JP2012232997A5 - - Google Patents
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- JP2012232997A5 JP2012232997A5 JP2012164081A JP2012164081A JP2012232997A5 JP 2012232997 A5 JP2012232997 A5 JP 2012232997A5 JP 2012164081 A JP2012164081 A JP 2012164081A JP 2012164081 A JP2012164081 A JP 2012164081A JP 2012232997 A5 JP2012232997 A5 JP 2012232997A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- aralkyl
- alkyl
- alkynyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003710 aryl alkyl group Chemical group 0.000 claims 29
- 125000000217 alkyl group Chemical group 0.000 claims 28
- 125000003342 alkenyl group Chemical group 0.000 claims 26
- 125000000304 alkynyl group Chemical group 0.000 claims 26
- 125000003118 aryl group Chemical group 0.000 claims 26
- 125000000753 cycloalkyl group Chemical group 0.000 claims 26
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 23
- 125000001072 heteroaryl group Chemical group 0.000 claims 23
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 23
- 125000003545 alkoxy group Chemical group 0.000 claims 20
- 125000004442 acylamino group Chemical group 0.000 claims 18
- 150000004820 halides Chemical class 0.000 claims 18
- 125000004423 acyloxy group Chemical group 0.000 claims 17
- 125000004104 aryloxy group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000003282 alkyl amino group Chemical group 0.000 claims 15
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 15
- 125000001769 aryl amino group Chemical group 0.000 claims 15
- 238000000034 method Methods 0.000 claims 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 15
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 125000004414 alkyl thio group Chemical group 0.000 claims 9
- 125000005110 aryl thio group Chemical group 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 6
- -1 aralkylthio Hydroxyl Chemical group 0.000 claims 5
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims 5
- 150000002825 nitriles Chemical class 0.000 claims 5
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 3
- 125000005035 acylthio group Chemical group 0.000 claims 3
- 150000003857 carboxamides Chemical class 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 150000003456 sulfonamides Chemical class 0.000 claims 3
- 239000007848 Bronsted acid Substances 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 239000002841 Lewis acid Substances 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 150000007517 lewis acids Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000009277 Neuroectodermal Tumors Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000005888 cyclopropanation reaction Methods 0.000 claims 1
- NZZFYRREKKOMAT-UHFFFAOYSA-N diiodomethane Chemical compound ICI NZZFYRREKKOMAT-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 claims 1
- 201000002025 prostate sarcoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60502004P | 2004-08-27 | 2004-08-27 | |
| US60/605,020 | 2004-08-27 | ||
| US61717004P | 2004-10-08 | 2004-10-08 | |
| US60/617,170 | 2004-10-08 | ||
| US62567604P | 2004-11-05 | 2004-11-05 | |
| US60/625,676 | 2004-11-05 | ||
| US68316905P | 2005-05-19 | 2005-05-19 | |
| US60/683,169 | 2005-05-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530162A Division JP5204486B2 (ja) | 2004-08-27 | 2005-08-26 | シクロパミンアナログ及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012232997A JP2012232997A (ja) | 2012-11-29 |
| JP2012232997A5 true JP2012232997A5 (https=) | 2013-02-07 |
Family
ID=36000609
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530162A Expired - Fee Related JP5204486B2 (ja) | 2004-08-27 | 2005-08-26 | シクロパミンアナログ及びその使用方法 |
| JP2012164081A Pending JP2012232997A (ja) | 2004-08-27 | 2012-07-24 | シクロパミンアナログ及びその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530162A Expired - Fee Related JP5204486B2 (ja) | 2004-08-27 | 2005-08-26 | シクロパミンアナログ及びその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7230004B2 (https=) |
| EP (3) | EP2316832B1 (https=) |
| JP (2) | JP5204486B2 (https=) |
| KR (1) | KR101487481B1 (https=) |
| CN (1) | CN102241727B (https=) |
| AU (1) | AU2005280112B2 (https=) |
| BR (1) | BRPI0514444A (https=) |
| CA (1) | CA2579078C (https=) |
| ES (1) | ES2578728T3 (https=) |
| IL (1) | IL181301A (https=) |
| NO (1) | NO341137B1 (https=) |
| WO (1) | WO2006026430A2 (https=) |
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| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US20170326118A1 (en) * | 2001-07-02 | 2017-11-16 | Sinan Tas | Drug treatment of tumors wherein hedgehog/smoothened signaling is utilized for inhibition of apoptosis of tumor cells |
| CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
| EP2316832B1 (en) | 2004-08-27 | 2017-03-08 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
| WO2008121102A2 (en) * | 2006-02-21 | 2008-10-09 | The Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
| WO2007123511A2 (en) * | 2006-03-24 | 2007-11-01 | Infinity Pharmaceuticals, Inc. | Dosing regimens for the treatment of cancer |
| JP2010504965A (ja) * | 2006-09-27 | 2010-02-18 | アイアールエム・リミテッド・ライアビリティ・カンパニー | リンパ腫および骨髄腫を処置するための方法および組成物 |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| WO2008109184A1 (en) | 2007-03-07 | 2008-09-12 | Infinity Pharmaceuticals, Inc. | Heterocyclic cyclopamine analogs and methods of use thereof |
| NZ579356A (en) * | 2007-03-07 | 2012-04-27 | Infinity Pharmaceuticals Inc | Cyclopamine lactam analogs and methods of use thereof |
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-
2005
- 2005-08-26 EP EP10012704.2A patent/EP2316832B1/en not_active Expired - Lifetime
- 2005-08-26 EP EP10012778.6A patent/EP2316833B1/en not_active Expired - Lifetime
- 2005-08-26 BR BRPI0514444-2A patent/BRPI0514444A/pt not_active Application Discontinuation
- 2005-08-26 ES ES10012778.6T patent/ES2578728T3/es not_active Expired - Lifetime
- 2005-08-26 CN CN201110094391.4A patent/CN102241727B/zh not_active Expired - Fee Related
- 2005-08-26 AU AU2005280112A patent/AU2005280112B2/en not_active Ceased
- 2005-08-26 EP EP05791140.6A patent/EP1817308B1/en not_active Expired - Lifetime
- 2005-08-26 JP JP2007530162A patent/JP5204486B2/ja not_active Expired - Fee Related
- 2005-08-26 CA CA2579078A patent/CA2579078C/en not_active Expired - Lifetime
- 2005-08-26 KR KR1020077006979A patent/KR101487481B1/ko not_active Expired - Fee Related
- 2005-08-26 WO PCT/US2005/030406 patent/WO2006026430A2/en not_active Ceased
- 2005-08-26 US US11/213,534 patent/US7230004B2/en not_active Expired - Lifetime
-
2007
- 2007-02-13 IL IL181301A patent/IL181301A/en active IP Right Grant
- 2007-03-08 NO NO20071264A patent/NO341137B1/no unknown
- 2007-04-18 US US11/737,035 patent/US7407967B2/en not_active Expired - Lifetime
-
2008
- 2008-07-10 US US12/171,208 patent/US7875628B2/en not_active Expired - Lifetime
-
2010
- 2010-12-15 US US12/969,024 patent/US8236956B2/en not_active Expired - Fee Related
-
2012
- 2012-07-24 JP JP2012164081A patent/JP2012232997A/ja active Pending
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