JP2012512262A5 - - Google Patents
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- Publication number
- JP2012512262A5 JP2012512262A5 JP2011542458A JP2011542458A JP2012512262A5 JP 2012512262 A5 JP2012512262 A5 JP 2012512262A5 JP 2011542458 A JP2011542458 A JP 2011542458A JP 2011542458 A JP2011542458 A JP 2011542458A JP 2012512262 A5 JP2012512262 A5 JP 2012512262A5
- Authority
- JP
- Japan
- Prior art keywords
- species
- aminomethyl
- benzo
- propoxy
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 5
- 125000001137 3-hydroxypropoxy group Chemical group [H]OC([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 4
- 206010035664 Pneumonia Diseases 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 4
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 238000002424 x-ray crystallography Methods 0.000 claims 3
- FXQIIDINBDJDKL-UHFFFAOYSA-N 3-[[3-(aminomethyl)-1-hydroxy-3h-2,1-benzoxaborol-7-yl]oxy]propan-1-ol Chemical compound C1=CC=C(OCCCO)C2=C1C(CN)OB2O FXQIIDINBDJDKL-UHFFFAOYSA-N 0.000 claims 2
- 208000031729 Bacteremia Diseases 0.000 claims 2
- 241000606161 Chlamydia Species 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 208000037386 Typhoid Diseases 0.000 claims 2
- 206010014665 endocarditis Diseases 0.000 claims 2
- 238000001704 evaporation Methods 0.000 claims 2
- 230000008020 evaporation Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000001953 recrystallisation Methods 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 201000008297 typhoid fever Diseases 0.000 claims 2
- 206010053555 Arthritis bacterial Diseases 0.000 claims 1
- 241000606125 Bacteroides Species 0.000 claims 1
- 241000588807 Bordetella Species 0.000 claims 1
- 241000589562 Brucella Species 0.000 claims 1
- 206010006500 Brucellosis Diseases 0.000 claims 1
- 241000589876 Campylobacter Species 0.000 claims 1
- 206010008631 Cholera Diseases 0.000 claims 1
- 206010061788 Corneal infection Diseases 0.000 claims 1
- 206010011409 Cross infection Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 241000588914 Enterobacter Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 208000002633 Febrile Neutropenia Diseases 0.000 claims 1
- 206010016936 Folliculitis Diseases 0.000 claims 1
- 241000589601 Francisella Species 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 208000005577 Gastroenteritis Diseases 0.000 claims 1
- 206010018612 Gonorrhoea Diseases 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 208000004575 Infectious Arthritis Diseases 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000589248 Legionella Species 0.000 claims 1
- 208000007764 Legionnaires' Disease Diseases 0.000 claims 1
- 208000016604 Lyme disease Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 206010029803 Nosocomial infection Diseases 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000005141 Otitis Diseases 0.000 claims 1
- 241000606860 Pasteurella Species 0.000 claims 1
- 206010058674 Pelvic Infection Diseases 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- 206010035148 Plague Diseases 0.000 claims 1
- 206010054161 Pontiac fever Diseases 0.000 claims 1
- 241000588769 Proteus <enterobacteria> Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 206010037596 Pyelonephritis Diseases 0.000 claims 1
- 238000001069 Raman spectroscopy Methods 0.000 claims 1
- 241000606701 Rickettsia Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000607768 Shigella Species 0.000 claims 1
- 206010044314 Tracheobronchitis Diseases 0.000 claims 1
- 208000034784 Tularaemia Diseases 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 201000008100 Vaginitis Diseases 0.000 claims 1
- 241000607598 Vibrio Species 0.000 claims 1
- 206010048038 Wound infection Diseases 0.000 claims 1
- 241000607734 Yersinia <bacteria> Species 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 208000023652 chronic gastritis Diseases 0.000 claims 1
- 208000019258 ear infection Diseases 0.000 claims 1
