
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009054791A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | Fused pyrrolidine 1,2,4-triazole derivatives as modulators of mglur5 |
| JP5627574B2 (ja) * | 2008-06-03 | 2014-11-19 | インターミューン， インコーポレイテッド | 炎症性および線維性疾患を治療するための化合物および方法 |
| EP2393360B1 (en) * | 2009-02-05 | 2015-11-04 | Takeda Pharmaceutical Company Limited | Pyridazinone compounds |
| TWI546302B (zh) | 2010-06-24 | 2016-08-21 | 武田藥品工業股份有限公司 | 稠合雜環化合物 |
| US20130116231A1 (en) * | 2010-07-12 | 2013-05-09 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| EP2602255B1 (en) * | 2010-08-04 | 2017-04-26 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring compound |
| JP5800813B2 (ja) | 2010-08-04 | 2015-10-28 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2012018909A1 (en) | 2010-08-04 | 2012-02-09 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| WO2012020780A1 (ja) | 2010-08-10 | 2012-02-16 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| JP2013234123A (ja) * | 2010-09-03 | 2013-11-21 | Taisho Pharmaceutical Co Ltd | ３−ピラゾリル−２−ピリドン誘導体 |
| KR20140009372A (ko) | 2011-02-18 | 2014-01-22 | 알러간, 인코포레이티드 | 포스포다이에스테라제 10(pde10a)의 억제제로서의 치환된 6,7-다이알콕시-3-아이소퀴놀리놀 유도체 |
| EP2687529B1 (en) | 2011-03-16 | 2016-07-13 | Takeda Pharmaceutical Company Limited | Condensed heterocyclic compound |
| US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
| CN103889974B (zh) * | 2011-08-22 | 2017-10-03 | 武田药品工业株式会社 | 放射性标记的化合物和它们在哺乳动物中作为磷酸二酯酶(pde10a)的定量成像的放射示踪剂的用途 |
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| UA111861C2 (uk) | 2011-11-15 | 2016-06-24 | Такеда Фармасьютікал Компані Лімітед | Ароматична гетероциклічна сполука дигідрокси |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
| EA201591540A1 (ru) * | 2013-02-21 | 2016-01-29 | Такеда Фармасьютикал Компани Лимитед | Способ получения производных пиридазинона |
| US9464076B2 (en) | 2013-03-15 | 2016-10-11 | Daiichi Sankyo Company, Limited | Benzothiophene derivative |
| WO2015006689A1 (en) | 2013-07-12 | 2015-01-15 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using pde10a inhibitors and methods to measure pde10a expression |
| CN105722831B (zh) * | 2013-09-12 | 2019-08-06 | 艾丽奥斯生物制药有限公司 | 哒嗪酮化合物及其用途 |
| AU2014318832B2 (en) | 2013-09-12 | 2018-11-29 | Janssen Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| ES2544869B2 (es) * | 2014-03-04 | 2016-01-18 | Universidade De Vigo | Derivados de piridazin-3(2H)-ona inhibidores selectivos de la isoforma B de la monoaminooxidasa |
| US10231929B2 (en) | 2014-03-18 | 2019-03-19 | Takeda Pharmaceutical Company Limited | Solid dispersion |
| CN106459042B (zh) | 2014-04-02 | 2019-06-28 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
| US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
| MX383931B (es) | 2015-03-11 | 2025-03-14 | Janssen Biopharma Inc | Compuestos de aza-piridona y usos de estos. |
| WO2016191935A1 (en) * | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| BR112018011817A2 (pt) | 2015-12-22 | 2018-12-04 | Jiangsu Hengrui Medicine Co | derivado de benzopiperidina, método de preparação do mesmo, e uso médico do mesmo |
| US10736894B2 (en) | 2018-02-15 | 2020-08-11 | Ovid Therapeutics Inc. | Methods of treating developmental syndromes with PDE10A inhibitors |
| CN108498868B (zh) * | 2018-04-03 | 2020-09-15 | 北京大学口腔医学院 | 具有细胞外基质电学拓扑特征的带电复合膜及其制备方法 |
