JP2012514630A5 - - Google Patents
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- Publication number
- JP2012514630A5 JP2012514630A5 JP2011544937A JP2011544937A JP2012514630A5 JP 2012514630 A5 JP2012514630 A5 JP 2012514630A5 JP 2011544937 A JP2011544937 A JP 2011544937A JP 2011544937 A JP2011544937 A JP 2011544937A JP 2012514630 A5 JP2012514630 A5 JP 2012514630A5
- Authority
- JP
- Japan
- Prior art keywords
- acetyl
- carbonitrile
- methyl
- pyrrolidine
- trimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC1(C)[C@@](C)(*)CC[C@@]1Cc1n[o]c(C(F)(F)F)n1 Chemical compound CC1(C)[C@@](C)(*)CC[C@@]1Cc1n[o]c(C(F)(F)F)n1 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN65CH2009 | 2009-01-09 | ||
| IN65/CHE/2009 | 2009-01-09 | ||
| PCT/IB2010/000008 WO2010079413A2 (en) | 2009-01-09 | 2010-01-07 | Dipeptidyl peptidase iv inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015024634A Division JP5775235B2 (ja) | 2009-01-09 | 2015-02-10 | ジペプチジルペプチダーゼｉｖ阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012514630A JP2012514630A (ja) | 2012-06-28 |
| JP2012514630A5 true JP2012514630A5 (enExample) | 2013-02-21 |
Family
ID=42316906
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011544937A Withdrawn JP2012514630A (ja) | 2009-01-09 | 2010-01-07 | ジペプチジルペプチダーゼｉｖ阻害剤 |
| JP2015024634A Expired - Fee Related JP5775235B2 (ja) | 2009-01-09 | 2015-02-10 | ジペプチジルペプチダーゼｉｖ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015024634A Expired - Fee Related JP5775235B2 (ja) | 2009-01-09 | 2015-02-10 | ジペプチジルペプチダーゼｉｖ阻害剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8466145B2 (enExample) |
| EP (1) | EP2376447B1 (enExample) |
| JP (2) | JP2012514630A (enExample) |
| KR (1) | KR101750420B1 (enExample) |
| CN (2) | CN102272099A (enExample) |
| AU (1) | AU2010204144B2 (enExample) |
| BR (1) | BRPI1006970A2 (enExample) |
| CA (1) | CA2749301C (enExample) |
| ES (1) | ES2653563T3 (enExample) |
| HU (1) | HUE035693T2 (enExample) |
| IL (1) | IL213105A (enExample) |
| MX (1) | MX2011007340A (enExample) |
| NZ (1) | NZ593361A (enExample) |
| PL (1) | PL2376447T3 (enExample) |
| PT (1) | PT2376447T (enExample) |
| SG (1) | SG172924A1 (enExample) |
| WO (1) | WO2010079413A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2653563T3 (es) * | 2009-01-09 | 2018-02-07 | Orchid Pharma Limited | Inhibidores de la dipeptidil peptidasas IV |
| CN103787960A (zh) * | 2014-02-27 | 2014-05-14 | 江苏省激素研究所股份有限公司 | 一种2-氯-5-三氯甲基吡啶的合成方法 |
| CN104496876A (zh) * | 2015-01-13 | 2015-04-08 | 佛山市赛维斯医药科技有限公司 | 一种羟基金刚烷酰胺衍生物、其制备方法和用途 |
| CN105596333A (zh) * | 2016-02-02 | 2016-05-25 | 白强 | 一种防治糖尿病及其并发症的药物组合物及其应用 |
| CN108707143B (zh) * | 2018-06-26 | 2020-06-26 | 中昱医学检验(广州)有限公司 | 一种dpp-4抑制剂及其制备和在糖尿病中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1567902A (en) * | 1975-10-15 | 1980-05-21 | Glaxo Lab Ltd | 1-aminoalkyl-7,7-dimethylnorbornanes |
| DE2659052A1 (de) * | 1976-12-27 | 1978-07-06 | Nattermann A & Cie | N-substituierte 1,2,2-trimethyl-3- carbamoyl-cyclopentan-carbonsaeuren(1) und deren physiologisch vertraegliche salze |
| DE3402623A1 (de) * | 1984-01-26 | 1985-08-01 | Bayer Ag, 5090 Leverkusen | Neue diisocyanate und ihre verwendung zur herstellung von polyurethankunststoffen |
| IT1201489B (it) * | 1985-11-13 | 1989-02-02 | Chiesi Farma Spa | Derivati di tiazolidina,loro procedimento di preparazione e formulazioni farmaceutiche |
| TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| PT991619E (pt) * | 1997-06-23 | 2004-02-27 | Upjohn Co | Inibidores da adesao celular mediada pela alfa4beta1 |
| CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
| US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
| TWI243162B (en) | 2000-11-10 | 2005-11-11 | Taisho Pharmaceutical Co Ltd | Cyanopyrrolidine derivatives |
