JP2012510990A5 - - Google Patents
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- JP2012510990A5 JP2012510990A5 JP2011539512A JP2011539512A JP2012510990A5 JP 2012510990 A5 JP2012510990 A5 JP 2012510990A5 JP 2011539512 A JP2011539512 A JP 2011539512A JP 2011539512 A JP2011539512 A JP 2011539512A JP 2012510990 A5 JP2012510990 A5 JP 2012510990A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- pharmaceutically acceptable
- acceptable salt
- compound
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20094508P | 2008-12-05 | 2008-12-05 | |
| US61/200,945 | 2008-12-05 | ||
| PCT/US2009/006391 WO2010065134A1 (en) | 2008-12-05 | 2009-12-04 | 5, 7-dihydro- 6h-pyrimido [ 5, 4-d] [ 1 ] benzazepin-6-thiones as plk inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014153744A Division JP2014221824A (ja) | 2008-12-05 | 2014-07-29 | Ｐｌｋ阻害剤としての５，７−ジヒドロ−６ｈ−ピリミド［５、−４ｄ］［１］ベンゾアゼピン−６−チオン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012510990A JP2012510990A (ja) | 2012-05-17 |
| JP2012510990A5 true JP2012510990A5 (enExample) | 2013-01-31 |
| JP5684719B2 JP5684719B2 (ja) | 2015-03-18 |
Family
ID=42076993
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011539512A Expired - Fee Related JP5684719B2 (ja) | 2008-12-05 | 2009-12-04 | Ｐｌｋ阻害剤としての５，７−ジヒドロ−６ｈ−ピリミド［５、−４ｄ］［１］ベンゾアゼピン−６−チオン |
| JP2014153744A Withdrawn JP2014221824A (ja) | 2008-12-05 | 2014-07-29 | Ｐｌｋ阻害剤としての５，７−ジヒドロ−６ｈ−ピリミド［５、−４ｄ］［１］ベンゾアゼピン−６−チオン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014153744A Withdrawn JP2014221824A (ja) | 2008-12-05 | 2014-07-29 | Ｐｌｋ阻害剤としての５，７−ジヒドロ−６ｈ−ピリミド［５、−４ｄ］［１］ベンゾアゼピン−６−チオン |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US7998952B2 (enExample) |
| EP (1) | EP2373657B1 (enExample) |
| JP (2) | JP5684719B2 (enExample) |
| AR (1) | AR074487A1 (enExample) |
| TW (1) | TW201026703A (enExample) |
| UY (1) | UY32303A (enExample) |
| WO (1) | WO2010065134A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1799684B1 (en) * | 2004-10-04 | 2014-12-03 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| GB201604970D0 (en) | 2016-03-23 | 2016-05-04 | Syngenta Participations Ag | Improvements in or relating to organic compounds |
| CN111763170B (zh) * | 2020-07-10 | 2022-03-18 | 江苏豪森药业集团有限公司 | 氟马替尼中间体的制备方法 |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| TW202530228A (zh) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06172355A (ja) * | 1992-04-14 | 1994-06-21 | Mect Corp | ピリミジン誘導体およびそれを有効成分とする血小板凝集阻止剤 |
| DE4332168A1 (de) | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5686445A (en) | 1993-07-29 | 1997-11-11 | American Cyanamid Company | Pyridobenzoxazepine and pyridobenzothiazepine vasopressin antagonists |
| US5428040A (en) | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| US5925635A (en) * | 1996-04-17 | 1999-07-20 | Dupont Pharmaceuticals Company | N-(amidinophenyl) cyclourea analogs as factor XA inhibitors |
| WO1997047601A1 (en) | 1996-06-11 | 1997-12-18 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and medicinal uses thereof |
| AU3296497A (en) * | 1996-06-13 | 1998-01-07 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US6057329A (en) * | 1996-12-23 | 2000-05-02 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives |
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
| FR2804959B1 (fr) | 2000-02-15 | 2006-04-28 | Centre Nat Rech Scient | Utilisation de derives de paullones pour la fabrication de medicaments |
| US6369222B1 (en) | 2000-07-18 | 2002-04-09 | Hoffmann-La Roche Inc. | mGluR antagonists and a method for their synthesis |
| US6610677B2 (en) | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| US7105667B2 (en) | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
| US6686352B2 (en) | 2001-05-18 | 2004-02-03 | Hoffmann-La Roche Inc. | Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives |
| EP1552842A1 (en) | 2002-06-07 | 2005-07-13 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| WO2004076424A1 (en) | 2003-02-27 | 2004-09-10 | Abbott Laboratories | Heterocyclic kinase inhibitors |
| JP2006528169A (ja) | 2003-07-21 | 2006-12-14 | ファイザー・プロダクツ・インク | ニコチン嗜癖を低減するヘテロアリール縮合アザ多環式化合物 |
| CN1897950A (zh) | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
| PL1771450T3 (pl) * | 2004-05-14 | 2008-05-30 | Millennium Pharm Inc | Związki i sposoby do inhibicji postępu mitozy przez hamowanie kinazy Aurora |
| EP1799684B1 (en) | 2004-10-04 | 2014-12-03 | Millennium Pharmaceuticals, Inc. | Lactam compounds useful as protein kinase inhibitors |
| PE20070171A1 (es) | 2005-06-30 | 2007-03-08 | Boehringer Ingelheim Int | GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa |
| CL2007003244A1 (es) * | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
-
2009
- 2009-12-04 TW TW098141596A patent/TW201026703A/zh unknown
- 2009-12-04 WO PCT/US2009/006391 patent/WO2010065134A1/en not_active Ceased
- 2009-12-04 EP EP09795577.7A patent/EP2373657B1/en active Active
- 2009-12-04 AR ARP090104716A patent/AR074487A1/es unknown
- 2009-12-04 JP JP2011539512A patent/JP5684719B2/ja not_active Expired - Fee Related
- 2009-12-04 US US12/631,144 patent/US7998952B2/en active Active
- 2009-12-07 UY UY0001032303A patent/UY32303A/es not_active Application Discontinuation
-
2011
- 2011-06-30 US US13/173,161 patent/US8268992B2/en active Active
-
2012
- 2012-08-09 US US13/570,486 patent/US8507667B2/en not_active Expired - Fee Related
- 2012-08-09 US US13/570,518 patent/US20120302551A1/en not_active Abandoned
-
2013
- 2013-11-07 US US14/074,506 patent/US20140194410A1/en not_active Abandoned
-
2014
- 2014-07-29 JP JP2014153744A patent/JP2014221824A/ja not_active Withdrawn
- 2014-10-29 US US14/526,699 patent/US20150175542A1/en not_active Abandoned
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