JP2012515776A5 - - Google Patents
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- Publication number
- JP2012515776A5 JP2012515776A5 JP2011547997A JP2011547997A JP2012515776A5 JP 2012515776 A5 JP2012515776 A5 JP 2012515776A5 JP 2011547997 A JP2011547997 A JP 2011547997A JP 2011547997 A JP2011547997 A JP 2011547997A JP 2012515776 A5 JP2012515776 A5 JP 2012515776A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- salt according
- heteroaryl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- -1 -C = NH Chemical group 0.000 claims 1
- 206010027665 Immune disorder Diseases 0.000 claims 1
- 206010021425 Immune system disease Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatoms Chemical group 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14700209P | 2009-01-23 | 2009-01-23 | |
| US61/147,002 | 2009-01-23 | ||
| US15649609P | 2009-02-28 | 2009-02-28 | |
| US61/156,496 | 2009-02-28 | ||
| US25215609P | 2009-10-15 | 2009-10-15 | |
| US61/252,156 | 2009-10-15 | ||
| US25265209P | 2009-10-17 | 2009-10-17 | |
| US61/252,652 | 2009-10-17 | ||
| PCT/US2010/020373 WO2010085377A2 (en) | 2009-01-23 | 2010-01-07 | Hydroxamic acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012515776A JP2012515776A (ja) | 2012-07-12 |
| JP2012515776A5 true JP2012515776A5 (US20080242721A1-20081002-C00053.png) | 2013-02-21 |
| JP5576402B2 JP5576402B2 (ja) | 2014-08-20 |
Family
ID=42356377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011547997A Active JP5576402B2 (ja) | 2009-01-23 | 2010-01-07 | ヒドロキサム酸誘導体 |
Country Status (17)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5749017B2 (ja) | 2008-01-22 | 2015-07-15 | ダウ アグロサイエンシィズ エルエルシー | ５−フルオロピリミジン誘導体 |
| USRE46144E1 (en) * | 2009-01-23 | 2016-09-13 | Purdue Pharmaceutical Products L.P. | Hydroxamic acid derivatives |
| PT2462134E (pt) | 2009-08-07 | 2014-07-28 | Dow Agrosciences Llc | Derivados de n1-sulfonil-5-fluoropirimidinona |
| UA112284C2 (uk) | 2009-08-07 | 2016-08-25 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні 5-фторпіримідинону |
| UA106889C2 (uk) | 2009-08-07 | 2014-10-27 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні n1-ацил-5-фторпіримідинону |
| UA107671C2 (en) | 2009-08-07 | 2015-02-10 | Dow Agrosciences Llc | N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives |
| EP2521452B1 (en) | 2010-01-07 | 2014-12-24 | Dow AgroSciences LLC | THIAZOLO[5,4-d]PYRIMIDINES AND THEIR USE AS AGROCHEMICALS |
| CN101928234B (zh) * | 2010-01-15 | 2012-12-12 | 北京欧凯纳斯科技有限公司 | 6/7-（杂）芳基-n-羟基己/庚酰胺化合物及其制备方法 |
| WO2011113175A1 (zh) * | 2010-03-15 | 2011-09-22 | Gao Feng | 阿糖胞苷前药衍生物及其在抗癌抗肿瘤中的用途 |
| CN103313992B (zh) * | 2011-01-12 | 2016-04-27 | 天堃医药科技（杭州）有限公司 | 具有hdac抑制作用的喜树碱衍生物 |
| RU2613451C2 (ru) | 2011-08-17 | 2017-03-16 | Адама Мактешим Лтд. | Производные 5-фтор-4-имино-3-(замещенного)-3, 4-дигидропиримидин-2(1н)она, композиция на их основе и спсоб борьбы с грибковыми заболеваниями |
| CN102993102B (zh) * | 2011-09-16 | 2016-08-24 | 杭州民生药业有限公司 | [1-甲基-2-(7’-庚异羟肟酸基)-5-n，n-二(2’-氯乙基)]-1h-苯并咪唑的合成方法 |
