JP2012508240A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012508240A5 JP2012508240A5 JP2011535633A JP2011535633A JP2012508240A5 JP 2012508240 A5 JP2012508240 A5 JP 2012508240A5 JP 2011535633 A JP2011535633 A JP 2011535633A JP 2011535633 A JP2011535633 A JP 2011535633A JP 2012508240 A5 JP2012508240 A5 JP 2012508240A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- small cell
- cell lung
- pyrazolo
- imidazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 4-Fluoro-3-trifluoromethyl-phenyl Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 229940121647 egfr inhibitor Drugs 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 4
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 4
- 206010041067 Small cell lung cancer Diseases 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000017662 Hodgkin disease lymphocyte depletion type stage unspecified Diseases 0.000 claims 2
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 2
- 206010049459 Lymphangioleiomyomatosis Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
- 229960004316 cisplatin Drugs 0.000 claims 2
- 201000010897 colon adenocarcinoma Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 229960005073 erlotinib hydrochloride Drugs 0.000 claims 2
- GTTBEUCJPZQMDZ-UHFFFAOYSA-N erlotinib hydrochloride Chemical group [H+].[Cl-].C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 GTTBEUCJPZQMDZ-UHFFFAOYSA-N 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 2
- FYXRSVDHGLUMHB-UHFFFAOYSA-N 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1h-pyrazolo[3,4-d]pyrimidine Chemical compound N1=C(C2CCN(CC2)C=2C=3C=NNC=3N=CN=2)N(C)C=C1C1=CC=C(F)C(C(F)(F)F)=C1 FYXRSVDHGLUMHB-UHFFFAOYSA-N 0.000 claims 1
- UEGFNRZYLNKXAD-UHFFFAOYSA-N 4-methylbenzenesulfonic acid;pyrimidine Chemical compound C1=CN=CN=C1.CC1=CC=C(S(O)(=O)=O)C=C1 UEGFNRZYLNKXAD-UHFFFAOYSA-N 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11327608P | 2008-11-11 | 2008-11-11 | |
| US61/113,276 | 2008-11-11 | ||
| PCT/US2009/063189 WO2010056575A1 (en) | 2008-11-11 | 2009-11-04 | P70 s6 kinase inhibitor and egfr inhibitor combination therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012508240A JP2012508240A (ja) | 2012-04-05 |
| JP2012508240A5 true JP2012508240A5 (enExample) | 2012-12-20 |
Family
ID=41664868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535633A Withdrawn JP2012508240A (ja) | 2008-11-11 | 2009-11-04 | Ｐ７０ｓ６キナーゼ阻害剤およびｅｇｆｒ阻害剤の併用療法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8334293B2 (enExample) |
| EP (1) | EP2355821A1 (enExample) |
| JP (1) | JP2012508240A (enExample) |
| KR (1) | KR20110075015A (enExample) |
| CN (1) | CN102209538B (enExample) |
| AU (1) | AU2009314336B2 (enExample) |
| BR (1) | BRPI0921888A2 (enExample) |
| CA (1) | CA2743295A1 (enExample) |
| EA (1) | EA018624B1 (enExample) |
| MX (1) | MX2011005002A (enExample) |
| WO (1) | WO2010056575A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140255471A1 (en) | 2013-03-11 | 2014-09-11 | Wake Forest University Health Sciences | Method of treating brain tumors |
| AR095202A1 (es) * | 2013-03-11 | 2015-09-30 | Merck Patent Gmbh | Heterociclos como moduladores de la actividad quinasa |
| US9457019B2 (en) * | 2013-11-07 | 2016-10-04 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
| RU2683276C2 (ru) * | 2014-04-04 | 2019-03-27 | Астразенека Аб | Комбинация ингибитора EGFR и ингибитора MEK для применения в лечении рака, вызванного мутировавшим NRAS |
| US11806326B2 (en) | 2018-01-29 | 2023-11-07 | Jonathan Sackner-Bernstein | Methods for dopamine modulation in human neurologic diseases |
| DE102018205152A1 (de) | 2018-04-05 | 2019-10-10 | Glatt Ingenieurtechnik Gmbh | Verfahren und Reaktor zur Herstellung von Partikeln |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0817775B1 (en) | 1995-03-30 | 2001-09-12 | Pfizer Inc. | Quinazoline derivatives |
