JP2012503992A5 - - Google Patents
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- JP2012503992A5 JP2012503992A5 JP2011529363A JP2011529363A JP2012503992A5 JP 2012503992 A5 JP2012503992 A5 JP 2012503992A5 JP 2011529363 A JP2011529363 A JP 2011529363A JP 2011529363 A JP2011529363 A JP 2011529363A JP 2012503992 A5 JP2012503992 A5 JP 2012503992A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- recombinant
- protein
- cluster
- recombinant yeast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 38
- 108090000623 proteins and genes Proteins 0.000 claims 22
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 20
- 235000018102 proteins Nutrition 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 108700016168 Dihydroxy-acid dehydratases Proteins 0.000 claims 9
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 6
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000002538 fungal effect Effects 0.000 claims 5
- 108010065027 Propanediol Dehydratase Proteins 0.000 claims 4
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims 4
- JTEYKUFKXGDTEU-UHFFFAOYSA-N 2,3-dihydroxy-3-methylbutanoic acid Chemical compound CC(C)(O)C(O)C(O)=O JTEYKUFKXGDTEU-UHFFFAOYSA-N 0.000 claims 3
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 3
- KPULXFNPTWGJQH-UHFFFAOYSA-N 3-hydroxy-4-oxo-4-propan-2-yloxybutanoic acid Chemical compound CC(C)OC(=O)C(O)CC(O)=O KPULXFNPTWGJQH-UHFFFAOYSA-N 0.000 claims 2
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 2
- 108090001042 Hydro-Lyases Proteins 0.000 claims 2
- 102000004867 Hydro-Lyases Human genes 0.000 claims 2
- 241000235648 Pichia Species 0.000 claims 2
- 241000235070 Saccharomyces Species 0.000 claims 2
- 108010009924 Aconitate hydratase Proteins 0.000 claims 1
- 101100452478 Arabidopsis thaliana DHAD gene Proteins 0.000 claims 1
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 claims 1
- 101710117026 Biotin synthase Proteins 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 1
- 102100039868 Cytoplasmic aconitate hydratase Human genes 0.000 claims 1
- 102000015782 Electron Transport Complex III Human genes 0.000 claims 1
- 108010024882 Electron Transport Complex III Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101100237347 Escherichia coli (strain K12) metN gene Proteins 0.000 claims 1
- 108010074122 Ferredoxins Proteins 0.000 claims 1
- 102000016901 Glutamate dehydrogenase Human genes 0.000 claims 1
- 108010063370 Homoaconitate hydratase Proteins 0.000 claims 1
- 102100025458 Inosine triphosphate pyrophosphatase Human genes 0.000 claims 1
- 241000235649 Kluyveromyces Species 0.000 claims 1
- 102100021174 Lipoyl synthase, mitochondrial Human genes 0.000 claims 1
- 101100444360 Mycoplasma mycoides subsp. mycoides SC (strain PG1) ecfA1 gene Proteins 0.000 claims 1
- 108010075285 Nucleoside-Triphosphatase Proteins 0.000 claims 1
- 101100464186 Oryzias latipes pkd1l1 gene Proteins 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 241000235346 Schizosaccharomyces Species 0.000 claims 1
- 241000194019 Streptococcus mutans Species 0.000 claims 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 claims 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 claims 1
- 108010027912 Sulfite Oxidase Proteins 0.000 claims 1
- 102000043440 Sulfite oxidase Human genes 0.000 claims 1
- 241000235013 Yarrowia Species 0.000 claims 1
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 150000001945 cysteines Chemical class 0.000 claims 1
- 210000000172 cytosol Anatomy 0.000 claims 1
- 108010037535 lipoic acid synthase Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 210000003470 mitochondria Anatomy 0.000 claims 1
