JP2012232997A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012232997A5 JP2012232997A5 JP2012164081A JP2012164081A JP2012232997A5 JP 2012232997 A5 JP2012232997 A5 JP 2012232997A5 JP 2012164081 A JP2012164081 A JP 2012164081A JP 2012164081 A JP2012164081 A JP 2012164081A JP 2012232997 A5 JP2012232997 A5 JP 2012232997A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- aralkyl
- alkyl
- alkynyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003710 aryl alkyl group Chemical group 0.000 claims 29
- 125000000217 alkyl group Chemical group 0.000 claims 28
- 125000003342 alkenyl group Chemical group 0.000 claims 26
- 125000000304 alkynyl group Chemical group 0.000 claims 26
- 125000003118 aryl group Chemical group 0.000 claims 26
- 125000000753 cycloalkyl group Chemical group 0.000 claims 26
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 23
- 125000001072 heteroaryl group Chemical group 0.000 claims 23
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 23
- 125000003545 alkoxy group Chemical group 0.000 claims 20
- 125000004442 acylamino group Chemical group 0.000 claims 18
- 150000004820 halides Chemical class 0.000 claims 18
- 125000004423 acyloxy group Chemical group 0.000 claims 17
- 125000004104 aryloxy group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000003282 alkyl amino group Chemical group 0.000 claims 15
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 15
- 125000001769 aryl amino group Chemical group 0.000 claims 15
- 238000000034 method Methods 0.000 claims 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 15
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 125000004414 alkyl thio group Chemical group 0.000 claims 9
- 125000005110 aryl thio group Chemical group 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- -1 aralkylthio Hydroxyl Chemical group 0.000 claims 5
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims 5
- 150000002825 nitriles Chemical class 0.000 claims 5
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 3
- 125000005035 acylthio group Chemical group 0.000 claims 3
- 150000003857 carboxamides Chemical class 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 150000003456 sulfonamides Chemical class 0.000 claims 3
- 239000007848 Bronsted acid Substances 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 239000002841 Lewis acid Substances 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000007517 lewis acids Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000009277 Neuroectodermal Tumors Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000005888 cyclopropanation reaction Methods 0.000 claims 1
- NZZFYRREKKOMAT-UHFFFAOYSA-N diiodomethane Chemical compound ICI NZZFYRREKKOMAT-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 claims 1
- 201000002025 prostate sarcoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60502004P | 2004-08-27 | 2004-08-27 | |
| US60/605,020 | 2004-08-27 | ||
| US61717004P | 2004-10-08 | 2004-10-08 | |
| US60/617,170 | 2004-10-08 | ||
| US62567604P | 2004-11-05 | 2004-11-05 | |
| US60/625,676 | 2004-11-05 | ||
| US68316905P | 2005-05-19 | 2005-05-19 | |
| US60/683,169 | 2005-05-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530162A Division JP5204486B2 (ja) | 2004-08-27 | 2005-08-26 | シクロパミンアナログ及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012232997A JP2012232997A (ja) | 2012-11-29 |
| JP2012232997A5 true JP2012232997A5 (https=) | 2013-02-07 |
Family
ID=36000609
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530162A Expired - Fee Related JP5204486B2 (ja) | 2004-08-27 | 2005-08-26 | シクロパミンアナログ及びその使用方法 |
| JP2012164081A Pending JP2012232997A (ja) | 2004-08-27 | 2012-07-24 | シクロパミンアナログ及びその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530162A Expired - Fee Related JP5204486B2 (ja) | 2004-08-27 | 2005-08-26 | シクロパミンアナログ及びその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7230004B2 (https=) |
| EP (3) | EP1817308B1 (https=) |
| JP (2) | JP5204486B2 (https=) |
| KR (1) | KR101487481B1 (https=) |
