JP2012506402A5 - - Google Patents

Info

Publication number

JP2012506402A5

JP2012506402A5 JP2011532609A JP2011532609A JP2012506402A5 JP 2012506402 A5 JP2012506402 A5 JP 2012506402A5 JP 2011532609 A JP2011532609 A JP 2011532609A JP 2011532609 A JP2011532609 A JP 2011532609A JP 2012506402 A5 JP2012506402 A5 JP 2012506402A5

Authority

JP

Japan

Prior art keywords

pramlintide

carboxy

carboxynonadecanoylamino

butyryl

his17

Prior art date

2009-10-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229960003611 pramlintide Drugs 0.000 claims 70
• -1 19-carboxynonadecanoyl Chemical group 0.000 claims 66
• 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 52
• 101100338242 Drosophila virilis His1.1 gene Proteins 0.000 claims 17
• 101100260702 Mus musculus Tinagl1 gene Proteins 0.000 claims 15
• 101150088826 arg1 gene Proteins 0.000 claims 15
• 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 14
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 8
• 101001081479 Homo sapiens Islet amyloid polypeptide Proteins 0.000 claims 6
• 150000001413 amino acids Chemical class 0.000 claims 5
• 101100455752 Caenorhabditis elegans lys-3 gene Proteins 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• 102000009027 Albumins Human genes 0.000 claims 2
• 108010088751 Albumins Proteins 0.000 claims 2
• KOSRFJWDECSPRO-WDSKDSINSA-N Glu-Glu Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(O)=O KOSRFJWDECSPRO-WDSKDSINSA-N 0.000 claims 2
• 239000000654 additive Substances 0.000 claims 2
• 230000000996 additive effect Effects 0.000 claims 2
• KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 claims 2
• PXVCMZCJAUJLJP-YUMQZZPRSA-N gamma-Glu-His Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(O)=O)CC1=CN=CN1 PXVCMZCJAUJLJP-YUMQZZPRSA-N 0.000 claims 2
• 108010055341 glutamyl-glutamic acid Proteins 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 208000011580 syndromic disease Diseases 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000028698 Cognitive impairment Diseases 0.000 claims 1
• SNPQGCDJHZAVOB-SOMABOLJSA-N D-glucosyl-N-tetracosanoylsphinganine Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)CCCCCCCCCCCCCCC)COC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SNPQGCDJHZAVOB-SOMABOLJSA-N 0.000 claims 1
• 208000032928 Dyslipidaemia Diseases 0.000 claims 1
• MPZWMIIOPAPAKE-BQBZGAKWSA-N Glu-Arg Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=N MPZWMIIOPAPAKE-BQBZGAKWSA-N 0.000 claims 1
• ILGFBUGLBSAQQB-GUBZILKMSA-N Glu-Glu-Arg Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O ILGFBUGLBSAQQB-GUBZILKMSA-N 0.000 claims 1
• BBBXWRGITSUJPB-YUMQZZPRSA-N Glu-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O BBBXWRGITSUJPB-YUMQZZPRSA-N 0.000 claims 1
• SJJHXJDSNQJMMW-SRVKXCTJSA-N Glu-Lys-Arg Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O SJJHXJDSNQJMMW-SRVKXCTJSA-N 0.000 claims 1
• 208000002705 Glucose Intolerance Diseases 0.000 claims 1
• 206010020772 Hypertension Diseases 0.000 claims 1
• 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims 1
• 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims 1
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
• 125000000729 N-terminal amino-acid group Chemical group 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 208000007107 Stomach Ulcer Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 150000001408 amides Chemical class 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 208000010877 cognitive disease Diseases 0.000 claims 1
• 208000029078 coronary artery disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 201000006549 dyspepsia Diseases 0.000 claims 1
• 230000002526 effect on cardiovascular system Effects 0.000 claims 1
• 201000001421 hyperglycemia Diseases 0.000 claims 1
• 230000002757 inflammatory effect Effects 0.000 claims 1
• 208000010125 myocardial infarction Diseases 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 201000009104 prediabetes syndrome Diseases 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1