JP2012516147A5 - - Google Patents
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- JP2012516147A5 JP2012516147A5 JP2011546955A JP2011546955A JP2012516147A5 JP 2012516147 A5 JP2012516147 A5 JP 2012516147A5 JP 2011546955 A JP2011546955 A JP 2011546955A JP 2011546955 A JP2011546955 A JP 2011546955A JP 2012516147 A5 JP2012516147 A5 JP 2012516147A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- protelomerase
- template
- sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 19
- 108020004414 DNA Proteins 0.000 claims 18
- 102000053602 DNA Human genes 0.000 claims 18
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 5
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108020004638 Circular DNA Proteins 0.000 claims 2
- 238000006073 displacement reaction Methods 0.000 claims 2
- 108700028149 Bacteriophage N15 protelomerase Proteins 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000003362 replicative effect Effects 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
- 230000005030 transcription termination Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0901593.4 | 2009-01-30 | ||
| GBGB0901593.4A GB0901593D0 (en) | 2009-01-30 | 2009-01-30 | Production of closed linear DNA |
| PCT/GB2010/000165 WO2010086626A1 (en) | 2009-01-30 | 2010-02-01 | Production of closed linear dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015175262A Division JP6454243B2 (ja) | 2009-01-30 | 2015-09-07 | 閉鎖型直鎖状ｄｎａの製造 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012516147A JP2012516147A (ja) | 2012-07-19 |
| JP2012516147A5 true JP2012516147A5 (cg-RX-API-DMAC7.html) | 2013-03-21 |
Family
ID=40469378
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546955A Pending JP2012516147A (ja) | 2009-01-30 | 2010-02-01 | 閉鎖型直鎖状ｄｎａの製造 |
| JP2015175262A Active JP6454243B2 (ja) | 2009-01-30 | 2015-09-07 | 閉鎖型直鎖状ｄｎａの製造 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015175262A Active JP6454243B2 (ja) | 2009-01-30 | 2015-09-07 | 閉鎖型直鎖状ｄｎａの製造 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9109250B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2612925B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2012516147A (cg-RX-API-DMAC7.html) |
| KR (1) | KR101926662B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN102301010B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010209532B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI1005683B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2751130C (cg-RX-API-DMAC7.html) |
| DK (2) | DK3150722T3 (cg-RX-API-DMAC7.html) |
| EA (1) | EA021069B1 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2749629T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0901593D0 (cg-RX-API-DMAC7.html) |
| IL (1) | IL213930A (cg-RX-API-DMAC7.html) |
| LT (1) | LT3150722T (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011007937A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ594004A (cg-RX-API-DMAC7.html) |
| SG (1) | SG173102A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010086626A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201105013B (cg-RX-API-DMAC7.html) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2351294B8 (es) * | 2009-07-02 | 2012-06-06 | Consejo Superior De Investigaciones Científicas (Csic) | Metodo para la replicación, amplificación, o secuenciación de un adn molde. |
| GB201013153D0 (en) * | 2010-08-04 | 2010-09-22 | Touchlight Genetics Ltd | Primer for production of closed linear DNA |
| US9290800B2 (en) | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
| GB201502645D0 (en) * | 2015-02-17 | 2015-04-01 | Touchlight Genetics Ltd | Method |
