JP2012144457A - 抗酸化剤、化粧料、飲食品組成物及び医薬品組成物 - Google Patents
抗酸化剤、化粧料、飲食品組成物及び医薬品組成物 Download PDFInfo
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- JP2012144457A JP2012144457A JP2011002156A JP2011002156A JP2012144457A JP 2012144457 A JP2012144457 A JP 2012144457A JP 2011002156 A JP2011002156 A JP 2011002156A JP 2011002156 A JP2011002156 A JP 2011002156A JP 2012144457 A JP2012144457 A JP 2012144457A
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- citrullyl
- acid
- glucose
- antioxidant
- fructosyl glucose
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- NJGBTKGETPDVIK-UHFFFAOYSA-N raspberry ketone Chemical compound CC(=O)CCC1=CC=C(O)C=C1 NJGBTKGETPDVIK-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
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Abstract
【解決手段】シトルリルフルクトシルグルコースを有効成分として含有する抗酸化剤である。またシトルリルフルクトシルグルコースを配合した化粧料であり、シトルリルフルクトシルグルコースを配合した飲食品組成物であり、シトルリルフルクトシルグルコースを配合した医薬品組成物である。
【選択図】なし
Description
テル等のショ糖脂肪酸エステル、テトラグリセリンモノステアリン酸エステル、テトラグリセリンモノオレイン酸エステル、テトラグリセリントリステアリン酸エステル、ヘキサグリセリンモノラウリン酸エステル、ヘキサグリセリンモノミリスチン酸エステル、ヘキサグリセリンモノステアリン酸エステル、ヘキサグリセリントリステアリン酸エステル、デカグリセリンモノラウリン酸エステル、デカグリセリンモノミリスチン酸エステル、デカグリセリンモノステアリン酸エステル、デカグリセリンジステアリン酸エステル、デカグリセリントリステアリン酸エステル、デカグリセリンペンタステアリン酸エステル、デカグリセリンモノイソステアリン酸エステル、デカグリセリンジイソステアリン酸エステル、デカグリセリンペンタイソステアリン酸エステル、デカグリセリンモノオレイン酸エステル、デカグリセリントリオレイン酸エステル、デカグリセリンペンタオレイン酸エステル等のポリグリセリン脂肪酸エステル、モノイソステアリン酸ソルビタン、セスキイソステアリン酸ソルビタン、トリイソステテアリン酸ソルビタン等のソルビタン分岐脂肪酸エステル、大豆レシチン、卵黄レシチン、水素添加大豆レシチン、水素添加卵黄レシチン、更にこれらのレシチン類を酵素処理によりモノアシル体としたリゾレシチン及び/または水素添加リゾレシチン、ヒドロキシル化したヒドロキシレシチン等のレシチン類、モノイソステアリン酸グリセリル、セスキイソステアリン酸グリセリル、ジイソステアリン酸グリセリル等のグリセリン分岐脂肪酸エステル等を挙げることができる。
グルト、酒類等)、香味料(ラズベリーフレーバー、アップルフレーバー、コーヒーフレーバー等)、湿化防止剤、電解質、抗酸化剤、保存料、湿潤剤、蛋白質、アミノ酸、ペプチド、食物繊維、有機酸(クエン酸、リンゴ酸、フマル酸、マロン酸、コハク酸、酒石酸、乳酸等)、ビタミン類(L−アスコルビン酸、dl−α−トコフェロール、ビタミンB1、ビタミンB2、ナイアシン、パントテン酸、ビタミンB6、ビタミンB12、葉酸、ビオチン、イノシトール等)、ミネラル(亜鉛、鉄、カルシウム、マグネシウム、クロム、セレン、カリウム、ナトリウム等)、グルコサミン、酵母、卵殻膜、リコピン、アスタキサンチン、その他カロテノイド、シルク、コンドロイチン、セラミド、プラセンタエキス、フカヒレエキス、深海鮫エキス、スクワレン、γ−アミノ酪酸、カゼインドデカペプチド、生栗皮抽出物、栗の葉抽出物、栗のいが抽出物、栗果肉抽出物、栗樹皮抽出物、キャベツ発酵エキス、バラの花びら抽出物、ブドウ葉抽出物、ブドウ種子抽出物、りんごポリフェノール、カミツレエキス、ライチ種子エキス、ゴツコラエキス、月桃葉エキス、ハス胚芽エキス、スターフルーツ葉エキス、桑葉抽出物、グァバ茶抽出物、赤ワイン、緑茶、紅茶、ウーロン茶、コーヒー、ココア、チョコレート、黒ゴマ、豆類、豆乳、ナッツ類、きのこ類、緑黄食野菜類、ヨード卵等の卵由来原料、カテキン類、その他ポリフェノール類、ラズベリーケトン、低分子アルギン酸、サイリウム種皮、イチョウ葉抽出物、松樹皮抽出物、ナットウキナーゼ、植物ステロール、ジアシルグリセロール、キトサン、ヒアルロン酸、メチルスルフォニルメタン、コウジ酸、エラグ酸、アルブチン、ルシノール、マグノリグナン、リン酸L−アスコルビン酸マグネシウム、CoQ10、α−リポ酸等が挙げられる。