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 230000007420 reactivation Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 claims 1
- 229940035936 ubiquinone Drugs 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10080608P | 2008-09-29 | 2008-09-29 | |
| US10080108P | 2008-09-29 | 2008-09-29 | |
| US61/100,806 | 2008-09-29 | ||
| US61/100,801 | 2008-09-29 | ||
| PCT/US2009/058826 WO2010037111A1 (en) | 2008-09-29 | 2009-09-29 | INCREASED HETEROLOGOUS Fe-S ENZYME ACTIIVTY IN YEAST |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503992A JP2012503992A (ja) | 2012-02-16 |
| JP2012503992A5 true JP2012503992A5 (enExample) | 2012-11-15 |
| JP5804946B2 JP5804946B2 (ja) | 2015-11-04 |
Family
ID=41267090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529363A Active JP5804946B2 (ja) | 2008-09-29 | 2009-09-29 | 酵母における異種性Ｆｅ−Ｓ酵素活性の増大 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9206447B2 (enExample) |
| EP (1) | EP2337856A1 (enExample) |
| JP (1) | JP5804946B2 (enExample) |
| KR (1) | KR20110063576A (enExample) |
| CN (1) | CN102186983A (enExample) |
| AU (1) | AU2009296224B2 (enExample) |
| BR (1) | BRPI0913552B1 (enExample) |
| CA (1) | CA2735945A1 (enExample) |
| MX (1) | MX2011003313A (enExample) |
| NZ (1) | NZ591126A (enExample) |
| WO (1) | WO2010037111A1 (enExample) |
| ZA (1) | ZA201101167B (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9303225B2 (en) | 2005-10-26 | 2016-04-05 | Butamax Advanced Biofuels Llc | Method for the production of isobutanol by recombinant yeast |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| KR101573775B1 (ko) | 2007-04-18 | 2015-12-04 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산 |
| US8188250B2 (en) * | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| BRPI0909989A2 (pt) | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
| US20160222370A1 (en) * | 2008-09-29 | 2016-08-04 | Butamax Advanced Biofuels Llc | Recombinant Yeast Host Cell With Fe-S Cluster Proteins And Methods Of Using Thereof |
| KR20110063576A (ko) | 2008-09-29 | 2011-06-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 효모에서 증가된 이종성 Ｆｅ-Ｓ 효소 활성 |
| MX2011003238A (es) | 2008-09-29 | 2011-04-28 | Butamax Tm Advanced Biofuels | Identificacion y uso de dihidroxiacido deshidratasas [2fe-2s] bacterianas. |
| CA2735948A1 (en) | 2008-09-29 | 2011-04-01 | Butamaxtm Advanced Biofuels Llc | Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria |
| WO2010037105A1 (en) * | 2008-09-29 | 2010-04-01 | Butamax™ Advanced Biofuels LLC | Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria |
| RU2422526C2 (ru) * | 2009-01-30 | 2011-06-27 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов (ФГУП ГосНИИгенетика) | СПОСОБ ПОЛУЧЕНИЯ ЯНТАРНОЙ КИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ ДРОЖЖЕЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Yarrowia |
| US8232089B2 (en) * | 2009-08-12 | 2012-07-31 | Gevo, Inc. | Cytosolic isobutanol pathway localization for the production of isobutanol |
| US20110244536A1 (en) | 2009-09-29 | 2011-10-06 | Butamax(Tm) Advanced Biofuels Llc | Fermentive production of isobutanol using highly effective ketol-acid reductoisomerase enzymes |
| WO2011041426A1 (en) | 2009-09-29 | 2011-04-07 | Butamax(Tm) Advanced Biofuels Llc | Improved yeast production host cells |
| JP2013511283A (ja) * | 2009-11-23 | 2013-04-04 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 電解質の添加を伴う抽出発酵を用いたブタノールの生成方法 |
| CA2779460A1 (en) * | 2009-11-23 | 2011-05-26 | Butamax(Tm) Advanced Biofuels Llc | Method for producing butanol using extractive fermentation with osmolyte addition |
