JP2012506904A - 難水溶性成分のためのメソ多孔性材料賦形剤 - Google Patents

難水溶性成分のためのメソ多孔性材料賦形剤 Download PDF

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Publication number
JP2012506904A
JP2012506904A JP2011534455A JP2011534455A JP2012506904A JP 2012506904 A JP2012506904 A JP 2012506904A JP 2011534455 A JP2011534455 A JP 2011534455A JP 2011534455 A JP2011534455 A JP 2011534455A JP 2012506904 A JP2012506904 A JP 2012506904A
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JP
Japan
Prior art keywords
mesoporous
active ingredient
pharmaceutical composition
pharmaceutically active
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011534455A
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English (en)
Japanese (ja)
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JP2012506904A5 (enExample
Inventor
シェン，ショウ−カン
キォン ン，ワイ
シェ，レオナルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agency for Science Technology and Research Singapore
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Agency for Science Technology and Research Singapore
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Publication of JP2012506904A publication Critical patent/JP2012506904A/ja
Publication of JP2012506904A5 publication Critical patent/JP2012506904A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011534455A 2008-10-28 2009-02-18 難水溶性成分のためのメソ多孔性材料賦形剤 Pending JP2012506904A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10901608P 2008-10-28 2008-10-28
US61/109,016 2008-10-28
PCT/SG2009/000053 WO2010050897A1 (en) 2008-10-28 2009-02-18 Mesoporous material excipients for poorly aqueous soluble ingredients

Publications (2)

Publication Number Publication Date
JP2012506904A true JP2012506904A (ja) 2012-03-22
JP2012506904A5 JP2012506904A5 (enExample) 2012-05-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011534455A Pending JP2012506904A (ja) 2008-10-28 2009-02-18 難水溶性成分のためのメソ多孔性材料賦形剤

Country Status (5)

Country Link
US (1) US8778401B2 (enExample)
EP (1) EP2349336B1 (enExample)
JP (1) JP2012506904A (enExample)
KR (1) KR20110110097A (enExample)
WO (1) WO2010050897A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017511331A (ja) * 2014-03-31 2017-04-20 ノバルティス ファーマ アーゲー 薬学的活性種を含む化合物を含有する多孔質材料
WO2018212275A1 (ja) * 2017-05-19 2018-11-22 株式会社トクヤマ 医薬原体担持体及びその製造方法
JP2020158410A (ja) * 2019-03-25 2020-10-01 株式会社ファンケル コエンザイムｑ１０の固体分散体
JP2021042173A (ja) * 2019-09-12 2021-03-18 株式会社ファンケル クルクミン固体分散体

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US10952965B2 (en) * 2009-05-15 2021-03-23 Baxter International Inc. Compositions and methods for drug delivery
CN103179955B (zh) 2010-09-14 2016-08-03 纳诺洛吉卡股份公司 用于不良水溶性的药物和化妆活性成分的过饱和释放赋形剂
KR101879474B1 (ko) 2011-06-20 2018-07-17 하. 룬드벡 아크티에셀스카브 정신 분열증의 치료를 위한 중수소화 1-피페라지노-3-페닐 인단
GB201212866D0 (en) * 2012-07-20 2012-09-05 Formac Pharmaceuticals Nv Dry granulates of mesoporous silica powders
SI2916852T1 (sl) * 2012-11-06 2021-08-31 Sigrid Therapeutics Ab Porozni silicijev dioksid za uporabo kot farmacevtska ali prehranska aktivna učinkovina
US9185928B2 (en) 2012-12-21 2015-11-17 National Health Research Institutes Mesoporous silica nanoparticles for oil absorption
CN104027814B (zh) * 2014-05-29 2016-02-24 福州大学 一种通过氨基修饰后双重载药的介孔二氧化硅
EP3517104A1 (en) * 2014-08-01 2019-07-31 Glenmark Pharmaceuticals S.A. Nanoparticulate formulation comprising a mpges-1 inhibitor
EP3174527B1 (en) * 2014-08-01 2021-02-17 Johnson & Johnson Consumer Inc. Dosage form of sodium ibuprofen dihydrate on mesoporous silica
GB201502073D0 (en) 2015-02-09 2015-03-25 Cubic Pharmaceuticals Ltd And Delta Pharmaceuticals Ltd HDEG technology
US10252251B2 (en) 2015-08-28 2019-04-09 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Production of organic materials using solid catalysts
US11903951B2 (en) * 2016-06-03 2024-02-20 M et P Pharma AG Nasal pharmaceutical compositions with a porous excipient
CN106755231B (zh) * 2016-11-29 2020-11-24 大连工业大学 一种血管紧张素转化酶抑制肽的提取方法
CA3050361A1 (en) 2017-01-20 2018-07-26 M et P Pharma AG Nasal pharmaceutical compositions for reducing the risks of exposure to air pollutants
BR112021008732A2 (pt) 2018-11-07 2021-08-03 Disruptive Materials Pharma Ab ingredientes farmacêuticos amorfos ativos compreendendo carbonato de magnésio mesoporoso substancialmente amorfo
US11123309B2 (en) 2018-11-15 2021-09-21 Imam Abdulrahman Bin Faisal University Methods for drug delivery, tumor imaging, and oxidative dehydrogenation using hierarchical ZSM-5 complex
EP3891134A1 (en) 2018-12-03 2021-10-13 H. Lundbeck A/S Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine
US20200188301A1 (en) 2018-12-14 2020-06-18 NuVessl, Inc. Method for Enhancing Passenger Molecule Loading
US20220096398A1 (en) * 2019-01-31 2022-03-31 Macquarie University Complexes and compositions comprising probucol and uses thereof
GB201909137D0 (en) * 2019-06-25 2019-08-07 Univ Aston Mesoporous polymeric particulate material
US20240016739A1 (en) * 2020-05-06 2024-01-18 Disruptive Pharma Ab Novel amorphous active pharmaceutical ingredients
CN115300448A (zh) * 2021-05-06 2022-11-08 香港中文大学 在纳米多孔模板内实现材料的纳米非晶态
US12458602B2 (en) 2021-05-06 2025-11-04 The Chinese University Of Hong Kong Realizing the nano-amorphous state of materials inside nano-porous templates
WO2022235934A2 (en) * 2021-05-06 2022-11-10 The Chinese University Of Hong Kong Realizing the nano-amorphous state of materials inside nano-porous templates