シトルリン2g、マルトース5g及び氷酢酸50mlの混合物を80℃で30分間加熱攪拌した。得られた溶液をろ過し、ろ液を濃縮し、乾燥して混合物5.7gを得た。これを50mlの水に再溶解し、陽イオン交換樹脂を充填したカラムに供し、1%アンモニア水で溶出させた。溶出液を濃縮し、凍結乾燥してシトルリルフルクトシルグルコースフラクション3.3gを得た。得られたシトルリルフルクトシルグルコースフラクション(3.3g)をシリカゲルカラム及びバイオゲルP−2にて精製し、シトルリルフルクトシルグルコース0.71gを得た。このシトルリルフルクトシルグルコースは一般式(1)で表される化合物と、一般式(2)で表される化合物の混合物である。
前記製造で得られたシトルリルフルクトシルグルコースについて、2,2−Dipheyl−1−picryldrazyl(Sigma社製、以下DPPHに略する。)を用いてラジカル消去作用を測定した。実験操作法としては、0.8mMのDPPH溶液0.1mlに80%エタノール0.1ml、2MのMES緩衝液(pH6.0)0.1ml及び表1に示す添加濃度となるように調製した添加被検物質の80%エタノール溶液0.1mlを加え、波長520nmにおける吸光度を測定した。吸光度の測定には、コロナ電気社製のSH−1000マイクロプレートリーダを用いた。シトルリルフルクトシルグルコースのラジカル消去作用の測定結果を表1に示す。
前記製造で得られたシトルリルフルクトシルグルコースについて、蛍光剤フルオレセインを用いてシトルリルフルクトシルグルコースの活性酸素吸収能を測定した。実験操作法としては、96穴マイクロプレートに75mMリン酸緩衝液(pH7.4)で溶解したフルオレセイン溶液(最終濃度200nM)0.1mlにシトルリルフルクトシルグルコース溶液0.025ml、ラジカル促進剤2,2‘−アゾビス(2−アミジノプロパン)ジハイドロクロライド(APPH)溶液(最終濃度15mM)0.025mlを加え、Flex Station 96ED(Molecular Devices)にて経時的にシトルリルフルクトシルグルコースの活性酸素吸収能を測定した。添加被検物質の添加濃度は、シトルリンが1mg/mlで、シトルリルフルクトシルグルコースが0.1mg/mlであった。なお、標準品として、Trolox(TE)を用いてTroloxの濃度1.25、2.5、5、10nmol/mlになるように標準曲線を作成した。Trolo
xの標準曲線に基づいて求めたシトルリルフルクトシルグルコースの活性酸素吸収能の測定結果を表2に示す。
前記製造で得られたシトルリルフルクトシルグルコースについて、ヒト正常新生児皮膚繊維芽細胞(NHDF)を用いて細胞毒性を評価した。実験操作法としては、ヒト正常新生児皮膚繊維芽細胞を10%牛血清含有するイーグルMEM培地を用いて培養した後、トリプシン/EDTA溶液処理により細胞を回収し、1×105cells/mLの濃度になるように2%牛血清含有するイーグルMEM培地で希釈した後、48穴培養プレートに2×104個ずつ播種し、5%CO2環境下、37℃で24時間培養した。培養終了後、シトルリルフルクトシルグルコース含有2%牛血清含有するイーグルMEM培地を加えて、さらに24時間培養を行い、細胞の生存率の測定によって細胞への影響を評価した。細胞生存率は、比較例1での細胞数を100%とし、各実施例での細胞数により算出した。数値が大きいほど細胞賦活作用を示し、細胞毒性を示さないことになる。一方、100%以下になると細胞毒性を示すことになる。
シトルリルフルクトシルグルコース 0.001
N−アセチルグルコサミン 0.05
エタノール 7.5
プラセンタエキス 0.05
D−パントテニルアルコール 0.1
グリチルリチン酸ジカリウム 0.1
フェノキシエタノール 0.3
モノラウリン酸ポリオキシエチレンソルビタン(20E.O.) 0.3
ポリオキシエチレン硬化ヒマシ油 0.05
エデト酸二ナトリウム 0.05
濃グリセリン 3.5
1,3−ブチレングリコール 2.5
ポリグリセリン 0.5
キサンタンガム 0.5
ソルビット液 5.0
カルボキシビニルポリマー 0.1
精製水 to100
シトルリルフルクトシルグルコース 0.001
D−パントテニルアルコール 0.1
グリチルリチン酸ジカリウム 0.1
流動パラフィン 11.5
濃グリセリン 5.0
