JP2012055888A - Emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an emulsion particle which includes: an antioxidant which has surface tension deterioration action, and its derivative; a liquefied matrix; a liposolubility or water-soluble substance; and a solvent, and in which the stability is good and the safety is high, and to provide applications thereof, and a method of manufacturing the same.SOLUTION: The emulsion composition is such that a part or the whole of an emulsion film is composed by the antioxidant which has the surface tension deterioration action.

Description

  The present invention has good stability composed of an antioxidant substance having a surface tension reducing action and its derivative, a liquid matrix, a fat-soluble or water-soluble substance contained in the emulsion particles, and a solvent in which the emulsion particles are dispersed. And highly safe emulsified particles, its use, and production method.

  Conventionally, as a method for obtaining finely emulsified particles, a method of blending an organic silicic acid, a method of blending a metal soap, and the like are known.

  Patent Document 1 discloses oxide particles or mixed oxide particles containing an antioxidant substance surrounded by an organosilicon group covalently bonded to oxide particles. Expensive because the oxide component is used in the prepolymer.

  U.S. Patent No. 6,057,032 teaches the use of acryloxyalkylsilanes to make emulsified particles containing antioxidants having reactive radiation curable groups.

  However, in the method of blending organosilicic acid, it is necessary to blend a large amount of these components for gelation, and there are problems such as poor extensibility, low safety, and skin irritation. Further, the emulsified particles were liable to collapse and the stability was not sufficient. As described above, none of the conventional emulsified particle compositions is sufficiently satisfactory. In addition, these conventional emulsified fine particles are prone to secondary agglomeration and are difficult to diffuse and apply to a single layer, and require processing such as pulverization, re-dispersion, and re-dissolution for use as industrial raw materials. However, there is a problem that the performance of particles containing an antioxidant is not sufficiently exhibited because it is complicated and difficult to handle. In particular, when the emulsion particles contain an antioxidant, the smaller the particle size, the more susceptible to oxidation by dissolved oxygen in the solvent, and the effects of light and free radicals. In addition, there is a problem of degeneration, and there is a problem of quality deterioration such as discoloration of products, generation of odor, precipitation and separation.

German patent DE 198 46 660 German patent DE 198464659

  The problem of the present invention is that aggregation of emulsified particles is made of water and / or a liquid matrix, a surfactant dissolved and dispersed in the matrix, and a fat-soluble substance with good stability, high safety and simplicity. An object of the present invention is to provide an emulsified particle containing an antioxidant that hardly causes separation, discoloration, and generation of odor and is difficult to decompose the antioxidant in the emulsified particle, and to provide its use and production method.

  The present invention has good stability, high safety, can stably contain an antioxidant in the emulsified particles, and is a pharmaceutical, pharmaceutical raw material, cosmetic, cosmetic raw material, external preparation, iontophoretic composition, Composition for introducing vibration, composition for introducing electromagnetic wave, composition for introducing heat, composition for introducing electrolysis, food, food additive, functional food, feed, feed additive, anti-aging agent, antioxidant, antioxidant An object of the present invention is to provide an emulsified particle composition containing an antioxidant substance suitable for an agent and the like, its use, and usage.

  As a result of intensive studies to solve the above problems, the present inventors have found that one or more of glycerin and / or liquid matrix or a composite thereof, and an antioxidant having a surface tension reducing action dissolved and dispersed therein. Good stability and safety by producing emulsified particles in water or liquid solvent with one or more simple substances or their composites and raw materials composed of one or more fat-soluble substances or their composites It was found that high emulsified particles can be prepared, and the present invention has been completed.

That is, the present invention relates to the following matters.
[Claim 1]
An emulsion composition in which a part or all of the emulsion film is composed of an antioxidant substance having a surface tension reducing action,
The antioxidant is L-ascorbic acid-2-glucoside-6-palmitate, L-ascorbic acid-2-glucoside-6-isopalmitate, L-ascorbic acid-2-glucoside-6-stearate, L-ascorbic acid 2-glucoside-6-isostearate, L-ascorbic acid-2-glucoside-6-tocopheryl, L-ascorbic acid-2-sulfuric acid-6-palmitate, L-ascorbic acid-2-sulfuric acid-6-isopalmitate, L-ascorbic acid-2-sulfate-6-stearate, L-ascorbic acid-2-sulfate-6-isostearate, L-ascorbic acid-2-sulfate-6-tocopheryl, L-ascorbic acid-2-malein Acid-6-palmitate, L-ascorbic acid-2-maleic acid-6-isopalmitate, L-asco Binic acid-2-maleic acid-6-stearate, L-ascorbic acid-2-maleic acid-6-isostearate, L-ascorbic acid-2-maleic acid-6-tocopheryl, tocopheryl 2-0-L- One or more selected from the group consisting of ascorbic acid phosphate, retinoyl 2-0-L-ascorbic acid phosphate, tocopheryl glucoside, tocopheryl sulfate, retinoyl phosphate, retinoyl glucoside, retinoyl sulfate and retinoyl dimethylglycine, or Salt,
One or more selected from the group consisting of glycerin, diglycerin, polyglycerin, ethanol, propanol, isopropanol, propylene glycol, polyethylene glycol, 1,3-butanediol and behenyl alcohol;
L-ascorbic acid tetrahexyldecanoic acid, retinol, retinoic acid, retinol palmitate, retinoic acid palmitate, retinoic acid isopalmitate, retinoic acid stearate, retinol stearate, astaxanthin, lutein, lycopene, β-carotene, α-carotene, α-tocopherol, β One or more selected from the group consisting of tocopherol, γ-tocopherol, ubiquinone, coenzyme A, tocotrienol, pycnogenol, pigment and magnetic powder;
Mineral oil, liquid paraffin, squalane, squalene, isopropyl palmitate, isopropyl myristate, isooctyl myristate, isotridecyl myristate, octadecyl myristate, octyldodecyl myristate, isostearyl cholesteryl ester, 2-ethylhexanoic acid triglyceride, 2-ethyl Cetyl hexanoate, sunflower oil, olive oil, jojoba oil, camellia oil, grape seed oil, avocado oil, macadamia nut oil, almond oil, rice germ oil, clove oil, orange oil, spruce oil, octamethyltrisiloxane, decamethyltetra Siloxane, methylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, methylcyclopolysiloxane Sun, methylpolysiloxane cyclosiloxane emulsion composition stabilized which encloses the one or more selected from the group consisting of methylphenyl polysiloxane and palmitic acid, a.
[Claim 2]
An emulsified composition in which emulsified particles comprising the emulsified composition according to claim 1 are dispersed in one or more of water and / or a liquid solvent or a composite thereof.
[Claim 3]
The emulsified composition according to claim 1 or 2, wherein the emulsified film is a multilayer molecular film.
[Claim 4]
The emulsified composition according to claim 2, wherein the concentration of the antioxidant substance having an effect of lowering the surface tension of the emulsified membrane is more than 10% (W / W) different from the concentration in the adjacent membrane solvent.
[Claim 5]
The emulsion composition according to claim 1, wherein an antioxidant substance or a substance that is easily denatured and decomposed by any of light, heat, oxygen, and free radicals is included in the emulsion composition.
[Claim 6]
The emulsified composition according to claim 1, wherein a fat-soluble substance or a water-soluble substance is encapsulated in the emulsified composition.
[Claim 7]
A solid containing the emulsified composition according to claim 1.
[Claim 8]
The emulsified composition according to claim 1, comprising a surfactant and / or an antioxidant other than an antioxidant having a surface tension lowering effect in the emulsion film constituent.
[Claim 9]
The emulsified composition according to claim 1, wherein the average emulsified particle diameter is in the range of 100 µm to 1 nm.
[Claim 10]
Applications of the emulsified composition are pharmaceuticals, pharmaceutical raw materials, cosmetics, cosmetic raw materials, external preparations, ion introduction compositions, vibration introduction compositions, electromagnetic wave introduction compositions, heat introduction compositions, electrolytic introduction compositions, foods , Food additives, functional foods, feed, feed additives, anti-aging agents, antioxidants, antioxidants, antibacterial agents, antiviral agents, paints, liquid crystal displays, toners, ink jet inks, inkjet printed circuit boards, The emulsified composition according to claim 1 selected from photosensitive particles for photographic film.
[Claim 11]
Claimed by mixing or penetrating or introducing the emulsified composition according to claim 1 into another substance by one or more simple methods or mixing methods selected from ion introduction, vibration introduction, electromagnetic wave introduction, heat introduction, and electrolysis introduction. A method for enhancing the effect of the use according to Item 10.
[Claim 12]
The method for producing an emulsified composition according to any one of claims 1 to 3, which is impact resistant and subjected to shear deformation at a shear rate of at least 15 / s and has an average particle size of less than 1000 nm dispersed in water and an aqueous solvent.
[Claim 13]
Shear deformation is performed using at least one dispersion device selected from the group consisting of static mixers, jet dispersers, microporous filters, membrane filters, escuttleders, microfluidizers, and Manton-Gaulin homogenizer nozzles. A method for producing the emulsion composition according to claim 12.

  One or more simple substances of a glycerin and / or liquid matrix or a composite thereof, one or more simple substances or a composite of an antioxidant having a surface tension reducing action dissolved and dispersed therein, and one or more of a fat-soluble substance. Emulsified particles with a raw material composed of a simple substance or a composite thereof in water or a liquid solvent to produce the emulsified particles and the emulsified particles having good stability and high safety of the substances contained therein, and uses thereof, A manufacturing method can be provided.

  Hereinafter, the present invention will be described in detail.

Antioxidant having surface tension reducing action that can be used in the present invention is a substance having both surface tension reducing action and antioxidant action when evaluated by the following surface tension reducing action test method and antioxidant action test method. That's fine.
Surface Tension Reducing Action Test Method If any one or more of the following two surface tension reducing action tests were positive, it was judged that the surface tension reducing action could be used in the present invention.
1. Water or solvent is put in a circular water tank with a diameter of 20 cm, and the oil contained in the corn extraction oil or emulsified particles is dropped on the water surface or the solvent surface to float the oil in a circular shape so as to have a diameter of 15 cm. . Next, when a test substance dissolved in purified water at a saturated concentration is dropped at the center of the oil in an environment of 20 ° C. and humidity 50%, and a state in which circular corn oil is dispersed and spread on the wall surface of the water tank is observed. Positive.
2. When measuring the surface tension of a saturated aqueous solution or saturated solvent solution of each test substance using an automatic surface tension meter (CBVP-A3) manufactured by Kyowa Interface Science Co., Ltd. A substance having a surface tension difference of 10% or more compared to the comparative solution when water or a control solvent is used is regarded as positive for surface tension lowering action.

