JP2012511506A - 新規インスリンアナログ - Google Patents
新規インスリンアナログ Download PDFInfo
- Publication number
- JP2012511506A JP2012511506A JP2011539029A JP2011539029A JP2012511506A JP 2012511506 A JP2012511506 A JP 2012511506A JP 2011539029 A JP2011539029 A JP 2011539029A JP 2011539029 A JP2011539029 A JP 2011539029A JP 2012511506 A JP2012511506 A JP 2012511506A
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- JP
- Japan
- Prior art keywords
- human insulin
- desb30
- insulin
- amino acid
- analogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229960001289 prazosin Drugs 0.000 description 1
- IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
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- FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 1
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- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08171086 | 2008-12-09 | ||
| EP08171086.5 | 2008-12-09 | ||
| PCT/EP2009/053017 WO2009115469A1 (en) | 2008-03-18 | 2009-03-13 | Protease stabilized, acylated insulin analogues |
| EPPCT/EP2009/053017 | 2009-03-13 | ||
| EP09161014.7 | 2009-05-25 | ||
| EP09161014 | 2009-05-25 | ||
| EP09161232 | 2009-05-27 | ||
| EP09161232.5 | 2009-05-27 | ||
| PCT/EP2009/066335 WO2010066636A1 (en) | 2008-12-09 | 2009-12-03 | Novel insulin analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012511506A true JP2012511506A (ja) | 2012-05-24 |
| JP2012511506A5 JP2012511506A5 (enExample) | 2014-06-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011539029A Withdrawn JP2012511506A (ja) | 2008-12-09 | 2009-12-03 | 新規インスリンアナログ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110294729A1 (enExample) |
| EP (1) | EP2376531A1 (enExample) |
| JP (1) | JP2012511506A (enExample) |
| CN (1) | CN102245633A (enExample) |
| WO (1) | WO2010066636A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2910570T (pt) | 2008-03-18 | 2017-01-24 | Novo Nordisk As | Análogos de insulina acilados, estabilizados contra proteases |
| JP6013330B2 (ja) | 2010-06-23 | 2016-10-25 | ノヴォ ノルディスク アー／エス | 追加のジスルフィド結合を含有するヒトインスリン |
| EP2585484A1 (en) * | 2010-06-23 | 2013-05-01 | Novo Nordisk A/S | Insulin analogues containing additional disulfide bonds |
| KR20130036290A (ko) | 2010-06-23 | 2013-04-11 | 노보 노르디스크 에이/에스 | 추가 이황화 결합을 함유하는 인슐린 유도체 |
| BR112014025132A2 (pt) | 2012-04-11 | 2017-07-11 | Novo Nordisk As | formulações de insulina |
| AU2013325099B2 (en) * | 2012-09-25 | 2018-11-15 | The Walter And Eliza Hall Institute Of Medical Research | Structure of insulin in complex with n- and c-terminal regions of the insulin receptor alpha-chain |
| US20140269611A1 (en) * | 2013-03-14 | 2014-09-18 | T-Mobile Usa, Inc. | Communication Handovers from Networks Using Unlicensed Spectrum to Circuit-Switched Networks |
| EP3487876A4 (en) * | 2016-07-22 | 2020-02-19 | University of Utah Research Foundation | INSULIN ANALOGS |
| PT3554534T (pt) | 2016-12-16 | 2021-11-05 | Novo Nordisk As | Composições farmacêuticas contendo insulina |
| BR112021011050A2 (pt) | 2018-12-11 | 2021-08-31 | Sanofi | Ligante peptídico |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03506023A (ja) * | 1988-07-20 | 1991-12-26 | ノボ ノルデイスク アクツイエセルスカプ | ポリペプチド |
| JP2003518917A (ja) * | 1999-05-19 | 2003-06-17 | ゼンコー | 糖尿病の処置に有用なインシュリン様活性を有する新規タンパク質 |
| WO2008034881A1 (en) * | 2006-09-22 | 2008-03-27 | Novo Nordisk A/S | Protease resistant insulin analogues |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
| AU631868B2 (en) * | 1989-04-20 | 1992-12-10 | Mount Sinai School Of Medicine Of The City University Of New York, The | Hepatospecific insulin analogues |
| US5268453A (en) * | 1991-08-08 | 1993-12-07 | Scios Inc. | Tissue-selective insulin analogs |
| US6746853B1 (en) * | 1999-05-19 | 2004-06-08 | Xencor, Inc. | Proteins with insulin-like activity useful in the treatment of diabetes |
| CN101970477B (zh) * | 2008-03-14 | 2014-12-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定的胰岛素类似物 |
| PT2910570T (pt) * | 2008-03-18 | 2017-01-24 | Novo Nordisk As | Análogos de insulina acilados, estabilizados contra proteases |
-
2009
- 2009-12-03 CN CN2009801494190A patent/CN102245633A/zh not_active Withdrawn
- 2009-12-03 US US13/133,465 patent/US20110294729A1/en not_active Abandoned
- 2009-12-03 EP EP09771326A patent/EP2376531A1/en not_active Withdrawn
- 2009-12-03 JP JP2011539029A patent/JP2012511506A/ja not_active Withdrawn
- 2009-12-03 WO PCT/EP2009/066335 patent/WO2010066636A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03506023A (ja) * | 1988-07-20 | 1991-12-26 | ノボ ノルデイスク アクツイエセルスカプ | ポリペプチド |
| JP2003518917A (ja) * | 1999-05-19 | 2003-06-17 | ゼンコー | 糖尿病の処置に有用なインシュリン様活性を有する新規タンパク質 |
| WO2008034881A1 (en) * | 2006-09-22 | 2008-03-27 | Novo Nordisk A/S | Protease resistant insulin analogues |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102245633A (zh) | 2011-11-16 |
| EP2376531A1 (en) | 2011-10-19 |
| US20110294729A1 (en) | 2011-12-01 |
| WO2010066636A1 (en) | 2010-06-17 |
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