JP2012509263A5 - - Google Patents
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- Publication number
- JP2012509263A5 JP2012509263A5 JP2011536395A JP2011536395A JP2012509263A5 JP 2012509263 A5 JP2012509263 A5 JP 2012509263A5 JP 2011536395 A JP2011536395 A JP 2011536395A JP 2011536395 A JP2011536395 A JP 2011536395A JP 2012509263 A5 JP2012509263 A5 JP 2012509263A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- trifluoromethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- -1 cyano, chloro, methyl Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000113 cyclohexyl group Chemical class [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11533208P | 2008-11-17 | 2008-11-17 | |
| US61/115,332 | 2008-11-17 | ||
| PCT/US2009/063370 WO2010056588A1 (en) | 2008-11-17 | 2009-11-05 | Tetrasubstituted pyridazine hedgehog pathway antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012509263A JP2012509263A (ja) | 2012-04-19 |
| JP2012509263A5 true JP2012509263A5 (Direct) | 2012-12-13 |
| JP5518887B2 JP5518887B2 (ja) | 2014-06-11 |
Family
ID=41722877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536395A Expired - Fee Related JP5518887B2 (ja) | 2008-11-17 | 2009-11-05 | 四置換ピリダジンヘッジホッグ経路アンタゴニスト |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8507490B2 (Direct) |
| EP (1) | EP2358698B1 (Direct) |
| JP (1) | JP5518887B2 (Direct) |
| KR (1) | KR101342184B1 (Direct) |
| CN (1) | CN102216285B (Direct) |
| AU (1) | AU2009314349B2 (Direct) |
| BR (1) | BRPI0921782A2 (Direct) |
| CA (1) | CA2743483C (Direct) |
| CY (1) | CY1113377T1 (Direct) |
| DK (1) | DK2358698T3 (Direct) |
| EA (1) | EA017386B1 (Direct) |
| ES (1) | ES2392759T3 (Direct) |
| HR (1) | HRP20120762T1 (Direct) |
| MX (1) | MX2011005177A (Direct) |
| PL (1) | PL2358698T3 (Direct) |
| PT (1) | PT2358698E (Direct) |
| SI (1) | SI2358698T1 (Direct) |
| WO (1) | WO2010056588A1 (Direct) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100029668A1 (en) * | 2006-07-17 | 2010-02-04 | Syngenta Crop Protection, Inc. | Novel pyridazine derivatives |
| UA102250C2 (ru) | 2008-04-29 | 2013-06-25 | Эли Лилли Энд Компани | Двухзамещенные фталазины - антагонисты проводящего пути hedgehog |
| PL2364185T3 (pl) | 2008-11-03 | 2013-10-31 | Lilly Co Eli | Dipodstawione ftalazyny jako antagoniści szlaku hedgehog |
| US8445493B2 (en) | 2008-11-17 | 2013-05-21 | Eli Lilly And Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| GB201309508D0 (en) | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| WO2015073691A1 (en) | 2013-11-14 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of bmp signaling |
| GB2528298A (en) * | 2014-07-16 | 2016-01-20 | Redx Pharma Plc | Compounds |
| CN105130980B (zh) * | 2015-09-09 | 2018-05-22 | 沈阳药科大学 | N-3-苯并咪唑噻唑胺类衍生物及其制备方法与应用 |
| CN107163028B (zh) * | 2017-05-24 | 2019-07-12 | 东南大学 | 一种苯甲酰胺类Hedgehog抑制剂及其制备方法和应用 |
| CN110208424A (zh) * | 2019-06-28 | 2019-09-06 | 江苏恒生检测有限公司 | 一种农药氟啶虫酰胺中含有杂质的分析方法 |
| WO2021071981A1 (en) * | 2019-10-08 | 2021-04-15 | Skyhawk Therapeutics, Inc. | Compounds for modulating splicing |
| AU2021360767A1 (en) | 2020-10-13 | 2023-04-27 | Endeavor Biomedicines, Inc. | Methods of treating fibrosis |
| WO2023034836A1 (en) * | 2021-08-30 | 2023-03-09 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2025188802A1 (en) | 2024-03-05 | 2025-09-12 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1293565A (en) | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| EP0876366B1 (en) | 1996-01-15 | 2001-07-25 | Janssen Pharmaceutica N.V. | Angiogenesis inhibiting pyridazinamines |