| BR112012012492A2 (pt) * | 2009-11-24 | 2019-09-24 | Gevo Inc | métodos para aumentar atividade de diidróxi ácido desidratase para aperfeiçoar produção de combustíveis, produtos químicos e aminoácidos |
| KR20120099509A (ko) | 2009-12-29 | 2012-09-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 재조합 숙주 세포에서 육탄당 키나아제의 발현 |
| CN102762722B (zh) | 2009-12-29 | 2015-05-20 | 布特马斯先进生物燃料有限责任公司 | 用于发酵生产低级烷基醇的醇脱氢酶(adh) |
| BR122021001265B1 (pt) | 2010-01-14 | 2022-02-22 | Monsanto Technology Llc | Molécula de dna compreendendo elementos reguladores de plantas |
| US9297016B2 (en) | 2010-02-17 | 2016-03-29 | Butamax Advanced Biofuels Llc | Activity of Fe—S cluster requiring proteins |
| EP3269806B1 (en) * | 2010-09-07 | 2020-05-27 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
| WO2012071121A1 (en) * | 2010-11-24 | 2012-05-31 | Gevo, Inc. | Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids |
| CA2831130C (en) | 2011-03-24 | 2021-10-26 | Butamax (Tm) Advanced Biofuels Llc | Host cells and methods for production of isobutanol |
| JP6093764B2 (ja) * | 2011-07-28 | 2017-03-08 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ケトイソ吉草酸デカルボキシラーゼ酵素およびその使用方法 |
| WO2013043801A1 (en) * | 2011-09-20 | 2013-03-28 | Gevo, Inc. | High-performance dihydroxy acid dehydratases |
| CA2861613A1 (en) | 2011-12-30 | 2013-07-04 | Butamax Advanced Biofuels Llc | Fermentative production of alcohols |
| CN104284981A (zh) | 2012-03-23 | 2015-01-14 | 布特马斯先进生物燃料有限责任公司 | 在针对产丁醇生物的培养基中补充乙酸盐 |
| WO2013176909A2 (en) | 2012-05-11 | 2013-11-28 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| BR112015003701A2 (pt) | 2012-08-22 | 2017-12-12 | Butamax Advanced Biofuels Llc | células hospedeiras recombinantes, método para aprimoramento, processo para a produção de um álcool, polinucleotídeo isolado, cassete de expressão e composição |
| US9840724B2 (en) | 2012-09-21 | 2017-12-12 | Butamax Advanced Biofuels Llc | Production of renewable hydrocarbon compositions |
| US9512408B2 (en) | 2012-09-26 | 2016-12-06 | Butamax Advanced Biofuels Llc | Polypeptides with ketol-acid reductoisomerase activity |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| WO2014106107A2 (en) | 2012-12-28 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Dhad variants for butanol production |
| WO2014160050A1 (en) | 2013-03-14 | 2014-10-02 | Butamax Advanced Biofuels Llc | Glycerol 3- phosphate dehydrogenase for butanol production |
| WO2014144643A1 (en) | 2013-03-15 | 2014-09-18 | Butamax Advanced Biofuels Llc | Method for producing butanol using extractive fermentation |
| WO2014151645A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Process for maximizing biomass growth and butanol yield by feedback control |
| WO2014151190A1 (en) * | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Dhad variants and methods of screening |
| US9771602B2 (en) | 2013-03-15 | 2017-09-26 | Butamax Advanced Biofuels Llc | Competitive growth and/or production advantage for butanologen microorganism |
| CA2901374A1 (en) | 2013-03-15 | 2014-09-18 | Butamax Advanced Biofuels Llc | Method for production of butanol using extractive fermentation |
| WO2015002913A1 (en) | 2013-07-03 | 2015-01-08 | Butamax Advanced Biofuels Llc | Partial adaptation for butanol production |
| CA2957920A1 (en) | 2014-08-11 | 2016-02-18 | Butamax Advanced Biofuels Llc | Yeast preparations and methods of making the same |
| US9920312B2 (en) * | 2014-08-11 | 2018-03-20 | Lallemand Hungary Liquidity Management Llc | Mutations in iron-sulfur cluster proteins that improve xylose utilization |
