JP2012509066A - 核酸送達系のための放出可能接合体 - Google Patents

核酸送達系のための放出可能接合体 Download PDF

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JP2012509066A
JP2012509066A JP2011536582A JP2011536582A JP2012509066A JP 2012509066 A JP2012509066 A JP 2012509066A JP 2011536582 A JP2011536582 A JP 2011536582A JP 2011536582 A JP2011536582 A JP 2011536582A JP 2012509066 A JP2012509066 A JP 2012509066A
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JP2012509066A5 (enExample
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ザオ,ホン
シァ,ジン
レディ,プラサンナ
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エンゾン ファーマシューティカルズ,インコーポレーテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2011536582A 2008-11-17 2009-11-17 核酸送達系のための放出可能接合体 Pending JP2012509066A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11532608P 2008-11-17 2008-11-17
US11535008P 2008-11-17 2008-11-17
US61/115,350 2008-11-17
US61/115,326 2008-11-17
PCT/US2009/064711 WO2010057154A1 (en) 2008-11-17 2009-11-17 Releasable conjugates for nucleic acids delivery systems

Publications (2)

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JP2012509066A true JP2012509066A (ja) 2012-04-19
JP2012509066A5 JP2012509066A5 (enExample) 2013-01-10

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JP2011536582A Pending JP2012509066A (ja) 2008-11-17 2009-11-17 核酸送達系のための放出可能接合体

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US (1) US20110230420A1 (enExample)
EP (1) EP2362729A1 (enExample)
JP (1) JP2012509066A (enExample)
CN (1) CN102231951A (enExample)
CA (1) CA2742842A1 (enExample)
TW (1) TW201029668A (enExample)
WO (1) WO2010057154A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018529632A (ja) * 2015-08-11 2018-10-11 コヒレント バイオファーマ 多リガンド−薬物複合体及びその使用

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US10766928B2 (en) 2012-10-05 2020-09-08 The University Of Kansas Targeted conformationally-constrained kinked endosomal disrupting peptides
US9701715B2 (en) * 2012-10-05 2017-07-11 The University Of Kansas Conformationally-constrained kinked endosomal-disrupting peptides
US9365599B2 (en) 2012-10-26 2016-06-14 Korea Atomic Energy Research Institute N3S1 chelator-folate derivatives, preparation method thereof and composition for diagnosis or treatment of cancer containing the same as an active ingredient
KR20180033586A (ko) 2015-08-04 2018-04-03 듀크 유니버시티 전달을 위한 유전적으로 인코딩된 내재적으로 무질서화된 스텔스 중합체 및 이의 이용 방법
CN106466484B (zh) * 2015-08-11 2021-05-04 同宜医药(苏州)有限公司 一种具有细胞内吞介导功能的多靶向配体-药物偶联体
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
US11135301B2 (en) 2016-09-14 2021-10-05 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
EP3515928A4 (en) 2016-09-23 2020-04-01 Duke University Unstructured non-repetitive polypeptides having lcst behavior
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
US11680083B2 (en) 2017-06-30 2023-06-20 Duke University Order and disorder as a design principle for stimuli-responsive biopolymer networks
CN107629118A (zh) * 2017-10-31 2018-01-26 天津大学 基于组氨酸的靶向性穿膜肽载体及用途
US12296018B2 (en) 2018-01-26 2025-05-13 Duke University Albumin binding peptide-drug (AlBiPeD) conjugates and methods of making and using same
US12257308B2 (en) 2018-04-30 2025-03-25 Duke University Stimuli-responsive PEG-like polymer-based drug delivery platform
WO2020028806A1 (en) 2018-08-02 2020-02-06 Duke University Dual agonist fusion proteins
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
US20250297258A1 (en) * 2021-07-07 2025-09-25 Ractigen Therapeutics Oligonucleotide-based delivery vehicle for oligonucleotides agents and methods of use thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505633A (ja) * 2004-07-07 2008-02-28 ザ ノルウェジアン ラディウム ホスピタル リサーチ ファウンデーション 正荷電ペプチドと複合化したpna分子を細胞質および/または核への光化学的内在化(pci)により導入する方法。
WO2008034124A2 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
WO2008034123A2 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Polymeric conjugates containing positively-charged moieties
JP2008520209A (ja) * 2004-11-17 2008-06-19 ユニヴァーシティ・オブ・メリーランド,バルチモア siRNAの有効なキャリアとしての高度に枝分かれしたHKペプチド
JP2008527993A (ja) * 2005-01-24 2008-07-31 アヴァリス・アクチエボラーグ 特異性及び送達の改善のためのsiRNA分子、shRNA分子又はアンチセンス分子及び機能的実体を含む複合体
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

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WO1999042091A2 (en) * 1998-02-19 1999-08-26 Massachusetts Institute Of Technology Use of polycations as endosomolytic agents
EP1389209B1 (en) * 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
HUE037352T2 (hu) * 2002-04-05 2018-08-28 Roche Innovation Ct Copenhagen As A HIF-1alfa expresszálódását módosító oligomer vegyületek
US7713738B2 (en) * 2003-02-10 2010-05-11 Enzon Pharmaceuticals, Inc. Oligomeric compounds for the modulation of survivin expression
EP2251039A3 (en) * 2003-05-30 2010-12-08 Nippon Shinyaku Co., Ltd. Oligo double-stranded rna inhibiting the expression of bcl-2 and pharmaceutical composition containing the same
CA2553221A1 (en) * 2004-01-22 2005-08-04 Immunomedics, Inc. Folate conjugates and complexes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505633A (ja) * 2004-07-07 2008-02-28 ザ ノルウェジアン ラディウム ホスピタル リサーチ ファウンデーション 正荷電ペプチドと複合化したpna分子を細胞質および/または核への光化学的内在化(pci)により導入する方法。
JP2008520209A (ja) * 2004-11-17 2008-06-19 ユニヴァーシティ・オブ・メリーランド,バルチモア siRNAの有効なキャリアとしての高度に枝分かれしたHKペプチド
JP2008527993A (ja) * 2005-01-24 2008-07-31 アヴァリス・アクチエボラーグ 特異性及び送達の改善のためのsiRNA分子、shRNA分子又はアンチセンス分子及び機能的実体を含む複合体
WO2008034124A2 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
WO2008034123A2 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Polymeric conjugates containing positively-charged moieties
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018529632A (ja) * 2015-08-11 2018-10-11 コヒレント バイオファーマ 多リガンド−薬物複合体及びその使用
JP2021006549A (ja) * 2015-08-11 2021-01-21 コヒレント バイオファーマ 多リガンド−薬物複合体及びその使用
JP2023025151A (ja) * 2015-08-11 2023-02-21 コヒレント バイオファーマ ワン,リミテッド 多リガンド-薬物複合体及びその使用
JP7573401B2 (ja) 2015-08-11 2024-10-25 コヒレント バイオファーマ ワン,リミテッド 多リガンド-薬物複合体及びその使用

Also Published As

Publication number Publication date
CN102231951A (zh) 2011-11-02
US20110230420A1 (en) 2011-09-22
EP2362729A1 (en) 2011-09-07
TW201029668A (en) 2010-08-16
WO2010057154A1 (en) 2010-05-20
CA2742842A1 (en) 2010-05-20

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