JP2012090633A5 - - Google Patents
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- Publication number
- JP2012090633A5 JP2012090633A5 JP2011266937A JP2011266937A JP2012090633A5 JP 2012090633 A5 JP2012090633 A5 JP 2012090633A5 JP 2011266937 A JP2011266937 A JP 2011266937A JP 2011266937 A JP2011266937 A JP 2011266937A JP 2012090633 A5 JP2012090633 A5 JP 2012090633A5
- Authority
- JP
- Japan
- Prior art keywords
- heterologous polypeptide
- cells
- rodent
- expression
- expression cassette
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 21
- 241000283984 Rodentia Species 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 238000000034 method Methods 0.000 claims 9
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 8
- 239000013612 plasmid Substances 0.000 claims 6
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 108020005091 Replication Origin Proteins 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 230000008488 polyadenylation Effects 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 230000010076 replication Effects 0.000 claims 4
- 108010008655 Epstein-Barr Virus Nuclear Antigens Proteins 0.000 claims 3
- 108091036066 Three prime untranslated region Proteins 0.000 claims 3
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 239000013613 expression plasmid Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 102000003693 Hedgehog Proteins Human genes 0.000 claims 1
- 108090000031 Hedgehog Proteins Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 102000036693 Thrombopoietin Human genes 0.000 claims 1
- 108010041111 Thrombopoietin Proteins 0.000 claims 1
- 108091023045 Untranslated Region Proteins 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 229940112869 bone morphogenetic protein Drugs 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 239000003248 enzyme activator Substances 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- 229940047122 interleukins Drugs 0.000 claims 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 238000003146 transient transfection Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05023611 | 2005-10-28 | ||
| EP05023611.6 | 2005-10-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008537000A Division JP5666776B2 (ja) | 2005-10-28 | 2006-10-26 | 齧歯動物細胞におけるタンパク質発現 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012090633A JP2012090633A (ja) | 2012-05-17 |
| JP2012090633A5 true JP2012090633A5 (https=) | 2013-01-31 |
Family
ID=36061413
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008537000A Expired - Fee Related JP5666776B2 (ja) | 2005-10-28 | 2006-10-26 | 齧歯動物細胞におけるタンパク質発現 |
| JP2011266937A Pending JP2012090633A (ja) | 2005-10-28 | 2011-12-06 | 齧歯動物細胞におけるタンパク質発現 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008537000A Expired - Fee Related JP5666776B2 (ja) | 2005-10-28 | 2006-10-26 | 齧歯動物細胞におけるタンパク質発現 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7892790B2 (https=) |
| EP (1) | EP1945781B1 (https=) |
| JP (2) | JP5666776B2 (https=) |
| CN (1) | CN101341252B (https=) |
| CA (1) | CA2624685C (https=) |
| ES (1) | ES2461591T3 (https=) |
| WO (1) | WO2007048601A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8530233B2 (en) * | 2007-10-02 | 2013-09-10 | Genetai Inc | Expression vector with enhanced gene expression capacity and method for using the same |
| CA2722835C (en) | 2008-05-15 | 2018-11-27 | National Research Council Of Canada | Process, vectors and engineered cell lines for enhanced large-scale transfection |
| US8822214B2 (en) * | 2009-09-15 | 2014-09-02 | Medimmune Limited | Cells for transient expression and uses thereof |
| CN102453729B (zh) * | 2010-10-29 | 2016-03-02 | 宁波安柯生物技术有限公司 | 一种快速高通量生产重组蛋白的平台 |
| WO2017032834A1 (en) * | 2015-08-25 | 2017-03-02 | Lonza Biologics Plc. | Mammalian expression system |
| US10464840B2 (en) * | 2016-10-05 | 2019-11-05 | Corning Incorporated | Near infrared shielding and laser-resistant window |
| CN114174540A (zh) * | 2019-07-25 | 2022-03-11 | 豪夫迈·罗氏有限公司 | 用于检测爱泼斯坦巴尔病毒(ebv)的组合物和方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4686186A (en) | 1984-09-26 | 1987-08-11 | Wisconsin Alumni Research Foundation | Recombinant vector and eukaryotic host transformed thereby |
| IE913929A1 (en) | 1990-11-13 | 1992-05-20 | Immunex Corp | Bifunctional selectable fusion genes |
| AU6953394A (en) | 1993-05-21 | 1994-12-20 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| EP0760861A1 (en) | 1994-05-20 | 1997-03-12 | The Board Of Trustees Of The Leland Stanford Junior University | An autonomous replication system for mammalian cells |
| US6479279B2 (en) | 1995-12-29 | 2002-11-12 | Estonian Biocentre | Episomal vectors and uses thereof |
| US5888809A (en) | 1997-05-01 | 1999-03-30 | Icos Corporation | Hamster EF-1α transcriptional regulatory DNA |
| US5976807A (en) | 1998-03-18 | 1999-11-02 | Pharmacopeia, Inc. | Eukaryotic cells stably expressing genes from multiple transfected episomes |
| MY139948A (en) | 2000-09-28 | 2009-11-30 | Bayer Corp | Enhanced transfection system |
| AU2002257440A1 (en) | 2001-05-07 | 2002-11-18 | National Research Council Of Canada | Enhanced production of recombinant proteins by transient transfection of suspension-growing mammalian cells |
| WO2004018506A2 (en) | 2002-08-22 | 2004-03-04 | Cytos Biotechnology Ag | Inducible alphaviral/orip based gene expression system |
| AU2003283174A1 (en) | 2002-12-11 | 2004-06-30 | Cytos Biotechnology Ag | Method for protein production |
| AR046071A1 (es) | 2003-07-10 | 2005-11-23 | Hoffmann La Roche | Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos |
| US7919270B2 (en) * | 2003-09-09 | 2011-04-05 | Acyte Biotech Pty Ltd | Mammalian expression system |
-
2006
- 2006-10-26 WO PCT/EP2006/010308 patent/WO2007048601A1/en not_active Ceased
- 2006-10-26 EP EP06806552.3A patent/EP1945781B1/en not_active Not-in-force
- 2006-10-26 CA CA2624685A patent/CA2624685C/en not_active Expired - Fee Related
- 2006-10-26 JP JP2008537000A patent/JP5666776B2/ja not_active Expired - Fee Related
- 2006-10-26 ES ES06806552.3T patent/ES2461591T3/es active Active
- 2006-10-26 CN CN200680040367XA patent/CN101341252B/zh not_active Expired - Fee Related
- 2006-10-26 US US12/083,535 patent/US7892790B2/en not_active Expired - Fee Related
-
2011
- 2011-12-06 JP JP2011266937A patent/JP2012090633A/ja active Pending
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