JP2012515353A5 - - Google Patents
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- JP2012515353A5 JP2012515353A5 JP2011546408A JP2011546408A JP2012515353A5 JP 2012515353 A5 JP2012515353 A5 JP 2012515353A5 JP 2011546408 A JP2011546408 A JP 2011546408A JP 2011546408 A JP2011546408 A JP 2011546408A JP 2012515353 A5 JP2012515353 A5 JP 2012515353A5
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- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 claims description 110
- 238000000034 method Methods 0.000 claims description 55
- 239000000710 homodimer Substances 0.000 claims description 32
- -1 Bc12 Proteins 0.000 claims description 24
- 201000011510 cancer Diseases 0.000 claims description 23
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- 239000000556 agonist Substances 0.000 claims description 19
- 239000012472 biological sample Substances 0.000 claims description 15
- 239000000523 sample Substances 0.000 claims description 14
- 239000000090 biomarker Substances 0.000 claims description 13
- 238000003556 assay Methods 0.000 claims description 8
- 239000000833 heterodimer Substances 0.000 claims description 5
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- 238000003745 diagnosis Methods 0.000 claims description 4
- 230000004850 protein–protein interaction Effects 0.000 claims description 4
- 102100032311 Aurora kinase A Human genes 0.000 claims description 3
- 101100220616 Caenorhabditis elegans chk-2 gene Proteins 0.000 claims description 3
- 102100021633 Cathepsin B Human genes 0.000 claims description 3
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- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims description 3
- 102000004328 Cytochrome P-450 CYP3A Human genes 0.000 claims description 3
- 102100022334 Dihydropyrimidine dehydrogenase [NADP(+)] Human genes 0.000 claims description 3
- 102100037024 E3 ubiquitin-protein ligase XIAP Human genes 0.000 claims description 3
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims description 3
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- 108010008599 Forkhead Box Protein M1 Proteins 0.000 claims description 3
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- 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 claims description 3
- 102100036534 Glutathione S-transferase Mu 1 Human genes 0.000 claims description 3
- 102100036528 Glutathione S-transferase Mu 3 Human genes 0.000 claims description 3
- 101000798300 Homo sapiens Aurora kinase A Proteins 0.000 claims description 3
- 101000971203 Homo sapiens Bcl-2-binding component 3, isoforms 1/2 Proteins 0.000 claims description 3
- 101000971209 Homo sapiens Bcl-2-binding component 3, isoforms 3/4 Proteins 0.000 claims description 3
- 101000898449 Homo sapiens Cathepsin B Proteins 0.000 claims description 3
- 101001081590 Homo sapiens DNA-binding protein inhibitor ID-1 Proteins 0.000 claims description 3
- 101000902632 Homo sapiens Dihydropyrimidine dehydrogenase [NADP(+)] Proteins 0.000 claims description 3
- 101001077852 Homo sapiens Epoxide hydrolase 1 Proteins 0.000 claims description 3
- 101000868643 Homo sapiens G2/mitotic-specific cyclin-B1 Proteins 0.000 claims description 3
- 101001071694 Homo sapiens Glutathione S-transferase Mu 1 Proteins 0.000 claims description 3
- 101001071716 Homo sapiens Glutathione S-transferase Mu 3 Proteins 0.000 claims description 3
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims description 3
- 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 claims description 3
- 101000624631 Homo sapiens M-phase inducer phosphatase 2 Proteins 0.000 claims description 3
- 101000979629 Homo sapiens Nucleoside diphosphate kinase A Proteins 0.000 claims description 3
- 101001051706 Homo sapiens Ribosomal protein S6 kinase beta-1 Proteins 0.000 claims description 3
- 101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 claims description 3
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims description 3
- 101000742596 Homo sapiens Vascular endothelial growth factor C Proteins 0.000 claims description 3
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims description 3
- 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 claims description 3
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- 108050008367 Transmembrane emp24 domain-containing protein 7 Proteins 0.000 claims description 3
- 102000008817 Trefoil Factor-1 Human genes 0.000 claims description 3