- 208000028104 epidemic louse-borne typhus Diseases 0.000 claims 1
- 208000001606 epiglottitis Diseases 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 210000004907 gland Anatomy 0.000 claims 1
- 208000001786 gonorrhea Diseases 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 230000001617 migratory effect Effects 0.000 claims 1
- 206010033072 otitis externa Diseases 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000001223 septic arthritis Diseases 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 230000009747 swallowing Effects 0.000 claims 1
- 208000006379 syphilis Diseases 0.000 claims 1
- 206010061393 typhus Diseases 0.000 claims 1
- 208000000143 urethritis Diseases 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13849008P | 2008-12-17 | 2008-12-17 | |
| US61/138,490 | 2008-12-17 | ||
| PCT/US2009/068609 WO2010080558A1 (en) | 2008-12-17 | 2009-12-17 | Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012512262A JP2012512262A (ja) | 2012-05-31 |
| JP2012512262A5 true JP2012512262A5 (cg-RX-API-DMAC7.html) | 2012-12-27 |
Family
ID=42316734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542458A Pending JP2012512262A (ja) | 2008-12-17 | 2009-12-17 | （ｓ）−３−アミノメチル−７−（３−ヒドロキシ−プロポキシ）−３ｈ−ベンゾ［ｃ］［１，２］オキサボロール−１−オールの多形体 |
Country Status (18)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1976536A4 (en) | 2005-12-30 | 2011-03-02 | Anacor Pharmaceuticals Inc | SMALL MOLECULES CONTAINING BORON |
| KR20150013941A (ko) | 2006-02-16 | 2015-02-05 | 아나코르 파마슈티칼스 인코포레이티드 | 항염증제로서 보론함유 소분자 |
| US8716478B2 (en) | 2010-01-27 | 2014-05-06 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| CN103180328B (zh) * | 2010-08-10 | 2016-10-26 | 莱姆派克斯制药公司 | 环硼酸酯衍生物及其治疗用途 |
| CA2810021C (en) * | 2010-09-07 | 2018-05-29 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| JP6031122B2 (ja) * | 2011-12-22 | 2016-11-24 | ミクウルク ファーマシューティカルズ，インコーポレイテッド | 抗微生物療法のための三環式ホウ素化合物 |
| PL2950644T3 (pl) | 2013-01-30 | 2017-10-31 | Agrofresh Inc | Stosowanie benzoksaboroli jako lotnych środków przeciwbakteryjnych na mięsach, roślinach lub częściach roślinnych |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US8669207B1 (en) | 2013-01-30 | 2014-03-11 | Dow Agrosciences, Llc. | Compounds and compositions |
| WO2014121124A1 (en) | 2013-02-01 | 2014-08-07 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| CA2919888C (en) | 2013-08-09 | 2022-10-18 | Anacor Pharmaceuticals, Inc. | Tricyclic benzoxaborole compounds and uses thereof |
| TW201625649A (zh) | 2014-07-01 | 2016-07-16 | 第一三共股份有限公司 | 作爲抗菌劑的三環化合物 |
| MA41494B1 (fr) | 2015-02-12 | 2020-10-28 | Glaxosmithkline Ip No 2 Ltd | Composés benzoxaborole substitués en position 4 et utilisations associées |
| TW201735792A (zh) | 2016-03-07 | 2017-10-16 | 農業保鮮股份有限公司 | 使用苯并氧雜硼雜環戊烯化合物和防腐氣體作為作物的抗微生物劑之協同方法 |
| EP3609504A4 (en) | 2017-03-01 | 2021-03-03 | Anacor Pharmaceuticals, Inc. | NEW OXABOROLE ANALOGUES AND USES OF THE LATEST |
| WO2022043936A1 (en) | 2020-08-31 | 2022-03-03 | Pfizer Inc. | Methods of protecting rna |
| US12228578B2 (en) | 2020-12-17 | 2025-02-18 | Idexx Laboratories, Inc. | Rocky mountain spotted fever detection and treatment |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2260336A (en) | 1939-10-16 | 1941-10-28 | Dow Chemical Co | Method of preparation of organic borates |
| GB1396904A (en) | 1972-08-11 | 1975-06-11 | Ici Ltd | Method for the control of micro-organisms |
| US4766113A (en) | 1975-10-24 | 1988-08-23 | Chapman Chemical Company | Antimicrobial compositions and methods of using same |
| US4602011A (en) | 1975-10-24 | 1986-07-22 | Chapman Chemical Company | Antimicrobial compositions and methods of using same |
| US4716035A (en) | 1985-05-24 | 1987-12-29 | The Procter & Gamble Company | Oral compositions and methods for treating gingivitis |
| US5962498A (en) | 1986-06-11 | 1999-10-05 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity |
| US4894220A (en) | 1987-01-30 | 1990-01-16 | Colgate-Palmolive Company | Antibacterial antiplaque oral composition |