| CN (1) | CN102241727B (https=) |
| AU (1) | AU2005280112B2 (https=) |
| BR (1) | BRPI0514444A (https=) |
| CA (1) | CA2579078C (https=) |
| ES (1) | ES2578728T3 (https=) |
| IL (1) | IL181301A (https=) |
| NO (1) | NO341137B1 (https=) |
| WO (1) | WO2006026430A2 (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| EP1411938B1 (en) * | 2001-07-02 | 2005-07-06 | Tas, Sinan | Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis |
| US20170326118A1 (en) * | 2001-07-02 | 2017-11-16 | Sinan Tas | Drug treatment of tumors wherein hedgehog/smoothened signaling is utilized for inhibition of apoptosis of tumor cells |
| AU2005280112B2 (en) * | 2004-08-27 | 2012-07-19 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
| US20080019961A1 (en) * | 2006-02-21 | 2008-01-24 | Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
| US20110034498A1 (en) * | 2006-03-24 | 2011-02-10 | Mcgovern Karen J | Dosing regimens for the treatment of cancer |
| US20110044991A1 (en) * | 2006-09-27 | 2011-02-24 | Irm Llc | Methods and compositions for treating lymphoma and myeloma |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| JP2010520295A (ja) * | 2007-03-07 | 2010-06-10 | インフィニティ・ディスカバリー・インコーポレイテッド | へテロ環状シクロパミン類似体及びその使用方法 |
| RU2009137012A (ru) | 2007-03-07 | 2011-04-20 | Инфинити Дискавери, Инк. (Us) | Аналоги циклопаминлактама и способы их применения |
| AU2008241527B2 (en) | 2007-04-18 | 2014-02-13 | Merck Sharp & Dohme Llc | Triazole derivatives which are Smo antagonists |
| WO2009058945A1 (en) | 2007-10-30 | 2009-05-07 | The Wistar Institute | Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer |
| US8669243B2 (en) | 2007-10-30 | 2014-03-11 | The Wistar Institute | Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer |
| US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
| US20100222287A1 (en) * | 2007-12-27 | 2010-09-02 | Mcgovern Karen J | Therapeutic Cancer Treatments |
| PE20091180A1 (es) * | 2007-12-27 | 2009-08-26 | Infinity Pharmaceuticals Inc | Tratamientos terapeuticos contra el cancer |
| CA2710858A1 (en) * | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| CN101990542A (zh) * | 2008-02-08 | 2011-03-23 | 德克萨斯大学董事会 | 环巴胺酒石酸盐及其用途 |
| EP2303275A4 (en) * | 2008-06-17 | 2012-05-09 | Univ Duke | STANDARD RECEPTOR MODULATORS |
| US20100080855A1 (en) * | 2008-09-12 | 2010-04-01 | The Board Of Trustees Of The Leland Stanford Junior University | Hedgehog signaling and cancer stem cells in hematopoietic cell malignancies |
| US20110275576A1 (en) * | 2009-01-06 | 2011-11-10 | Utah State University | Carbohydrate-Cyclopamine Conjugates as Anticancer Agents |
| EP2233566A1 (en) | 2009-03-17 | 2010-09-29 | Vrije Universiteit Brussel | Generation of pancreatic progenitor cells |
| AU2010279325B2 (en) | 2009-08-05 | 2016-10-20 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| US20110135739A1 (en) * | 2009-11-06 | 2011-06-09 | Bennett Carter | Oral Formulations of a Hedgehog Pathway Inhibitor |
| SMT202100234T1 (it) * | 2009-12-04 | 2021-05-07 | Oncoc4 Lnc | Usi di inibitori di fattori inducibili da ipossia |
| US20110183948A1 (en) * | 2010-01-15 | 2011-07-28 | Infinity Pharmaceuticals, Inc. | Treatment of fibrotic conditions using hedgehog inhibitors |
| CN102167812B (zh) * | 2010-02-26 | 2016-04-20 | 北京科美森医药研发有限公司 | 聚乙二醇化环巴胺类似物及其制备方法和用途 |
| CA2799579A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| WO2011156329A2 (en) * | 2010-06-11 | 2011-12-15 | Board Of Regents, The University Of Texas System | Methods of treating pain and morphine tolerance via modulation of hedgehog signalling pathway |
| US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環化合物及びその使用 |
| ES2637113T3 (es) | 2011-01-10 | 2017-10-10 | Infinity Pharmaceuticals, Inc. | Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas |
| AR088218A1 (es) | 2011-07-19 | 2014-05-21 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos utiles como inhibidores de pi3k |
| HK1198443A1 (en) | 2011-07-19 | 2015-04-24 | 无限药品股份有限公司 | Heterocyclic compounds and uses thereof |