Antioxidant Test Method Antioxidant having surface tension reducing action that can be used in the present invention is a substance having the ability to eliminate free radicals in one or more tests by the following two antioxidant test methods. A substance having an antioxidant action that can be used.
1. Superoxide (O2.-), which is a kind of active oxygen in xanthine-xanthine oxidase (X-XOD) system, is generated in a 10% (w / w) human serum dilution, and a test substance with a saturated concentration amount Was added, and supplemented with 5,5-Dymethyl-1-Pyrrollne-N-Oxide (DMPO) and measured by ESR. In the evaluation, the signal ratio of each sample was obtained on the basis of the signal of manganese oxide (MnO) which is an internal standard substance, and the comparison was made using the non-added section as a control. A substance that was confirmed to have a superoxide scavenging activity of 10% or more compared to the signal intensity of the additive-free control was regarded as having a positive antioxidant effect.
2. Hydroxyl radical (.OH), which is a kind of active oxygen, is generated in a 10% (w / w) human serum diluted solution by Fenton reaction, and a test substance with a saturating concentration is added to form 5,5-Dymethyl. It supplemented with -1-Pyrrollne-N-Oxide (DMPO) and measured by ESR. In the evaluation, the signal ratio of each sample was obtained on the basis of the signal of manganese oxide (MnO) which is an internal standard substance, and the comparison was made using the non-added section as a control. A substance that was confirmed to have a hydroxyl radical scavenging activity of 10% or more compared to the signal intensity of the additive-free control was regarded as having positive antioxidant action.

In addition to the above, examples of antioxidant substances having a surface tension reducing action that can be used in the present invention are shown below.
A substance in which the antioxidant having a surface tension reducing action is one or a mixture of two or more compounds selected from the compounds represented by the following chemical structural formulas (I), (II) and (III), or a salt thereof .

式中、Ｒ^１、Ｒ^２、Ｒ^３及びＲ^４は、各々独立に水酸基またはその水酸基と無機もしくは有機酸とのエステル基または糖との配糖体基、もしくはその水酸基のうち隣接した２個の水酸基とケトンとのケタール基もしくはアルデヒドとのアセタール基から選択され同時にＲ^１、Ｒ^２、Ｒ^３及びＲ^４のうちいずれか一つ以上が高級脂肪酸残基を表わす。好ましくはこの高級脂肪酸残基が、炭素原子数８〜２２の脂肪酸残基であり、さらに好ましくはラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、トコフェロール、トコトリエノール、レチノール、レチノイン酸、２−ヘキシルデカン酸、イソステアリン酸、パルミチン酸、２−ヘキシルデカン酸の残基であることを特徴とする請求項１に記載の乳化組成物。
上記化学式（Ｉ）の基本骨格であるアスコルビン酸はＬ−アスコルビン酸が好ましいが工業用途ではＤ−アスコルビン酸も使用することができる。

In the formula, R ¹ , R ² , R ³ and R ⁴ are each independently a hydroxyl group, an ester group of a hydroxyl group with an inorganic or organic acid, or a glycoside group of a sugar, or two adjacent hydroxyl groups. At ^{least one} of R ¹ , R ² , R ^3, and R ⁴ is a higher fatty acid residue selected from a ketal group of a hydroxyl group and a ketone or an acetal group of an aldehyde. Preferably, the higher fatty acid residue is a fatty acid residue having 8 to 22 carbon atoms, more preferably lauric acid, myristic acid, palmitic acid, stearic acid, tocopherol, tocotrienol, retinol, retinoic acid, 2-hexyldecanoic acid. The emulsion composition according to claim 1, which is a residue of isostearic acid, palmitic acid, or 2-hexyldecanoic acid.
Ascorbic acid which is the basic skeleton of the above chemical formula (I) is preferably L-ascorbic acid, but D-ascorbic acid can also be used in industrial applications.

式中、Ｒ_１〜Ｒ_３はメチル基または水素を、Ｒ_４は、無機もしくは有機酸とのエステル基または糖との配糖体基、もしくはアルデヒドとのアセタール基であり、好ましくはＲ_４が水溶性のエステル基であり、さらに好ましくは水溶性エステルがアスコルビン酸、リン酸、酢酸、硫酸、クエン酸、乳酸、ピルビン酸、アミノ酸等の水溶性有機酸エステルであることを特徴とする請求項１に記載の乳化組成物。上記化学式（ＩＩ）の基本骨格であるトコフェロール、トコトリエノールはＤ体が又はＤＬ体が望ましいが、工業用途ではＬ体も使用できる。上記化学式（ＩＩ）の基本骨格であるトコフェロール、トコトリエノールは、α型、β型、γ型、δ型のいづれも使用できる。

In the formula, R _{1 to} R ₃ are a methyl group or hydrogen, R ₄ is an ester group with an inorganic or organic acid, a glycoside group with a sugar, or an acetal group with an aldehyde, preferably R ₄ is A water-soluble ester group, more preferably, the water-soluble ester is a water-soluble organic acid ester such as ascorbic acid, phosphoric acid, acetic acid, sulfuric acid, citric acid, lactic acid, pyruvic acid, amino acid, etc. 2. The emulsified composition according to 1. The tocopherol and tocotrienol, which are basic skeletons of the above chemical formula (II), are preferably D-form or DL-form, but L-form can also be used for industrial applications. Any of α-type, β-type, γ-type, and δ-type can be used as the tocopherol and tocotrienol, which are the basic skeleton of the chemical formula (II).

式中、Ｒ１は、レチノール、レチノイン酸、アスタキサンチン、ゼアキサンチン、クリプトキサンチンから選択され、Ｒ２は、無機もしくは有機酸とのエステル基または糖との配糖体基、もしくはアルデヒドとのアセタール基であり、好ましくはＲ２が水溶性のエステル基であり、さらに好ましくは水溶性エステルがアスコルビン酸、リン酸、酢酸、硫酸、クエン酸、乳酸、ピルビン酸、アミノ酸等の水溶性有機酸エステルであることを特徴とする請求項１に記載の乳化組成物。上記化学式Ｒ１のレチノール、レチノイン酸及びカロチノイド類は、シス型、トランス型、オールシス型、オールトランス型のいずれも使用できる。

Wherein R1 is selected from retinol, retinoic acid, astaxanthin, zeaxanthin, cryptoxanthin, R2 is an ester group with an inorganic or organic acid, a glycoside group with a sugar, or an acetal group with an aldehyde, Preferably, R2 is a water-soluble ester group, and more preferably, the water-soluble ester is a water-soluble organic acid ester such as ascorbic acid, phosphoric acid, acetic acid, sulfuric acid, citric acid, lactic acid, pyruvic acid, and amino acid. The emulsion composition according to claim 1. As the retinol, retinoic acid and carotenoids represented by the chemical formula R1, any of cis type, trans type, all cis type and all trans type can be used.

  In addition to the above, examples of antioxidant substances having a surface tension reducing action that can be used in the present invention are shown below.

The emulsion composition according to claim 1, wherein the antioxidant having a surface tension reducing action according to the present invention is one or a mixture of two or more selected from the following compounds or salts thereof. Methyl L-ascorbate, ethyl L-ascorbate, propyl L-ascorbate, butyl L-ascorbate, pentyl L-ascorbate, L-ascorbic acid-2-palmitate, L-ascorbic acid-2-isopalmitate, L- Ascorbic acid-2-stearate, L-ascorbic acid-2-isostearate, L-ascorbic acid-6-palmitate, L-ascorbic acid-6 isopalmitate, L-ascorbic acid-6-stearate, L-ascorbic acid -6-isostearate, L-ascorbic acid-2,6-dipalmitate, L-ascorbic acid-2,6-diisopalmitate, L-ascorbic acid-2,6-distearate, L-ascorbic acid-2, 6-Diisostearate, L-ascorbic acid-2-glucose Do-6-palmitate, L-ascorbic acid-2-glucoside-6-isopalmitate, L-ascorbic acid-2-glucoside-6-stearate, L-ascorbic acid-2-glucoside-6-isostearate, L- Ascorbic acid-2-glucoside-6-tocopheryl, L-ascorbic acid-2-sulfuric acid-6-palmitate, L-ascorbic acid-2-sulfuric acid-6-isopalmitate, L-ascorbic acid-2-sulfuric acid-6-stearate L-ascorbic acid-2-sulfate-6-isostearate, L-ascorbic acid-2-sulfate-6-tocopheryl, L-ascorbic acid-2-maleic acid-6-palmitate, L-ascorbic acid-2- Maleic acid-6-isopalmitate, L-ascorbic acid-2-maleic acid-6-stearate, L- Scorbic acid-2-maleic acid-6-isostearate, L-ascorbic acid-2-maleic acid-6-tocopheryl, L-ascorbic acid-2-phosphate-6-palmitate, L-ascorbic acid-2-phosphorus Acid-6-isopalmitate, L-ascorbic acid-2-phosphate-6-stearate, L-ascorbic acid-2-phosphate-6-isostearate, L-ascorbic acid-2-phosphate-6-tocopheryl , Palmitoyl 2-0-L-ascorbic acid, isopalmitoyl 2-0-L-ascorbic acid phosphate, stearyl 2-0-L-ascorbic acid phosphate, isostearyl 2-0-L-ascorbic acid phosphate, tocopheryl 2-0-L-ascorbic acid phosphate, retinoyl 2-0-L-ascorbic acid phosphate, tocopheryl phosphate, tocotrie It is a mixture of one or more compounds selected from norphosphoric acid, tocopheryl glucoside, tocopheryl sulfate, tocopheryl dimethyl glycine, retinoyl phosphate, retinoyl glucoside, retinoyl sulfate, retinoyl dimethyl glycine compound, or a salt thereof. It is characterized by.
L-ascorbic acid that can be used in the present invention described above is preferably L-form, but D-form can also be used. Tocopherol and tocotrienol can be used in any of α-type, β-type, and γ-type, and retinol, retinoin. As the acid and carotenoid, any of cis type, trans type, all cis type, and all trans type can be used.

  The salt of the antioxidant substance having a surface tension reducing action that can be used in the present invention is an alkali metal such as calcium, sodium, potassium, zinc, aluminum, iron, copper, cobalt, hydrochloride, alkaline earth metal, inorganic A salt such as an acid can also be used.

In the present invention, the liquid matrix means glycerin, polyhydric alcohol, ethanol, propanol, isopropanol, gelling agent, glycerin, methyl laurate, lauryl alcohol, glycerol monolaurate, oleic acid, oleyl alcohol, glycerol monooleate, dioleic acid Glycerol and glycerol trioleate, nicotinic acid, 2-pyrazinecarboxylic acid, sinapinic acid (3,5-dimethoxy-4-hydroxycinnamic acid), 2,5-dihydroxybenzoic acid, 5-methoxysalicylic acid, α-cyano- Examples include 4-hydroxycinnamic acid, 3-hydroxypicolinic acid, diaminonaphthalene, 2- (4-hydroxyphenylazo) benzoic acid, disranol, succinic acid, and 5- (trifluoromethyl) uracil. Among these, as polyhydric alcohol, for example, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, ethylene glycol, diethylene glycol, polyethylene glycol, 1,3-butanediol, sorbitol, maltitol, erythritol, Pentaerythritol, glucose, saccharose, maltose, xylose, trehalose and the like can be exemplified, and these may be used alone or in combination of two or more. Of these, preferred are trihydric or higher polyhydric alcohols such as glycerin, diglycerin, polyglycerin, sorbitol, maltitol, erythritol, pentaerythritol, glucose, saccharose, maltose, xylose, trehalose, and particularly preferred is glycerin. Sorbitol.
The emulsified composition of the present invention may be either liquid crystal or non-liquid crystal, but liquid crystal is preferred from the viewpoint of emulsion stability, fine particle forming ability, and dispersibility.