| FR3042121A1 (fr) * | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| EP3701963A1 (en) | 2015-12-22 | 2020-09-02 | CureVac AG | Method for producing rna molecule compositions |
| RU2616279C1 (ru) * | 2015-12-28 | 2017-04-13 | Федеральное государственное бюджетное учреждение науки Институт биохимии и генетики Уфимского научного центра Российской академии наук (ИБГ УНЦ РАН) | Способ получения маркерных лестниц для гель-электрофоретического определения размеров фрагментов нуклеиновых кислот |
| US10077459B2 (en) | 2016-05-04 | 2018-09-18 | General Electric Company | Cell-free protein expression using rolling circle amplification product |
| CN116732145A (zh) | 2016-08-16 | 2023-09-12 | 塔驰莱特Ip有限公司 | 闭合线性dna的生产 |
| WO2019118806A1 (en) * | 2017-12-14 | 2019-06-20 | Solid Biosciences Inc. | Non-viral production and delivery of genes |
| GB201721846D0 (en) * | 2017-12-22 | 2018-02-07 | Arecor Ltd | Novel composition |
| CN109971825B (zh) * | 2017-12-28 | 2020-11-10 | 南京金斯瑞生物科技有限公司 | 快速制备桑格测序模板的方法 |
| GB201805683D0 (en) * | 2018-04-05 | 2018-05-23 | Touchlight Ip Ltd | Reprogramming vectors |
| AU2019290228A1 (en) * | 2018-06-22 | 2021-01-28 | AskBio Inc. | Vectors for gene delivery that persist within cells |
| WO2020092904A1 (en) * | 2018-11-02 | 2020-05-07 | Nikegen, Llc | Recombinant parvoviral vectors and method of making and use thereof |
| GB201905651D0 (en) * | 2019-04-24 | 2019-06-05 | Lightbio Ltd | Nucleic acid constructs and methods for their manufacture |
| WO2020255007A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai |
| WO2020255010A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines |
| WO2020255011A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 or anti-pd-l1 antibody |
| CN114206379A (zh) | 2019-06-18 | 2022-03-18 | 爱尔兰詹森科学公司 | 乙型肝炎病毒(hbv)疫苗和抗pd-1抗体的组合 |
| MA56520A (fr) | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Co | Construction de l'interleukine 12 recombinante et ses utilisations |
| WO2020254876A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Virus-like particle delivery of hepatitis b virus (hbv) vaccines |
| CA3143679A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai |
| WO2020255062A1 (en) | 2019-06-20 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines |
| AU2020297019A1 (en) | 2019-06-20 | 2022-02-17 | Janssen Sciences Ireland Unlimited Company | Carbohydrate nanocarrier delivery of hepatitis B virus (HBV) vaccines |
| EP3792367A1 (en) | 2019-09-11 | 2021-03-17 | Universität Bielefeld | Method for the production of raav and method for the in vitro generation of genetically engineered, linear, single-stranded nucleic acid fragments containing itr sequences flanking a gene of interest |
| JP2022549138A (ja) | 2019-09-18 | 2022-11-24 | インターガラクティック セラピューティクス インコーポレイテッド | 合成ｄｎａベクターおよびその使用法 |
| GB201915163D0 (en) | 2019-10-18 | 2019-12-04 | Univ Southampton | Cancer vaccine |
| WO2021123062A1 (en) | 2019-12-20 | 2021-06-24 | Keygene N.V. | Ngs library preparation using covalently closed nucleic acid molecule ends |
| US20230048994A1 (en) * | 2020-01-17 | 2023-02-16 | Asklepios Biopharmaceutical, Inc. | Recombinant aav production |
| KR20220134001A (ko) * | 2020-01-31 | 2022-10-05 | 타이리스 테라뷰틱스, 에스.엘. | 닫힌 선형 dna의 제조방법 |
| AU2021230546A1 (en) | 2020-03-04 | 2022-10-13 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| GB202007428D0 (en) | 2020-05-19 | 2020-07-01 | Fabricnano Ltd | Polynucleotide synthesis |
| JP2023533174A (ja) | 2020-06-12 | 2023-08-02 | ユニバーシティ オブ ロチェスター | ＡＣＥ－ｔＲＮＡのコード化及び発現 |
| BR112023002195A2 (pt) | 2020-08-26 | 2023-03-14 | Scancell Ltd | Ácido nucleico que codifica um polipeptídeo, vetor, peptídeo, e composição de vacina |