| MX2014002542A (es) | 2011-08-29 | 2014-07-09 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos. |
| WO2013049332A1 (en) | 2011-09-29 | 2013-04-04 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| AU2013337717B2 (en) | 2012-11-01 | 2018-10-25 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using PI3 kinase isoform modulators |
| EP2925363A4 (en) | 2012-11-29 | 2016-11-09 | Strasspharma Llc | METHOD FOR MODULATING FOLLICLE-STIMULATING HORMONACTIVITY |
| WO2014151386A1 (en) | 2013-03-15 | 2014-09-25 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
| CA2914284A1 (en) | 2013-05-30 | 2014-12-04 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PT3052485T (pt) | 2013-10-04 | 2021-10-22 | Infinity Pharmaceuticals Inc | Compostos heterocíclicos e suas utilizações |
| US20160244452A1 (en) | 2013-10-21 | 2016-08-25 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MX382033B (es) | 2014-03-19 | 2025-03-13 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma. |
| US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PL3302428T3 (pl) | 2015-06-04 | 2026-04-13 | Sol-Gel Technologies Ltd. | Preparaty do zastosowania miejscowego do dostarczania związków inhibitora hedgehog i ich zastosowanie |
| WO2017048702A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| WO2017139497A1 (en) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Hedgehog inhibitor for use in relief of and treatment of pruritus or itching |
| CN105622708B (zh) * | 2016-02-14 | 2017-10-10 | 山东大学 | 治疗呼吸道合胞病毒感染的化合物及其制备方法与用途 |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| SG11201811237WA (en) | 2016-06-24 | 2019-01-30 | Infinity Pharmaceuticals Inc | Combination therapies |
| US10548908B2 (en) * | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
| EP4065112A4 (en) * | 2019-11-22 | 2023-12-27 | The Regents of the University of California | Taspase1 inhibitors and uses thereof |
| WO2021261601A1 (ja) | 2020-06-26 | 2021-12-30 | ラクオリア創薬株式会社 | レチノイドとがん治療薬との併用療法が有効ながん患者の選択方法およびレチノイドとがん治療薬との併用医薬 |
| RU2739294C1 (ru) * | 2020-07-02 | 2020-12-22 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии" Министерства здравоохранения Российской Федерации | Способ лечения местно-распространенного рака ротоглотки |
| WO2022019920A1 (en) | 2020-07-24 | 2022-01-27 | Verastem, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2851054B2 (ja) * | 1989-03-15 | 1999-01-27 | サントリー株式会社 | ベンズオキセピン誘導体 |
| EP0741783B1 (en) | 1993-12-30 | 2009-03-18 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing hedgehog-like proteins |
| US6281332B1 (en) | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
| US6238876B1 (en) | 1997-06-20 | 2001-05-29 | New York University | Methods and materials for the diagnosis and treatment of sporadic basal cell carcinoma |
| US7709454B2 (en) | 1997-06-20 | 2010-05-04 | New York University | Methods and compositions for inhibiting tumorigenesis |
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| US6867216B1 (en) | 1998-04-09 | 2005-03-15 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signal pathways, compositions and uses related thereto |
| US6432970B2 (en) | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| US6291516B1 (en) * | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
| EP1235851B1 (en) | 1999-10-13 | 2006-05-31 | Johns Hopkins University School of Medicine | Regulators of the hedgehog pathway, compositions and uses related thereto |
| IL133809A0 (en) | 1999-12-30 | 2001-04-30 | Yeda Res & Dev | Steroidal alkaloids and pharmaceutical compositions comprising them |
| US20040060568A1 (en) | 2000-10-13 | 2004-04-01 | Henryk Dudek | Hedgehog antagonists, methods and uses related thereto |
| US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
| EP1401469A2 (en) | 2001-04-09 | 2004-03-31 | Lorantis Limited | Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways |
| EP1411938B1 (en) | 2001-07-02 | 2005-07-06 | Tas, Sinan | Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis |
| JP2003192919A (ja) * | 2001-10-17 | 2003-07-09 | Asahi Denka Kogyo Kk | 難燃性合成樹脂組成物 |