  The water used in the present invention is purified water having a pH of 1 to 13, ion exchange water, distilled water, natural water, alkali ion water, acid water, electrolytic ion water, negative ion water, strong acid water, strong alkali water. Etc. There is no particular limitation.

Any surfactant can be used as the surfactant of the present invention as long as the emulsified composition of the present invention can be prepared, and a surfactant having a lipopeptide structure is particularly suitable. Examples of the surfactant having a lipopeptide structure include surfactin sodium, amino acid surfactants and related compounds, and / or salts thereof.
Specific examples of the surfactant that can be used in the present invention include anionic, cationic, nonionic and amphoteric surfactants. In the present invention, any of the following surfactants can be used. Surfactants are fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate and ammonium lauryl sulfate; polyoxyethylene such as sodium laureth sulfate and triethanolamine laureth sulfate Alkyl sulfates; acyl N-methyl such as cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanolamine, sodium lauroyl glutamate methylalanine sodium, etc. Amino acid salt: Sodium cocoyl glutamate, Triethanol cocoyl glutamate Acyl amino acid salts such as min, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; lauroyl monoethanolamide succinate Fatty acid alkanolamide ether carboxylate; acyl lactate; polyoxyethylene fatty amine sulfate; fatty acid alkanolamide sulfate; fatty acid glyceride sulfate such as sodium glyceryl sulfate; fatty acid glyceryl sulfate; Polyoxyethylene sulfate; olefin sulfonate such as sodium α-olefin sulfonate; sulfo Alkyl sulfosuccinates such as disodium lauryl succinate and dioctyl sodium sulfosuccinate; alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate; tetra Alkylbenzene sulfonates such as sodium decylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalene sulfonates; alkane sulfonates; α-sulfo fatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates Alkyl sulfoacetates; sodium laureth phosphate, sodium dilaureth phosphate, trilaureth Alkyl ether phosphate esters such as sodium phosphate and sodium monooles; alkyl phosphate esters such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphates; fatty acid amide ether phosphates; phosphatidylglycerol, phosphatidylinositol Phospholipids such as phosphatidic acid; anionic surfactants such as silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphoric acid-modified silicone and sulfuric acid-modified silicone; laureth (polyoxyethylene lauryl ether), Ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), isosteare (polyoxyethylene ether) Sostearyl ethers), octyldodeces (polyoxyethylene octyldodecyl ether), and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; polyoxyethylene hydrogenated castor oil, polyoxyethylene Castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid, etc. Oil and hydrogenated castor oil derivatives; polyoxyethylene phytosterols; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; poly Xylethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, poly Polyoxyethylene and polyoxypropylene alkyl ethers such as oxyethylene and polyoxypropylene glycerin ether; Polyoxyethylene and polyoxypropylene glycol; (Poly) glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; Glyceryl stearate, isostearic acid Glyceryl acid, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut fatty acid, Cottonseed oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glycerin fatty acid partial esters such as α, α'-oleic acid pyroglutamate glycerin, monostearic acid glycerin malic acid; polyglyceryl stearate-2, 3, 4 5, 6, 8, 10, polyglyceryl-6 distearate, 10, polyglyceryl tristearate-2, polyglyceryl decastearate-10, polyglyceryl-2 isostearate 3, 3, 4, 5, 6, 8, 8, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 10, polyglyceryl triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl decaisostearate-10, oleic acid Polyglyceryl fatty acid esters, such as polyglyceryl-2, 3, 4, 5, 6, 8, 10, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleate polyglyceryl-10; mono Ethylene glycol monofatty acid esters such as ethylene glycol stearate; Propylene glycol monofatty acid esters such as propylene glycol monostearate; Pentaerythritol partial fatty acid ester; Sorbitol partial fatty acid ester; Maltitol partial fatty acid ester; Maltitol ether; Sorbitan monooleate Sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan triole Salts, sorbitan fatty acid esters such as penta-2-ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl diglycerol sorbitan; sucrose fatty acid esters, methyl glucoside fatty acid esters, sugar derivatives partial esters such as undecylenic acid trehalose; caprylyl Alkyl glucosides such as glucoside; alkyl polyglycosides; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acids such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate Mono and diesters; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene glycerin monostearate, polyoxyethylene glycerin Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as monoisostearate and polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan Polyoxyethylene sorbitan fatty acid esters such as monooleate and polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, polyoxyethylene sorbitol monostearate Such as polyoxyethylene sorbitol fatty acid ester; polyoxyethylene methyl glucoside fatty acid ester; Oxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; Alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, and batyl alcohol; Polyhydric alcohol alkyl ether; Poly Oxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil Fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DE) ), Fatty acid alkanolamides such as lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamidomethyl MEA); Alkyldimethylamine oxides such as oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; polyether-modified silicone such as dimethicone copolyol; polysiloxane / oxyalkylene copolymer Nonionic surfactants such as silicone, nonionic surfactants such as coalesced polyglycerin-modified silicones and sugar-modified silicones; As the surfactant, alkyltrimethylammonium chloride such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; alkyltrimethylammonium bromide such as stearyltrimonium bromide; distearyldimonium chloride, dicocodimonium Dialkyldimethylammonium chloride such as chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ether amines and salts or quaternary salts thereof such as stearoxypropyldimethylamine; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl lanolin sulfate fatty acid aminopropylethyldimethylan Fatty acid amide type quaternary ammonium salts such as nium; polyoxyethylene alkylamine and salts or quaternary salts thereof; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyl dimethicone and amodimethicone; Silicone cationic surfactants such as silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, etc .; lauryl betaine (lauryl dimethylamino vinegar) N-alkyl-N, N-dimethylamino acid betaines such as betaine); fatty acid amide alkyl-N, N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline types such as sodium cocoamphoacetate and sodium lauroamphoacetate Betaine; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, etc. Sphingophospholipid, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, Phospholipids such as hydroxylated lecithin; amphoteric surfactants such as silicone-based amphoteric surfactants; polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymers; various silicone-based surfactants Examples thereof include, but are not limited to, one or more surfactants selected from polymer surfactants such as

The fat-soluble substance of claim 6 of the present invention includes, for example, hydrocarbons, higher alcohol esters, higher fatty acid esters, triglycerides, silicone oils, higher alcohols, higher fatty acids, animal and plant oils, cholesterol fatty acids Esters, sterols, sterol esters, polyphenols, fullerenes, tars, tar dyes, fat-soluble conductive substances, fat-soluble magnetic substances, fat-soluble pigments, fat-soluble dyes, etc. Can be used.
Lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid , Higher fatty acids such as isohexadecanoic acid, antiisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts thereof And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squale , Vaseline, solid paraffin and other carbides; candelilla wax, carnauba wax, rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax Waxes such as ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, Kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, mint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, flaxseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, kaka Vegetable oils such as oil, shea, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanolin, adsorbed purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin Lanolins such as alcohol, lanolin acetate alcohol, acetic acid (cetyl lanolyl) ester; sphingophospholipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phosphatidic acid, Phospholipids such as zolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol Sterols such as cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L- Dilutamate (phytosteryl / octyldodecyl), acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, isostearic acid phytosteryl, soft lanolin fatty acid cholesteryl, hard lanolin Sterol esters such as fatty acid cholesteryl, long-chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid / cholesterol complex, phospholipid / phytosterol complex; octyldodecyl myristate, hexyldecyl myristate Octyldodecyl isostearate, cetyl parimitinate, octyldodecyl palmitate, cetyl octanoate Hexyldecyl octoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, ricinolein oleate Octyldodecyl acid, octyldodecyl lanolin fatty acid, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate , Lanolin fatty acid isopropyl, diethyl sebacate, diisopropiate sebacate , Monoalcohol carboxylates such as dioctyl sebacate, diisopropyl adipate, dibutyl octyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate; cetyl lactate, diisostearyl malate, monoisostearate hydrogenated castor oil Oxyesters such as: glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic acid / capric acid), tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl , Hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trii Trimethylol propane stearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated Rosin pentaerythrityl, triethylhexanoic acid ditrimethylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, triethylhexanoic acid pentaerythrityl, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diisostearate diglyceryl, tetraisostearin Polyglyceryl acid, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) polyglycerin -8, polyhydric alcohol fatty acid esters such as (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate); diisopropyl dimerolinolate, diisostearyl dimerlinoleate, dimerlinol Dimerisolinate (disteostearic acid / phytosteryl), dimerlinolinic acid (phytosteryl / behenyl), dimerlinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimerlinolinic acid dimerlinolinol Dimer acid or dimerioo such as rail, dimerinolinoleic hydrogenated rosin condensate, dimerlinoleic acid hydrogenated castor oil, hydroxyalkyl dimerinolinoleyl ether Derivatives of palm oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide ( Lauramide MIPA), fatty acid alkanolamides such as palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (Highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, dipheny Amino-modified silicones such as rubimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, aminopropyldimethicone and amodimethicone, cation-modified silicone , Polyether modified silicone such as dimethicone copolyol, polyglycerin modified silicone, sugar modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone , Peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, Non-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, silicones such as polysiloxane / oxyalkylene copolymers; selected from fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether Although it is 1 type or 2 types or more, Preferably, what becomes liquid in the range of 0 to 100 degreeC is suitable.

As an example of the antioxidant of claim 5 of the present invention, more preferably, it is an antioxidant having an erasing effect such as superoxide, hydroxy radical, singlet oxygen, hydrogen peroxide, NO radical, lipid peroxide, More specifically, tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Examples of the reducing agent include thioglycolic acid, cysteine, cysteamine, carotenoids, glutathione, cysteine, selenium, vitamin A, coenzyme Q10, fullerene, lipoic acid, polyphenol, catechins, L-ascorbic acid tetrahexyldecanoic acid, tocopherol retinoate, etc. Antioxidant vitamins and derivatives thereof and salts thereof may be used.
As an example of the antioxidant substance of the claim of the present invention, the antioxidant substance having the surface tension reducing action of the first aspect of the present invention may be used.