| CN105820965B (zh) * | 2015-01-08 | 2019-08-13 | 深圳华大基因研究院 | 一株人工合成ii号染色体的酿酒酵母菌株 |
| CN105238733A (zh) * | 2015-11-24 | 2016-01-13 | 山东大学 | 一株高效表达2[4Fe4S]铁氧还蛋白的重组大肠杆菌及其应用 |
| CN113185589B (zh) * | 2021-04-23 | 2023-05-30 | 东北农业大学 | 一种抗草甘膦相关蛋白及其编码基因与应用 |
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| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
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| US8906666B2 (en) | 2008-05-22 | 2014-12-09 | Butamax Advanced Biofuels Llc | Engineering resistance to aliphatic alcohols |
| NZ588988A (en) | 2008-06-04 | 2012-08-31 | Butamax Tm Advanced Biofuels | A method for producing butanol using two-phase extractive fermentation |
| BRPI0909989A2 (pt) | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
| CA2735948A1 (en) | 2008-09-29 | 2011-04-01 | Butamaxtm Advanced Biofuels Llc | Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria |
| MX2011003238A (es) | 2008-09-29 | 2011-04-28 | Butamax Tm Advanced Biofuels | Identificacion y uso de dihidroxiacido deshidratasas [2fe-2s] bacterianas. |
| WO2010037105A1 (en) | 2008-09-29 | 2010-04-01 | Butamax™ Advanced Biofuels LLC | Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria |
| KR20110063576A (ko) * | 2008-09-29 | 2011-06-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 효모에서 증가된 이종성 Ｆｅ-Ｓ 효소 활성 |
| BRPI0913680A2 (pt) | 2008-09-29 | 2019-09-24 | Butamax Advanced Biofuels Llc | "célula bacteriana ácido-láctica, método para aumentar a atividade de um polipeptídeo dihidroxi-ácido desidratase heterólogo em uma célula bacteriana ácido-láctica e método de produção de insobutanol" |
| BRPI0914521A2 (pt) | 2008-10-27 | 2016-07-26 | Butamax Advanced Biofuels Llc | célula hospedeira microbiana recombinante, método de aumento da produção de isobutanol e método de produção de isobutanol |
| US8828694B2 (en) | 2008-11-13 | 2014-09-09 | Butamax Advanced Biofuels Llc | Production of isobutanol in yeast mitochondria |
| US8465964B2 (en) | 2008-11-13 | 2013-06-18 | Butamax (TM) Advanced Biofules LLC | Increased production of isobutanol in yeast with reduced mitochondrial amino acid biosynthesis |
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| US8557562B2 (en) | 2008-12-29 | 2013-10-15 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving filamentous growth response |
| US8795992B2 (en) | 2008-12-29 | 2014-08-05 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving cell wall integrity pathway |
| US8614085B2 (en) | 2009-02-27 | 2013-12-24 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
| US20120058541A1 (en) | 2009-05-22 | 2012-03-08 | Butamax(Tm) Advanced Biofuels Llc | Engineering resistance to aliphatic alcohols |
| US8232089B2 (en) | 2009-08-12 | 2012-07-31 | Gevo, Inc. | Cytosolic isobutanol pathway localization for the production of isobutanol |
| IN2012DN02396A (enExample) | 2009-09-29 | 2015-08-21 | Butamax Tm Advanced Biofuels | |
| WO2011041426A1 (en) | 2009-09-29 | 2011-04-07 | Butamax(Tm) Advanced Biofuels Llc | Improved yeast production host cells |
| US20110244536A1 (en) | 2009-09-29 | 2011-10-06 | Butamax(Tm) Advanced Biofuels Llc | Fermentive production of isobutanol using highly effective ketol-acid reductoisomerase enzymes |
| US20110195505A1 (en) | 2009-10-08 | 2011-08-11 | Butamax(Tm) Advanced Biofuels Llc | Bacterial strains for butanol production |
| JP2013511283A (ja) | 2009-11-23 | 2013-04-04 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 電解質の添加を伴う抽出発酵を用いたブタノールの生成方法 |