| SG47101A1 (en) | 1992-07-31 | 1998-03-20 | Us Bioscience | Crystalline amifostine compositions and methods for the preparation and use of same |
| US5348948A (en) | 1993-05-07 | 1994-09-20 | American Cyanamid Company | 2,2-diaryl-1-(oxa and thia)-2a-azonia-2-borataacenaphthene fungicidal |
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| GB9411587D0 (en) * | 1994-06-09 | 1994-08-03 | Zeneca Ltd | Compound, composition and use |
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| GB9604926D0 (en) | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
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| EP1155698A4 (en) | 1999-01-29 | 2003-01-15 | Nitto Kasei Co Ltd | ORGANOBORAL COMPOUNDS HAVING COCCIDIOSTAT ACTIVITY |
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| WO2006062731A1 (en) | 2004-11-19 | 2006-06-15 | University Of North Texas Health Science Center At Fort Worth | Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye |
| GB0501944D0 (en) | 2005-01-31 | 2005-03-09 | Univ Cambridge Tech | Compounds for use in chemical detection and/or quantitation |
| KR101337045B1 (ko) | 2005-02-16 | 2013-12-05 | 아나코르 파마슈티칼스 인코포레이티드 | 보론함유 소분자 |
| US20060251689A1 (en) | 2005-03-30 | 2006-11-09 | Astion Development A/S | Treatment or prevention of pruritus |
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| EP1976536A4 (en) | 2005-12-30 | 2011-03-02 | Anacor Pharmaceuticals Inc | SMALL MOLECULES CONTAINING BORON |
| KR20150013941A (ko) | 2006-02-16 | 2015-02-05 | 아나코르 파마슈티칼스 인코포레이티드 | 항염증제로서 보론함유 소분자 |
| RU2008152367A (ru) | 2006-06-12 | 2010-07-20 | Анакор Фармасьютикалз, Инк. (Us) | Соединения для лечения периодонтального заболевания |
| US20070286822A1 (en) | 2006-06-12 | 2007-12-13 | Anacor Pharmaceuticals Inc. | Compounds for the Treatment of Periodontal Disease |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| KR100895300B1 (ko) | 2007-07-20 | 2009-05-07 | 한국전자통신연구원 | 생체신호 측정의복과 생체신호 처리시스템 |
| WO2009111676A2 (en) | 2008-03-06 | 2009-09-11 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules as anti-inflammatory agents |
| WO2009140309A2 (en) | 2008-05-12 | 2009-11-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US8461336B2 (en) | 2008-09-04 | 2013-06-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| WO2010045503A1 (en) | 2008-10-15 | 2010-04-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
| WO2010045505A1 (en) | 2008-10-15 | 2010-04-22 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules as anti-protozoal agents |
-
2009
- 2009-12-17 CA CA2744231A patent/CA2744231A1/en not_active Abandoned
- 2009-12-17 EP EP09837955A patent/EP2378886A4/en not_active Withdrawn
- 2009-12-17 AU AU2009335744A patent/AU2009335744A1/en not_active Abandoned
- 2009-12-17 US US12/641,318 patent/US8461364B2/en not_active Expired - Fee Related
- 2009-12-17 PE PE2011001246A patent/PE20120052A1/es not_active Application Discontinuation
- 2009-12-17 EA EA201190034A patent/EA201190034A1/ru unknown
- 2009-12-17 KR KR1020117016565A patent/KR20110111407A/ko not_active Withdrawn
- 2009-12-17 WO PCT/US2009/068609 patent/WO2010080558A1/en not_active Ceased
- 2009-12-17 BR BRPI0922566A patent/BRPI0922566A2/pt not_active IP Right Cessation
- 2009-12-17 CN CN2009801506662A patent/CN102256494A/zh active Pending
- 2009-12-17 SG SG2011041894A patent/SG172040A1/en unknown
- 2009-12-17 JP JP2011542458A patent/JP2012512262A/ja active Pending
- 2009-12-17 MX MX2011006334A patent/MX2011006334A/es not_active Application Discontinuation
- 2009-12-17 MA MA34028A patent/MA32977B1/fr unknown
-
2011
- 2011-05-23 IL IL213060A patent/IL213060A0/en unknown
- 2011-06-09 CO CO11071901A patent/CO6390029A2/es not_active Application Discontinuation
- 2011-06-13 DO DO2011000183A patent/DOP2011000183A/es unknown
- 2011-06-23 CR CR20110357A patent/CR20110357A/es unknown
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