  As the fat-soluble substance according to claim 6 of the present invention, ascorbic acid isopalmitic acid, ascorbic acid-2-phosphate-6-palmitate, ascorbic acid-2-phosphate-6-isopalmitate, ascorbic acid are preferable. Tetrahexyldecanoic acid, ascorbic acid-6-palmitate, ascorbic acid-2, 6-dipalmitate, ascorbic acid-6-stearate, retinol, retinoic acid, retinol palmitate, tocopheryl retinoate, retinoic acid palmitate, retinoic acid isopalmitate, Retinoic acid stearate, retinol stearate, astaxanthin, lutein, lycopene, β-carotene, α-carotene, α-tocopherol, β-tocopherol, γ-tocopherol, dimethylglycine tocopherol, ubiquit Non, coenzyme A, tocotrienol, mineral oil, liquid paraffin, squalane, isopropyl palmitate, isopropyl myristate, isooctyl myristate, isotridecyl myristate, octadecyl myristate, octyldodecyl myristate, isostearyl cholesteryl ester, 2-ethylhexanoic acid Triglycerides, cetyl 2-ethylhexanoate, examples of antioxidants according to the present invention may be antioxidant natural oils, such as sunflower oil, olive oil, jojoba oil, camellia oil, grape Seed oil, avocado oil, macadamia nut oil, almond oil, rice germ oil, clove oil, orange oil, spruce oil, pycnogenol, coenzyme A, iris extract oil, ashitaba extract oil, asnalo Extract oil, Asparagus extract oil, Avocado extract oil, Achacha extract oil, Almond extract oil, Altea extract oil, Arnica extract oil, Aloe extract oil, Apricot extract oil, Apricot extract oil, Ginkgo biloba extract oil, Inch extract oil, Fennel Extraction Oil, Turmeric Extraction Oil, Oolong Tea Extraction Oil, Peony Extract Oil, Ages Extract Oil, Echinacea Leaf Extraction Oil, Enmezo Extraction Oil, Ogon Extraction Oil, Oat Extract Oil, Oen Extraction Oil, Barley Extraction Oil, Ginseng Extract Oil, Hypericum Extract Oil, Oyster extract oil, Ononis extract oil, Dutch mustard extract oil, Orange extract oil, Seawater dried product, Seaweed extract oil, Oyster leaf extract oil, Oyster extract oil , Hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cuckoo extract oil, chamomile extract oil, carrot extract oil, kawara mugi extract oil, oat extract oil, calcade extract oil, licorice extract oil, oil-soluble licorice extract oil, kiwi Extraction oil, kiou extract oil, jellyfish extract oil, kina extract oil, cucumber extract oil, killi leaf extract oil, guanosine, guava extract oil, cucumber extract oil, gardenia extract oil, kumazasa extract oil, clara extract oil, walnut extract oil, Chestnut extract oil, grapefruit extract oil, clematis extract oil, black rice extract oil, fat-soluble black sugar extract, fat-soluble black vinegar extract, chlorella extract oil, mulberry extract oil, gentian extract oil, Gennoshoco extract Extraction oil, black tea extraction oil, yeast extraction oil, Kokuboku extraction oil, coffee extraction oil, burdock extraction oil, rice extraction oil, rice fermentation extraction oil, rice bran fermentation extraction oil, rice germ oil, comfrey extraction oil, collagen, bilberry extraction Oil, Saishin extract oil, Psycho extract oil, Saitai extract, Saffron extract oil, Salvia extract oil, Soap extract oil, Sasa extract oil, Hawthorn extract oil, Sansha extract oil, Salamander extract oil, Shiitake extract oil, Giant extract oil , Sicon extract oil, perilla extract oil, linden extract oil, citrus extract oil, jatoba extract oil, peony extract oil, ginger extract oil, ginger root extract oil, birch extract oil, white jellyfish extract oil, Gina extract oil, Stevia extract oil, Stevia fermented product, Nishikawa willow extract oil, Kizuta extract oil, Hawthorn extract oil, Elderflower extract oil, Yarrow extract oil, Saddle extract oil, Sage extract oil, Zeny mallow extract oil, Senkyu extract oil, assembly extract oil, Sakuhakuhi extract oil, Daio extract oil, soybean extract oil, tiso extract oil, thyme extract oil, dandelion extract oil, lichen extract oil, tea extract oil, clove extract oil, chigaya extract oil, chimpi Extraction oil, tea tree oil, persimmon tea extraction oil, pepper extract oil, toki extract oil, red pepper extract oil, tonin extract oil, spruce extract oil, dokudami extract oil, tomato extract Ill, Natto Extract Oil, Carrot Extract Oil, Garlic Extract Oil, Novara Extract Oil, Hibiscus Extract Oil, Bacmond Extract Oil, Lotus Extract Oil, Parsley Extract Oil, Birch Extract Oil, Honey, Hamamelis Extract Oil, Parietalia Extract Oil, Hikikoshi Extract Oil, bisabolol, hinoki extract oil, bifidobacteria extract oil, loquat extract oil, dandelion extract oil, burdock extract oil, butterfly extract oil, butcher bloom extract oil, grape extract oil, grape seed extract oil, propolis, loofah extract oil, safflower Extraction oil, Peppermint extraction oil, Bodaige extraction oil, Button extraction oil, Hop extraction oil, Mikaika extraction oil, Pine extraction oil, Marronnier extraction oil, Mizubasho Extraction oil, Mucuro extract oil, Melissa extract oil, Mozuku extract oil, Peach extract oil, Cornflower extract oil, Eucalyptus extract oil, Yukinoshita extract oil, Yuzu extract oil, Lily extract oil, Yokuinin extract oil, Artemisia extract oil, Lavender extract oil , Green tea extract oil, eggshell membrane extract oil, apple extract oil, rooibos tea extract oil, litchi extract oil, lettuce extract oil, lemon extract oil, forsythia extract oil, forsythia extract oil, rose extract oil, rosemary extract oil, roman chamomile Extraction oil, royal jelly extraction oil, bitumen extract oil, dimethyl silicone oil such as octamethyltrisiloxane, decamethyltetrasiloxane, methylpolysiloxane, highly polymerized methylpolysiloxane; Cyclic silicone oils such as tamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, methylcyclopolysiloxane, and methylpolycyclosiloxane; polyether-modified silicone oils, methylphenyl silicone oils such as methylphenylpolysiloxane, etc. Is mentioned. These may be used alone or in combination of two or more.

As the fat-soluble substance of the present invention, fat-soluble pigments and fat-soluble dyes can be used, and specific examples thereof include Heucophhal (registered trademark) Blue BT-585-P, Toluidine Red Y (C.I. Pigment). Red 3), Quindo (R) Magenta (Pigment Red 122), Magenta RV-6831 press cake (Mobay Chemical. Harmon Division, Haledon, NJ), Sunfast (R) Magenta 122 (Sun Chemical Corp.). Cincinnati, Ohio), Indo (registered trademark) Brilliant Scarlet (Pigment Red 123, CI No. 71145), Toluidine Red B (CI Pigment Red 3), Watchchun (Registered trademark) Red B (CI Pigment Red 48), Permanent Rubine F6B13-1731 (Pigment Red 184), Hansa (registered trademark) Yellow (Pigment Yellow 98), Dalamar (registered trademark) Yellow YT-839-P (Pigment Yellow 74, CI No. 117174, Sunbrite (registered trademark) Yellowe 17) (Sun Chemical Corp. Cincinnati, Ohio), Toluidine Yellow G (CI Pigment Yellow 1), Pigment Scarlet (C.I Pigment Red 60), Auric Brown (C.I. Pigment Brown 6), and the like. Other typical pigments useful in formulating the inks of the present invention include phthalocyanine blue (C.I. 74260), phthalocyanine green (C.I. 74260), Hanza Yellow 3G (C.I. 11670), diazo yellow. GR (C.I. 21100), Permanent Red 4R (CI. 12335), Brilliant Carmine 6B (C.I. 15850) and Quinacridone Red (C.I. 46500). When these pigments and dyes have low fat-soluble properties, it is also possible to use a composition dispersed in the above-described fat-soluble substance at a content of 0.1 to 95% by weight.
As the fat-soluble substance of the present invention, fat-soluble conductive substances, fat-soluble magnetic substances, and the following metal or metal oxide fine particles containing an antioxidant substance as a fat-soluble pigment are added to the fat-soluble substance in an amount of 0.1 to 0.1. It is also possible to use oily compositions of metals or metal oxides dispersed in a content of 95% by weight. The metals and metal oxides that can be used at this time are suitable for the production of magnetic ink jet inks, for example. Fine particle size oxides such as silica, alumina, titania and the like may also be selected. In addition, finely ground metal particles such as copper, iron, steel, aluminum and alloys can be selected for suitable applications.

Particularly preferred pigments for use in fat-soluble pigments and fat-soluble dyes that can be used as the fat-soluble substance of the present invention are C.I. I. Pigment red 122, C.I. I. Pigment yellow 74 and C.I. I. Pigment Blue 15. The present invention is particularly advantageous when used for color pigments. The amount of the pigment contained in the emulsified composition is usually 10 to 50% by weight with respect to the total composition. More preferably, the amount of pigment is in the range of 10-25% by weight.
As the fat-soluble substance of the present invention, fat-soluble conductive substances, fat-soluble magnetic substances, and polymer electrolytes can be used, and a polymer carboxylate is preferable. This salt may be a sodium salt, potassium salt, lithium salt or ammonium salt of carboxylic acid.

  The polymeric carboxylates that can be used in the present invention are in particular the salts of the following polymers: polyacrylic acid, acrylic acid-acrylonitrile copolymer, potassium acrylate-acrylonitrile copolymer, vinyl acetate-acrylic acid ester copolymer and acrylic acid- Acrylic resins such as alkyl acrylate copolymers, styrene-acrylic acid copolymers, styrene-methacrylic acid copolymers, styrene-methacrylic acid-acrylic acid alkyl ester copolymers, styrene-α-methylstyrene-acrylic acid copolymers and styrene-α-methyl. Styrene acrylic resins such as styrene-acrylic acid-alkyl acrylate ester copolymers; styrene-maleic acid copolymers, styrene-maleic anhydride copolymers; vinylnaphthalene-acrylic Vinyl acetate resins such as lauric acid copolymers, vinyl acetate-ethylene copolymers, vinyl acetate-fatty acid vinyl ethylene copolymers, vinyl acetate-maleic acid ester copolymers, vinyl oxalate-crotonic acid copolymers and vinyl acetate-acrylic acid copolymers; and optional Polyester or cellulose polymer salts can also be used.

  Surfactants suitable as polyelectrolytes include, for example, polymeric alkyl sulfates, polymeric alcohol sulfate salts, condensation products of polymeric fatty acids and amino acids, sulfosuccinates, naphthanates, and liquid fatty oil sulfates. Anionic surfactants such as salts and alkyl allyl sulfates; cationic surfactants such as quaternary ammonium salts, sulfonium salts and phosphonium: and such as polyoxyethylene alkyl esters, sorbitan alkyl esters and polyoxyethylene sorbitan alkyl esters Nonionic surfactants. Suitable amounts of polyelectrolyte range from about 0.05 to 10% by weight, preferably 0.1 to 3% by weight, based on the total composition.

  The preferable content of water and / or liquid matrix in the emulsified composition of the present invention is 0.01 to 99.99 mass%, preferably 0.01 to 99 mass%, based on the total amount of the composition.

Any aqueous solution dissolved in water can be used as the liquid solvent of claim 2 of the present invention, and it is not particularly limited as long as it is a water-soluble substance among the liquid matrix in the present invention. Substances that test positive are preferred. The preferable content of the fat-soluble substance or the water-soluble substance in the emulsion composition of the present invention is 1 to 99.9% by mass, and more preferably 50 to 95% by mass with respect to the total amount of the composition.
In addition, as the water-soluble substance of claim 6 of the present invention, all aqueous solutions dissolved in water can be used, and the liquid matrix in the present invention is not particularly limited as long as it is a water-soluble substance. Substances that are positive in the antioxidant test are preferred. The preferable content of the fat-soluble substance or the water-soluble substance in the emulsion composition of the present invention is 1 to 99.9% by mass, and more preferably 50 to 95% by mass with respect to the total amount of the composition.

