JP2012503673A - ミネラルコーティングされたマイクロスフェア - Google Patents

ミネラルコーティングされたマイクロスフェア Download PDF

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Publication number
JP2012503673A
JP2012503673A JP2011529272A JP2011529272A JP2012503673A JP 2012503673 A JP2012503673 A JP 2012503673A JP 2011529272 A JP2011529272 A JP 2011529272A JP 2011529272 A JP2011529272 A JP 2011529272A JP 2012503673 A JP2012503673 A JP 2012503673A
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Prior art keywords
microsphere
compound
calcium
microspheres
mineral
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JP2011529272A
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JP2012503673A5 (enExample
Inventor
ウィリアム エル マーフィー
リーナポーン ジョンパイブーンキット
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ティッシュ リジェネレーション システムズ インコーポレイテッド
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Publication of JP2012503673A publication Critical patent/JP2012503673A/ja
Publication of JP2012503673A5 publication Critical patent/JP2012503673A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/501Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011529272A 2008-09-25 2009-09-25 ミネラルコーティングされたマイクロスフェア Pending JP2012503673A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10006208P 2008-09-25 2008-09-25
US61/100,062 2008-09-25
PCT/US2009/058419 WO2010036919A1 (en) 2008-09-25 2009-09-25 Mineral-coated microspheres

Publications (2)

Publication Number Publication Date
JP2012503673A true JP2012503673A (ja) 2012-02-09
JP2012503673A5 JP2012503673A5 (enExample) 2012-11-15

Family

ID=42060103

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011529272A Pending JP2012503673A (ja) 2008-09-25 2009-09-25 ミネラルコーティングされたマイクロスフェア

Country Status (5)

Country Link
US (1) US11607391B2 (enExample)
EP (2) EP4011363B1 (enExample)
JP (1) JP2012503673A (enExample)
CA (1) CA2740633C (enExample)
WO (1) WO2010036919A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018510743A (ja) * 2015-03-03 2018-04-19 ティッシュ リジェネレーション システムズ インコーポレイテッド コーティングスキャフォールド
JP2021523151A (ja) * 2018-05-11 2021-09-02 ホスホレックス、インコーポレイテッド 負の表面電荷を有するマイクロ粒子及びナノ粒子

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* Cited by examiner, † Cited by third party
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US12171904B2 (en) 2006-10-30 2024-12-24 Trs Holdings Llc Mineral coated scaffolds
WO2012071013A1 (en) 2010-11-24 2012-05-31 Nanyang Technological University Method for encapsulating particles
SG10201509138XA (en) * 2010-11-24 2015-12-30 Univ Nanyang Tech Method for coating particles with calcium phosphate and particles, microparticles and nanoparticles formed thereof
US20140141047A1 (en) * 2012-11-19 2014-05-22 Wisconsin Alumni Research Foundation Selection of platelet rich plasma components via mineral binding
CA2925087C (en) * 2013-09-24 2024-02-13 The Feinstein Institute For Medical Research Peptides inhibiting cold-inducible rna binding protein activity
CN103611193B (zh) * 2013-11-26 2015-05-27 中山大学 一种碳酸钙微球-细胞外基质复合材料及其制备方法和应用
US10682442B2 (en) 2014-04-04 2020-06-16 University Of Kentucky Research Foundation Small molecule drug release from in situ forming degradable scaffolds incorporating hydrogels and bioceramic microparticles
US20150306595A1 (en) * 2014-04-25 2015-10-29 The Trustees Of Princeton University Nanoparticulate Apatite Coated Calcite/Limestone Filter Materials for Removing Contaminants from Contaminated Water
US10449155B2 (en) * 2015-11-09 2019-10-22 Medical Corporation Ijunkai Drug introducing agent for administration into a living body and manufacturing method
EP3606512A4 (en) * 2017-04-03 2021-01-13 Wisconsin Alumni Research Foundation MINERAL COATED MICROPARTICLES INTENDED FOR THE PROLONGED DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES
US11628227B2 (en) 2017-07-05 2023-04-18 Wisconsin Alumni Research Foundation Mineral coated microparticles for gene delivery in chronic wound therapy
CN107823189B (zh) * 2017-11-25 2021-04-06 杭州高成生物营养技术有限公司 一种氯化钾缓释微丸及其制备方法与应用
US12465573B2 (en) 2018-04-06 2025-11-11 Wisconsin Alumni Research Foundation Structured nanocoatings for the stabilization of pluripotent stem cell media components
AU2020274535A1 (en) * 2019-05-10 2021-12-09 Commonwealth Scientific And Industrial Research Organisation Microcapsule
EP4027949A4 (en) 2019-09-11 2023-06-14 Warsaw Orthopedic, Inc. HYDRATABLE COMPOSITIONS COMPRISING MACROPARTICLES AND METHODS OF MAKING THEM
WO2021240539A1 (en) * 2020-05-25 2021-12-02 SHREY, Dhawan Ion-substituted bovine hydroxyapatite for bone regeneration
CN113425896A (zh) * 2021-05-08 2021-09-24 上海大学 用于牙槽骨缺损修复的聚氨基酸微载体及其制备方法
CN113769162B (zh) * 2021-09-14 2022-09-13 武汉大学 一种用于治疗感染性骨缺损的负载聚乙烯吡咯烷酮碘的仿生矿化微球的制备方法
WO2023086816A1 (en) * 2021-11-09 2023-05-19 Wisconsin Alumni Research Foundation Mineral-coated substrates for stabilization of rna-based therapeutic compositions
US11747269B2 (en) 2021-11-09 2023-09-05 Warsaw Orthopedic, Inc. Systems and methods for identifying a coating on an implant
US12048628B2 (en) 2021-11-09 2024-07-30 Warsaw Orthopedic, Inc. Systems and methods of coating bone material
US20230390070A1 (en) 2022-06-07 2023-12-07 Warsaw Orthopedic, Inc. Methods and apparatus for coating bone particles using a mesh