| US7183290B2 (en) | 2001-06-27 | 2007-02-27 | Smithkline Beecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
| UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| ATE373660T1 (de) | 2002-03-25 | 2007-10-15 | Merck & Co Inc | Heterocyclische beta-aminoverbindungen als inhibitoren der dipeptidylpeptidase zur behandlung bzw. prävention von diabetes |
| CA2512546A1 (en) | 2003-01-17 | 2004-08-05 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| TW200519105A (en) * | 2003-10-20 | 2005-06-16 | Lg Life Science Ltd | Novel inhibitors of DPP-IV, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent |
| WO2005075426A1 (en) * | 2004-02-03 | 2005-08-18 | Glenmark Pharmaceuticals Ltd. | Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof |
| CN101684089A (zh) * | 2004-02-05 | 2010-03-31 | 杏林制药株式会社 | 双环酯类衍生物 |
| KR20060124712A (ko) | 2004-02-20 | 2006-12-05 | 노파르티스 아게 | 신경퇴행 및 인지 장애를 치료하기 위한 ｄｐｐ ⅳ 억제제 |
| WO2005095339A1 (en) | 2004-03-31 | 2005-10-13 | Pfizer Products Inc. | Dicyanopyrrolidines as dipeptidyl peptidase iv inhibitors |
| AU2005267093B2 (en) * | 2004-07-23 | 2009-10-01 | Nuada Llc | Peptidase inhibitors |
| WO2006011035A1 (en) * | 2004-07-23 | 2006-02-02 | Glenmark Pharmaceuticals Ltd. | Novel dipeptidyl peptidase iv inhibitors; process for their preparation and compositions containing them |
| WO2006012441A1 (en) | 2004-07-23 | 2006-02-02 | Susan Marie Royalty | Peptidase inhibitors |
| NZ554515A (en) * | 2004-10-12 | 2009-12-24 | Glenmark Pharmaceuticals Sa | Novel dipeptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and process for their preparation |
| EP2004601B1 (en) | 2006-04-03 | 2011-03-02 | Matrix Laboratories Limited | Novel dipeptidyl peptidase iv inhibitors and processes for their preparation and pharmaceutical compositions containing them |
| JP2009190971A (ja) * | 2006-06-06 | 2009-08-27 | Mitsubishi Tanabe Pharma Corp | ２−シアノピロリジン誘導体 |
| EP2035395A2 (en) * | 2006-06-27 | 2009-03-18 | Glenmark Pharmaceuticals S.A. | Novel processes for the preparation of dpp iv inhibitors |
| EP2123636B1 (en) * | 2007-03-22 | 2012-03-21 | Kyorin Pharmaceutical Co., Ltd. | Method for producing aminoacetylpyrrolidinecarbonitrile derivative |
| ES2653563T3 (es) * | 2009-01-09 | 2018-02-07 | Orchid Pharma Limited | Inhibidores de la dipeptidil peptidasas IV |
-
2010
- 2010-01-07 ES ES10729125.4T patent/ES2653563T3/es active Active
- 2010-01-07 HU HUE10729125A patent/HUE035693T2/hu unknown
- 2010-01-07 CA CA2749301A patent/CA2749301C/en not_active Expired - Fee Related
- 2010-01-07 CN CN2010800038403A patent/CN102272099A/zh active Pending
- 2010-01-07 JP JP2011544937A patent/JP2012514630A/ja not_active Withdrawn
- 2010-01-07 US US13/140,997 patent/US8466145B2/en not_active Expired - Fee Related
- 2010-01-07 AU AU2010204144A patent/AU2010204144B2/en not_active Ceased
- 2010-01-07 MX MX2011007340A patent/MX2011007340A/es active IP Right Grant
- 2010-01-07 SG SG2011050085A patent/SG172924A1/en unknown
- 2010-01-07 CN CN201510549976.9A patent/CN105384726A/zh active Pending
- 2010-01-07 BR BRPI1006970A patent/BRPI1006970A2/pt not_active Application Discontinuation
- 2010-01-07 KR KR1020117016632A patent/KR101750420B1/ko not_active Expired - Fee Related
- 2010-01-07 WO PCT/IB2010/000008 patent/WO2010079413A2/en not_active Ceased
- 2010-01-07 NZ NZ593361A patent/NZ593361A/xx not_active IP Right Cessation
- 2010-01-07 PT PT107291254T patent/PT2376447T/pt unknown
- 2010-01-07 PL PL10729125T patent/PL2376447T3/pl unknown
- 2010-01-07 EP EP10729125.4A patent/EP2376447B1/en not_active Not-in-force
-
2011
- 2011-05-24 IL IL213105A patent/IL213105A/en not_active IP Right Cessation
-
2015
- 2015-02-10 JP JP2015024634A patent/JP5775235B2/ja not_active Expired - Fee Related
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