  Although there is no restriction | limiting in particular in the content of the emulsion film | membrane structural component which has the surface tension reduction effect | action of this invention and an antioxidant effect | action, Preferably it is 0.0001-45 mass% with respect to the composition whole quantity, More preferably, 0.01- 20% by mass. If the amount of the emulsion film constituent having both surface tension lowering action and antioxidant action is less than 0.01% by mass, emulsion particles showing sufficient antioxidant action cannot be produced. Is not preferable because it becomes too high.

  The content of the surfactant that can be added to the emulsion film constituent having both the surface tension lowering action and the antioxidant action of the present invention is not an essential ingredient that must be added, but is preferable for further improving the stability of the emulsion film. Is 0.0001 to 40% by mass, more preferably 0.001 to 40% by mass, based on the total amount of the composition. On the other hand, if it exceeds 45% by mass, the antioxidant action is weakened and the viscosity becomes too high, which is not preferable.

  The lipid or fat-soluble substance in the present invention is preferably liquid or pasty at 1 atm 0 to 100 □, and is preferably liquid oil.

  When other components are added to the emulsified composition of the present invention, the total amount of the fat-soluble substance is added, whether it is added before adding the fat-soluble substance or dissolved or dispersed in the fat-soluble substance. Even if it adds after carrying out, it does not matter even if it adds in the middle of adding a fat-soluble substance. The polyhydric alcohol and / or water may be added in the total amount at first, or a part of the added amount may be used first and the rest may be added later.

  The stability of the emulsion composition of the present invention can be kept good if it is an emulsion composition having an average particle diameter in the range of 100 μm or less, preferably in the range of 10 μm to 30 nm.

  The emulsified composition of the present invention is extremely hypoallergenic to living tissue such as skin. The reason why the emulsified composition of the present invention is hypoallergenic to the living body is that the emulsified component of the present invention uses a provitamin derived from a living body component and its related compounds, and therefore has good biocompatibility. it is conceivable that.

  Applications of the emulsified composition of the present invention include pharmaceuticals, pharmaceutical raw materials, cosmetics, cosmetic raw materials, external preparations, ion introduction compositions, vibration introduction compositions, electromagnetic wave introduction compositions, heat introduction compositions, electrolytic introductions. It may be one or more simple substances or mixtures selected from compositions for foods, foods, food additives, functional foods, feeds, feed additives, antioxidants, antioxidants and antioxidants.

  Applications of the emulsified composition of the present invention include pharmaceuticals, pharmaceutical raw materials, cosmetics, cosmetic raw materials, external preparations, ion introduction compositions, vibration introduction compositions, electromagnetic wave introduction compositions, thermal introduction compositions, and electrolytic introductions. Addition of lipids and fat-soluble substances in the case of one or more simple substances or mixtures selected from compositions, foods, food additives, functional foods, feeds, feed additives, antioxidants, antioxidants and antioxidants The amount may be added in the range of 0.005% to 90% by weight with respect to the total weight of the final preparation.

  This is because it becomes difficult to produce emulsified particles when it is 90% or more, and the effect is lowered when it is 0.005% or less.

  Applications of the emulsified composition of the present invention include pharmaceuticals, pharmaceutical raw materials, cosmetics, cosmetic raw materials, external preparations, ion introduction compositions, vibration introduction compositions, electromagnetic wave introduction compositions, thermal introduction compositions, and electrolytic introductions. Addition amount to humans or organisms in the case of one or more simple substances or mixtures selected from compositions, foods, food additives, functional foods, feeds, feed additives, antioxidants, antioxidants and antioxidants Is different depending on the type of fat-soluble substance, but it is sufficient to administer, apply, and add an emulsion composition containing the expression amount of the effect of the fat-soluble substance within a physiologically acceptable range. Specifically, the amount of the emulsion composition As long as it is 300 ppb to 10 g / day in terms of a person or living organism having a weight of 1 kg.

  For formulation and stabilization of the emulsified composition of the present invention, the pH may be 1 to 13.

  In addition, the use of the emulsion composition of the present invention includes pharmaceuticals, pharmaceutical raw materials, cosmetics, cosmetic raw materials, external preparations, ion introduction compositions, vibration introduction compositions, electromagnetic wave introduction compositions, heat introduction compositions, electrolysis In the case of one or more simple substances or mixtures selected from introduction compositions, foods, food additives, functional foods, feeds, feed additives, anti-aging agents, antioxidants and antioxidants, their specifics Effects include whitening, pigmentation improvement, acne treatment, wrinkle improvement, rough skin improvement, oily skin improvement, dry skin improvement, pore reduction, scar treatment, red face treatment, hair loss treatment, hair growth It can have therapeutic and preventive effects on promotion, burn treatment, skin sterilization, skin mite killing and skin texture improvement.

  Moreover, although the density | concentration of the emulsion composition of this invention required in order to acquire these effects changes with concentration etc. of an emulsion composition or its clathrate, what is necessary is just 0.1 ppm-100% weight.

  The 100% weight may be formulated as the final preparation of the original emulsified composition of the present invention. However, considering the feeling of use, the concentration of the emulsified composition in the preparation is preferably 0.001 to 50% by weight. At this concentration, the amount of the emulsified composition of the present invention added to the living body is 0.01 mg to 10 g per square centimeter of skin when applied to the skin, and is 0 per 60 kg of body weight when administered orally or by injection. It may be from 0.01 mg to 100 g.

  Applications of the emulsified composition of the present invention include pharmaceuticals, pharmaceutical raw materials, cosmetics, cosmetic raw materials, external preparations, ion introduction compositions, vibration introduction compositions, electromagnetic wave introduction compositions, thermal introduction compositions, and electrolytic introductions. In the case of one or more simple substances or mixtures selected from compositions, foods, food additives, functional foods, feeds, feed additives, antioxidants, antioxidants, antioxidants, the following physiologically acceptable Can be formulated into a dosage form.

  The emulsified composition of the present invention can also be prepared by blending with various forms of bases in accordance with conventional methods. For example, various forms such as liquid, emulsion, cream, powder, ointment, dispersed liquid, multilayer, paste, gel, solid, powder, pellet, granule, emulsified particle, etc. are selected. be able to.

  Moreover, the emulsion composition of this invention can also be prepared by mix | blending with the base of the various form known as a composition for external use according to a conventional method. For example, basic cosmetics such as milky lotion, cream, lotion, cosmetic liquid, pack, oil, nail care product, lip balm, hair restorer, hair nourishing agent, bathing agent, antiperspirant, facial cleanser such as shampoo, rinse, and whole body cleanser , Foundation, white powder, makeup cosmetics such as makeup base, ointments, dispersions, etc., liquid, multilayer, emulsion, paste, gel, solid, powder, granule Various forms such as a shape can be selected.

  In addition to the components described above, the emulsion composition of the present invention includes components used for various preparations, that is, water (purified water, hot spring water, deep water, etc.), oil agent, as long as the effects of the present invention are not impaired. , Surfactant, metal soap, gelling agent, powder, alcohol, water-soluble polymer, film-forming agent, resin, clathrate compound, moisturizer, antibacterial agent, fragrance, deodorant, salt, pH adjuster , Fresheners, animal / microbe-derived extracts, plant extracts, vitamins, amino acids, nucleic acids, hormones, cell activators, blood circulation promoters, astringents, antiseborrheic agents, active oxygen scavengers, keratolytic agents In addition, one or two or more enzymes may be added as appropriate in the range of 0.001 to 90% by weight, more preferably 0.01 to 50% by weight.

  Specific examples of the additive that can be added to the emulsified composition of the present invention include natural oils, synthetic oils, solids, semi-solids, as long as they are used in ordinary cosmetics. Any oil such as hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorinated oils and the like can be used regardless of properties such as liquid. For example, hydrocarbons such as ozokerite, squalane, squalene, ceresin, paraffin, paraffin wax, liquid paraffin, pristane, polyisobutylene, microcrystalline wax, petroleum jelly, waxes such as beeswax, carnauba wax, candelilla wax, whale wax, beef fat , Beef leg fat, beef bone fat, hardened beef fat, hardened oil, turtle oil, pork fat, horse fat, mink oil, liver oil, egg yolk oil and other animal oils, lanolin, liquid lanolin, reduced lanolin, lanolin alcohol, hard lanolin, acetic acid Lanolin derivatives such as lanolin, lanolin fatty acid isopropyl, phospholipid, phosphadylcholine, POE lanolin alcohol ether, POE lanolin alcohol acetate, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, lauric Fatty acids such as acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid, linoleic acid, arachidonic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), isostearic acid, 12-hydroxystearic acid Lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol, oleyl alcohol, isostearyl alcohol, hexyl decanol, octyldodecanol, cetostearyl alcohol-2-decyltetradecinol, cholesterol, phytosterol , Sitosterol, lanosterol, POE cholesterol ether, monostearyl glycerol ether (batyl alcohol), etc. Coal, diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene di-2-ethylhexanoate Glycol-2-ethylhexanoate cetyl, tri-2-ethylhexanoate trimethylolpropane, tetra-2-ethylhexanoate pentaerythritol, cetyl octoate, octyldodecyl gum ester, oleic oleate, octyldodecyl oleate, oleic acid Decyl, neopentyl glycol dicaprate, triethyl citrate, 2-ethylhexyl succinate, amyl acetate, ethyl acetate, butyl acetate, isocetyl stearate, butyl stearate, Diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptyl undecyl palmitate, cholesteryl 12-hydroxystearylate, Dipentaerythritol fatty acid ester, isopropyl myristate, octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, 2-octyl N-lauroyl-L-glutamate Ester oil such as dodecyl ester, diisostearyl malate, acetoglyceride, triisooctanoic acid glyceride, triisostearic acid glyceride, Glyceride oil such as glyceride of lysopalmitic acid, glyceride of tri-2-ethylhexanoic acid, glyceride of monostearic acid, glyceride of di-2-heptylundecanoic acid, glyceride of trimyristic acid, dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogen Higher alkoxy-modified silicones such as polysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydrogencyclotetrasiloxane, stearoxysilicone, higher fatty acid-modified silicone, silicone resin, silicone rubber Silicone oil such as silicone resin, perfluoropolyether, perfluorodecalin, perfluorooctane Motokei oil and the like.