Citations (2)

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JP2004530675A (ja) * 2001-04-20 2004-10-07 ザ ユニバーシティ オブ ブリティッシュ コロンビア In−situの薬剤カプセル化のための生体機能性ハイドロキシアパタイトコーティング及びミクロスフィア
US20070059437A1 (en) * 1999-03-19 2007-03-15 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces

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US6743779B1 (en) * 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
CA2285430C (en) * 1997-04-01 2008-11-18 Cap Biotechnology, Inc. Calcium phosphate microcarriers and microspheres
AU8681098A (en) 1997-08-01 1999-03-08 Massachusetts Institute Of Technology Three-dimensional polymer matrices
CA2370063C (en) 1999-03-19 2012-10-02 The Regents Of The University Of Michigan Mineralization and cellular patterning on biomaterial surfaces
US7829074B2 (en) * 2001-10-18 2010-11-09 Nektar Therapeutics Hydroxypatite-targeting poly(ethylene glycol) and related polymers
US7776600B2 (en) * 2002-04-18 2010-08-17 Carnegie Mellon University Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids
US7090868B2 (en) * 2002-09-13 2006-08-15 University Of Florida Materials and methods for drug delivery and uptake
WO2004085998A2 (en) 2003-03-28 2004-10-07 The Children's Hospital Of Philadelphia Biomimetic hierarchies using functionalized nanoparticles as building blocks
US20050249697A1 (en) * 2003-09-24 2005-11-10 Uhrich Kathryn E Compositions and methods for the inhibition of bone growth and resorption
EP1729675A4 (en) * 2004-03-05 2011-05-18 Univ Columbia MULTI-PHASE BIODEGRADABLE AND EAST-INTEGRATIVE COMPOSITE SCULPTURE FOR THE BIOLOGICAL FIXATION OF SKELETAL MOLECULAR WEAVE ON BONE
US20080090760A2 (en) * 2005-12-09 2008-04-17 Todd Hembrough Compositions and Methods for Inhibiting Cellular Proliferation
US9295755B2 (en) 2006-10-18 2016-03-29 Wisconsin Alumni Research Foundation Multilayer tissue regeneration system
US8275594B2 (en) 2006-10-30 2012-09-25 The Regents Of The University Of Michigan Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration
US9439948B2 (en) 2006-10-30 2016-09-13 The Regents Of The University Of Michigan Degradable cage coated with mineral layers for spinal interbody fusion

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070059437A1 (en) * 1999-03-19 2007-03-15 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
JP2004530675A (ja) * 2001-04-20 2004-10-07 ザ ユニバーシティ オブ ブリティッシュ コロンビア In−situの薬剤カプセル化のための生体機能性ハイドロキシアパタイトコーティング及びミクロスフィア

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018510743A (ja) * 2015-03-03 2018-04-19 ティッシュ リジェネレーション システムズ インコーポレイテッド コーティングスキャフォールド
JP2021079116A (ja) * 2015-03-03 2021-05-27 ティーアールエス ホールディングス リミテッド ライアビリティ カンパニー コーティングスキャフォールド
US11491261B2 (en) 2015-03-03 2022-11-08 Warsaw Orthopedic, Inc. Coating scaffolds
JP2021523151A (ja) * 2018-05-11 2021-09-02 ホスホレックス、インコーポレイテッド 負の表面電荷を有するマイクロ粒子及びナノ粒子

Also Published As

Publication number Publication date
EP2349212A1 (en) 2011-08-03
CA2740633C (en) 2019-02-26
US20140161886A1 (en) 2014-06-12
EP4011363B1 (en) 2024-10-30
WO2010036919A1 (en) 2010-04-01
EP4011363A1 (en) 2022-06-15
EP2349212A4 (en) 2014-07-30
EP2349212B1 (en) 2022-01-19
AU2009296439A1 (en) 2010-04-01
CA2740633A1 (en) 2010-04-01
US11607391B2 (en) 2023-03-21

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