| ES2911427T3 (es) * | 2011-09-18 | 2022-05-19 | Euro Celtique Sa | Composición farmacéutica que comprende un inhibidor HDAC y un ciclopolisacárido |
| CN102432654A (zh) * | 2011-09-26 | 2012-05-02 | 宋云龙 | 吉西他滨酰胺衍生物及其制备方法和用途 |
| TWI573792B (zh) | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
| CN102584737A (zh) * | 2012-02-07 | 2012-07-18 | 盛世泰科生物医药技术(苏州)有限公司 | 抑制组蛋白去乙酰酶的物质的组成和使用 |
| EP2725029A1 (en) * | 2012-10-29 | 2014-04-30 | Laboratoire Biodim | New antibacterial compounds and biological applications thereof |
| CN104994859B (zh) | 2012-12-28 | 2018-10-26 | 阿达玛马克西姆股份有限公司 | 1-(取代的苯甲酰基)-5-氟-4-亚氨基-3-甲基-3,4-二氢嘧啶-2(1h)-酮衍生物 |
| CA2893778A1 (en) | 2012-12-28 | 2014-07-03 | Dow Agrosciences Llc | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2h)-carboxylate derivatives |
| JP6258969B2 (ja) | 2012-12-28 | 2018-01-10 | アダマ・マクテシム・リミテッド | Ｎ−（置換）−５−フルオロ−４−イミノ−３−メチル−２−オキソ−３，４−ジヒドロピリミジン−１（２ｈ）−カルボキサミド誘導体 |
| AU2013370494B2 (en) | 2012-12-31 | 2017-08-17 | Adama Makhteshim Ltd. | 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1H)-one derivatives as fungicides |
| CN103340845B (zh) * | 2013-06-26 | 2015-03-18 | 浙江省食品药品检验研究院 | 药物组合物 |
| CN104693256B (zh) * | 2013-12-04 | 2018-07-10 | 杭州源昶医药科技有限公司 | 吉西他滨衍生物、含该衍生物的组合物及所述衍生物的制药用途 |
| CA2935601C (en) | 2013-12-31 | 2023-03-14 | Adama Makhteshim Ltd. | 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1h)-one and processes for their preparation |
| BR112016015158A2 (pt) | 2013-12-31 | 2017-08-08 | Adama Makhteshim Ltd | Misturas fungicidas sinergísticas para controle de fungos em cereais |
| WO2015117118A1 (en) | 2014-02-03 | 2015-08-06 | Halliburton Energy Services, Inc. | Geomechanical and geophysical computational model for oil and gas stimulation and production |
| GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409471D0 (en) * | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| AU2015338042A1 (en) * | 2014-10-28 | 2017-04-27 | Shionogi & Co., Ltd. | Heterocyclic derivative having AMPK activating effect |
| EP3297992B1 (en) | 2015-05-22 | 2020-02-05 | Chong Kun Dang Pharmaceutical Corp. | Heterocyclicalkyl derivative compounds as selective histone deacetylase inhibitors and pharmaceutical compositions comprising the same |
| US10434160B2 (en) | 2015-09-10 | 2019-10-08 | Becton, Dickinson And Company | Cyclophosphamide analogs for use as immunogens and assay conjugates for an immunoassay of cyclophosphamide and ifosfamide |
| AU2016426574B2 (en) * | 2016-10-11 | 2023-07-13 | Euro-Celtique S.A. | Hodgkin lymphoma therapy |
| CN106905191B (zh) * | 2017-03-05 | 2019-03-29 | 北京化工大学 | 一种含有羟肟酸基团的氮芥类化合物及其制备方法和用途 |
| CN106883217B (zh) * | 2017-04-01 | 2020-05-22 | 清华大学深圳研究生院 | 一种核苷碱基异羟肟酸衍生化合物及其制备方法与应用 |
| GB201709405D0 (en) * | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709403D0 (en) * | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| CA3071345A1 (en) * | 2017-07-28 | 2019-01-31 | Yale University | Anticancer drugs and methods of making and using same |
| EP3684944A4 (en) | 2017-09-21 | 2021-05-26 | Becton, Dickinson and Company | KIT FOR SAMPLING HAZARDOUS POLLUTANTS AND QUICK TEST |