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- 102100038232 Vascular endothelial growth factor C Human genes 0.000 claims description 3
- 108700031544 X-Linked Inhibitor of Apoptosis Proteins 0.000 claims description 3
- 108010048626 Y-Box-Binding Protein 1 Proteins 0.000 claims description 3
- 102100022224 Y-box-binding protein 1 Human genes 0.000 claims description 3
- 101150113535 chek1 gene Proteins 0.000 claims description 3
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 2
- 238000004904 shortening Methods 0.000 claims description 2
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- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 3
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- 201000009030 Carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
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- 229960000575 trastuzumab Drugs 0.000 claims 2
- OONFNUWBHFSNBT-HXUWFJFHSA-N AEE788 Chemical compound C1CN(CC)CCN1CC1=CC=C(C=2NC3=NC=NC(N[C@H](C)C=4C=CC=CC=4)=C3C=2)C=C1 OONFNUWBHFSNBT-HXUWFJFHSA-N 0.000 claims 1
- 102100021572 Bcl-2-binding component 3, isoforms 1/2 Human genes 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 206010073069 Hepatic cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
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- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 1
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- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
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- 206010047741 Vulval cancer Diseases 0.000 claims 1
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- 238000000225 bioluminescence resonance energy transfer Methods 0.000 claims 1
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- 230000000875 corresponding effect Effects 0.000 claims 1
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- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
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- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 1
- 229960004891 lapatinib Drugs 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- JXLVPHOTGHZUCE-ZSIUJALASA-N methyl n-[4-[5-chloro-2-[(1s)-1-[[(e)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-3-morpholin-4-yl-3-oxopropyl]-1h-imidazol-4-yl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OC)=CC=C1C1=C(Cl)NC([C@H](CC(=O)N2CCOCC2)NC(=O)\C=C\C=2C(=CC=C(Cl)C=2)N2N=NN=C2)=N1 JXLVPHOTGHZUCE-ZSIUJALASA-N 0.000 claims 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
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- 201000005102 vulva cancer Diseases 0.000 claims 1
- 238000004393 prognosis Methods 0.000 description 6
- 102100021573 Bcl-2-binding component 3, isoforms 3/4 Human genes 0.000 description 2
- 206010055113 Breast cancer metastatic Diseases 0.000 description 2
- 102100033189 Diablo IAP-binding mitochondrial protein Human genes 0.000 description 2
- 101000871228 Homo sapiens Diablo IAP-binding mitochondrial protein Proteins 0.000 description 2
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 2
- 238000009098 adjuvant therapy Methods 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14502909P | 2009-01-15 | 2009-01-15 | |
| US61/145,029 | 2009-01-15 | ||
| PCT/US2010/021272 WO2010083463A1 (en) | 2009-01-15 | 2010-01-15 | Methods of determining patient response by measurement of her-2 expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014006601A Division JP5615986B2 (ja) | 2009-01-15 | 2014-01-17 | Ｈｅｒ−２発現の測定による患者の反応を判定する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012515353A JP2012515353A (ja) | 2012-07-05 |
| JP2012515353A5 true JP2012515353A5 (enExample) | 2013-03-07 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546408A Withdrawn JP2012515353A (ja) | 2009-01-15 | 2010-01-15 | Ｈｅｒ−２発現の測定による患者の反応を判定する方法 |
| JP2014006601A Active JP5615986B2 (ja) | 2009-01-15 | 2014-01-17 | Ｈｅｒ−２発現の測定による患者の反応を判定する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014006601A Active JP5615986B2 (ja) | 2009-01-15 | 2014-01-17 | Ｈｅｒ−２発現の測定による患者の反応を判定する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20100233732A1 (enExample) |
| EP (1) | EP2387717B1 (enExample) |
| JP (2) | JP2012515353A (enExample) |
| KR (1) | KR20110120890A (enExample) |
| CN (1) | CN102439452B (enExample) |
| AU (1) | AU2010204576A1 (enExample) |
| BR (1) | BRPI1007048A2 (enExample) |
| CA (1) | CA2749817A1 (enExample) |
