JP2012511920A5 - - Google Patents
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- Publication number
- JP2012511920A5 JP2012511920A5 JP2011541376A JP2011541376A JP2012511920A5 JP 2012511920 A5 JP2012511920 A5 JP 2012511920A5 JP 2011541376 A JP2011541376 A JP 2011541376A JP 2011541376 A JP2011541376 A JP 2011541376A JP 2012511920 A5 JP2012511920 A5 JP 2012511920A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- molecule
- binding site
- display
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 42
- 229920001184 polypeptide Polymers 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 101710186708 Agglutinin Proteins 0.000 claims 2
- 101710194180 Alcohol oxidase 1 Proteins 0.000 claims 2
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 claims 2
- 102000016359 Fibronectins Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 108010001498 Galectin 1 Proteins 0.000 claims 2
- 102100021736 Galectin-1 Human genes 0.000 claims 2
- 101710146024 Horcolin Proteins 0.000 claims 2
- 101710189395 Lectin Proteins 0.000 claims 2
- 101710179758 Mannose-specific lectin Proteins 0.000 claims 2
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 claims 2
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 claims 2
- 102000000470 PDZ domains Human genes 0.000 claims 2
- 108050008994 PDZ domains Proteins 0.000 claims 2
- 239000000910 agglutinin Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000003248 secreting effect Effects 0.000 claims 2
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims 1
- 101710204410 Scaffold protein Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 102000027450 oncoproteins Human genes 0.000 claims 1
- 108091008819 oncoproteins Proteins 0.000 claims 1
- 102000034285 signal transducing proteins Human genes 0.000 claims 1
- 108091006024 signal transducing proteins Proteins 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12291008P | 2008-12-16 | 2008-12-16 | |
| US61/122,910 | 2008-12-16 | ||
| PCT/EP2009/067066 WO2010069913A1 (en) | 2008-12-16 | 2009-12-14 | Yeast display systems |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012511920A JP2012511920A (ja) | 2012-05-31 |
| JP2012511920A5 true JP2012511920A5 (https=) | 2012-12-06 |
| JP5985826B2 JP5985826B2 (ja) | 2016-09-06 |
Family
ID=42115977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541376A Active JP5985826B2 (ja) | 2008-12-16 | 2009-12-14 | 酵母ディスプレイ系 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20110275535A1 (https=) |
| EP (1) | EP2379718B2 (https=) |
| JP (1) | JP5985826B2 (https=) |
| KR (1) | KR20110104052A (https=) |
| CN (1) | CN102245771B (https=) |
| AU (1) | AU2009327189B2 (https=) |
| CA (1) | CA2746840A1 (https=) |
| EA (1) | EA201100943A1 (https=) |
| ES (1) | ES2410579T5 (https=) |
| MX (1) | MX2011006483A (https=) |
| WO (1) | WO2010069913A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1711196A4 (en) | 2003-12-05 | 2011-09-14 | Bristol Myers Squibb Co | INHIBITORS OF TYPE-2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS |
| MX2009005466A (es) | 2006-11-22 | 2009-08-17 | Adnexus A Bristol Myers Sqibb | Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i. |
| AU2009213141A1 (en) | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind EGFR |
| WO2009142773A2 (en) | 2008-05-22 | 2009-11-26 | Bristol-Myers Squibb Company | Multivalent fibronectin based scaffold domain proteins |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之ｅｇｆｒ／ｉｇｆｉｒ結合分子 |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| JP6023703B2 (ja) | 2010-05-26 | 2016-11-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 改善された安定性を有するフィブロネクチンをベースとする足場タンパク質 |
| JP2014504503A (ja) * | 2010-12-28 | 2014-02-24 | ゾーマ テクノロジー リミテッド | Ｐｄｚドメインを用いた細胞表面提示 |
| EP3415528B1 (en) | 2011-04-13 | 2021-05-26 | Bristol-Myers Squibb Company | Fc fusion proteins comprising novel linkers or arrangements |
| EP2709669A1 (en) | 2011-05-17 | 2014-03-26 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| CN102276707B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw19及其表面展示系统和构建方法 |
| CN102276702B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw30及其表面展示系统和构建方法 |
| CN102260335B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw3及其表面展示系统和构建方法 |
| CN102276703B (zh) * | 2011-07-29 | 2013-09-25 | 华南理工大学 | 毕赤酵母壁蛋白Gcw51及其表面展示系统和构建方法 |
| JP2015504038A (ja) | 2011-10-31 | 2015-02-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 低減した免疫原性を有するフィブロネクチン結合ドメイン |
| PT2692865E (pt) | 2012-07-30 | 2015-02-06 | Nbe Therapeutics Llc | Identificação mediada por transposição de proteínas funcionais ou de ligação específicas |
| ES2984405T3 (es) | 2012-09-13 | 2024-10-29 | Bristol Myers Squibb Co | Proteínas de dominio de andamio basadas en fibronectina que se unen a la miostatina |
