JP2012508240A5 - - Google Patents
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- Publication number
- JP2012508240A5 JP2012508240A5 JP2011535633A JP2011535633A JP2012508240A5 JP 2012508240 A5 JP2012508240 A5 JP 2012508240A5 JP 2011535633 A JP2011535633 A JP 2011535633A JP 2011535633 A JP2011535633 A JP 2011535633A JP 2012508240 A5 JP2012508240 A5 JP 2012508240A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- small cell
- cell lung
- pyrazolo
- imidazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 4-Fluoro-3-trifluoromethyl-phenyl Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 229940121647 egfr inhibitor Drugs 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 4
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 4
- 206010041067 Small cell lung cancer Diseases 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000017662 Hodgkin disease lymphocyte depletion type stage unspecified Diseases 0.000 claims 2
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 2
- 206010049459 Lymphangioleiomyomatosis Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
- 229960004316 cisplatin Drugs 0.000 claims 2
- 201000010897 colon adenocarcinoma Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 229960005073 erlotinib hydrochloride Drugs 0.000 claims 2
- GTTBEUCJPZQMDZ-UHFFFAOYSA-N erlotinib hydrochloride Chemical group [H+].[Cl-].C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 GTTBEUCJPZQMDZ-UHFFFAOYSA-N 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 2
- FYXRSVDHGLUMHB-UHFFFAOYSA-N 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1h-pyrazolo[3,4-d]pyrimidine Chemical compound N1=C(C2CCN(CC2)C=2C=3C=NNC=3N=CN=2)N(C)C=C1C1=CC=C(F)C(C(F)(F)F)=C1 FYXRSVDHGLUMHB-UHFFFAOYSA-N 0.000 claims 1
- UEGFNRZYLNKXAD-UHFFFAOYSA-N 4-methylbenzenesulfonic acid;pyrimidine Chemical compound C1=CN=CN=C1.CC1=CC=C(S(O)(=O)=O)C=C1 UEGFNRZYLNKXAD-UHFFFAOYSA-N 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11327608P | 2008-11-11 | 2008-11-11 | |
| US61/113,276 | 2008-11-11 | ||
| PCT/US2009/063189 WO2010056575A1 (en) | 2008-11-11 | 2009-11-04 | P70 s6 kinase inhibitor and egfr inhibitor combination therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012508240A JP2012508240A (ja) | 2012-04-05 |
| JP2012508240A5 true JP2012508240A5 (enExample) | 2012-12-20 |
Family
ID=41664868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535633A Withdrawn JP2012508240A (ja) | 2008-11-11 | 2009-11-04 | Ｐ７０ｓ６キナーゼ阻害剤およびｅｇｆｒ阻害剤の併用療法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8334293B2 (enExample) |
| EP (1) | EP2355821A1 (enExample) |
| JP (1) | JP2012508240A (enExample) |
| KR (1) | KR20110075015A (enExample) |
| CN (1) | CN102209538B (enExample) |
| AU (1) | AU2009314336B2 (enExample) |
| BR (1) | BRPI0921888A2 (enExample) |
| CA (1) | CA2743295A1 (enExample) |
| EA (1) | EA018624B1 (enExample) |
| MX (1) | MX2011005002A (enExample) |
| WO (1) | WO2010056575A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140255471A1 (en) | 2013-03-11 | 2014-09-11 | Wake Forest University Health Sciences | Method of treating brain tumors |
| SG11201505999VA (en) * | 2013-03-11 | 2015-08-28 | Merck Patent Gmbh | 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity |
| US9457019B2 (en) * | 2013-11-07 | 2016-10-04 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
| CN106456774A (zh) * | 2014-04-04 | 2017-02-22 | 阿斯利康(瑞典)有限公司 | Nras突变的癌症的治疗中使用的egfr抑制剂及mek抑制剂的组合 |
| WO2019147934A1 (en) * | 2018-01-29 | 2019-08-01 | Sackner Bernstein Jonathan | Methods for dopamine modulation in human neurologic diseases |
| DE102018205152A1 (de) | 2018-04-05 | 2019-10-10 | Glatt Ingenieurtechnik Gmbh | Verfahren und Reaktor zur Herstellung von Partikeln |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2332984T3 (es) | 1995-03-30 | 2010-02-16 | Pfizer Products Inc. | Derivados de quinazolinas. |
| CA2563699C (en) * | 2004-04-23 | 2014-03-25 | Exelixis, Inc. | Kinase modulators and method of use |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| EP1848719B1 (en) | 2004-12-28 | 2012-02-01 | Exelixis, Inc. | [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| EP1946120A2 (en) | 2005-10-18 | 2008-07-23 | George Mason Intellectual Properties, Inc. | Mtor pathway theranostic |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| UA99284C2 (ru) * | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
-
2009
- 2009-11-04 BR BRPI0921888A patent/BRPI0921888A2/pt not_active IP Right Cessation
- 2009-11-04 CN CN2009801448775A patent/CN102209538B/zh not_active Expired - Fee Related
- 2009-11-04 CA CA2743295A patent/CA2743295A1/en not_active Abandoned
- 2009-11-04 AU AU2009314336A patent/AU2009314336B2/en not_active Expired - Fee Related
- 2009-11-04 MX MX2011005002A patent/MX2011005002A/es not_active Application Discontinuation
- 2009-11-04 EA EA201170682A patent/EA018624B1/ru not_active IP Right Cessation
- 2009-11-04 EP EP09752049A patent/EP2355821A1/en not_active Withdrawn
- 2009-11-04 KR KR1020117010621A patent/KR20110075015A/ko not_active Abandoned
- 2009-11-04 WO PCT/US2009/063189 patent/WO2010056575A1/en not_active Ceased
- 2009-11-04 JP JP2011535633A patent/JP2012508240A/ja not_active Withdrawn
- 2009-11-04 US US13/126,484 patent/US8334293B2/en not_active Expired - Fee Related
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