JP2012511920A5 - - Google Patents
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- Publication number
- JP2012511920A5 JP2012511920A5 JP2011541376A JP2011541376A JP2012511920A5 JP 2012511920 A5 JP2012511920 A5 JP 2012511920A5 JP 2011541376 A JP2011541376 A JP 2011541376A JP 2011541376 A JP2011541376 A JP 2011541376A JP 2012511920 A5 JP2012511920 A5 JP 2012511920A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- molecule
- binding site
- display
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 42
- 229920001184 polypeptide Polymers 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 101710186708 Agglutinin Proteins 0.000 claims 2
- 101710194180 Alcohol oxidase 1 Proteins 0.000 claims 2
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 claims 2
- 102000016359 Fibronectins Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 108010001498 Galectin 1 Proteins 0.000 claims 2
- 102100021736 Galectin-1 Human genes 0.000 claims 2
- 101710146024 Horcolin Proteins 0.000 claims 2
- 101710189395 Lectin Proteins 0.000 claims 2
- 101710179758 Mannose-specific lectin Proteins 0.000 claims 2
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 claims 2
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 claims 2
- 102000000470 PDZ domains Human genes 0.000 claims 2
- 108050008994 PDZ domains Proteins 0.000 claims 2
- 239000000910 agglutinin Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000003248 secreting effect Effects 0.000 claims 2
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims 1
- 101710204410 Scaffold protein Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 102000027450 oncoproteins Human genes 0.000 claims 1
- 108091008819 oncoproteins Proteins 0.000 claims 1
- 102000034285 signal transducing proteins Human genes 0.000 claims 1
- 108091006024 signal transducing proteins Proteins 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12291008P | 2008-12-16 | 2008-12-16 | |
| US61/122,910 | 2008-12-16 | ||
| PCT/EP2009/067066 WO2010069913A1 (en) | 2008-12-16 | 2009-12-14 | Yeast display systems |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511920A JP2012511920A (ja) | 2012-05-31 |
| JP2012511920A5 true JP2012511920A5 (https=) | 2012-12-06 |
| JP5985826B2 JP5985826B2 (ja) | 2016-09-06 |
Family
ID=42115977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541376A Active JP5985826B2 (ja) | 2008-12-16 | 2009-12-14 | 酵母ディスプレイ系 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20110275535A1 (https=) |
| EP (1) | EP2379718B2 (https=) |
| JP (1) | JP5985826B2 (https=) |
| KR (1) | KR20110104052A (https=) |
| CN (1) | CN102245771B (https=) |
| AU (1) | AU2009327189B2 (https=) |
| CA (1) | CA2746840A1 (https=) |
| EA (1) | EA201100943A1 (https=) |
| ES (1) | ES2410579T5 (https=) |
| MX (1) | MX2011006483A (https=) |
| WO (1) | WO2010069913A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1946417A (zh) | 2003-12-05 | 2007-04-11 | 阿德内克休斯治疗公司 | 2型血管内皮生长因子受体的抑制剂 |
| CA2670471A1 (en) | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir |
| CN102007145A (zh) | 2008-02-14 | 2011-04-06 | 百时美施贵宝公司 | 基于结合egfr的工程化蛋白质的靶向治疗剂 |
| PE20091931A1 (es) | 2008-05-22 | 2009-12-31 | Bristol Myers Squibb Co | Proteinas de dominio de armazon basadas en fibronectina multivalentes |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子 |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| ES2573108T3 (es) | 2010-05-26 | 2016-06-06 | Bristol-Myers Squibb Company | Proteínas de armazón a base de fibronectina que tienen estabilidad mejorada |
| US20140038842A1 (en) * | 2010-12-28 | 2014-02-06 | Xoma Technology | Cell surface display using pdz domains |
| RS55609B1 (sr) | 2011-04-13 | 2017-06-30 | Bristol Myers Squibb Co | Fc fuzioni proteini koji sadrže nove linkere ili aranžmane |
| EP2709669A1 (en) | 2011-05-17 | 2014-03-26 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| CN102276702B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw30及其表面展示系统和构建方法 |
| CN102276703B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw51及其表面展示系统和构建方法 |
| CN102260335B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw3及其表面展示系统和构建方法 |
| CN102276707B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw19及其表面展示系统和构建方法 |
| EP2773659A2 (en) | 2011-10-31 | 2014-09-10 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
| ES2528892T3 (es) | 2012-07-30 | 2015-02-13 | Nbe-Therapeutics Llc | Identificación mediada por trasposición de proteínas de unión o funcionales específicas |
| TWI633117B (zh) | 2012-09-13 | 2018-08-21 | 必治妥美雅史谷比公司 | 結合至肌肉生長抑制素（ｍｙｏｓｔａｔｉｎ）以纖維連接蛋白爲主之支架結構域蛋白質 |
| EP2929351B1 (en) * | 2012-12-10 | 2019-10-09 | The University of Queensland | Cell-free biofragment compositions and related systems, devices, and methods |
| EP2951206A2 (en) | 2013-02-01 | 2015-12-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins |
| ES2689372T3 (es) | 2013-02-06 | 2018-11-13 | Bristol-Myers Squibb Company | Proteínas de dominio de fibronectina tipo III con solubilidad mejorada |
| ES2870802T3 (es) | 2013-02-12 | 2021-10-27 | Bristol Myers Squibb Co | Métodos de replegado de proteínas a elevado pH |
| WO2015100058A1 (en) | 2013-12-23 | 2015-07-02 | Research Corporation Technologies, Inc. | Pichia pastoris surface display system |
| CN103834630A (zh) * | 2014-01-17 | 2014-06-04 | 中国药科大学 | 一种制备重组牛肠激酶催化亚基的方法 |
| EP3129401B1 (en) | 2014-03-20 | 2019-06-12 | Bristol-Myers Squibb Company | Serum albumin-binding fibronectin type iii domains |
| EP3708580B1 (en) | 2015-09-23 | 2023-11-01 | Bristol-Myers Squibb Company | Fast-off rate serum albumin binding fibronectin type iii domains |
| WO2018041740A1 (en) | 2016-09-01 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | Non-covalent display system using fimgt/dsf |
| CN110268108B (zh) | 2016-12-12 | 2022-09-06 | 埃克切拉生物科学公司 | 用于使用微毛细管阵列进行筛选的方法和系统 |
| JP6839424B2 (ja) | 2016-12-27 | 2021-03-10 | 国立大学法人 鹿児島大学 | 真菌におけるタンパク質の選択的分泌技術 |
| EP3562796B1 (en) | 2016-12-30 | 2023-04-19 | Xcella Biosciences, Inc. | Multi-stage sample recovery system |
| JP7194112B2 (ja) * | 2017-03-13 | 2022-12-21 | ラレマンド ハンガリー リクィディティー マネジメント エルエルシー | 細胞結合型異種タンパク質を発現する組換え酵母宿主細胞 |
| SG11201908384XA (en) | 2017-03-24 | 2019-10-30 | Lankenau Inst Medical Res | Methods and compositions for inducible extracellular membrane capture of monoclonal immunoglobulins secreted by hybridomas |
| ES3039910T3 (en) | 2018-12-06 | 2025-10-27 | Xcella Biosciences Inc | Lateral loading of microcapillary arrays |
| WO2020177719A1 (zh) * | 2019-03-05 | 2020-09-10 | 信达生物制药(苏州)有限公司 | 展示与分泌目的多肽的酵母展示系统及其用途 |
| CN111378676B (zh) * | 2020-02-28 | 2021-08-20 | 武汉华美生物工程有限公司 | 一种pCUP1载体质粒的构建及其应用 |
| ES2955461B2 (es) | 2022-05-24 | 2024-12-27 | Univ Valencia Politecnica | Levadura y plasmido para la exposicion de proteinas en superficie |
| WO2024123891A1 (en) * | 2022-12-07 | 2024-06-13 | The University Of North Carolina At Chapel Hill Office Of Technology Commercialization | Engineered microorganism compositions and applications thereof |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4486533A (en) | 1982-09-02 | 1984-12-04 | St. Louis University | Filamentous fungi functional replicating extrachromosomal element |
| US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
| US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
| US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
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| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| RU95105899A (ru) | 1992-07-08 | 1997-03-20 | Унилевер Н.В. (NL) | Способ иммобилизации фермента, полинуклеотид, вектор, химерный блок, низшие эукариоты, способ осуществления ферментативного процесса |
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| US6300065B1 (en) * | 1996-05-31 | 2001-10-09 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6699658B1 (en) * | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
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| US7309575B2 (en) | 2002-01-16 | 2007-12-18 | The University Of North Carolina At Chapel Hill | Protein purification and detection methods |
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| WO2008031098A1 (en) | 2006-09-09 | 2008-03-13 | The University Of Chicago | Binary amino acid libraries for fibronectin type iii polypeptide monobodies |
| CA2670471A1 (en) * | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir |
| WO2008118476A2 (en) † | 2007-03-26 | 2008-10-02 | Codon Devices, Inc. | Cell surface display, screening and production of proteins of interest |
| MX2009011226A (es) * | 2007-04-17 | 2010-04-01 | Imclone Llc | Inhibidores especificos pdgfrbeta. |
| MX2009012343A (es) * | 2007-05-14 | 2010-02-10 | Biogen Idec Inc | Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello. |
-
2009
- 2009-12-14 US US13/139,332 patent/US20110275535A1/en not_active Abandoned
- 2009-12-14 AU AU2009327189A patent/AU2009327189B2/en not_active Ceased
- 2009-12-14 ES ES09774904T patent/ES2410579T5/es active Active
- 2009-12-14 KR KR1020117016542A patent/KR20110104052A/ko not_active Ceased
- 2009-12-14 WO PCT/EP2009/067066 patent/WO2010069913A1/en not_active Ceased
- 2009-12-14 EP EP09774904.8A patent/EP2379718B2/en active Active
- 2009-12-14 MX MX2011006483A patent/MX2011006483A/es not_active Application Discontinuation
- 2009-12-14 CN CN2009801503306A patent/CN102245771B/zh active Active
- 2009-12-14 EA EA201100943A patent/EA201100943A1/ru unknown
- 2009-12-14 CA CA2746840A patent/CA2746840A1/en not_active Abandoned
- 2009-12-14 JP JP2011541376A patent/JP5985826B2/ja active Active
-
2016
- 2016-04-21 US US15/135,438 patent/US10041064B2/en active Active
-
2018
- 2018-07-24 US US16/043,936 patent/US10301616B2/en active Active
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