JP2012516344A - 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩 - Google Patents

結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩 Download PDF

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JP2012516344A
JP2012516344A JP2011548275A JP2011548275A JP2012516344A JP 2012516344 A JP2012516344 A JP 2012516344A JP 2011548275 A JP2011548275 A JP 2011548275A JP 2011548275 A JP2011548275 A JP 2011548275A JP 2012516344 A JP2012516344 A JP 2012516344A
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cancer
leukemia
chloro
methyl
inhibitor
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JP2012516344A5 (https=
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ピンユン、ワイ.チェン
ジェフリー、ゴールディング
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GlaxoSmithKline LLC
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41551,2-Diazoles non condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2011548275A 2009-01-30 2010-01-28 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩 Pending JP2012516344A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14849009P 2009-01-30 2009-01-30
US61/148,490 2009-01-30
PCT/US2010/022323 WO2010088331A1 (en) 2009-01-30 2010-01-28 Crystalline n-{(1-s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

Related Child Applications (1)

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JP2015114505A Division JP6328590B2 (ja) 2009-01-30 2015-06-05 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩

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JP2012516344A true JP2012516344A (ja) 2012-07-19
JP2012516344A5 JP2012516344A5 (https=) 2012-10-11

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JP2011548275A Pending JP2012516344A (ja) 2009-01-30 2010-01-28 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩
JP2015114505A Active JP6328590B2 (ja) 2009-01-30 2015-06-05 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩
JP2016235681A Withdrawn JP2017061559A (ja) 2009-01-30 2016-12-05 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩
JP2019057789A Active JP6924794B2 (ja) 2009-01-30 2019-03-26 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩

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JP2015114505A Active JP6328590B2 (ja) 2009-01-30 2015-06-05 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩
JP2016235681A Withdrawn JP2017061559A (ja) 2009-01-30 2016-12-05 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩
JP2019057789A Active JP6924794B2 (ja) 2009-01-30 2019-03-26 結晶質n−{(1s)−2−アミノ−1−[(3−フルオロフェニル)メチル]エチル}−5−クロロ−4−(4−クロロ−1−メチル−1h−ピラゾール−5−イル)−2−チオフェンカルボキサミド塩酸塩

Country Status (25)

Country Link
US (5) US20110288142A1 (https=)
EP (2) EP4242206A1 (https=)
JP (4) JP2012516344A (https=)
KR (1) KR101420484B1 (https=)
CN (1) CN102405047B (https=)
AR (1) AR075153A1 (https=)
AU (1) AU2010208265B2 (https=)
BR (1) BRPI1006896B1 (https=)
CA (1) CA2750565C (https=)
CL (1) CL2011001830A1 (https=)
CO (1) CO6400189A2 (https=)
CR (1) CR20110422A (https=)
EA (1) EA018907B1 (https=)
IL (1) IL214023A (https=)
MA (1) MA32998B1 (https=)
MX (1) MX2011008073A (https=)
MY (1) MY161598A (https=)
NZ (1) NZ594064A (https=)
PE (1) PE20120003A1 (https=)
SG (1) SG172926A1 (https=)
TW (1) TWI503317B (https=)
UA (1) UA106740C2 (https=)
UY (1) UY32407A (https=)
WO (1) WO2010088331A1 (https=)
ZA (1) ZA201105033B (https=)

Cited By (5)

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JP2016523818A (ja) * 2013-04-18 2016-08-12 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル それを必要とする被験体におけるt細胞増殖を阻害するための方法及び医薬組成物(ctps1阻害剤、例えばノルロイシン)
JP2016531884A (ja) * 2013-10-01 2016-10-13 ノバルティス アーゲー 組合せ物
JP2016531881A (ja) * 2013-10-01 2016-10-13 ノバルティス アーゲー がんを治療するためのアフレセルチブと組み合わせたエンザルタミド
JP2017507963A (ja) * 2014-03-12 2017-03-23 ノバルティス アーゲー Btk阻害薬とakt阻害薬を含む組み合わせ
US10449226B2 (en) 2011-01-11 2019-10-22 Novartis Ag Combination

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CN102405047B (zh) 2009-01-30 2014-07-09 葛兰素史密斯克莱有限责任公司 结晶型的n-{(1s)-2-氨基-1-[(3-氟苯基)甲基]乙基}-5-氯-4-(4-氯-1-甲基-1h-吡唑-5-基)-2-噻吩甲酰胺盐酸盐
WO2011146710A1 (en) 2010-05-21 2011-11-24 Glaxosmithkline Llc Combination
US20130237554A1 (en) * 2010-05-26 2013-09-12 Rakesh Kumar Combination
US20150087683A1 (en) 2012-04-24 2015-03-26 Glaxosmithkline Intellectual Property (No.2) Limited Treatment method for steroid responsive dermatoses
ES2909576T3 (es) 2016-10-11 2022-05-09 Univ Duke Tratamiento con lasofoxifeno del cáncer de mama ER+
JP6515944B2 (ja) 2016-12-20 2019-05-22 株式会社デンソー 半導体装置およびその製造方法
US11497730B2 (en) 2018-04-10 2022-11-15 Duke University Lasofoxifene treatment of breast cancer
TWI857119B (zh) 2019-08-08 2024-10-01 香港商來凱有限公司 治療癌症之方法
US11915283B1 (en) 2019-08-13 2024-02-27 Splitcart Llc Cost sharing platform and system
US12067592B2 (en) 2019-08-13 2024-08-20 Splitcart Llc Co-purchasing system and method
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