| CN108299313B (zh) * | 2018-01-16 | 2020-10-02 | 长沙霍滋生物科技有限公司 | 一种化合物及其在药学上的应用 |
| CN109516957A (zh) * | 2018-08-03 | 2019-03-26 | 杭州梯诺医药科技有限公司 | Nl-101多晶型及其制备方法 |
| WO2020026054A1 (en) * | 2018-08-03 | 2020-02-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of cancer |
| JP7180923B2 (ja) * | 2018-09-01 | 2022-11-30 | ベイジン ショウバイ ファーマシューティカル カンパニー，リミティッド | 白金系化合物リン酸塩及びその製造方法 |
| EP3897626A1 (en) | 2018-12-18 | 2021-10-27 | Mundipharma International Corporation Limited | Compounds for treating multiple myeloma |
| CN212748381U (zh) | 2019-01-28 | 2021-03-19 | 贝克顿·迪金森公司 | 一种有害污染物检测系统和一种有害污染物收集装置 |
| CN112209884B (zh) * | 2019-07-12 | 2022-11-11 | 杭州梯诺医药科技有限公司 | 1-h苯并咪唑衍生物、制备方法及其应用 |
| CN113307829B (zh) * | 2021-05-08 | 2022-05-24 | 苏州科技大学 | 一种以异羟肟酸衍生物为配体的铂(ii)配合物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| JP2004509941A (ja) | 2000-09-29 | 2004-04-02 | プロリフィクス リミテッド | Ｈｄａｃインヒビターとしてのアミド結合を含むカルバミン酸化合物 |
| CN101010298A (zh) * | 2004-04-05 | 2007-08-01 | 默克Hdac研究有限责任公司 | 组蛋白脱乙酰酶抑制剂前药 |
| WO2007134169A2 (en) | 2006-05-10 | 2007-11-22 | Nuada, Llc | Indole, benzimidazole, and benzolactam boronic acid compounds, analogs thereof and methods of use thereof |
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| GB0621160D0 (en) | 2006-10-24 | 2006-12-06 | Imp College Innovations Ltd | Compounds and uses thereof |
| WO2009100045A1 (en) * | 2008-02-04 | 2009-08-13 | Translational Genomics Research Institute | Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives |
| USRE46144E1 (en) * | 2009-01-23 | 2016-09-13 | Purdue Pharmaceutical Products L.P. | Hydroxamic acid derivatives |
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2010
- 2010-01-07 US US14/972,750 patent/USRE46144E1/en active Active
- 2010-01-07 PT PT107337479T patent/PT2389375E/pt unknown
- 2010-01-07 ME MEP-2015-541A patent/ME02254B/me unknown
- 2010-01-07 WO PCT/US2010/020373 patent/WO2010085377A2/en active Application Filing
- 2010-01-07 CA CA2750413A patent/CA2750413C/en active Active
- 2010-01-07 PL PL10733747T patent/PL2389375T3/pl unknown
- 2010-01-07 SI SI201030986T patent/SI2389375T1/sl unknown
- 2010-01-07 JP JP2011547997A patent/JP5576402B2/ja active Active
- 2010-01-07 ES ES10733747.9T patent/ES2544803T3/es active Active
- 2010-01-07 DK DK10733747.9T patent/DK2389375T3/en active
- 2010-01-07 HU HUE10733747A patent/HUE025349T2/en unknown
- 2010-01-07 EP EP20100733747 patent/EP2389375B1/en active Active
- 2010-01-07 RS RS20150541A patent/RS54192B1/en unknown
- 2010-01-07 US US13/143,155 patent/US8609864B2/en not_active Ceased
- 2010-01-07 CN CN201080002890.XA patent/CN102186842B/zh active Active
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2013
- 2013-11-08 US US14/075,145 patent/US9096627B2/en active Active
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2015
- 2015-07-15 HR HRP20150778TT patent/HRP20150778T1/hr unknown
- 2015-08-13 SM SM201500196T patent/SMT201500196B/xx unknown
- 2015-08-13 CY CY20151100709T patent/CY1116602T1/el unknown
