EA018624B1 - Комбинированная терапия ингибитором киназы p70 s6 и ингибитором egfr - Google Patents
Комбинированная терапия ингибитором киназы p70 s6 и ингибитором egfr Download PDFInfo
- Publication number
- EA018624B1 EA018624B1 EA201170682A EA201170682A EA018624B1 EA 018624 B1 EA018624 B1 EA 018624B1 EA 201170682 A EA201170682 A EA 201170682A EA 201170682 A EA201170682 A EA 201170682A EA 018624 B1 EA018624 B1 EA 018624B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- fluoro
- trifluoromethylphenyl
- imidazol
- pyrimidine
- cancer
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
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- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US11327608P | 2008-11-11 | 2008-11-11 | |
| PCT/US2009/063189 WO2010056575A1 (en) | 2008-11-11 | 2009-11-04 | P70 s6 kinase inhibitor and egfr inhibitor combination therapy |
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| EA201170682A1 EA201170682A1 (ru) | 2011-10-31 |
| EA018624B1 true EA018624B1 (ru) | 2013-09-30 |
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| EA201170682A EA018624B1 (ru) | 2008-11-11 | 2009-11-04 | Комбинированная терапия ингибитором киназы p70 s6 и ингибитором egfr |
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| EP (1) | EP2355821A1 (enExample) |
| JP (1) | JP2012508240A (enExample) |
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| CN (1) | CN102209538B (enExample) |
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| WO (1) | WO2010056575A1 (enExample) |
Cited By (1)
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|---|---|---|---|---|
| RU2683276C2 (ru) * | 2014-04-04 | 2019-03-27 | Астразенека Аб | Комбинация ингибитора EGFR и ингибитора MEK для применения в лечении рака, вызванного мутировавшим NRAS |
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| US20140255471A1 (en) | 2013-03-11 | 2014-09-11 | Wake Forest University Health Sciences | Method of treating brain tumors |
| AR095202A1 (es) * | 2013-03-11 | 2015-09-30 | Merck Patent Gmbh | Heterociclos como moduladores de la actividad quinasa |
| US9457019B2 (en) * | 2013-11-07 | 2016-10-04 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
| US11806326B2 (en) | 2018-01-29 | 2023-11-07 | Jonathan Sackner-Bernstein | Methods for dopamine modulation in human neurologic diseases |
| DE102018205152A1 (de) | 2018-04-05 | 2019-10-10 | Glatt Ingenieurtechnik Gmbh | Verfahren und Reaktor zur Herstellung von Partikeln |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117909A2 (en) * | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| WO2006071819A1 (en) * | 2004-12-28 | 2006-07-06 | Exelixis, Inc. | [1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| WO2007047754A2 (en) * | 2005-10-18 | 2007-04-26 | George Mason Intellectual Properties, Inc. | Mtor pathway theranostic |
| WO2008075109A1 (en) * | 2006-12-21 | 2008-06-26 | Astex Therapeutics Limited | Substituted piperidines having protein kinase inhibiting activity |
| WO2008140947A1 (en) * | 2007-05-11 | 2008-11-20 | Eli Lilly And Company | P70 s6 kinase inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0817775B1 (en) | 1995-03-30 | 2001-09-12 | Pfizer Inc. | Quinazoline derivatives |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
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2009
- 2009-11-04 BR BRPI0921888A patent/BRPI0921888A2/pt not_active IP Right Cessation
- 2009-11-04 EP EP09752049A patent/EP2355821A1/en not_active Withdrawn
- 2009-11-04 MX MX2011005002A patent/MX2011005002A/es not_active Application Discontinuation
- 2009-11-04 CN CN2009801448775A patent/CN102209538B/zh not_active Expired - Fee Related
- 2009-11-04 CA CA2743295A patent/CA2743295A1/en not_active Abandoned
- 2009-11-04 AU AU2009314336A patent/AU2009314336B2/en not_active Expired - Fee Related
- 2009-11-04 WO PCT/US2009/063189 patent/WO2010056575A1/en not_active Ceased
- 2009-11-04 EA EA201170682A patent/EA018624B1/ru not_active IP Right Cessation
- 2009-11-04 KR KR1020117010621A patent/KR20110075015A/ko not_active Abandoned
- 2009-11-04 JP JP2011535633A patent/JP2012508240A/ja not_active Withdrawn
- 2009-11-04 US US13/126,484 patent/US8334293B2/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117909A2 (en) * | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| WO2006071819A1 (en) * | 2004-12-28 | 2006-07-06 | Exelixis, Inc. | [1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| WO2007047754A2 (en) * | 2005-10-18 | 2007-04-26 | George Mason Intellectual Properties, Inc. | Mtor pathway theranostic |
| WO2008075109A1 (en) * | 2006-12-21 | 2008-06-26 | Astex Therapeutics Limited | Substituted piperidines having protein kinase inhibiting activity |
| WO2008140947A1 (en) * | 2007-05-11 | 2008-11-20 | Eli Lilly And Company | P70 s6 kinase inhibitors |
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| AZZARITI ET AL.: "Synergic antiproliferative and anti angiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 75, no. 5, 3 December 2007 (2007-12-03), pages 1035-1044, XP022457982, ISSN: 0006-2952, page 1042, left-hand column, paragraph 2 * |
| MASIELLO D. ET AL.: "Combining an mTOR antagonist and receptor tyrosine kinase inhibitors for the treatment of prostate cancer", CANCER BIOLOGY AND THERAPY, LANDES BIOSCIENCE, US, vol. 6 , no. 2 , 1 February 2007 (2007-02-01), pages 195-201, XP008097352, ISSN: 1538-4047, page e6, left-hand column, paragraphs 2, 4 * |
| WIESLAWA H. DRAGOWSKA ET AL.: "Decreased levels of hypoxic cells in gefitinib treated ER+ HER-2 overexpressing MCF-7 breast cancer tumors are associated with hyperactivation of the mTOR pathway: therapeutic implications for combination therapy with rapamycin", BREAST CANCER RESEARCH AND TREATMENT, KLUWER ACADEMIC PUBLISHERS, BO, vol. 106, no. 3, 9 March 2007 (2007-03-09), pages 319-331, XP019549057, ISSN: 1573-7217, page 328, left-hand column * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2683276C2 (ru) * | 2014-04-04 | 2019-03-27 | Астразенека Аб | Комбинация ингибитора EGFR и ингибитора MEK для применения в лечении рака, вызванного мутировавшим NRAS |
Also Published As
| Publication number | Publication date |
|---|---|
| US8334293B2 (en) | 2012-12-18 |
| CN102209538B (zh) | 2013-06-12 |
| EA201170682A1 (ru) | 2011-10-31 |
| AU2009314336B2 (en) | 2013-09-12 |
| AU2009314336A1 (en) | 2010-05-20 |
| KR20110075015A (ko) | 2011-07-05 |
| JP2012508240A (ja) | 2012-04-05 |
| US20110207752A1 (en) | 2011-08-25 |
| CN102209538A (zh) | 2011-10-05 |
| MX2011005002A (es) | 2011-05-25 |
| EP2355821A1 (en) | 2011-08-17 |
| CA2743295A1 (en) | 2010-05-20 |
| WO2010056575A1 (en) | 2010-05-20 |
| BRPI0921888A2 (pt) | 2015-12-29 |
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