JP2012513471A5 - - Google Patents

Info

Publication number

JP2012513471A5

JP2012513471A5 JP2011543615A JP2011543615A JP2012513471A5 JP 2012513471 A5 JP2012513471 A5 JP 2012513471A5 JP 2011543615 A JP2011543615 A JP 2011543615A JP 2011543615 A JP2011543615 A JP 2011543615A JP 2012513471 A5 JP2012513471 A5 JP 2012513471A5

Authority

JP

Japan

Prior art keywords

compound

pharmaceutically acceptable

acceptable salt

item

composition

Prior art date

2009-12-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims description 299
• 150000003839 salts Chemical class 0.000 claims description 183
• 230000004770 neurodegeneration Effects 0.000 claims description 128
• 208000015122 neurodegenerative disease Diseases 0.000 claims description 128
• 125000000217 alkyl group Chemical group 0.000 claims description 102
• 206010028980 Neoplasm Diseases 0.000 claims description 84
• 201000011510 cancer Diseases 0.000 claims description 84
• -1 cyano, amino, hydroxy Chemical group 0.000 claims description 68
• 125000005843 halogen group Chemical group 0.000 claims description 63
• 125000003545 alkoxy group Chemical group 0.000 claims description 51
• 208000024827 Alzheimer disease Diseases 0.000 claims description 44
• 239000003937 drug carrier Substances 0.000 claims description 36
• 239000003981 vehicle Substances 0.000 claims description 36
• 125000004953 trihalomethyl group Chemical group 0.000 claims description 28
• 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims description 25
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 22
• 125000004450 alkenylene group Chemical group 0.000 claims description 19
• 125000002947 alkylene group Chemical group 0.000 claims description 19
• 125000001153 fluoro group Chemical group F* 0.000 claims description 14
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
• 208000024891 symptom Diseases 0.000 claims description 4
• 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
• 125000002346 iodo group Chemical group I* 0.000 claims description 3
• SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 3
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
• 238000000034 method Methods 0.000 description 142
• 230000002265 prevention Effects 0.000 description 47
• 229910052760 oxygen Inorganic materials 0.000 description 31
• 229910052717 sulfur Inorganic materials 0.000 description 29
• 229910052736 halogen Inorganic materials 0.000 description 6
• 150000002367 halogens Chemical class 0.000 description 6
• 125000003342 alkenyl group Chemical group 0.000 description 5
• 125000000753 cycloalkyl group Chemical group 0.000 description 4
• 0 *=C1OC2=CC=CCC2C(O)=C1C(C=Cc(cc1F)cc(F)c1F)C(C(Oc1ccccc11)=*)=C1O Chemical compound *=C1OC2=CC=CCC2C(O)=C1C(C=Cc(cc1F)cc(F)c1F)C(C(Oc1ccccc11)=*)=C1O 0.000 description 3
• 229910052739 hydrogen Inorganic materials 0.000 description 2
• 239000001257 hydrogen Substances 0.000 description 2
• PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• RJGXYXAPGWLDLL-UHFFFAOYSA-N OC(c1ccccc1O1)=C(C(Cc2cc(F)cc(F)c2)=O)C1=O Chemical compound OC(c1ccccc1O1)=C(C(Cc2cc(F)cc(F)c2)=O)C1=O RJGXYXAPGWLDLL-UHFFFAOYSA-N 0.000 description 1
• XEXPFPFJCOWETQ-UHFFFAOYSA-N OC(c1ccccc1O1)=C(C(c2cc(F)cc(F)c2)C(C(Oc2ccccc22)=O)=C2O)C1=O Chemical compound OC(c1ccccc1O1)=C(C(c2cc(F)cc(F)c2)C(C(Oc2ccccc22)=O)=C2O)C1=O XEXPFPFJCOWETQ-UHFFFAOYSA-N 0.000 description 1
• 150000002431 hydrogen Chemical class 0.000 description 1