| CN110407806B (zh) * | 2018-04-28 | 2021-08-17 | 深圳微芯生物科技股份有限公司 | 甲酰胺类化合物、其制备方法及其应用 |
| WO2019241787A1 (en) * | 2018-06-15 | 2019-12-19 | The Regents Of The University Of Colorado A Body Corporate | Novel cyclic gmp-amp synthase (cgas) inhibitors and their method of use |
| WO2020065583A1 (en) * | 2018-09-28 | 2020-04-02 | Takeda Pharmaceutical Company Limited | Balipodect for treating or preventing autism spectrum disorders |
| MX2019008440A (es) | 2019-07-15 | 2021-01-18 | Dva Farma Mexicana S A De C V | Composiciones de recubrimientos en pelicula para tabletas con brillantez incrementada, procedimiento de preparacion y aplicacion. |
| EP3805206A1 (en) * | 2019-10-08 | 2021-04-14 | Novaled GmbH | Compound and an organic semiconducting layer, an organic electronic device, a display device and a lighting device comprising the same |
| GB202002926D0 (en) | 2020-02-28 | 2020-04-15 | Benevolentai Tech Limited | Compositions and uses thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0011693A1 (de) * | 1978-10-03 | 1980-06-11 | Ciba-Geigy Ag | Neue N-(trifluormethansulfonylaminophenyl)-substituierte N-Heterocyclen, ihre Herstellung, sie enthaltende Mittel und ihre Verwendung zur Beeinflussung des Pflanzenwachstums |
| FR2648135B1 (fr) | 1989-06-07 | 1991-09-27 | Pf Medicament | Derives de phenyl-1-dihydro-1,4 amino-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique |
| GB9506382D0 (en) | 1995-03-29 | 1995-05-17 | Boots Co Plc | Pharmaceutical compositions |
| AU756275B2 (en) | 1998-08-14 | 2003-01-09 | Nihon Nohyaku Co., Ltd. | Pyridazinone derivatives |
| US20070060606A1 (en) * | 1999-10-07 | 2007-03-15 | Robertson Harold A | Compounds and methods for modulating phosphodiesterase 10A |
| GB0013383D0 (en) | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Therapeutic benzamide derivatives |
| DK1318997T3 (da) | 2000-09-15 | 2006-09-25 | Vertex Pharma | Pyrazolforbindelser der er nyttige som proteinkinase-inhibitorer |
| US7005432B2 (en) | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
| EP1755611A1 (en) | 2004-06-07 | 2007-02-28 | Pfizer Products Inc. | Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions |
| RU2346996C2 (ru) | 2004-06-29 | 2009-02-20 | ЮРОПИЭН НИКЕЛЬ ПиЭлСи | Усовершенствованное выщелачивание основных металлов |
| ATE472543T1 (de) | 2005-01-07 | 2010-07-15 | Pfizer Prod Inc | Heteroaromatische chinolinverbindungen und deren verwendung als pde10-inhibitoren |
| JP4890439B2 (ja) * | 2005-03-07 | 2012-03-07 | 杏林製薬株式会社 | ピラゾロピリジン−４−イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするｐｄｅ阻害剤 |
| CA2654394A1 (en) | 2006-06-26 | 2008-01-03 | Pfizer Products Inc. | Tricyclic heteroaryl compounds as pde10 inhibitors |
| TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
| US20080090834A1 (en) | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
| US8642660B2 (en) | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2010000020A1 (en) | 2008-06-30 | 2010-01-07 | Cathrx Ltd | A catheter |
| TW201030001A (en) | 2008-11-14 | 2010-08-16 | Amgen Inc | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors |
| TWI396689B (zh) | 2008-11-14 | 2013-05-21 | Amgen Inc | 作為磷酸二酯酶１０抑制劑之吡衍生物 |
| SG171954A1 (en) * | 2008-12-04 | 2011-07-28 | Hoffmann La Roche | Pyridazinone derivatives |
| EP2393360B1 (en) | 2009-02-05 | 2015-11-04 | Takeda Pharmaceutical Company Limited | Pyridazinone compounds |