| EP4225914A1 (en) | 2020-10-06 | 2023-08-16 | Keygene N.V. | Targeted sequence addition |
| EP4317424A4 (en) | 2021-03-29 | 2025-10-22 | Kaneka Corp | VECTOR, METHOD FOR PREPARING COVALENTLY BONDED CLOSED LINEAR DNA USING SAME, METHOD FOR PREPARING PARVOVIRAL VECTOR, AND PARVOVIRAL VECTOR PRODUCTION CELL |
| JP2024520797A (ja) | 2021-06-08 | 2024-05-24 | タッチライト・アイピー・リミテッド | レンチウイルスベクター |
| GB202108176D0 (en) | 2021-06-08 | 2021-07-21 | Touchlight Ip Ltd | Vector |
| WO2022272297A1 (en) | 2021-06-25 | 2022-12-29 | Oxford Biomedica Solutions Llc | Adeno-associated virus packaging systems |
| WO2023285976A1 (en) | 2021-07-13 | 2023-01-19 | Stonehaven Incubate AG | Composition and uses thereof |
| EP4124660A1 (en) | 2021-07-30 | 2023-02-01 | 4basebio, S.L.U. | Linear dna with enhanced resistance against exonucleases and methods for the production thereof |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| GB202114105D0 (en) | 2021-10-01 | 2021-11-17 | Fabricnano Ltd | Nucleotide synthesis |
| US20250027107A1 (en) | 2021-10-18 | 2025-01-23 | Flagship Pioneering Innovations Vii, Llc | Dna compositions and related methods |
| US20230279433A1 (en) | 2021-12-15 | 2023-09-07 | Oxford Biomedica Solutions Llc | Methods and compositions for the production of adeno-associated virus |
| JP2025500458A (ja) * | 2021-12-23 | 2025-01-09 | ジェネレーション バイオ カンパニー | 閉端ｄｎａベクターの拡張可能かつ高純度の無細胞合成 |
| CN114561372B (zh) * | 2022-04-27 | 2022-07-26 | 南京巨匠生物科技有限公司 | Bst DNA聚合酶突变体及其应用和产品、基因、重组质粒和基因工程菌 |
| EP4293101A1 (en) | 2022-06-14 | 2023-12-20 | Asklepios Biopharmaceutical, Inc. | Reactor with temperature control and method of using the same |
| WO2024032690A1 (zh) | 2022-08-10 | 2024-02-15 | 江苏金斯瑞蓬勃生物科技有限公司 | 线性闭合dna的制备方法及该方法所用质粒 |
| JPWO2024058155A1 (cg-RX-API-DMAC7.html) | 2022-09-12 | 2024-03-21 | ||
| EP4593877A1 (en) | 2022-09-29 | 2025-08-06 | Ceva Hampton Limited | Vaccine construct and uses thereof |
| EP4365303A1 (en) | 2022-11-02 | 2024-05-08 | 4basebio, S.L.U. | Purification of linear dna products |
| EP4612320A1 (en) | 2022-11-02 | 2025-09-10 | 4basebio UK Ltd | Purification of linear dna products |
| KR102753513B1 (ko) * | 2022-11-18 | 2025-01-13 | 최낙식 | Direct RNA 추출 버퍼 및 이의 용도 |
| WO2024121354A1 (en) | 2022-12-08 | 2024-06-13 | Keygene N.V. | Duplex sequencing with covalently closed dna ends |
| WO2024132094A1 (en) | 2022-12-19 | 2024-06-27 | Thermo Fisher Scientific Geneart Gmbh | Retrieval of sequence-verified nucleic acid molecules |
| EP4410992B1 (en) | 2023-02-01 | 2025-12-17 | 4basebio UK Ltd | Linear dna with enhanced resistance against exonucleases and methods for the production thereof |
| EP4410995A1 (en) | 2023-02-01 | 2024-08-07 | 4basebio, S.L.U. | Linear dna with enhanced resistance against exonucleases and methods for the production thereof |
| WO2024197081A1 (en) | 2023-03-20 | 2024-09-26 | Hc Bioscience, Inc. | Minimally-sized dna threads for trna therapy |
| CN116606834A (zh) * | 2023-04-10 | 2023-08-18 | 天津中合基因科技有限公司 | 多种具有切割连接活性的原端酶及其应用 |
| WO2024218190A1 (en) | 2023-04-18 | 2024-10-24 | Uniqure Biopharma B.V. | Generation of adeno-associated virus capsid libraries for insect cells |
| WO2024256842A1 (en) | 2023-06-16 | 2024-12-19 | Touchlight IP Limited | Therapeutic transfection |
| US11981936B1 (en) | 2023-09-29 | 2024-05-14 | New England Biolabs, Inc. | TelA variants, compositions, and methods |
| EP4553156A1 (en) | 2023-11-08 | 2025-05-14 | 4basebio UK Ltd | Synthetic dna production using cas nuclease |
| GB202319998D0 (en) | 2023-12-22 | 2024-02-07 | Touchlight Ip Ltd | duplexing method |