| ES (1) | ES2526519T3 (enExample) |
| IL (1) | IL214067A0 (enExample) |
| SG (1) | SG172984A1 (enExample) |
| WO (1) | WO2010083463A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040229294A1 (en) | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| US20040091850A1 (en) * | 2002-11-08 | 2004-05-13 | Travis Boone | Single cell analysis of membrane molecules |
| US7402398B2 (en) | 2003-07-17 | 2008-07-22 | Monogram Biosciences, Inc. | Measuring receptor homodimerization |
| US8357277B2 (en) | 2007-11-27 | 2013-01-22 | Laboratory Corp. of America Holdings | Enhanced method for detecting and/or quantifying an analyte in a sample |
| US10416162B2 (en) * | 2007-12-20 | 2019-09-17 | Monogram Biosciences, Inc. | Her2 diagnostic methods |
| US11401344B2 (en) | 2008-12-01 | 2022-08-02 | Laboratory Corporation Of America Holdings | Methods for determining the likelihood of survival and for predicting likelihood of metastasis in cancer patients |
| WO2010065568A2 (en) | 2008-12-01 | 2010-06-10 | Laboratory Corporation Of America Holdings | METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95 |
| SG172983A1 (en) | 2009-01-15 | 2011-08-29 | Lab Corp America Holdings | Methods of determining patient response by measurement of her-3 |
| MX338883B (es) | 2010-07-27 | 2016-05-04 | Genomic Health Inc | Metodo para usar expresion de gen para determinar el pronostico de cancer de prostata. |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| ES2615265T3 (es) | 2011-05-19 | 2017-06-06 | Laboratory Corporation Of America Holdings | Métodos para determinar la probabilidad de supervivencia y para predecir la probabilidad de metástasis en el cáncer |
| FR2993668B1 (fr) * | 2012-07-17 | 2015-07-03 | Cisbio Bioassays | Methode theranostique basee sur la detection de dimeres her2-her2 |
| EP2981828A1 (en) * | 2013-04-05 | 2016-02-10 | Laboratory Corporation of America Holdings | Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation |
| AU2015352625B2 (en) | 2014-11-25 | 2019-07-25 | Ventana Medical Systems, Inc. | Proximity assays using chemical ligation and hapten transfer |
| US20180209981A1 (en) * | 2015-07-23 | 2018-07-26 | National University Of Singapore | Wbp2 as a co-prognostic factor with her2 for stratification of patients for treatment |
| CA3016914C (en) | 2016-03-15 | 2019-08-27 | Laboratory Corporation Of America Holdings | Methods of assessing protein interactions between cells |
| WO2018060301A1 (en) | 2016-09-30 | 2018-04-05 | F. Hoffmann-La Roche Ag | Bispecific antibodies against cd3 |
| JP6922444B2 (ja) * | 2016-11-11 | 2021-08-18 | コニカミノルタ株式会社 | 蛍光ナノ粒子を用いた、病理学的完全奏効（ｐＣＲ）の予測を支援するための検査支援方法 |
| US20210239702A1 (en) * | 2018-06-14 | 2021-08-05 | Memorial Sloan Kettering Cancer Center | Methods for predicting responsiveness of lung cancer patients to her2-targeting therapies |
| KR102317202B1 (ko) * | 2018-10-19 | 2021-10-25 | 주식회사 프로티나 | 유방암 재발 예측 방법 |
| KR20230134232A (ko) | 2022-03-14 | 2023-09-21 | 부산대학교 산학협력단 | 백금계 항암제에 대한 난소암 환자의 약물 반응성 예측용 다중 바이오마커 조성물 및 이를 이용한 진단방법 |
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-
2010
- 2010-01-15 EP EP10732178.8A patent/EP2387717B1/en not_active Revoked
- 2010-01-15 KR KR1020117018898A patent/KR20110120890A/ko not_active Withdrawn
- 2010-01-15 US US12/688,766 patent/US20100233732A1/en not_active Abandoned
- 2010-01-15 BR BRPI1007048A patent/BRPI1007048A2/pt not_active Application Discontinuation
- 2010-01-15 JP JP2011546408A patent/JP2012515353A/ja not_active Withdrawn
- 2010-01-15 SG SG2011051000A patent/SG172984A1/en unknown
- 2010-01-15 CN CN201080009544.4A patent/CN102439452B/zh not_active Expired - Fee Related
- 2010-01-15 CA CA2749817A patent/CA2749817A1/en not_active Abandoned
- 2010-01-15 WO PCT/US2010/021272 patent/WO2010083463A1/en not_active Ceased
- 2010-01-15 ES ES10732178.8T patent/ES2526519T3/es active Active
- 2010-01-15 AU AU2010204576A patent/AU2010204576A1/en not_active Abandoned
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2011
- 2011-07-13 IL IL214067A patent/IL214067A0/en unknown
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2014
- 2014-01-17 JP JP2014006601A patent/JP5615986B2/ja active Active
- 2014-07-02 US US14/322,317 patent/US20140370523A1/en not_active Abandoned
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2016
- 2016-06-15 US US15/183,151 patent/US20170082626A1/en not_active Abandoned
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