| US9187455B2 (en) | 2009-02-23 | 2015-11-17 | Hoffmann-La Roche Inc. | Substituted pyridazines as PDE10A inhibitors |
| US8415381B2 (en) | 2009-07-30 | 2013-04-09 | Novartis Ag | Heteroaryl compounds and their uses |
| EP2602255B1 (en) * | 2010-08-04 | 2017-04-26 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring compound |
| WO2012020780A1 (ja) * | 2010-08-10 | 2012-02-16 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
-
2010
- 2010-02-04 EP EP10738857.1A patent/EP2393360B1/en active Active
- 2010-02-04 ME MEP-2016-194A patent/ME02337B/me unknown
- 2010-02-04 CA CA2751565A patent/CA2751565C/en active Active
- 2010-02-04 JP JP2011549157A patent/JP5659166B2/ja active Active
- 2010-02-04 TW TW099103286A patent/TWI457333B/zh active
- 2010-02-04 MY MYPI2011003610A patent/MY170610A/en unknown
- 2010-02-04 JO JOP/2010/0038A patent/JO3114B1/ar active
- 2010-02-04 HR HRP20160065TT patent/HRP20160065T1/hr unknown
- 2010-02-04 SG SG2011054491A patent/SG173175A1/en unknown
- 2010-02-04 BR BRPI1008498A patent/BRPI1008498B8/pt active IP Right Grant
- 2010-02-04 PE PE2011001434A patent/PE20110991A1/es active IP Right Grant
- 2010-02-04 GE GEAP201012363A patent/GEP20146004B/en unknown
- 2010-02-04 US US13/148,172 patent/US8354411B2/en active Active
- 2010-02-04 MX MX2011008305A patent/MX2011008305A/es active IP Right Grant
- 2010-02-04 ES ES10738857.1T patent/ES2561181T3/es active Active
- 2010-02-04 EA EA201171004A patent/EA020690B1/ru not_active IP Right Cessation
- 2010-02-04 AR ARP100100304A patent/AR075238A1/es active IP Right Grant
- 2010-02-04 US US12/656,605 patent/US8916566B2/en active Active
- 2010-02-04 WO PCT/US2010/000307 patent/WO2010090737A1/en not_active Ceased
- 2010-02-04 PL PL10738857T patent/PL2393360T3/pl unknown
- 2010-02-04 AU AU2010211050A patent/AU2010211050B2/en active Active
- 2010-02-04 MA MA34133A patent/MA33072B1/fr unknown
- 2010-02-04 CN CN201080014965.6A patent/CN102365020B/zh active Active
- 2010-02-04 EP EP15192646.6A patent/EP3006031A1/en not_active Withdrawn
- 2010-02-04 DK DK10738857.1T patent/DK2393360T3/en active
- 2010-02-04 HU HUE10738857A patent/HUE027478T2/en unknown
- 2010-02-04 RS RS20150859A patent/RS54504B1/sr unknown
- 2010-02-04 KR KR1020117020556A patent/KR101730665B1/ko active Active
- 2010-02-04 SI SI201031103T patent/SI2393360T1/sl unknown
- 2010-02-04 NZ NZ594851A patent/NZ594851A/xx unknown
- 2010-02-04 UY UY0001032417A patent/UY32417A/es not_active Application Discontinuation
-
2011
- 2011-07-18 IL IL214137A patent/IL214137A/en active IP Right Grant
- 2011-07-22 TN TN2011000362A patent/TN2011000362A1/fr unknown
- 2011-08-03 DO DO2011000254A patent/DOP2011000254A/es unknown
- 2011-08-17 CR CR20110440A patent/CR20110440A/es unknown
- 2011-08-18 ZA ZA2011/06074A patent/ZA201106074B/en unknown
- 2011-08-23 CO CO11106877A patent/CO6410258A2/es active IP Right Grant
- 2011-09-05 EC EC2011011305A patent/ECSP11011305A/es unknown
-
2012
- 2012-07-06 US US13/543,332 patent/US8435995B2/en active Active
- 2012-07-06 US US13/543,296 patent/US8513251B2/en active Active
- 2012-07-06 US US13/543,207 patent/US8778944B2/en active Active
-
2014
- 2014-10-17 US US14/517,313 patent/US9550756B2/en active Active
-
2016
- 2016-01-08 SM SM201600008T patent/SMT201600008B/it unknown
- 2016-12-13 US US15/377,149 patent/US20170114044A1/en not_active Abandoned
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