The surfactant that can be added as an additive to the emulsion composition of the present invention includes anionic, cationic, nonionic and amphoteric surfactants. In the present invention, a nonionic surfactant can be used.
Examples of the anionic surfactant that can be added as an additive to the emulsion composition of the present invention include fatty acid soaps such as sodium stearate and triethanolamine palmitate, alkyl ether carboxylic acids and salts thereof, and carboxylic acids such as condensation of amino acids and fatty acids. Acid salt, alkyl sulfonic acid, alkene sulfonate, fatty acid ester sulfonate, fatty acid amide sulfonate, alkyl sulfonate and its formalin condensate sulfonate, alkyl sulfate ester, secondary higher alcohol Sulfate esters, alkyl and allyl ether sulfates, sulfate esters of fatty acid esters, sulfate esters of fatty acid alkylolamides, sulfate esters such as funnel oil, alkyl phosphates, ether phosphates, alkyl allyl ether phosphoruss Acid salt, amido Acid salts, N-acyl amino acid based surfactants, etc .; cationic surfactants include alkylamine salts, amine salts such as polyamines and aminoalcohol fatty acid derivatives, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridium salts Nonionic surfactants include sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, polyethylene glycol fatty acid ester, sucrose fatty acid ester, polyoxyethylene alkyl ether, poly Oxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fat Acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene phytostanol ether, polyoxyethylene phytosterol ether, polyoxyethylene cholestanol ether , Polyoxyethylene cholesteryl ether, polyoxyalkylene-modified organopolysiloxane, polyoxyalkylene / alkyl co-modified organopolysiloxane, alkanolamide, sugar ether, sugar amide, etc .; amphoteric surfactants include betaine, aminocarboxylate, Examples include, but are not limited to, imidazoline derivatives.

  The metal soap that can be added to the emulsified composition of the present invention includes 12-hydroxyaluminum stearate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, magnesium myristate, zinc cetyl phosphate, calcium cetyl phosphate , Zinc sodium cetyl phosphate, zinc laurate, zinc undecylenate and the like.

  Examples of the gelling agent that can be added as an additive to the emulsion composition of the present invention include amino acid derivatives such as N-lauroyl-L-glutamic acid and α, γ-di-n-butylamine, dextrin palmitate, dextrin stearate, Dextrin 2-ethylhexanoic acid palmitic acid ester such as dextrin fatty acid ester, sucrose palmitic acid ester, sucrose fatty acid ester such as sucrose stearate ester, monobenzylidene sorbitol, benzylidene derivative of sorbitol such as dibenzylidene sorbitol, dimethylbenzyl dodecyl And organic modified clay minerals such as ammonium montmorillonite clay and dimethyldioctadecyl ammonium montmorillonite clay.

  As a powder that can be added as an additive to the emulsified composition of the present invention, the shape (spherical, needle-like, plate-like, etc.) and particle size (smoke-like, Any fine powder, pigment grade, etc.) and particle structure (porous, non-porous, etc.) can be used. For example, inorganic powder that can be added to the composition containing the emulsified composition of the present invention As the body, magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, talc, synthetic mica, mica, kaolin, sericite, muscovite, synthetic mica, phlogopite, saucite, biotite, lithia Mica, silicic acid, anhydrous silicic acid, aluminum silicate, magnesium silicate, magnesium aluminum silicate, calcium silicate, barium silicate, strontium silicate, tongue Metal phosphate, hydroxyapatite, vermiculite, hydrite, montmorillonite, zeolite, ceramic powder, dicalcium phosphate, alumina, aluminum hydroxide, boron nitride, boron nitride, etc .; organic powders include polyamide powder, polyester powder, polyethylene Powder, polypropylene powder, polystyrene powder, polyurethane, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene powder, polymethyl methacrylate powder, cellulose, silk powder, nylon powder, 12 nylon, 6 nylon, styrene / acrylic acid copolymer, Divinylbenzene / styrene copolymer, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin Acrylic resin, melamine resin, epoxy resin, polycarbonate resin, microcrystalline fiber powder, lauroyl lysine, etc .; Colored pigments include inorganic red pigments such as iron oxide, iron hydroxide and iron titanate, and inorganic brown such as γ-iron oxide -Based pigments, inorganic yellow pigments such as yellow iron oxide and ocher, inorganic black pigments such as black iron oxide and carbon black, inorganic purple pigments such as manganese violet and cobalt violet, chromium hydroxide, chromium oxide, cobalt oxide and titanic acid Inorganic green pigments such as cobalt, inorganic blue pigments such as bitumen and ultramarine blue, tal pigments raked, natural pigments raked, and composite powders obtained by combining these powders; pearl pigments, etc. As titanium oxide-coated mica, titanium oxide-coated mica, bismuth oxychloride, titanium oxide-coated bismuth oxychloride, titanium oxide-coated titanium , Fish scale foil, titanium oxide-coated colored mica, etc .; as metal powder pigments, aluminum powder, copper powder, stainless steel powder, etc .; as tar pigments, red No. 3, red 104, red 106, red 201, red 202, Red 204, Red 205, Red 220, Red 226, Red 227, Red 228, Red 230, Red 401, Red 505, Yellow 4, Yellow 5, Yellow 202 , Yellow 203, yellow 204, yellow 401, blue 1, blue 2, blue 201, blue 404, green 3, green 201, green 204, green 205, orange 201, orange 203, orange 204, orange 206, orange 207, etc .; natural pigments include carminic acid, laccaic acid, calsamine, bradylin, crocin, etc. Barrel powder, or composite of these powder, oil, silicone, or fluorine compound may be a powder was subjected to surface treatment.

  Examples of alcohols that can be added as an additive to the emulsion composition of the present invention include lower alcohols such as ethanol and isopropanol, glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1, Examples include 3-butylene glycol, sorbitol, erythritol, maltitol, maltose, xylitol, xylose, trehalose, inositol, glucose, mannitol, and polyhydric alcohols such as polyethylene glycol.

  Water-soluble polymers that can be added as additives to the emulsion composition of the present invention include mucopolysaccharides and salts thereof selected from chondroitin sulfate, hyaluronic acid, mucin, dermatan sulfate, heparin and keratan sulfate, gum arabic, tragacanth, galactan , Plant polymers such as carob gum, guar gum, caraya gum, carrageenan, pectin, agar, quince seed, algae colloid, tranto gum, locust bean gum, galactomannan, microbial polymers such as xanthan gum, dextran, succinoglucan, pullulan, Animal polymers such as collagen, casein, albumin and gelatin, starch polymers such as starch, carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, ethylcellulose and methylhydroxyl Propyl cellulose, carboxymethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, nitrocellulose, sodium cellulose sulfate, sodium carboxymethyl cellulose, crystalline cellulose, cellulose polymer of cellulose powder, sodium alginate, propylene glycol alginate, etc., polyvinyl Vinyl polymers such as methyl ether, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, polyoxyethylene polymers, polyoxyethylene polyoxypropylene copolymer polymers, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc. Acrylic polymer, polyethyleneimine, cationic polymer, bentonite, laponai , And inorganic water-soluble polymers such as hectorite. Also included are film forming agents such as polyvinyl alcohol and polyvinyl pyrrolidone.

  Antibacterial agents that can be added as additives to the emulsified composition of the present invention include benzoic acid, sodium benzoate, salicylic acid, carboxylic acid, sorbic acid, potassium sorbate, p-hydroxybenzoic acid ester, parachlorometacresol, hexachlorophene, and benzil chloride. Examples thereof include ruthenium, chlorhexidine chloride, trichlorocarbanilide, photosensitizer, bis (2-pyridylthio-1-oxide) zinc, pentadiol, iturin, surfactin, polyglycine, ethanol, phenoxyethanol, and isopropylmethylphenol.

  As a pH adjuster that can be added as an additive to the emulsion composition of the present invention, lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, potassium carbonate, sodium bicarbonate, ammonium bicarbonate, etc. , L-menthol, camphor and the like.

  Examples of animal-derived and microorganism-derived extracts that can be added as additives to the emulsified composition of the present invention include blood extracts such as pigs and cows, serum deproteinized extracts, spleen extracts, avian egg components, chicken crowns Extract, fish extract, squid, chitin, chitosan, shell extract, shell extract, royal jelly, silk protein and its degradation product or their derivatives, hemoglobin or its degradation product, milk, casein and its derivatives or their derivatives Degradation products, lactoferrin or degradation products thereof, collagen and derivatives thereof or hydrolysis products thereof, elastin and derivatives thereof or hydrolysis products thereof, keratin and derivatives thereof or degradation products thereof, mammals, birds, fish, mollusks , Crustaceans, shellfish, insects and other animal-derived extracts; yeast metabolites, fermentation metabolites, yeast extracts, lactic acid bacteria extract Things, extracts from microorganisms such as bifidobacteria extract.

Natural extracts that can be added as an additive to the emulsified composition of the present invention include glabrizine, glabrene, liquiritin, isoliquiritin and licorice extract containing these, placenta extract, carotenoids and animal and plant extracts containing these, neo Agarobiose, agarose oligosaccharide, asparagus extract, ibukitorano extract, pea extract, age extract, ogon extract, onionis extract, seaweed extract, raspberry extract, cucumber extract, caquette extract , Gokahi extract, vegetable oil containing linoleic acid, Saisin extract, Hawthorn extract, Sunpens extract, Shirayuri extract, Peonies extract, Sempukuka extract, Sohakuhi extract, soybean extract, tea extract, Toki extract , Molasses extract, beechlen extract, beech Extract, grape seed extract, flow demanita extract, hop extract, micaika extract, mokka extract, yukinoshita extract, yokuinin extract and rahan fruit extract, asparagus, akane, red grape, akamegasiwa, akebi, Asa, morning glory, azuki bean, asenyaku, achacha, amacha eel, itadori, fig, ginkgo, ylang ylang, moray eel, ume, cormorant, walrus, shrimp, sorghum, shrimp, enju, pea, plantain, okra, ogrema, minced oak , Oysters, persimmons, cashews, cashews, valerian, calla lilies, quince, guarana, kyoto, chrysanthemum, catalpa, scallops, gymnema sylvestre, goldfish, guava, wolfberry, crap, camphor, chestnut, cake Cormorant, bay, cahi, strawberry, pepper, coffee, sesame seed, colombo, sasanqua, salamander, saffron, cherry blossom, pomegranate, sandscon, sunpens, zion, shobu, watermelon, stevia, plum, citrus kizuta, pear, yarrow Horseshoe, horseradish, buffalo, scallops, seri, senega, senna, daiou, daidai, tamarind, arachnid, dandelion, chicory, clove, datura, chorei, primrose, communis, communis, tsuruna, teuchigurumi, tougan, tochua, toruo Natsumikan, Nanten, Nigaki, Yarrow, Pineapple, Hibiscus, Papaya, Basil, Lotus, Hadakamugi, Hagi, Peanut, Hikikoshi, Hishi, Pistachio , Hiba, himematsutake, peony, loquat, dandelion, fushinoki, fujibakama, blueberry, boufuu, physalis, honoki, bokeh, maikai, maou, mango, garlic mushroom, shimasaicho, misohagi, honey bee, mimosa, momo ron , Morohaya, Palm, Yakuchi, Yakumo, Cornflower, Palm, Yashajitsu, Mistletoe, Willow tree, Prunus, Prunus, Yuzuriha, Mugwort, Rye, Orchid, Longan, Apple, Ganoderma, Forsythia and the like.

  Examples of vitamins include vitamin Fs such as linolenic acid and its derivatives; vitamin Ks such as phytonadione, menaquinone, menadione and menadiol; vitamins P such as eriocitrin and hesperidin; other biotin, carcinine, ferulic acid and the like It is done.