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02184621A (ja) * 1988-11-28 1990-07-19 Vectorpharma Internnatl Spa 溶解率を向上した担体支持薬剤およびその製造方法
JP2005501820A (ja) * 2001-06-22 2005-01-20 ファイザー・プロダクツ・インク 非晶質薬剤の吸着物の医薬組成物
JP2007523817A (ja) * 2003-06-27 2007-08-23 カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント 薬物を固定および制御放出するために有用な結晶性メソポーラス酸化物を基剤とする材料

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4327063A1 (de) 1993-08-12 1995-02-16 Kirsten Dr Westesen Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften
US5922299A (en) * 1996-11-26 1999-07-13 Battelle Memorial Institute Mesoporous-silica films, fibers, and powders by evaporation
US7919119B2 (en) 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US7172770B2 (en) 2001-02-19 2007-02-06 Board Of Regents, The University Of Texas System Mesoporous compositions for use in drug delivery
US6630170B2 (en) * 2001-04-26 2003-10-07 Board Of Regents The University Of Texas System Mesoporous compositions and method of preparation
US6653319B1 (en) 2001-08-10 2003-11-25 University Of Kentucky Research Foundation Pharmaceutical formulation for poorly water soluble camptothecin analogues
WO2005082277A1 (en) 2004-02-18 2005-09-09 Stanford University Drug delivery systems using mesoporous oxide films
WO2005110592A1 (en) * 2004-05-17 2005-11-24 Yki, Ytkemiska Institutet Ab Mesoporous particles loaded with active substance

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02184621A (ja) * 1988-11-28 1990-07-19 Vectorpharma Internnatl Spa 溶解率を向上した担体支持薬剤およびその製造方法
JP2005501820A (ja) * 2001-06-22 2005-01-20 ファイザー・プロダクツ・インク 非晶質薬剤の吸着物の医薬組成物
JP2007523817A (ja) * 2003-06-27 2007-08-23 カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント 薬物を固定および制御放出するために有用な結晶性メソポーラス酸化物を基剤とする材料

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6013042968; Ｃｈｅｍ　Ｐｈａｒｍ　Ｂｕｌｌ，　ｖｏｌ．５５，　ｐ．９８５-９９１　（２００７） *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017511331A (ja) * 2014-03-31 2017-04-20 ノバルティス ファーマ アーゲー 薬学的活性種を含む化合物を含有する多孔質材料
WO2018212275A1 (ja) * 2017-05-19 2018-11-22 株式会社トクヤマ 医薬原体担持体及びその製造方法
JPWO2018212275A1 (ja) * 2017-05-19 2020-03-19 株式会社トクヤマ 医薬原体担持体及びその製造方法
US11246931B2 (en) 2017-05-19 2022-02-15 Tokuyama Corporation Active pharmaceutical ingredient carrier and production method of the same
JP7200097B2 (ja) 2017-05-19 2023-01-06 株式会社トクヤマ 医薬原体担持体及びその製造方法
JP2020158410A (ja) * 2019-03-25 2020-10-01 株式会社ファンケル コエンザイムｑ１０の固体分散体
JP7260353B2 (ja) 2019-03-25 2023-04-18 株式会社ファンケル コエンザイムｑ１０の固体分散体
JP2021042173A (ja) * 2019-09-12 2021-03-18 株式会社ファンケル クルクミン固体分散体

Also Published As

Publication number Publication date
EP2349336A4 (en) 2013-10-23
US20110244002A1 (en) 2011-10-06
EP2349336A1 (en) 2011-08-03
KR20110110097A (ko) 2011-10-06
US8778401B2 (en) 2014-07-15
WO2010050897A1 (en) 2010-05-06
EP2349336B1 (en) 2017-11-22

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