| CA2779460A1 (en) | 2009-11-23 | 2011-05-26 | Butamax(Tm) Advanced Biofuels Llc | Method for producing butanol using extractive fermentation with osmolyte addition |
| BR112012012492A2 (pt) | 2009-11-24 | 2019-09-24 | Gevo Inc | métodos para aumentar atividade de diidróxi ácido desidratase para aperfeiçoar produção de combustíveis, produtos químicos e aminoácidos |
| CN102762722B (zh) | 2009-12-29 | 2015-05-20 | 布特马斯先进生物燃料有限责任公司 | 用于发酵生产低级烷基醇的醇脱氢酶(adh) |
| KR20120099509A (ko) | 2009-12-29 | 2012-09-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 재조합 숙주 세포에서 육탄당 키나아제의 발현 |
| US9297016B2 (en) | 2010-02-17 | 2016-03-29 | Butamax Advanced Biofuels Llc | Activity of Fe—S cluster requiring proteins |
| BR112012031847A2 (pt) | 2010-06-17 | 2016-02-16 | Butamax Tm Advanced Biofuels | cultura de produção para a produção fermentativa de butanol, método de produção de butanol, método para a produção de butanol, método para aumentar a tolerância de uma cultura de produção para a produção fermentativa de butanol e cultura de produção para produção fermentativa de butanol |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| EP3269806B1 (en) | 2010-09-07 | 2020-05-27 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
| CA2831130C (en) | 2011-03-24 | 2021-10-26 | Butamax (Tm) Advanced Biofuels Llc | Host cells and methods for production of isobutanol |
| US20120258873A1 (en) | 2011-04-06 | 2012-10-11 | Butamax(Tm) Advanced Biofuels Llc | Reduction of 2,3-dihydroxy-2-methyl butyrate (dhmb) in butanol production |
| CA2838519A1 (en) | 2011-06-17 | 2012-12-20 | Butamax Advanced Biofuels Llc | Lignocellulosic hydrolysates as feedstocks for isobutanol fermentation |
| JP6093764B2 (ja) | 2011-07-28 | 2017-03-08 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ケトイソ吉草酸デカルボキシラーゼ酵素およびその使用方法 |
| AU2012362144A1 (en) | 2011-12-30 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Genetic switches for butanol production |
| CN104284981A (zh) | 2012-03-23 | 2015-01-14 | 布特马斯先进生物燃料有限责任公司 | 在针对产丁醇生物的培养基中补充乙酸盐 |
| WO2013176909A2 (en) | 2012-05-11 | 2013-11-28 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| US9512408B2 (en) | 2012-09-26 | 2016-12-06 | Butamax Advanced Biofuels Llc | Polypeptides with ketol-acid reductoisomerase activity |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| US20140186911A1 (en) | 2012-12-28 | 2014-07-03 | Butamax Advanced Biofuels Llc | Recombinant host cells and methods for producing butanol |
| WO2014106107A2 (en) | 2012-12-28 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Dhad variants for butanol production |
-
2009
- 2009-09-29 KR KR1020117009698A patent/KR20110063576A/ko not_active Ceased
- 2009-09-29 EP EP09793125A patent/EP2337856A1/en not_active Withdrawn
- 2009-09-29 CA CA2735945A patent/CA2735945A1/en not_active Abandoned
- 2009-09-29 CN CN2009801384379A patent/CN102186983A/zh active Pending
- 2009-09-29 JP JP2011529363A patent/JP5804946B2/ja active Active
- 2009-09-29 WO PCT/US2009/058826 patent/WO2010037111A1/en not_active Ceased
- 2009-09-29 US US12/569,069 patent/US9206447B2/en active Active
- 2009-09-29 MX MX2011003313A patent/MX2011003313A/es active IP Right Grant
- 2009-09-29 AU AU2009296224A patent/AU2009296224B2/en active Active
- 2009-09-29 BR BRPI0913552-9A patent/BRPI0913552B1/pt active IP Right Grant
- 2009-09-29 NZ NZ591126A patent/NZ591126A/xx not_active IP Right Cessation
-
2011
- 2011-02-14 ZA ZA2011/01167A patent/ZA201101167B/en unknown
- 2011-11-15 US US13/296,944 patent/US8241878B2/en active Active
-
2015
- 2015-10-02 US US14/873,956 patent/US20160024534A1/en not_active Abandoned
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