CA2740633C - Mineral-coated microspheres - Google Patents

Mineral-coated microspheres Download PDF

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Publication number
CA2740633C
CA2740633C CA2740633A CA2740633A CA2740633C CA 2740633 C CA2740633 C CA 2740633C CA 2740633 A CA2740633 A CA 2740633A CA 2740633 A CA2740633 A CA 2740633A CA 2740633 C CA2740633 C CA 2740633C
Authority
CA
Canada
Prior art keywords
microsphere
calcium
biologically active
active compound
mineral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2740633A
Other languages
English (en)
French (fr)
Other versions
CA2740633A1 (en
Inventor
William L. Murphy
Leenaporn Jongpaiboonkit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trs Holdings LLC
Original Assignee
Tissue Regeneration Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tissue Regeneration Systems Inc filed Critical Tissue Regeneration Systems Inc
Publication of CA2740633A1 publication Critical patent/CA2740633A1/en
Application granted granted Critical
Publication of CA2740633C publication Critical patent/CA2740633C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2740633A 2008-09-25 2009-09-25 Mineral-coated microspheres Active CA2740633C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10006208P 2008-09-25 2008-09-25
US61/100,062 2008-09-25
PCT/US2009/058419 WO2010036919A1 (en) 2008-09-25 2009-09-25 Mineral-coated microspheres

Publications (2)

Publication Number Publication Date
CA2740633A1 CA2740633A1 (en) 2010-04-01
CA2740633C true CA2740633C (en) 2019-02-26

Family

ID=42060103

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2740633A Active CA2740633C (en) 2008-09-25 2009-09-25 Mineral-coated microspheres

Country Status (5)