ジプロピレングリコール 10.0
ソルビット液 5.0
サラシミツロウ 0.5
親油型モノステアリン酸グリセリル 0.1
ステアリン酸 0.3
メチルポリシロキサン 1.0
ワセリン 1.0
コレステロール 0.02
ベントナイト 0.1
N−ステアロイル−L−グルタミン酸ナトリウム 0.3
キサンタンガム 0.2
ベヘニルアルコール 0.3
フェノキシエタノール 0.2
ヒアルロン酸ナトリウム(2) 0.05
水溶性コラーゲン(F) 0.1
鮭卵巣抽出物 0.1
パラオキシ安息香酸エステル 0.1
N−アセチルグルコサミン 0.05
精製水 to100
シトルリルフルクトシルグルコース 0.01
D−パントテニルアルコール 1.0
グリチルリチン酸ジカリウム 0.5
流動パラフィン 4.0
サラシミツロウ 0.5
コレステロール 1.0
メチルシクロポリシロキサン 2.0
ジプロピレングリコール 7.0
親油型モノステアリン酸グリセリル 0.3
セチル硫酸ナトリウム 1.0
モノステアリン酸ポリエチレングリコール 1.0
ヒアルロン酸ナトリウム(2) 0.5
水溶性コラーゲン(F) 0.1
フェノキシエタノール 0.5
エデト酸二ナトリウム 0.05
N−アセチルグルコサミン 0.05
精製水 to100
シトルリルフルクトシルグルコース 0.01
ステアリン酸 2.5
ステアリルアルコール 8.0
スクワラン 5.0
オクチルドデカノール 7.0
グリセリルモノステアレート 4.0
防腐剤 適 量
香料 適 量
グリセリン 6.0
ソルビトール 13.0
乳酸カリウム 0.5
精製水 to100
シトルリルフルクトシルグルコース 0.01
キャンデリラロウ 12.0
固形パラフィン 8.0
ミツロウ 5.0
カルナバロウ 2.0
ラノリン 14.0
マンニット 15.0
イソプロピルミリステート 10.0
香料 適 量
酸化防止剤 適 量
ヒマシ油 to100
シトルリルフルクトシルグルコース 0.05
タルク 25.0
プロピレングリコール 6.0
塩化カリウム 0.1
香料 適 量
カオリン to100
シトルリルフルクトシルグルコース 0.05
ステアリン酸 2.0
セタノール 2.0
ワセリン 2.0
ラノリンアルコール 1.5
流動パラフィン 9.0
スクワラン 3.5
ソルビトール 10.0
トリエタノールアミン 1.0
プロピレングリコール 5.0
防腐剤 適 量
香料 適 量
精製水 to100
シトルリルフルクトシルグルコース 1.0
ステアリン酸 2.0
ステアリルアルコール 8.0
還元ラノリン 2.0
スクワラン 8.0
オクチルドデカノール 6.0
防腐剤 適 量
香料 適 量
プロピレングリコール 5.0
グリセリン 3.0
乳酸 0.3
クエン酸ナトリウム 0.5
精製水 to100
シトルリルフルクトシルグルコース 2.0
グリセリン 60.0
ポリエチレングリコール200 14.0
ポリビニルアルコール 0.2
精製水 to100
シトルリルフルクトシルグルコース 3.0
ラウリン酸 10.0
水酸化カリウム 2.8
ヤシ油脂肪酸カリウム液 30.0
エデト酸2ナトリウム 0.15
メチルセルロース 0.5
ラウリン酸アミノプロピルベタイン液 2.0
グリセリン 8.0
香料 適 量
精製水 to100
シトルリルフルクトシルグルコース 0.5
カフェイン 0.1
カルボキシビニルポリマー 0.5
ポリビニルアルコール 3.0
グリセリン 35.0
ポリエチレングリコール400 45.0
エタノール 適 量
防腐剤 適 量
精製水 to100
シトルリルフルクトシルグルコース 5.0
デンプン 30.0
乳糖 49.0
結晶セルロース to100
シトルリルフルクトシルグルコース 1.0
結晶セルロース 1.5
ビタミンC 20.0
香料 1.0
グアガム 0.1
ショ糖脂肪酸エステル 1.5
粉糖 to100
シトルリルフルクトシルグルコース 3.0
ビタミンE 20.0
小麦胚芽油 15.0
グリセリン脂肪酸エステル 5.0
ミツロウ 2.0
シソ油 to100
シトルリルフルクトシルグルコース 15.0
アスコルビン酸ナトリウム 18.0
デキストリン 24.0
グリセリン脂肪酸 0.5
粉糖 to100
Claims (4)
- シトルリルフルクトシルグルコースを有効成分として含有することを特徴とする抗酸化剤。
- シトルリルフルクトシルグルコースを配合したことを特徴とする化粧料。
- シトルリルフルクトシルグルコースを配合したことを特徴とする飲食品組成物。
- シトルリルフルクトシルグルコースを配合したことを特徴とする医薬品組成物。
