JP2012509300A - 色素コンジュゲートイメージング剤 - Google Patents

色素コンジュゲートイメージング剤 Download PDF

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Publication number
JP2012509300A
JP2012509300A JP2011536864A JP2011536864A JP2012509300A JP 2012509300 A JP2012509300 A JP 2012509300A JP 2011536864 A JP2011536864 A JP 2011536864A JP 2011536864 A JP2011536864 A JP 2011536864A JP 2012509300 A JP2012509300 A JP 2012509300A
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JP
Japan
Prior art keywords
group
btm
imaging agent
dye
imaging
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Pending
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JP2011536864A
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English (en)
Japanese (ja)
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JP2012509300A5 (enExample
Inventor
ネアーン,ロバート・ジェームス・ドメット
ジャクソン,アレキサンダー
Original Assignee
ジーイー・ヘルスケア・アクスイェ・セルスカプ
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Application filed by ジーイー・ヘルスケア・アクスイェ・セルスカプ filed Critical ジーイー・ヘルスケア・アクスイェ・セルスカプ
Publication of JP2012509300A publication Critical patent/JP2012509300A/ja
Publication of JP2012509300A5 publication Critical patent/JP2012509300A5/ja
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/86Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4842Monitoring progression or stage of a disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2011536864A 2008-11-20 2009-11-19 色素コンジュゲートイメージング剤 Pending JP2012509300A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08169526 2008-11-20
EP08169526.4 2008-11-20
PCT/EP2009/065461 WO2010057944A1 (en) 2008-11-20 2009-11-19 Dye conjugate imaging agents

Publications (2)

Publication Number Publication Date
JP2012509300A true JP2012509300A (ja) 2012-04-19
JP2012509300A5 JP2012509300A5 (enExample) 2012-06-07

Family

ID=40427489

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011536864A Pending JP2012509300A (ja) 2008-11-20 2009-11-19 色素コンジュゲートイメージング剤

Country Status (5)

Country Link
US (1) US20110280806A1 (enExample)
EP (1) EP2373349A1 (enExample)
JP (1) JP2012509300A (enExample)
CN (1) CN102281904A (enExample)
WO (1) WO2010057944A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR102743A1 (es) 2014-11-26 2017-03-22 Li Cor Inc Medios de contraste ir para imágenes por fluorescencia
CN108329255A (zh) * 2018-03-19 2018-07-27 华南理工大学 一种六氢咔唑酮衍生物的合成方法
US20200184558A1 (en) * 2018-12-05 2020-06-11 Abaxx Technologies Inc. System and computer method for trading a commodity with carry costs
CN115386081B (zh) * 2022-09-01 2023-07-28 武汉大学 一种原位热交联反应构筑二阶非线性光学聚合物材料的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625165A (ja) * 1992-03-16 1994-02-01 Minnesota Mining & Mfg Co <3M> 2−メチル−4,4a−ジヒドロ−3H−カルバゾリウム塩及びそれらから誘導される染料
JPH10510250A (ja) * 1994-12-07 1998-10-06 インスティトゥート・フュア・ディアゴノスティクフォルシュング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・アン・デル・フライエン・ウニヴェルジテート・ベルリン Nir光を利用したイン・ビボ診断のための方法
JP2001521530A (ja) * 1997-04-23 2001-11-06 インスティトゥート フュア ディアグノスティックフォルシュング ゲゼルシャフト ミット ベシュレンクテル ハフツング アン デア フライエン ウニヴェルジテート ベルリン 近赤外線を用いた診断法および治療のための酸不安定性で酵素的に分割可能な染料構造体
WO2005061456A1 (ja) * 2003-12-19 2005-07-07 Konica Minolta Medical & Graphic, Inc. 近赤外蛍光造影剤
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001294859A1 (en) * 2000-09-29 2002-04-08 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
EP1934202B1 (en) * 2005-09-02 2019-01-09 Visen Medical, Inc. Nicotinic acid and picolinic acid derived near-infrared fluorophores
CN101100465A (zh) * 2007-06-12 2008-01-09 山东大学 阳离子咔唑类化合物及其作为双光子核酸荧光探针的应用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0625165A (ja) * 1992-03-16 1994-02-01 Minnesota Mining & Mfg Co <3M> 2−メチル−4,4a−ジヒドロ−3H−カルバゾリウム塩及びそれらから誘導される染料
JPH10510250A (ja) * 1994-12-07 1998-10-06 インスティトゥート・フュア・ディアゴノスティクフォルシュング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・アン・デル・フライエン・ウニヴェルジテート・ベルリン Nir光を利用したイン・ビボ診断のための方法
JP2001521530A (ja) * 1997-04-23 2001-11-06 インスティトゥート フュア ディアグノスティックフォルシュング ゲゼルシャフト ミット ベシュレンクテル ハフツング アン デア フライエン ウニヴェルジテート ベルリン 近赤外線を用いた診断法および治療のための酸不安定性で酵素的に分割可能な染料構造体
WO2005061456A1 (ja) * 2003-12-19 2005-07-07 Konica Minolta Medical & Graphic, Inc. 近赤外蛍光造影剤
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤

Also Published As

Publication number Publication date
EP2373349A1 (en) 2011-10-12
WO2010057944A1 (en) 2010-05-27
CN102281904A (zh) 2011-12-14
US20110280806A1 (en) 2011-11-17
WO2010057944A9 (en) 2010-09-16

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