| EP2929351B1 (en) | 2012-12-10 | 2019-10-09 | The University of Queensland | Cell-free biofragment compositions and related systems, devices, and methods |
| EP2951206A2 (en) | 2013-02-01 | 2015-12-09 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins |
| EP2953968B1 (en) | 2013-02-06 | 2018-07-25 | Bristol-Myers Squibb Company | Fibronectin type iii domain proteins with enhanced solubility |
| US10065987B2 (en) | 2013-02-12 | 2018-09-04 | Bristol-Myers Squibb Company | High pH protein refolding methods |
| WO2015100058A1 (en) | 2013-12-23 | 2015-07-02 | Research Corporation Technologies, Inc. | Pichia pastoris surface display system |
| CN103834630A (zh) * | 2014-01-17 | 2014-06-04 | 中国药科大学 | 一种制备重组牛肠激酶催化亚基的方法 |
| ES2736127T3 (es) | 2014-03-20 | 2019-12-26 | Bristol Myers Squibb Co | Dominios de tipo III de fibronectina de unión a seroalbúmina |
| CN108290941A (zh) | 2015-09-23 | 2018-07-17 | 百时美施贵宝公司 | 快解离速率的血清白蛋白结合性纤连蛋白iii型结构域 |
| WO2018041740A1 (en) | 2016-09-01 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | Non-covalent display system using fimgt/dsf |
| US11473081B2 (en) | 2016-12-12 | 2022-10-18 | xCella Biosciences, Inc. | Methods and systems for screening using microcapillary arrays |
| EP3564358A4 (en) | 2016-12-27 | 2020-12-16 | Kagoshima University | SELECTIVE PROTEIN SECRETION TECHNOLOGY IN A MUSHROOM |
| JP7208902B2 (ja) | 2016-12-30 | 2023-01-19 | エクセラ・バイオサイエンシーズ・インコーポレイテッド | マルチステージサンプル回収システム |
| JP7194112B2 (ja) * | 2017-03-13 | 2022-12-21 | ラレマンド ハンガリー リクィディティー マネジメント エルエルシー | 細胞結合型異種タンパク質を発現する組換え酵母宿主細胞 |
| IL312457A (en) | 2017-03-24 | 2024-06-01 | Lankenau Inst Medical Res | Methods and compositions for inducible extracellular membrane trapping of monoclonal immunoglobulins secreted by hybridomas |
| EP3890876B1 (en) | 2018-12-06 | 2024-05-01 | Xcella Biosciences, Inc. | Lateral loading of microcapillary arrays |
| CN113544275A (zh) * | 2019-03-05 | 2021-10-22 | 信达生物制药(苏州)有限公司 | 展示与分泌目的多肽的酵母展示系统及其用途 |
| CN111378676B (zh) * | 2020-02-28 | 2021-08-20 | 武汉华美生物工程有限公司 | 一种pCUP1载体质粒的构建及其应用 |
| ES2955461B2 (es) | 2022-05-24 | 2024-12-27 | Univ Valencia Politecnica | Levadura y plasmido para la exposicion de proteinas en superficie |
| WO2024123891A1 (en) * | 2022-12-07 | 2024-06-13 | The University Of North Carolina At Chapel Hill Office Of Technology Commercialization | Engineered microorganism compositions and applications thereof |
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|---|---|---|---|---|
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4486533A (en) | 1982-09-02 | 1984-12-04 | St. Louis University | Filamentous fungi functional replicating extrachromosomal element |
| US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
| US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
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| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| JP3681385B2 (ja) | 1992-07-08 | 2005-08-10 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 融合タンパク質の製造によって酵素を微生物細胞の細胞壁に固定化する方法 |
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| WO2008031098A1 (en) | 2006-09-09 | 2008-03-13 | The University Of Chicago | Binary amino acid libraries for fibronectin type iii polypeptide monobodies |
| MX2009005466A (es) * | 2006-11-22 | 2009-08-17 | Adnexus A Bristol Myers Sqibb | Terapeuticos dirigidos a base de proteinas manipuladas para receptores de tirosina cinasas, incluyendo receptor de factor de crecimiento tipo insulina-i. |
| EP2617827A1 (en) † | 2007-03-26 | 2013-07-24 | Celexion, LLC | Method for displaying engineered proteins on a cell surface |
| CA2682390A1 (en) * | 2007-04-17 | 2008-10-30 | Imclone Llc | Pdgfr.beta.-specific inhibitors |
| EP2158318A2 (en) * | 2007-05-14 | 2010-03-03 | Biogen Idec MA, Inc. | Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto |
-
2009
- 2009-12-14 ES ES09774904T patent/ES2410579T5/es active Active
- 2009-12-14 KR KR1020117016542A patent/KR20110104052A/ko not_active Ceased
- 2009-12-14 CA CA2746840A patent/CA2746840A1/en not_active Abandoned
- 2009-12-14 US US13/139,332 patent/US20110275535A1/en not_active Abandoned
- 2009-12-14 AU AU2009327189A patent/AU2009327189B2/en not_active Ceased
- 2009-12-14 MX MX2011006483A patent/MX2011006483A/es not_active Application Discontinuation
- 2009-12-14 EP EP09774904.8A patent/EP2379718B2/en active Active
- 2009-12-14 WO PCT/EP2009/067066 patent/WO2010069913A1/en not_active Ceased
- 2009-12-14 JP JP2011541376A patent/JP5985826B2/ja active Active
- 2009-12-14 CN CN2009801503306A patent/CN102245771B/zh active Active
- 2009-12-14 EA EA201100943A patent/EA201100943A1/ru unknown
-
2016
- 2016-04-21 US US15/135,438 patent/US10041064B2/en active Active
-
2018
- 2018-07-24 US US16/043,936 patent/US10301616B2/en active Active
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