| GB0221539D0 (en) | 2002-09-17 | 2002-10-23 | Medical Res Council | Methods of treatment |
| US20080118493A1 (en) | 2003-07-15 | 2008-05-22 | Beachy Philip A | Elevated Hedgehog Pathway Activity In Digestive System Tumors, And Methods Of Treating Digestive Sytem Tumors Having Elevated Hedgehog Pathway Activity |
| WO2005032343A2 (en) | 2003-10-01 | 2005-04-14 | The Johns Hopkins University | Hedgehog signaling in prostate regeneration neoplasia and metastasis |
| US20070231828A1 (en) | 2003-10-01 | 2007-10-04 | Johns Hopkins University | Methods of predicting behavior of cancers |
| WO2005042700A2 (en) | 2003-10-20 | 2005-05-12 | The Johns Hopkins University | Use of hedgehog pathway inhibitors in small-cell lung cancer |
| JP4239907B2 (ja) * | 2004-06-21 | 2009-03-18 | 沖電気工業株式会社 | レベルシフタ回路、表示装置の駆動回路、表示装置、及び階調選択回路のストレステスト方法 |
| AU2005280112B2 (en) * | 2004-08-27 | 2012-07-19 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
| JP2008514726A (ja) | 2004-09-30 | 2008-05-08 | ザ ユニヴァーシティー オヴ シカゴ | ヘッジホッグ阻害剤、放射線及び化学療法薬の併用療法 |
| US20080019961A1 (en) | 2006-02-21 | 2008-01-24 | Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
| US20110034498A1 (en) | 2006-03-24 | 2011-02-10 | Mcgovern Karen J | Dosing regimens for the treatment of cancer |
| TWI433674B (zh) * | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| WO2008089123A2 (en) | 2007-01-12 | 2008-07-24 | Infinity Discovery, Inc. | Methods for analysis of hedgehog pathway inhibitors |
| RU2009137012A (ru) * | 2007-03-07 | 2011-04-20 | Инфинити Дискавери, Инк. (Us) | Аналоги циклопаминлактама и способы их применения |
-
2005
- 2005-08-26 AU AU2005280112A patent/AU2005280112B2/en not_active Ceased
- 2005-08-26 CA CA2579078A patent/CA2579078C/en not_active Expired - Lifetime
- 2005-08-26 US US11/213,534 patent/US7230004B2/en not_active Expired - Lifetime
- 2005-08-26 JP JP2007530162A patent/JP5204486B2/ja not_active Expired - Fee Related
- 2005-08-26 BR BRPI0514444-2A patent/BRPI0514444A/pt not_active Application Discontinuation
- 2005-08-26 EP EP05791140.6A patent/EP1817308B1/en not_active Expired - Lifetime
- 2005-08-26 KR KR1020077006979A patent/KR101487481B1/ko not_active Expired - Fee Related
- 2005-08-26 EP EP10012704.2A patent/EP2316832B1/en not_active Expired - Lifetime
- 2005-08-26 ES ES10012778.6T patent/ES2578728T3/es not_active Expired - Lifetime
- 2005-08-26 EP EP10012778.6A patent/EP2316833B1/en not_active Expired - Lifetime
- 2005-08-26 CN CN201110094391.4A patent/CN102241727B/zh not_active Expired - Fee Related
- 2005-08-26 WO PCT/US2005/030406 patent/WO2006026430A2/en not_active Ceased
-
2007
- 2007-02-13 IL IL181301A patent/IL181301A/en active IP Right Grant
- 2007-03-08 NO NO20071264A patent/NO341137B1/no unknown
- 2007-04-18 US US11/737,035 patent/US7407967B2/en not_active Expired - Lifetime
-
2008
- 2008-07-10 US US12/171,208 patent/US7875628B2/en not_active Expired - Lifetime
-
2010
- 2010-12-15 US US12/969,024 patent/US8236956B2/en not_active Expired - Fee Related
-
2012
- 2012-07-24 JP JP2012164081A patent/JP2012232997A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012232997A5 (https=) | ||
| JP2013535491A5 (https=) | ||
| JP2008511635A5 (https=) | ||
| JP2016537368A5 (https=) | ||
| EP4329431A3 (en) | Novel heteroleptic iridium complexes | |
| JP2017525753A5 (https=) | ||
| JP2013504593A5 (https=) | ||
| JP2017533263A5 (https=) | ||
| JP2018504379A5 (https=) | ||
| JP2015524406A5 (https=) | ||
| JP2012515776A5 (https=) | ||
| JP2011037841A5 (https=) | ||
| JP2015051994A5 (https=) | ||
| JP2016513122A5 (https=) | ||
| JP2014526533A5 (https=) | ||
| JP2014530838A5 (https=) | ||
| JP2016536360A5 (https=) | ||
| JP2014524476A5 (https=) | ||
| JP2013536227A5 (https=) | ||
| JP2016532647A5 (https=) | ||
| JP2018535261A5 (https=) | ||
| JP2017513852A5 (https=) | ||
| EP2684917A4 (en) | ZINC OXIDE FILM-FORMING COMPOSITION, ZINC OXIDE FILM MANUFACTURING METHOD AND ZINC CONNECTION | |
| JP2016539168A5 (https=) | ||
| JP2013525355A5 (https=) |