JP2012509300A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012509300A5 JP2012509300A5 JP2011536864A JP2011536864A JP2012509300A5 JP 2012509300 A5 JP2012509300 A5 JP 2012509300A5 JP 2011536864 A JP2011536864 A JP 2011536864A JP 2011536864 A JP2011536864 A JP 2011536864A JP 2012509300 A5 JP2012509300 A5 JP 2012509300A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- independently
- btm
- imaging agent
- agent according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000001727 in vivo Methods 0.000 claims description 4
- 238000012634 optical imaging Methods 0.000 claims description 3
- 230000008685 targeting Effects 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 230000021615 conjugation Effects 0.000 claims description 2
- 239000012216 imaging agent Substances 0.000 claims 13
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 125000004964 sulfoalkyl group Chemical group 0.000 claims 4
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000000542 sulfonic acid group Chemical group 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 150000002337 glycosamines Chemical class 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 description 6
- 238000002189 fluorescence spectrum Methods 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 description 2
- 229910052724 xenon Inorganic materials 0.000 description 2
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 2
- GDIYMWAMJKRXRE-UHFFFAOYSA-N (2z)-2-[(2e)-2-[2-chloro-3-[(z)-2-(1,3,3-trimethylindol-1-ium-2-yl)ethenyl]cyclohex-2-en-1-ylidene]ethylidene]-1,3,3-trimethylindole Chemical compound CC1(C)C2=CC=CC=C2N(C)C1=CC=C1C(Cl)=C(C=CC=2C(C3=CC=CC=C3[N+]=2C)(C)C)CCC1 GDIYMWAMJKRXRE-UHFFFAOYSA-N 0.000 description 1
- 239000012897 dilution medium Substances 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 238000006862 quantum yield reaction Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08169526.4 | 2008-11-20 | ||
| EP08169526 | 2008-11-20 | ||
| PCT/EP2009/065461 WO2010057944A1 (en) | 2008-11-20 | 2009-11-19 | Dye conjugate imaging agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012509300A JP2012509300A (ja) | 2012-04-19 |
| JP2012509300A5 true JP2012509300A5 (enExample) | 2012-06-07 |
Family
ID=40427489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536864A Pending JP2012509300A (ja) | 2008-11-20 | 2009-11-19 | 色素コンジュゲートイメージング剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110280806A1 (enExample) |
| EP (1) | EP2373349A1 (enExample) |
| JP (1) | JP2012509300A (enExample) |
| CN (1) | CN102281904A (enExample) |
| WO (1) | WO2010057944A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR102743A1 (es) | 2014-11-26 | 2017-03-22 | Li Cor Inc | Medios de contraste ir para imágenes por fluorescencia |
| CN108329255A (zh) * | 2018-03-19 | 2018-07-27 | 华南理工大学 | 一种六氢咔唑酮衍生物的合成方法 |
| US20200184558A1 (en) * | 2018-12-05 | 2020-06-11 | Abaxx Technologies Inc. | System and computer method for trading a commodity with carry costs |
| CN115386081B (zh) * | 2022-09-01 | 2023-07-28 | 武汉大学 | 一种原位热交联反应构筑二阶非线性光学聚合物材料的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5831098A (en) * | 1992-03-16 | 1998-11-03 | Minnesota Mining And Manufacturing Company | 2-methyl-4,4a-dihydro-3H-carbazolium salts and dyes derived therefrom |
| DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| DE19717904A1 (de) * | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| EP2325263B1 (en) * | 2000-09-29 | 2013-01-23 | Life Technologies Corporation | Modified carbocyanine dyes and their conjugates |
| US7682602B2 (en) * | 2003-12-19 | 2010-03-23 | Konica Minolta Medical & Graphic, Inc. | Near-infrared fluorescent contrast medium |
| JP2005220045A (ja) * | 2004-02-04 | 2005-08-18 | Konica Minolta Medical & Graphic Inc | 蛍光造影剤 |
| WO2007028118A2 (en) * | 2005-09-02 | 2007-03-08 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| CN101100465A (zh) * | 2007-06-12 | 2008-01-09 | 山东大学 | 阳离子咔唑类化合物及其作为双光子核酸荧光探针的应用 |
-
2009
- 2009-11-19 CN CN2009801554191A patent/CN102281904A/zh active Pending
- 2009-11-19 US US13/130,075 patent/US20110280806A1/en not_active Abandoned
- 2009-11-19 WO PCT/EP2009/065461 patent/WO2010057944A1/en not_active Ceased
- 2009-11-19 EP EP09752849A patent/EP2373349A1/en not_active Withdrawn
- 2009-11-19 JP JP2011536864A patent/JP2012509300A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5341757B2 (ja) | 非対称フルオロ置換ポリメチン色素 | |
| JP3836687B2 (ja) | 生体内診断剤に適する化合物 | |
| AU2010210547B2 (en) | Charge-balanced imaging agents | |
| US8927719B2 (en) | Cyanine dyes and their conjugates | |
| RU2475266C2 (ru) | Оптические агенты визуализации | |
| AU2012312041B2 (en) | Application of reduced dyes in imaging | |
| US20100323389A1 (en) | Fluorescent imaging with substituted cyanine dyes | |
| JP2006513293A (ja) | 親水性チオール−反応性シアニン色素及び蛍光診断のための生物分子との接合体 | |
| JP2010527922A (ja) | 光学造影剤 | |
| JP2010534712A (ja) | 光学イメージング剤 | |
| US7282514B1 (en) | Reactive probes for two-photon fluorescent imaging and sensing | |
| JP2012509300A5 (enExample) | ||
| Markova et al. | Water soluble indodicarbocyanine dyes based on 2, 3-dimethyl-3-(4-sulfobutyl)-3H-indole-5-sulfonic acid | |
| US20100015054A1 (en) | Fluoro-substituted benzoxazole polymethine dyes | |
| US8916137B2 (en) | Monofunctional carbocyanine dyes for in vivo and in vitro imaging | |
| JP2012509300A (ja) | 色素コンジュゲートイメージング剤 | |
| Gragg | Synthesis of near-infrared heptamethine cyanine dyes | |
| Chazeau et al. | Near-Infrared Organic Structures with Extended Lifetimes to Unlock the Potential of In Vivo Fluorescence Lifetime Imaging | |
| JP2013534557A (ja) | 色素組成物及び色素合成法 | |
| HK1145140A (en) | Optical imaging agents |