Country Link
US (1) US11607391B2 (enExample)
EP (2) EP2349212B1 (enExample)
JP (1) JP2012503673A (enExample)
CA (1) CA2740633C (enExample)
WO (1) WO2010036919A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12171904B2 (en) 2006-10-30 2024-12-24 Trs Holdings Llc Mineral coated scaffolds
SG190009A1 (en) 2010-11-24 2013-06-28 Univ Nanyang Tech Method for encapsulating particles
US20130295186A1 (en) * 2010-11-24 2013-11-07 Say Chye Joachim Loo Method for coating particles with calcium phosphate and particles, microparticles and nanoparticles formed thereof
US20140141047A1 (en) * 2012-11-19 2014-05-22 Wisconsin Alumni Research Foundation Selection of platelet rich plasma components via mineral binding
EP3049438B1 (en) * 2013-09-24 2018-07-25 The Feinstein Institute for Medical Research Peptides inhibiting cold-inducible rna binding protein activity
CN103611193B (zh) * 2013-11-26 2015-05-27 中山大学 一种碳酸钙微球-细胞外基质复合材料及其制备方法和应用
US10682442B2 (en) 2014-04-04 2020-06-16 University Of Kentucky Research Foundation Small molecule drug release from in situ forming degradable scaffolds incorporating hydrogels and bioceramic microparticles
US20150306595A1 (en) * 2014-04-25 2015-10-29 The Trustees Of Princeton University Nanoparticulate Apatite Coated Calcite/Limestone Filter Materials for Removing Contaminants from Contaminated Water
JP6827960B2 (ja) * 2015-03-03 2021-02-10 ティーアールエス ホールディングス リミテッド ライアビリティ カンパニー コーティングスキャフォールド
US10449155B2 (en) * 2015-11-09 2019-10-22 Medical Corporation Ijunkai Drug introducing agent for administration into a living body and manufacturing method
AU2018249816B2 (en) * 2017-04-03 2025-04-17 Wisconsin Alumni Research Foundation Mineral coated microparticles for sustained delivery of biologically active molecules
WO2019010304A1 (en) * 2017-07-05 2019-01-10 Wisconsin Alumni Research Foundation MICROPARTICLES COATED WITH MINERALS FOR GENES ADMINISTRATION IN CHRONIC WOUND THERAPY
CN107823189B (zh) * 2017-11-25 2021-04-06 杭州高成生物营养技术有限公司 一种氯化钾缓释微丸及其制备方法与应用
EP3773519A4 (en) * 2018-04-06 2021-12-29 Wisconsin Alumni Research Foundation Structured nanocoatings for the stabilization of pluripotent stem cell media components
CA3098873A1 (en) * 2018-05-11 2019-11-14 Phosphorex, Inc. Microparticles and nanoparticles having negative surface charges
US20220212156A1 (en) * 2019-05-10 2022-07-07 Commonwealth Scientific And Industrial Research Organisation Microcapsule
US12076462B2 (en) 2019-09-11 2024-09-03 Warsaw Orthopedic, Inc. Hydratable compositions comprising macroparticles and methods of making them
WO2021240539A1 (en) * 2020-05-25 2021-12-02 SHREY, Dhawan Ion-substituted bovine hydroxyapatite for bone regeneration
CN113425896A (zh) * 2021-05-08 2021-09-24 上海大学 用于牙槽骨缺损修复的聚氨基酸微载体及其制备方法
CN113769162B (zh) * 2021-09-14 2022-09-13 武汉大学 一种用于治疗感染性骨缺损的负载聚乙烯吡咯烷酮碘的仿生矿化微球的制备方法
US11747269B2 (en) 2021-11-09 2023-09-05 Warsaw Orthopedic, Inc. Systems and methods for identifying a coating on an implant
WO2023086816A1 (en) * 2021-11-09 2023-05-19 Wisconsin Alumni Research Foundation Mineral-coated substrates for stabilization of rna-based therapeutic compositions
US12048628B2 (en) 2021-11-09 2024-07-30 Warsaw Orthopedic, Inc. Systems and methods of coating bone material
US20230390070A1 (en) 2022-06-07 2023-12-07 Warsaw Orthopedic, Inc. Methods and apparatus for coating bone particles using a mesh
CN117257767A (zh) * 2023-08-08 2023-12-22 上海市伤骨科研究所 一种捕获氢离子的细胞微环境稳定剂及其制备方法与应用
CN121668378A (zh) * 2026-02-09 2026-03-17 上海腾复医疗科技有限公司 一种具有抗体药物负载能力的栓塞微球及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743779B1 (en) * 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
CA2285430C (en) * 1997-04-01 2008-11-18 Cap Biotechnology, Inc. Calcium phosphate microcarriers and microspheres
US6471993B1 (en) * 1997-08-01 2002-10-29 Massachusetts Institute Of Technology Three-dimensional polymer matrices
ES2199815T3 (es) 1999-03-19 2004-03-01 The Regents Of The University Of Michigan Mineralizacion y desarrollo celular supeerficial sobre biomateriales.
US6767928B1 (en) * 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
US7829074B2 (en) * 2001-10-18 2010-11-09 Nektar Therapeutics Hydroxypatite-targeting poly(ethylene glycol) and related polymers
US6730324B2 (en) * 2001-04-20 2004-05-04 The University Of British Columbia Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation
US7776600B2 (en) * 2002-04-18 2010-08-17 Carnegie Mellon University Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids
US7090868B2 (en) * 2002-09-13 2006-08-15 University Of Florida Materials and methods for drug delivery and uptake
US20070026069A1 (en) 2003-03-28 2007-02-01 Shastri Venkatram P Biommetic hierarchies using functionalized nanoparticles as building blocks
US20050249697A1 (en) * 2003-09-24 2005-11-10 Uhrich Kathryn E Compositions and methods for the inhibition of bone growth and resorption
EP1729675A4 (en) * 2004-03-05 2011-05-18 Univ Columbia MULTI-PHASE BIODEGRADABLE AND EAST-INTEGRATIVE COMPOSITE SCULPTURE FOR THE BIOLOGICAL FIXATION OF SKELETAL MOLECULAR WEAVE ON BONE
US20080090760A2 (en) 2005-12-09 2008-04-17 Todd Hembrough Compositions and Methods for Inhibiting Cellular Proliferation
US9295755B2 (en) 2006-10-18 2016-03-29 Wisconsin Alumni Research Foundation Multilayer tissue regeneration system
US9439948B2 (en) 2006-10-30 2016-09-13 The Regents Of The University Of Michigan Degradable cage coated with mineral layers for spinal interbody fusion
US8275594B2 (en) 2006-10-30 2012-09-25 The Regents Of The University Of Michigan Engineered scaffolds for intervertebral disc repair and regeneration and for articulating joint repair and regeneration

Also Published As

Publication number Publication date
EP2349212A1 (en) 2011-08-03
EP2349212B1 (en) 2022-01-19
US20140161886A1 (en) 2014-06-12
WO2010036919A1 (en) 2010-04-01
EP4011363A1 (en) 2022-06-15
US11607391B2 (en) 2023-03-21
AU2009296439A1 (en) 2010-04-01
EP4011363B1 (en) 2024-10-30
JP2012503673A (ja) 2012-02-09
CA2740633A1 (en) 2010-04-01
EP2349212A4 (en) 2014-07-30

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Effective date: 20140425

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