| EP4596713A1 (en) | 2024-02-05 | 2025-08-06 | 4basebio UK Ltd | Dna with enhanced resistance against exonucleases and methods for the production thereof |
| FR3160186A1 (fr) | 2024-03-13 | 2025-09-19 | Odimma Therapeutics | Vecteur non-viral pour transcription augmentee |
| WO2025194042A1 (en) | 2024-03-14 | 2025-09-18 | Affinia Therapeutics Inc. | Plasmid system for production of recombinant adenoassociated virus |
| WO2025202929A1 (en) * | 2024-03-29 | 2025-10-02 | Pfizer Inc. | Methods for producing nucleic acids |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| AU649066B2 (en) | 1990-07-25 | 1994-05-12 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
| FR2675803B1 (fr) | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
| US6953676B1 (en) | 1992-05-01 | 2005-10-11 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
| WO1994003624A1 (en) | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
| US5714320A (en) | 1993-04-15 | 1998-02-03 | University Of Rochester | Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides |
| ATE208658T1 (de) | 1993-07-28 | 2001-11-15 | Pe Corp Ny | Vorrichtung und verfahren zur nukleinsäurevervielfältigung |
| FR2732971B1 (fr) | 1995-04-13 | 1997-07-04 | Genset Sa | Oligonucleotide sens inhibiteur de virus herpes simplex (hsv) a structure en haltere |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US6143495A (en) | 1995-11-21 | 2000-11-07 | Yale University | Unimolecular segment amplification and sequencing |
| DE19648625A1 (de) | 1996-11-13 | 1998-05-14 | Soft Gene Gmbh | Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer |
| JPH10234399A (ja) | 1997-02-28 | 1998-09-08 | Shinkinrui Kinou Kaihatsu Kenkyusho:Kk | ピシウム属菌検出用の核酸配列 |
| WO1999033559A1 (en) | 1997-12-24 | 1999-07-08 | Cepheid | Integrated fluid manipulation cartridge |
| US6124120A (en) | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
| US6054274A (en) * | 1997-11-12 | 2000-04-25 | Hewlett-Packard Company | Method of amplifying the signal of target nucleic acid sequence analyte |
| ATE346158T1 (de) | 1998-01-09 | 2006-12-15 | Univ Utah Res Found | Verfahren zur in vitro amplifikation zirkulärer dna |
| DE19826758C1 (de) | 1998-06-15 | 1999-10-21 | Soft Gene Gmbh | Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte |
| JP2002525049A (ja) | 1998-09-15 | 2002-08-13 | イェール ユニバーシティ | ローリングサークル増幅を用いる分子クローニング |
| ATE294857T1 (de) * | 1999-07-08 | 2005-05-15 | Mologen Forschungs Entwicklung | Impfstoff gegen infektionen mit lentiviren, wie dem felinen immunschwäche-virus der katze |
| EP1268856A2 (de) | 2000-04-07 | 2003-01-02 | Epigenomics AG | Detektion von snp's und cytosin-methylierungen |
| GB0018120D0 (en) | 2000-07-24 | 2000-09-13 | Fermentas Ab | Nuclease |
| US6977148B2 (en) | 2001-10-15 | 2005-12-20 | Qiagen Gmbh | Multiple displacement amplification |
| US20030077611A1 (en) | 2001-10-24 | 2003-04-24 | Sention | Methods and systems for dynamic gene expression profiling |
| US20030170693A1 (en) | 2001-12-21 | 2003-09-11 | George Chaconas | Assay for identifying modulators of Borrelia telomere resolvase |
| US7081339B2 (en) | 2002-04-12 | 2006-07-25 | Primera Biosystems, Inc. | Methods for variation detection |
| WO2004007684A2 (en) | 2002-07-12 | 2004-01-22 | Affymetrix, Inc. | Synthetic tag genes |
| US20040022764A1 (en) | 2002-07-31 | 2004-02-05 | Hanan Polansky | Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease |
| DE50304603D1 (de) * | 2002-09-23 | 2006-09-21 | Mologen Ag | Impfstoff gegen infektionen mit onkoviren, wie dem felinen leukosevirus der katze |
| US7955795B2 (en) | 2003-06-06 | 2011-06-07 | Qiagen Gmbh | Method of whole genome amplification with reduced artifact production |