  The amino acids that can be added as an additive to the emulsion composition of the present invention include glycine, alanine, valine, isoleucine, serine, threonine, aspartic acid, glutamic acid, asparagine, glutamine, lysine, hydroxylysine, arginine, cystine, methionine, phenylalanine. Amino acids such as tyrosine, proline, hydroxyproline, ortinin, citrulline, theanine, and derivatives thereof, and salts thereof, or amino acid derivatives such as pyrrolidone carboxylic acid, or derivatives thereof. Examples of nucleic acid-related substances include deoxyribonucleic acid and salts thereof, adenylic acid derivatives selected from adenosine triphosphate, adenosine diphosphate and adenosine monophosphate and salts thereof, ribonucleic acid and salts thereof, cyclic AMP, and cyclic GMP Examples of the flavin adenine nucleotide, guanine, adenine, cytosine, thymine, xanthine and their derivatives caffeine, theophylline, and salts and hormones thereof include estradiol, etenyl estradiol and the like. Examples of the enzyme include lipase and papain.

  Examples of the blood circulation promoter that can be added as an additive to the emulsion composition of the present invention include nonyl acid wallenylamide, capsaicin, gingerone, cantalis tincture, ictamol, α-borneol, inositol hexanicotinate, cyclandrate, cinnarizine, trazoline, acetylcholine Examples of skin astringents such as verapamil, cephalanthin, and γ-oryzanol include tannic acid, and examples of antiseborrheic agents include sulfur and thianthol.

  When using the emulsion composition of this invention for the use of cosmetics, the following arbitrary components can also be mix | blended.

  Examples of such components include hydrocarbons such as petrolatum and microcrystalline wax; esters such as octyldodecyl myristate and isopropyl myristate; glyceryl triisooctanoate and triglycerides such as olive oil; methylphenylpolysiloxane, methyl Silicone oils such as polysiloxane; higher alcohols such as cetanol and behenyl alcohol; fatty acids such as stearic acid and oleic acid; polyhydric alcohols such as glycerin, 1,3-butanediol, and propylene glycol; ethanol, isopropyl alcohol, etc. Lower alcohols: nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, thickeners, UV absorbers, antioxidants, emollients, emulsifiers, solubilizers, anti Inflammatory agent Humectants, preservatives, germicides, pH adjusting agents, dyes, perfumes, powders such as water and the like.

  Furthermore, the composition containing the emulsified composition of the present invention has a general concentration of raw materials described in the existing raw material specifications or official documents, for example, preferably the entire composition containing the emulsified composition of the present invention. It can also be added at 100 ppm to 90% by weight with respect to the amount. Examples of the raw materials described in the above-mentioned existing raw material standards or official documents include, for example, the 14th revised Japanese Pharmacopoeia, edited by the Japan Standards Association, issued by Jiho Co., Ltd., issued in April 2001. Commentary on the second edition of the standards, edited by the Japanese Official Church, 1984 (Pharmaceutical Daily Report), Standards for Ingredients for Cosmetic Ingredients, Supervised by the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, 1993 (Pharmaceutical Daily Report), Supplement for Standards for Ingredients for Cosmetic Ingredients, Ministry of Health and Welfare Supervised by the Pharmaceutical Affairs Bureau Screening Division, 1993 (Pharmaceutical Daily Report), Permit Cosmetics Permitted Standard, Ministry of Health and Welfare Pharmacy Bureau Screening Division Supervision, 1993 (Pharmaceutical Daily Report), and International Cosmetic Inditionary and Handbook 2002 Ninth Edition Vol. All raw materials described in 1-4, byCTFA, cosmetic raw material dictionary 1991 (Nikko Chemicals) and the like can be used.

  The emulsified composition of the present invention further enhances the effect of the use of claim 4 by introducing it by one or more single methods or mixing methods selected from ion introduction, vibration introduction, electromagnetic wave introduction, heat introduction, and electrolysis introduction. Can do.

  The method for producing an emulsified composition of the present invention may be formed by dispersing the composition of claims 4 and 5 in a solvent such as water, and the emulsified composition of the present invention has impact resistance and emulsified particles. It can also be produced by shear deformation. The impact resistance can easily produce the emulsion composition of the present invention by colliding a water flow at a certain pressure or higher against the emulsion composition of the present invention. When the average particle size of the particles is 200 nm or less, it is preferable to use an apparatus that applies shear deformation. More preferably, when the emulsion composition is subjected to shear deformation at a shear rate of at least 15 / s, fine emulsion particles having an average particle diameter of less than 1000 nm dispersed in water and an aqueous solvent can be produced. The water flow at a constant pressure mentioned here does not require a special pressurizing device, and a pressure of about the water pressure of tap water is sufficient. Or the shear rate of the grade which mixes the emulsion composition stored in the tank and water with a normal stirrer may be sufficient.

  Specific examples of the apparatus for applying shear deformation include a stirrer, a stirrer mill, a stirrer mixer, a homomixer, a screw mixer, and a drill mixer, and more preferably a static mixer, a jet disperser, a microporous filter, and a microfluidizer. And at least one disperser selected from the group consisting of Manton-Gaulin homogenizer nozzles.

  In addition, a jet dispersator that dissipates pressure energy into a small volume object in a depressurizing nozzle can be used as the emulsion composition production apparatus of the present invention. Examples of other suitable static dispersion devices include microporous filters, microporous glass filters, microfluidizers and Manton-Gaulin homogenizer nozzles. A jet dispagator is a preferred device.

Thus, one important feature of the present invention is that shear deformation by the method of the present invention reduces the average particle size of the emulsion composition (denoted herein as “d _w ”) and reduces the size distribution of the particles. The width (expressed as “d _w / d _n ” in the present specification, where _dn indicates the number average particle size) is reduced. When applying a speed shear deformation disclosed in the present invention according to the methods of the present invention, d _w and d _{w /} d _n is based on the value obtained by the method without shearing stresses above the speed at least 20%, Preferably it is reduced by 30%.

  This shear stress is applied after the phase inversion is completed. The jet displacer has a depressurizing nozzle in which the available pressure energy is dissipated in the smallest possible volume in the dispersion region, which is used to obtain a high volumetric specific dispersion force.

  Examples of suitable static mixers include those available from Sulzer, Winterthur, Switzerland / Germany (commercially identified SMX). The common point of all static mixers is that the fluid flow in the tube is constantly separated, rearranged, combined and redistributed by internal components. The static mixer is thereby operated in a manner similar to a jet dispersator, i.e. the available pressure energy is dissipated in the static mixer.

  The volumetric flow rate through which the polymer solution containing the emulsified composition particles is transferred through the shearing device is high, and a pressure drop of between 0.01 and 500 bar, preferably between 0.5 and 50 bar appears. An operating pressure of 0.5 to 50 bar can be generated with a relatively simple and inexpensive pump. The shear rate (velocity gradient, shear rate) in the shearing apparatus is high, at least 100 / s, preferably 1000 to 20000000 / s, most preferably 35000 to 1500,000 / s. This shear rate is set by the pressure drop.

  EXAMPLES Hereinafter, although an Example demonstrates this invention further in detail, this invention is not limited to these Examples at all. The glycerin listed below was used with a content of 98% by mass or more. The displayed% is weight%. APPS (NaL-ascorbic acid-2-phosphate-6-palmitate), VEP (Na-phosphate tocopherol), VCIP (L-ascorbic acid tetrahexyldecanoate), TDMG (α-tocopheryldimethylglycine)

Example 1: Emulsified composition 1 part by mass of APPS was dissolved in 20 parts by mass of glycerin and stirred until it became uniform to prepare a composition for an emulsion composition production raw material.

Example 2:
To the emulsified composition of Example 1, 1 part by weight of squalane and 1 part by weight of VCIP were added and stirred until uniform. This operation was repeated 4 times. Next, 4 parts by mass of squalane was added and stirred until uniform. This operation was repeated twice to obtain an emulsified composition of the present invention.

Example 3: Raw material composition for emulsion composition APPS, VEP, TDMG, and surfactin sodium were added to glycerin and dissolved in the following formulation, and an oil mixture having the following composition was added little by little while stirring. Further, water and 1,3-butanediol were slowly added while stirring, and finally the oil mixture 60%, glycerin 23%, 1,3-butanediol 13%, and water 3%. APPS 1%, VEP 0.5
%, TDMG 0.5%, Surfactin sodium 1% emulsified composition of the present invention was obtained.

(Composition of oil mixture)
Each of the following fat-soluble substances was mixed by 0.5% by weight, and finally squalane was added as a residue to make 100% by weight.
Ascorbic acid isopalmitic acid, ascorbic acid-2-phosphate-6-palmitate, ascorbic acid-2-phosphate-6-isopalmitate, ascorbic acid-6-palmitate, ascorbic acid-2,6-dipalmitate, ascorbic acid-6 Stearate, retinol, retinoic acid, retinol palmitate, retinoic acid palmitate, retinoic acid isopalmitate, retinoic acid stearate, retinol stearate, astaxanthin, lutein, lycopene, β carotene, α carotene, α tocopherol, β tocopherol, γ tocopherol , Dimethylglycine tocopherol, ubiquinone, coenzyme A, tocotrienol, mineral oil, liquid paraffin, squalene, isopropyl palmitate, isopyristate Lopyr, isooctyl myristate, isotridecyl myristate, octadecyl myristate, octyldodecyl myristate, rice germ oil, mineral oil, liquid paraffin, isostearyl cholesteryl ester, 2-ethylhexanoic acid triglyceride, cetyl 2-ethylhexanoate, sunflower oil , Olive oil, jojoba oil, camellia oil, grape seed oil, avocado oil, macadamia nut oil, almond oil, rice germ oil, clove oil, orange oil, spruce oil, octamethyltrisiloxane, decamethyltetrasiloxane, methylpolysiloxane, Octamethylcyclotetrasiloxane, Pycnogenol, Coenzyme A, Decamethylcyclopentasiloxane, Dodecamethylcyclohexasiloxane, Methylcyclopolysiloxane, Methylpolycyclo Rokisan, methylphenyl polysiloxane

Example 4: Emulsified composition for external use (for cosmetics, pharmaceuticals, quasi drugs)
In the following formulation A, APPS was dissolved in glycerin, and a fat-soluble substance was added little by little while stirring to prepare a gel.
The gel of formulation A was heated to 80 ° C., and the formulation B solution dissolved by heating to 80 ° C. was added, and the mixture was homogenized by stirring at 5000 rpm for 5 minutes with a homomixer. Further, the arginine aqueous solution of Formulation C was added with stirring, the mixture was cooled with paddle stirring, the stirring was stopped at 40 ° C. or lower, and the mixture was allowed to stand. It was 300 nm when the average particle diameter of the emulsion composition was measured.
12.5 g of NaOH was added to 2.5 L of water and mixed well. 9 L of corn oil was gradually added. When the temperature dropped to 50 ° C. or lower, 10 g of the gel was added and solidified.

