CA2740633C - Mineral-coated microspheres - Google Patents
Mineral-coated microspheres Download PDFInfo
- Publication number
- CA2740633C CA2740633C CA2740633A CA2740633A CA2740633C CA 2740633 C CA2740633 C CA 2740633C CA 2740633 A CA2740633 A CA 2740633A CA 2740633 A CA2740633 A CA 2740633A CA 2740633 C CA2740633 C CA 2740633C
- Authority
- CA
- Canada
- Prior art keywords
- microsphere
- calcium
- biologically active
- active compound
- mineral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000004005 microsphere Substances 0.000 title claims abstract description 328
- 229910052500 inorganic mineral Inorganic materials 0.000 title claims abstract description 278
- 239000011707 mineral Substances 0.000 title claims abstract description 275
- 150000001875 compounds Chemical class 0.000 claims abstract description 136
- 239000011575 calcium Substances 0.000 claims abstract description 104
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 101
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 92
- 238000000034 method Methods 0.000 claims abstract description 67
- 239000011324 bead Substances 0.000 claims abstract description 52
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims abstract description 20
- 235000010755 mineral Nutrition 0.000 claims description 272
- 238000000576 coating method Methods 0.000 claims description 81
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 66
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 66
- 235000018102 proteins Nutrition 0.000 claims description 59
- 108090000623 proteins and genes Proteins 0.000 claims description 59
- 102000004169 proteins and genes Human genes 0.000 claims description 59
- 239000011248 coating agent Substances 0.000 claims description 45
- 239000000243 solution Substances 0.000 claims description 43
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 30
- 229910019142 PO4 Inorganic materials 0.000 claims description 25
- 239000001506 calcium phosphate Substances 0.000 claims description 25
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 25
- 239000010452 phosphate Substances 0.000 claims description 22
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- 125000000524 functional group Chemical group 0.000 claims description 18
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 17
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- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 14
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 12
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- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 11
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- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 11
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- 150000001669 calcium Chemical class 0.000 claims description 9
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 9
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- 229910000392 octacalcium phosphate Inorganic materials 0.000 claims description 8
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 claims description 8
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- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 7
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- 150000002894 organic compounds Chemical class 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10006208P | 2008-09-25 | 2008-09-25 | |
| US61/100,062 | 2008-09-25 | ||
| PCT/US2009/058419 WO2010036919A1 (en) | 2008-09-25 | 2009-09-25 | Mineral-coated microspheres |
Publications (2)
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| CA2740633A1 CA2740633A1 (en) | 2010-04-01 |
| CA2740633C true CA2740633C (en) | 2019-02-26 |
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| CA2740633A Active CA2740633C (en) | 2008-09-25 | 2009-09-25 | Mineral-coated microspheres |
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| US (1) | US11607391B2 (enExample) |
| EP (2) | EP4011363B1 (enExample) |
| JP (1) | JP2012503673A (enExample) |
| CA (1) | CA2740633C (enExample) |
| WO (1) | WO2010036919A1 (enExample) |
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| US12171904B2 (en) | 2006-10-30 | 2024-12-24 | Trs Holdings Llc | Mineral coated scaffolds |
| WO2012071013A1 (en) | 2010-11-24 | 2012-05-31 | Nanyang Technological University | Method for encapsulating particles |
| SG10201509138XA (en) * | 2010-11-24 | 2015-12-30 | Univ Nanyang Tech | Method for coating particles with calcium phosphate and particles, microparticles and nanoparticles formed thereof |
| US20140141047A1 (en) * | 2012-11-19 | 2014-05-22 | Wisconsin Alumni Research Foundation | Selection of platelet rich plasma components via mineral binding |
| CA2925087C (en) * | 2013-09-24 | 2024-02-13 | The Feinstein Institute For Medical Research | Peptides inhibiting cold-inducible rna binding protein activity |
| CN103611193B (zh) * | 2013-11-26 | 2015-05-27 | 中山大学 | 一种碳酸钙微球-细胞外基质复合材料及其制备方法和应用 |
| US10682442B2 (en) | 2014-04-04 | 2020-06-16 | University Of Kentucky Research Foundation | Small molecule drug release from in situ forming degradable scaffolds incorporating hydrogels and bioceramic microparticles |
| US20150306595A1 (en) * | 2014-04-25 | 2015-10-29 | The Trustees Of Princeton University | Nanoparticulate Apatite Coated Calcite/Limestone Filter Materials for Removing Contaminants from Contaminated Water |