| US7452699B2 (en) | 2003-01-15 | 2008-11-18 | Dana-Farber Cancer Institute, Inc. | Amplification of DNA in a hairpin structure, and applications |
| EP1594987B1 (en) | 2003-02-21 | 2009-05-27 | GeneForm Technologies Limited | Nucleic acid sequencing methods, kits and reagents |
| WO2005054435A2 (en) | 2003-11-26 | 2005-06-16 | Eppendorf Ag | Methods and compositions for in vitro amplification of extrachromosomal nucleic acid |
| EP1819828A2 (en) * | 2004-12-11 | 2007-08-22 | CytoGenix, Inc. | Cell free biosynthesis of high-quality nucleic acid and uses thereof |
| EP1871897B1 (en) | 2005-04-12 | 2010-09-29 | Olink AB | Methods for production of oligonucleotides |
| EP1885880B1 (en) | 2005-04-29 | 2010-07-21 | Synthetic Genomics, Inc. | Amplification and cloning of single dna molecules using rolling circle amplification |
| JP2009511019A (ja) | 2005-10-06 | 2009-03-19 | ルシジェン コーポレイション | 耐熱性ウィルス性ポリメラーゼ及びその使用法 |
| WO2007087478A2 (en) | 2006-01-12 | 2007-08-02 | Lucigen Corporation | Linear vectors, host cells and cloning methods |
| EP3527671A1 (en) | 2006-10-06 | 2019-08-21 | Applied DNA Sciences Inc. | System for a continuous rapid thermal cycle system |
| WO2008151023A2 (en) * | 2007-06-01 | 2008-12-11 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
| US8921072B2 (en) | 2008-09-02 | 2014-12-30 | General Electric Compnay | Methods to generate DNA mini-circles |
| GB201013153D0 (en) * | 2010-08-04 | 2010-09-22 | Touchlight Genetics Ltd | Primer for production of closed linear DNA |
| US9114399B2 (en) | 2010-08-31 | 2015-08-25 | Canon U.S. Life Sciences, Inc. | System and method for serial processing of multiple nucleic acid assays |
| EP2692870A1 (en) | 2012-08-03 | 2014-02-05 | Alacris Theranostics GmbH | Method for nucleic acid amplification |
| KR102014989B1 (ko) | 2013-04-15 | 2019-08-27 | 삼성전자주식회사 | 폴리뉴클레오티드 및 그의 용도 |
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2009
- 2009-01-30 GB GBGB0901593.4A patent/GB0901593D0/en not_active Ceased
-
2010
- 2010-02-01 AU AU2010209532A patent/AU2010209532B2/en active Active
- 2010-02-01 US US13/146,350 patent/US9109250B2/en active Active
- 2010-02-01 EP EP13152077.7A patent/EP2612925B1/en active Active
- 2010-02-01 CN CN201080006024.8A patent/CN102301010B/zh active Active
- 2010-02-01 MX MX2011007937A patent/MX2011007937A/es active IP Right Grant
- 2010-02-01 NZ NZ594004A patent/NZ594004A/xx unknown
- 2010-02-01 BR BRPI1005683-1A patent/BRPI1005683B1/pt active IP Right Grant
- 2010-02-01 CA CA2751130A patent/CA2751130C/en active Active
- 2010-02-01 WO PCT/GB2010/000165 patent/WO2010086626A1/en not_active Ceased
- 2010-02-01 CN CN201510314041.2A patent/CN104911177A/zh active Pending
- 2010-02-01 DK DK16195596.8T patent/DK3150722T3/da active
- 2010-02-01 SG SG2011053014A patent/SG173102A1/en unknown
- 2010-02-01 EP EP10702726A patent/EP2391731B1/en active Active
- 2010-02-01 LT LT16195596T patent/LT3150722T/lt unknown
- 2010-02-01 KR KR1020117018730A patent/KR101926662B1/ko active Active
- 2010-02-01 JP JP2011546955A patent/JP2012516147A/ja active Pending
- 2010-02-01 DK DK10702726.0T patent/DK2391731T3/da active
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- 2010-02-01 ES ES10702726T patent/ES2400890T3/es active Active
- 2010-02-01 EP EP16195596.8A patent/EP3150722B1/en not_active Revoked
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2011
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2015
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2019
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2022
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