JP2012092341A5 - - Google Patents

Info

Publication number

JP2012092341A5

JP2012092341A5 JP2011255723A JP2011255723A JP2012092341A5 JP 2012092341 A5 JP2012092341 A5 JP 2012092341A5 JP 2011255723 A JP2011255723 A JP 2011255723A JP 2011255723 A JP2011255723 A JP 2011255723A JP 2012092341 A5 JP2012092341 A5 JP 2012092341A5

Authority

JP

Japan

Prior art keywords

use according

conjunctivitis

compound

acid

length

Prior art date

2011-11-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 5
• 206010010741 Conjunctivitis Diseases 0.000 claims 3
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 2
• 239000002202 Polyethylene glycol Substances 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 229920001223 polyethylene glycol Polymers 0.000 claims 2
• 229920006395 saturated elastomer Polymers 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims 1
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 1
• UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims 1
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical group FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
• 102000009027 Albumins Human genes 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
• 239000004380 Cholic acid Substances 0.000 claims 1
• 229920001287 Chondroitin sulfate Chemical group 0.000 claims 1
• 206010010755 Conjunctivitis viral Diseases 0.000 claims 1
• 229920002307 Dextran Polymers 0.000 claims 1
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
• 229920002971 Heparan sulfate Chemical group 0.000 claims 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical group OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
• 229920001612 Hydroxyethyl starch Polymers 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 1
• 208000005914 Viral Conjunctivitis Diseases 0.000 claims 1
• 229940068372 acetyl salicylate Drugs 0.000 claims 1
• 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 229940050528 albumin Drugs 0.000 claims 1
• 229940072056 alginate Drugs 0.000 claims 1
• 229920000615 alginic acid Polymers 0.000 claims 1
• 235000010443 alginic acid Nutrition 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 125000004429 atom Chemical group 0.000 claims 1
• 201000007032 bacterial conjunctivitis Diseases 0.000 claims 1
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
• WLNARFZDISHUGS-MIXBDBMTSA-N cholesteryl hemisuccinate Chemical compound C1C=C2C[C@@H](OC(=O)CCC(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 WLNARFZDISHUGS-MIXBDBMTSA-N 0.000 claims 1
• BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 1
• 235000019416 cholic acid Nutrition 0.000 claims 1
• 229960002471 cholic acid Drugs 0.000 claims 1
• 229940059329 chondroitin sulfate Drugs 0.000 claims 1
• KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 1
• 229960002086 dextran Drugs 0.000 claims 1
• 239000000539 dimer Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 229940050526 hydroxyethylstarch Drugs 0.000 claims 1
• 239000002085 irritant Substances 0.000 claims 1
• 231100000021 irritant Toxicity 0.000 claims 1
• 229940099563 lactobionic acid Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000178 monomer Substances 0.000 claims 1
• IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 1
• -1 polygelin Polymers 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000006850 spacer group Chemical group 0.000 claims 1
• TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical group CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1