| US6432970B2 (en) | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| JP5067986B2 (ja) | 1998-04-09 | 2012-11-07 | ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン | ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用 |
| GB0013674D0 (en) | 1999-06-08 | 2000-07-26 | Lorantis Ltd | Therapeutic use |
| DE60322869D1 (de) | 2002-04-22 | 2008-09-25 | Univ Johns Hopkins | Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen |
| WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
| WO2005033288A2 (en) | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
| TW200533356A (en) | 2004-02-24 | 2005-10-16 | Mitsubishi Pharma Corp | Fused pyridazine derivatives |
| WO2006004589A2 (en) | 2004-05-08 | 2006-01-12 | Neurogen Corporation | 3-aryl-5,6-disubstituted pyridazines |
| US7888364B2 (en) | 2004-09-02 | 2011-02-15 | Curis, Inc. | Pyridyl inhibitors of hedgehog signalling |
| EP1900731A1 (de) | 2006-09-07 | 2008-03-19 | Bayer Schering Pharma Aktiengesellschaft | N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren |
| BRPI0809193A2 (pt) * | 2007-03-15 | 2014-09-23 | Novartis Ag | Compostos orgânicos e seus usos |
| EP2170866B1 (en) | 2007-06-25 | 2014-08-13 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
| CA2697682A1 (en) | 2007-09-07 | 2009-03-19 | Amgen Inc. | Annelated pyridazines for the treatment of tumors driven by inapropriate hedgehog signalling |
| UA102250C2 (ru) | 2008-04-29 | 2013-06-25 | Эли Лилли Энд Компани | Двухзамещенные фталазины - антагонисты проводящего пути hedgehog |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| PL2364185T3 (pl) | 2008-11-03 | 2013-10-31 | Lilly Co Eli | Dipodstawione ftalazyny jako antagoniści szlaku hedgehog |
| US8445493B2 (en) | 2008-11-17 | 2013-05-21 | Eli Lilly And Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
-
2009
- 2009-11-05 PT PT09752059T patent/PT2358698E/pt unknown
- 2009-11-05 AU AU2009314349A patent/AU2009314349B2/en not_active Ceased
- 2009-11-05 DK DK09752059.7T patent/DK2358698T3/da active
- 2009-11-05 KR KR1020117011148A patent/KR101342184B1/ko not_active Expired - Fee Related
- 2009-11-05 SI SI200930351T patent/SI2358698T1/sl unknown
- 2009-11-05 US US13/122,216 patent/US8507490B2/en not_active Expired - Fee Related
- 2009-11-05 CA CA2743483A patent/CA2743483C/en not_active Expired - Fee Related
- 2009-11-05 HR HRP20120762AT patent/HRP20120762T1/hr unknown
- 2009-11-05 BR BRPI0921782A patent/BRPI0921782A2/pt not_active IP Right Cessation
- 2009-11-05 EP EP09752059A patent/EP2358698B1/en not_active Not-in-force
- 2009-11-05 PL PL09752059T patent/PL2358698T3/pl unknown
- 2009-11-05 MX MX2011005177A patent/MX2011005177A/es active IP Right Grant
- 2009-11-05 ES ES09752059T patent/ES2392759T3/es active Active
- 2009-11-05 EA EA201170699A patent/EA017386B1/ru not_active IP Right Cessation
- 2009-11-05 JP JP2011536395A patent/JP5518887B2/ja not_active Expired - Fee Related
- 2009-11-05 CN CN200980145554.8A patent/CN102216285B/zh not_active Expired - Fee Related
- 2009-11-05 WO PCT/US2009/063370 patent/WO2010056588A1/en not_active Ceased
-
2012
- 2012-10-25 CY CY20121101019T patent/CY1113377T1/el unknown
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