| AU2005249380C1 (en) * | 2004-04-23 | 2012-09-20 | Exelixis, Inc. | Kinase modulators and methods of use |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| WO2006071819A1 (en) | 2004-12-28 | 2006-07-06 | Exelixis, Inc. | [1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| WO2007047754A2 (en) | 2005-10-18 | 2007-04-26 | George Mason Intellectual Properties, Inc. | Mtor pathway theranostic |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| UA99284C2 (ru) * | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
-
2009
- 2009-11-04 BR BRPI0921888A patent/BRPI0921888A2/pt not_active IP Right Cessation
- 2009-11-04 EP EP09752049A patent/EP2355821A1/en not_active Withdrawn
- 2009-11-04 MX MX2011005002A patent/MX2011005002A/es not_active Application Discontinuation
- 2009-11-04 CN CN2009801448775A patent/CN102209538B/zh not_active Expired - Fee Related
- 2009-11-04 CA CA2743295A patent/CA2743295A1/en not_active Abandoned
- 2009-11-04 AU AU2009314336A patent/AU2009314336B2/en not_active Expired - Fee Related
- 2009-11-04 WO PCT/US2009/063189 patent/WO2010056575A1/en not_active Ceased
- 2009-11-04 EA EA201170682A patent/EA018624B1/ru not_active IP Right Cessation
- 2009-11-04 KR KR1020117010621A patent/KR20110075015A/ko not_active Abandoned
- 2009-11-04 JP JP2011535633A patent/JP2012508240A/ja not_active Withdrawn
- 2009-11-04 US US13/126,484 patent/US8334293B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2009071480A3 (en) | Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors | |
| US8518930B2 (en) | Therapeutic combination comprising a CDKS inhibitor and an antineoplastic agent | |
| AU2009268469B2 (en) | Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of Ras/Raf/Mek pathway | |
| EP3251674A3 (en) | Antiviral azasugar-containing nucleosides | |
| IL191196A (en) | Pyrido-, Pirazo-, and Pyrimido-Pyrimidine Derivatives as Mtor Inhibitors, Pharmaceuticals Containing Them and Using Them as Medicines and Manufacturing Drugs to Create Anti-Cancer Effect in a Warm Blood Animal | |
| JP2012508240A5 (enExample) | ||
| JP2006508953A5 (enExample) | ||
| MX2009006613A (es) | Derivados de pirazolo-quinazolina sustituidos, proceso para su preparacion y su uso como inhibidores de cinasa. | |
| EA201170249A1 (ru) | 3,4-диарилпиразолы в качестве ингибиторов протеинкиназ | |
| CY1119381T1 (el) | Παραγωγα 2-μεθυλομορφολινο πυριδο-, πυραζο- και πυριμιδο-πυριμιδινης ως αναστολεις mtor | |
| WO2009007749A3 (en) | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases | |
| PH12013501594A1 (en) | Substituted indazole derivatives active as kinase inhibitors | |
| JP2011503071A5 (ja) | ヨードニトロベンズアミド化合物と抗腫瘍剤の組み合わせによる卵巣がんの治療 | |
| IL197128A (en) | History of pyridone, pharmaceutical preparations containing them and their use in the preparation of drugs that affect eating behavior. | |
| HRP20120918T1 (hr) | Aminopirazolski spoj | |
| JP2012517427A5 (enExample) | ||
| JP2012508239A5 (enExample) | ||
| IS8132A (is) | Pýrósóló-kínasólín afleiður, aðferð við framleiðslu þeirra og notkun sem kínasa hindrar | |
| EA201000091A1 (ru) | ПРОИЗВОДНЫЕ МОРФОЛИНОПИРИМИДИНА, ИСПОЛЬЗУЕМЫЕ ПРИ ЗАБОЛЕВАНИЯХ, СВЯЗАННЫХ С mTOR КИНАЗОЙ И/ИЛИ PI3K | |
| JP2010536849A5 (enExample) | ||
| HRP20161522T1 (hr) | Derivati 6.7-dialkoksi kinazolina korisni za liječenje poremećaja povezanih s rakom | |
| IL203936A (en) | HISTORY 4 - Pyrimidinsulfamide, Process for Preparation, Pharmaceutical Preparations Containing and Using it for Medication Preparation | |
| JP2009542581A5 (enExample) | ||
| IL207972A (en) | History of pyridine-2-ram, pharmaceuticals containing them and their use in the preparation of medicines | |
| IL201730A (en) | History 1h - Benzaimidazole – 2 – Il – Profile – Methyl – Amino – Ethyl – 5 – Aryl – Bicyclo [2.2.2] Oct – 5 – Ann – 2 – All, Pharmaceutical preparations containing them and their use in the preparation of drugs |