JP2012515540A5 - - Google Patents
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- Publication number
- JP2012515540A5 JP2012515540A5 JP2011546813A JP2011546813A JP2012515540A5 JP 2012515540 A5 JP2012515540 A5 JP 2012515540A5 JP 2011546813 A JP2011546813 A JP 2011546813A JP 2011546813 A JP2011546813 A JP 2011546813A JP 2012515540 A5 JP2012515540 A5 JP 2012515540A5
- Authority
- JP
- Japan
- Prior art keywords
- replaced
- region
- nucleic acid
- heavy chain
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200900118 | 2009-01-26 | ||
| DKPA200900118 | 2009-01-26 | ||
| PCT/EP2010/050822 WO2010084197A1 (en) | 2009-01-26 | 2010-01-26 | Methods for producing mixtures of antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016052035A Division JP2016165285A (ja) | 2009-01-26 | 2016-03-16 | 抗体混合物を産生するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012515540A JP2012515540A (ja) | 2012-07-12 |
| JP2012515540A5 true JP2012515540A5 (enExample) | 2013-03-14 |
Family
ID=42060888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546813A Ceased JP2012515540A (ja) | 2009-01-26 | 2010-01-26 | 抗体混合物を産生するための方法 |
| JP2016052035A Pending JP2016165285A (ja) | 2009-01-26 | 2016-03-16 | 抗体混合物を産生するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016052035A Pending JP2016165285A (ja) | 2009-01-26 | 2016-03-16 | 抗体混合物を産生するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120020952A1 (enExample) |
| EP (1) | EP2389392A1 (enExample) |
| JP (2) | JP2012515540A (enExample) |
| CN (2) | CN104262483A (enExample) |
| SG (1) | SG172977A1 (enExample) |
| WO (1) | WO2010084197A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| EP2064325B1 (en) | 2006-09-01 | 2011-12-07 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| CA2745439C (en) * | 2008-12-03 | 2019-10-15 | Genmab A/S | Antibody variants having modifications in the constant region |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| CN101983968B (zh) * | 2010-09-26 | 2013-03-06 | 浙江海洋学院 | 乌贼墨寡肽的酶解制备方法 |
| JP5768147B2 (ja) | 2011-02-28 | 2015-08-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 一価抗原結合タンパク質 |
| WO2012116926A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Antigen binding proteins |
| JP6031735B2 (ja) * | 2011-06-13 | 2016-11-24 | ソニー株式会社 | 情報処理装置、情報処理方法およびコンピュータプログラム |
| WO2013157953A1 (en) | 2012-04-20 | 2013-10-24 | Merus B.V. | Methods and means for the production of ig-like molecules |
| CN102851338A (zh) | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | 利用电荷排斥作用制备同二聚体蛋白混合物的方法 |
| BR112015006824A2 (pt) | 2012-09-27 | 2017-07-04 | Merus B V | anticorpo igg biespecífico, método para produzir um anticorpo igg biespecífico, anticorpo, composição farmacêutica e uso de um anticorpo igg biespecífico |
| BR112016006929A2 (pt) | 2013-10-11 | 2017-09-19 | Hoffmann La Roche | Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo |
| TW201609805A (zh) | 2013-12-23 | 2016-03-16 | 美國禮來大藥廠 | 結合ｅｇｆｒ及ｍｅｔ之多功能抗體 |
| DK3805268T3 (da) | 2014-02-28 | 2025-01-20 | Merus Nv | Antistof, der binder erbb-2 og erbb-3 |
| CA2941030C (en) | 2014-02-28 | 2025-05-13 | Merus N.V. | ANTIBODIES THAT BIND TO EGFR AND ERBB3 |
| CR20160519A (es) | 2014-05-13 | 2017-01-27 | The Trustees Of The Univ Of Pennysylvania | Composiciones que comprenden avv que expresa constructos de anticuerpos duales y sus usos |
| CN110658340B (zh) * | 2015-01-08 | 2023-10-31 | 苏州康宁杰瑞生物科技有限公司 | 具有共同轻链的双特异性抗体或抗体混合物 |
| WO2017010874A1 (en) | 2015-07-10 | 2017-01-19 | Merus N.V. | Human cd3 binding antibody |
| JP7296728B2 (ja) | 2015-10-23 | 2023-06-23 | メルス ナムローゼ フェンノートシャップ | 癌の成長を抑制する結合分子 |
| CA3025162A1 (en) * | 2016-05-26 | 2017-11-30 | Qilu Puget Sound Biotherapeutics Corporation | Mixtures of antibodies |
| JP7737220B2 (ja) | 2017-03-31 | 2025-09-10 | メルス ナムローゼ フェンノートシャップ | ＮＲＧ１融合遺伝子を有する細胞の処置における使用のためのＥｒｂＢ－２及びＥｒｂＢ３結合二重特異性抗体 |
| EP3625264B9 (en) | 2017-05-17 | 2023-10-25 | Merus N.V. | Combination of an erbb-2/erbb-3 bispecific antibody with endocrine therapy for breast cancer |
| RS66708B9 (sr) | 2017-08-09 | 2025-08-29 | Merus Nv | Antitela koja se vezuju za egfr i cmet |
| EP4644413A1 (en) | 2024-05-03 | 2025-11-05 | Genmab B.V. | Binding agents having altered fc-mediated effector functions |
| WO2025228542A1 (en) | 2024-05-03 | 2025-11-06 | Genmab B.V. | Method for co-expression of a plurality of antibodies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003217912A1 (en) * | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| NZ537277A (en) * | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| AU2003284062A1 (en) * | 2002-10-09 | 2004-05-04 | Integrigen, Inc. | Recombinant catalytic polypeptides and their uses |
| WO2004106375A1 (en) * | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| CA2689895A1 (en) * | 2007-05-31 | 2008-12-04 | Genmab A/S | Non-glycosylated recombinant monovalent antibodies |
| EP3663318A1 (en) * | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
-
2010
- 2010-01-26 CN CN201410421605.8A patent/CN104262483A/zh active Pending
- 2010-01-26 SG SG2011050903A patent/SG172977A1/en unknown
- 2010-01-26 EP EP10701360A patent/EP2389392A1/en not_active Withdrawn
- 2010-01-26 US US13/146,297 patent/US20120020952A1/en not_active Abandoned
- 2010-01-26 WO PCT/EP2010/050822 patent/WO2010084197A1/en not_active Ceased
- 2010-01-26 CN CN2010800137659A patent/CN102365296A/zh active Pending
- 2010-01-26 JP JP2011546813A patent/JP2012515540A/ja not_active Ceased
-
2016
- 2016-03-16 JP JP2016052035A patent/JP2016165285A/ja active Pending
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