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KR101819206B1 (ko) | 2016-12-22 | 2018-01-16 | 주식회사 엠랩 | 당류화합물과 미네랄복합제를 유효성분으로 포함하는 항균, 항바이러스 약학적 및 화장료 조성물 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60215609A (ja) * | 1984-04-09 | 1985-10-29 | Ichimaru Fuarukosu Kk | メラノイジン含有皮膚化粧料 |
JPS6410971A (en) * | 1987-07-03 | 1989-01-13 | Taiyo Fishery Co Ltd | Production of antioxidant substance |
JPH09110777A (ja) * | 1995-10-20 | 1997-04-28 | T Hasegawa Co Ltd | ドコサヘキサエン酸類の酸化防止剤 |
JPH09316091A (ja) * | 1996-05-24 | 1997-12-09 | Bizen Kasei Kk | アルギニルフラクトシルグルコース類の製造法 |
JP2002226370A (ja) * | 2001-02-05 | 2002-08-14 | Nara Institute Of Science & Technology | シトルリンを含有する活性酸素消去剤 |
WO2008105325A1 (ja) * | 2007-02-23 | 2008-09-04 | Kyowa Hakko Bio Co., Ltd. | シトルリン含有飲料 |
JP2010090076A (ja) * | 2008-10-10 | 2010-04-22 | Maruzen Pharmaceut Co Ltd | 抗炎症剤、抗老化剤、一酸化窒素産生促進剤及び皮膚化粧料 |
WO2012033523A1 (en) * | 2010-09-10 | 2012-03-15 | Kalamazoo Holding, Inc. | Methods for enhancing the stability of foods, beverages, and cosmetics using natural flavoring blends |
-
2011
- 2011-01-07 JP JP2011002156A patent/JP5665117B2/ja active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60215609A (ja) * | 1984-04-09 | 1985-10-29 | Ichimaru Fuarukosu Kk | メラノイジン含有皮膚化粧料 |
JPS6410971A (en) * | 1987-07-03 | 1989-01-13 | Taiyo Fishery Co Ltd | Production of antioxidant substance |
JPH09110777A (ja) * | 1995-10-20 | 1997-04-28 | T Hasegawa Co Ltd | ドコサヘキサエン酸類の酸化防止剤 |
JPH09316091A (ja) * | 1996-05-24 | 1997-12-09 | Bizen Kasei Kk | アルギニルフラクトシルグルコース類の製造法 |
JP2002226370A (ja) * | 2001-02-05 | 2002-08-14 | Nara Institute Of Science & Technology | シトルリンを含有する活性酸素消去剤 |
WO2008105325A1 (ja) * | 2007-02-23 | 2008-09-04 | Kyowa Hakko Bio Co., Ltd. | シトルリン含有飲料 |
JP2010090076A (ja) * | 2008-10-10 | 2010-04-22 | Maruzen Pharmaceut Co Ltd | 抗炎症剤、抗老化剤、一酸化窒素産生促進剤及び皮膚化粧料 |
WO2012033523A1 (en) * | 2010-09-10 | 2012-03-15 | Kalamazoo Holding, Inc. | Methods for enhancing the stability of foods, beverages, and cosmetics using natural flavoring blends |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101819206B1 (ko) | 2016-12-22 | 2018-01-16 | 주식회사 엠랩 | 당류화합물과 미네랄복합제를 유효성분으로 포함하는 항균, 항바이러스 약학적 및 화장료 조성물 |
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