| WO2016141242A1 (en) * | 2015-03-03 | 2016-09-09 | Tissue Regeneration Systems, Inc. | Coating scaffolds |
| US10449155B2 (en) * | 2015-11-09 | 2019-10-22 | Medical Corporation Ijunkai | Drug introducing agent for administration into a living body and manufacturing method |
| EP3606512A4 (en) * | 2017-04-03 | 2021-01-13 | Wisconsin Alumni Research Foundation | MINERAL COATED MICROPARTICLES INTENDED FOR THE PROLONGED DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES |
| US11628227B2 (en) | 2017-07-05 | 2023-04-18 | Wisconsin Alumni Research Foundation | Mineral coated microparticles for gene delivery in chronic wound therapy |
| CN107823189B (zh) * | 2017-11-25 | 2021-04-06 | 杭州高成生物营养技术有限公司 | 一种氯化钾缓释微丸及其制备方法与应用 |
| US12465573B2 (en) | 2018-04-06 | 2025-11-11 | Wisconsin Alumni Research Foundation | Structured nanocoatings for the stabilization of pluripotent stem cell media components |
| JP2021523151A (ja) * | 2018-05-11 | 2021-09-02 | ホスホレックス、インコーポレイテッド | 負の表面電荷を有するマイクロ粒子及びナノ粒子 |
| AU2020274535A1 (en) * | 2019-05-10 | 2021-12-09 | Commonwealth Scientific And Industrial Research Organisation | Microcapsule |
| EP4027949A4 (en) | 2019-09-11 | 2023-06-14 | Warsaw Orthopedic, Inc. | HYDRATABLE COMPOSITIONS COMPRISING MACROPARTICLES AND METHODS OF MAKING THEM |
| WO2021240539A1 (en) * | 2020-05-25 | 2021-12-02 | SHREY, Dhawan | Ion-substituted bovine hydroxyapatite for bone regeneration |
| CN113425896A (zh) * | 2021-05-08 | 2021-09-24 | 上海大学 | 用于牙槽骨缺损修复的聚氨基酸微载体及其制备方法 |
| CN113769162B (zh) * | 2021-09-14 | 2022-09-13 | 武汉大学 | 一种用于治疗感染性骨缺损的负载聚乙烯吡咯烷酮碘的仿生矿化微球的制备方法 |
| WO2023086816A1 (en) * | 2021-11-09 | 2023-05-19 | Wisconsin Alumni Research Foundation | Mineral-coated substrates for stabilization of rna-based therapeutic compositions |
| US11747269B2 (en) | 2021-11-09 | 2023-09-05 | Warsaw Orthopedic, Inc. | Systems and methods for identifying a coating on an implant |
| US12048628B2 (en) | 2021-11-09 | 2024-07-30 | Warsaw Orthopedic, Inc. | Systems and methods of coating bone material |
| US20230390070A1 (en) | 2022-06-07 | 2023-12-07 | Warsaw Orthopedic, Inc. | Methods and apparatus for coating bone particles using a mesh |
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| US6743779B1 (en) * | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
| CA2285430C (en) * | 1997-04-01 | 2008-11-18 | Cap Biotechnology, Inc. | Calcium phosphate microcarriers and microspheres |
| AU8681098A (en) | 1997-08-01 | 1999-03-08 | Massachusetts Institute Of Technology | Three-dimensional polymer matrices |
| CA2370063C (en) | 1999-03-19 | 2012-10-02 | The Regents Of The University Of Michigan | Mineralization and cellular patterning on biomaterial surfaces |
| US6767928B1 (en) | 1999-03-19 | 2004-07-27 | The Regents Of The University Of Michigan | Mineralization and biological modification of biomaterial surfaces |
| US7829074B2 (en) * | 2001-10-18 | 2010-11-09 | Nektar Therapeutics | Hydroxypatite-targeting poly(ethylene glycol) and related polymers |
| US6730324B2 (en) * | 2001-04-20 | 2004-05-04 | The University Of British Columbia | Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation |
| US7776600B2 (en) * | 2002-04-18 | 2010-08-17 | Carnegie Mellon University | Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids |
| US7090868B2 (en) * | 2002-09-13 | 2006-08-15 | University Of Florida | Materials and methods for drug delivery and uptake |
| WO2004085998A2 (en) | 2003-03-28 | 2004-10-07 | The Children's Hospital Of Philadelphia | Biomimetic hierarchies using functionalized nanoparticles as building blocks |
| US20050249697A1 (en) * | 2003-09-24 | 2005-11-10 | Uhrich Kathryn E | Compositions and methods for the inhibition of bone growth and resorption |
| EP1729675A4 (en) * | 2004-03-05 | 2011-05-18 | Univ Columbia | MULTI-PHASE BIODEGRADABLE AND EAST-INTEGRATIVE COMPOSITE SCULPTURE FOR THE BIOLOGICAL FIXATION OF SKELETAL MOLECULAR WEAVE ON BONE |
| US20080090760A2 (en) * | 2005-12-09 | 2008-04-17 | Todd Hembrough | Compositions and Methods for Inhibiting Cellular Proliferation |
| US9295755B2 (en) | 2006-10-18 | 2016-03-29 | Wisconsin Alumni Research Foundation | Multilayer tissue regeneration system |
| US8275594B2 (en) | 2006-10-30 | 2012-09-25 | The Regents Of The University Of Michigan | Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration |
| US9439948B2 (en) | 2006-10-30 | 2016-09-13 | The Regents Of The University Of Michigan | Degradable cage coated with mineral layers for spinal interbody fusion |
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- 2009-09-25 CA CA2740633A patent/CA2740633C/en active Active
- 2009-09-25 US US13/879,178 patent/US11607391B2/en active Active
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| EP2349212A1 (en) | 2011-08-03 |
| US20140161886A1 (en) | 2014-06-12 |
| EP4011363B1 (en) | 2024-10-30 |
| WO2010036919A1 (en) | 2010-04-01 |
| EP4011363A1 (en) | 2022-06-15 |
| EP2349212A4 (en) | 2014-07-30 |
| EP2349212B1 (en) | 2022-01-19 |
| AU2009296439A1 (en) | 2010-04-01 |
| JP2012503673A (ja) | 2012-02-09 |
| CA2740633A1 (en) | 2010-04-01 |
| US11607391B2 (en) | 2023-03-21 |
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