Formula A
A 16% fat-soluble mixture, 4% glycerin, 0.2% APPS, and a fat-soluble mixture were mixed according to the following formulation.
Ascorbic acid isopalmitic acid, ascorbic acid-2-phosphate-6-palmitate, ascorbic acid-2-phosphate-6-isopalmitate, ascorbic acid-6-palmitate, ascorbic acid-2,6-dipalmitate, ascorbic acid-6 Stearate, retinol, retinoic acid, retinol palmitate, retinoic acid palmitate, retinoic acid isopalmitate, retinoic acid stearate, retinol stearate, astaxanthin, lutein, lycopene, β carotene, α carotene, α tocopherol, β tocopherol, γ tocopherol , Dimethyl glycine tocopherol, dimethyl glycine α-tocopherol, ubiquinone, coenzyme A, tocotrienol 0.1% each and adding squalene as the residue 10 % And the.

Formula B
2% behenyl alcohol and 0.5% stearic acid

Formula C
L-Arginine 0.1%
Water balance

Example 5: Water-dispersed emulsion composition Surfactin sodium was dissolved in glycerin according to the following formulation A, the following fat-soluble substances were added little by little with stirring, and after sufficient mixing, degassed to prepare a gel. The finished gel showed liquid crystal properties.

Formula A
The following fat-soluble mixture: 16%, glycerin 4%, APPS 0.1%, VEP 0.01%, TDMG 0.01%, surfactin sodium 0.2%. The composition of the fat-soluble mixture is as follows.
Ascorbic acid palmitic acid, ascorbic acid-2-phosphate-6-palmitate, ascorbic acid-6-palmitate, ascorbic acid-2, 6-dipalmitate, ascorbic acid-6-stearate, alpha tocopherol, beta tocopherol, gamma tocopherol, 1% each of dimethylglycine tocopherol, ubiquinone, coenzyme A, tocotrienol and 0.01% retinol palmitate were mixed, and squalene was added as a residue to make 100%.

Formula B
2% behenyl alcohol and 0.5% stearic acid

  Water balance

  The gel of formulation A was heated to 80 ° C., and the formulation B solution dissolved by heating to 80 ° C. was added, and the mixture was homogenized by stirring at 5000 rpm for 5 minutes with a homomixer. Further, the arginine aqueous solution of Formulation C was added with stirring, the mixture was cooled with paddle stirring, the stirring was stopped at 40 ° C. or less, and the mixture was allowed to stand to prepare the emulsion composition of the present invention. It was 350 nm when the average particle diameter of the emulsion composition was measured.

  This emulsified composition is used as a cosmetic for pigmentation treatment and wrinkle removal, and is applied externally for 90 days to 17 men and women including placebo suffering from pigmentation and wrinkles twice a day (4CC per time). When observed with an in-forward skin optical analyzer, the pigmentation index decreased after 90 days and the number of wrinkles decreased compared to the time of starting use. Furthermore, when the same test was used in combination with an ion introducer and an ultrasonic introducer manufactured by Kagoshima Ultrasonic Research Laboratories, both wrinkles and pigmentation were improved more than twice.

  In addition, when this emulsified particle is added at 0.5% concentration as an antioxidant component of feed, feed additives, antioxidants, and antioxidants, the respective oxidation is suppressed, discoloration and odor generation are suppressed, and the quality of the product is reduced. It was confirmed that the lifetime can be extended by about twice and an excellent antioxidant effect can be exhibited. Further, the conventional method of simply mixing with the same composition as in Example 5 without making the emulsified composition of the present invention with the same composition as the cosmetic of the present invention, that is, without using the blending method described in Example 5. The non-liquid crystal emulsified cosmetics were manufactured by the above, and the accelerated test was conducted in a room temperature bath at 40 ° C. using the cosmetics as a control zone, and after quality inspection was conducted after one month, it was significantly controlled compared to the cosmetics of the present invention. In the case of cosmetics, the contents of cosmetics were colored brown and separated to release off-flavors. In addition, when 12 samples were used after completion of the acceleration test, longitude erythema was observed within one month in all patients using the control cosmetics, but no abnormalities were found in the skin of the cosmetics of the present invention. Safety was confirmed. When TBARS of lipid in each cosmetic was measured, the TBARS value of the control was significantly higher than that of the cosmetic of the present invention, and the occurrence of erythema was thought to be due to the influence of lipid peroxide.

Example 6: Water-dispersed emulsion composition Surfactin sodium was dissolved in glycerin according to the following formulation A, and the following fat-soluble substances were added little by little while stirring to prepare a raw material for producing an emulsion composition of the present invention. .

Formula A
The following fat-soluble mixture 16%, glycerin 4%, surfactin sodium 0.2% A
PPS 0.1%
The composition of the fat-soluble mixture is as follows.
Ascorbic acid isopalmitic acid, ascorbic acid-2-phosphate-6-palmitate, ascorbic acid-2-phosphate-6-isopalmitate, ascorbic acid-6-palmitate, ascorbic acid-2,6-dipalmitate, ascorbic acid-6 Stearate, retinol, retinoic acid, retinol palmitate, retinoic acid palmitate, retinoic acid isopalmitate, retinoic acid stearate, retinol stearate, astaxanthin, lutein, lycopene, β carotene, α carotene, α tocopherol, β tocopherol, γ tocopherol , Dimethylglycine tocopherol, dimethylglycine α-tocopherol, ubiquinone, coenzyme A, tocotrienol 1% each, and squalene added as the residue, 100% It was.

Formula B
2% behenyl alcohol and 0.5% stearic acid

  Water balance

The raw material for manufacturing the emulsion composition of formulation A was heated to 80 ° C., and the formulation B solution dissolved by heating to 80 ° C. was added, and the mixture was homogenized by stirring at 5000 rpm for 5 minutes. Furthermore, the AB mixture and water (remainder) were sheared and mixed uniformly with a static mixer, a jet dispersator, a microporous filter, a microfluidizer, and a Manton-Gaulin homogenizer nozzle, and naturally cooled to room temperature.
The average particle size of the emulsified composition dispersed by each shear deformation method was measured and found to be a static mixer 234 nm, a jet dispersator 217 nm, a microporous filter 210 nm, a microfluidizer 94 nm, and a Manton-Gaulin homogenizer nozzle 153 nm.

Example 7:
Emulsion Surfactin sodium was dissolved in glycerin with the following formulation A, and squalane was added little by little with stirring to prepare a gel. The gel of formulation A was heated to 70 ° C., the formulation B solution dissolved by heating to 70 ° C. was added, and the mixture was homogenized by stirring at 5000 rpm for 5 minutes with a homomixer. Further, water was added in an amount of Formulation C with stirring, and the mixture was cooled with paddle stirring, and the stirring was stopped at 40 ° C. or lower and left standing.

Formula A
Squalane 16% Glycerin 4% Surfactin sodium 0.1%, APPS 0.7%, TDMG 0.1%, VEP 0.1%

Formula B
Stearate 0.5% behenyl alcohol 2% Preservative

Formula C
Arginine 0.1%
Water balance

Example 8: Water-dispersed emulsion composition Surfactin sodium was dissolved in glycerin according to the following formulation A, and the following fat-soluble substances were added little by little with stirring to prepare a gel.

Formula A
The following fat-soluble mixture 5%, glycerin 4%, APPS 0.2%. The composition of the fat-soluble mixture is as follows.
10% of Red No. 3 and 1% of α-tocopherol were mixed, and palmitic acid was added as a residue to make 100%.

Formula B
2% behenyl alcohol and 0.5% stearic acid

  Water balance

  The gel of formulation A was heated to 80 ° C., and the formulation B solution dissolved by heating to 80 ° C. was added, and the mixture was homogenized by stirring at 5000 rpm for 5 minutes with a homomixer. Further, the arginine aqueous solution of Formulation C was added with stirring, the mixture was cooled with paddle stirring, the stirring was stopped at 40 ° C. or less, and the mixture was allowed to stand to prepare the emulsion composition of the present invention. When the emulsion composition was measured and analyzed, the emulsion film was a mixture of single-layer molecules and multilayer molecular liquid crystal structure particles, and the average particle size was 34 nm.

  Using this emulsified composition as a coloring material, pharmaceuticals, pharmaceutical raw materials, cosmetics, cosmetic raw materials, foods, food additives, external preparations, ion introduction compositions, vibration introduction compositions, electromagnetic wave introduction compositions, heat introduction compositions , Composition for electrolytic introduction, functional food, anti-aging agent, feed, feed additive, antioxidant, antioxidant, paint, liquid crystal display, toner, ink jet ink, ink for inkjet printed circuit board, photographic film When added at a concentration of 0.5% as a dye for the photosensitive particles, the life until the dye of each product fades can be extended by a factor of three, and the fine dye particles make the resolution excellent and stable. It was confirmed that it could be pigment particles containing an oxidizing substance.

Example 9: Water-dispersed emulsion composition APPS and surfactin sodium were dissolved in glycerin according to the following formulation A, and the following fat-soluble substances were added little by little with stirring to prepare a gel.

Formula A
The following fat-soluble mixture 12%, glycerin 4%, APPS 0.1%, VEP 0.01%, surfactin sodium 0.1%. The composition of the fat-soluble mixture is as follows.
5% magnetic iron powder having an average particle diameter of 100 nm and 1% each of α-tocopherol were mixed, and palmitic acid was added as a residue and mixed to 100%, and kneaded well to obtain a uniform magnetic iron powder-dispersed fat-soluble mixture.

Formula B
2% behenyl alcohol and 0.5% stearic acid

  Water balance

  The gel of formulation A was heated to 80 ° C., and the formulation B solution dissolved by heating to 80 ° C. was added, and the mixture was homogenized by stirring at 5000 rpm for 5 minutes with a homomixer. Further, the arginine aqueous solution of Formulation C was added with stirring, the mixture was cooled with paddle stirring, the stirring was stopped at 40 ° C. or less, and the mixture was allowed to stand to prepare the emulsion composition of the present invention. It was 345 nm when the average particle diameter of the emulsion composition was measured.

  Using this emulsified composition as a magnetic material for pharmaceuticals, cosmetics, vibration-introducing compositions, electromagnetic wave-introducing compositions, thermal-introducing compositions, electrolytic-introducing compositions, paints, toners, inks for ink jets, magnetic memory materials When added to a normal binder at a concentration of 5% as an emulsified composition, the particles are fine and the secondary agglomeration of the powder is unlikely to occur, so the storage density is improved, and a storage medium with high stability and high storage density can be created. It was confirmed.

Example 10: Water-dispersed emulsion composition APPS was dissolved in glycerin according to the following formulation A, and the following fat-soluble substances were added little by little while stirring to prepare a gel.

Formula A
10% of the following fat-soluble mixture, 4% of the provitamin glycerin mixture of the following formulation, APPS 0.1%, Surfactin Na 0.1%.
A provitamin glycerin mixture was prepared by adding glycerin to a provitamin mixture containing 100 ppm of the following materials at 100%.
Methyl L-ascorbate, ethyl L-ascorbate, propyl L-ascorbate, butyl L-ascorbate, pentyl L-ascorbate, L-ascorbic acid-2-palmitate, L-ascorbic acid-2-isopalmitate, L- Ascorbic acid-2-stearate, L-ascorbic acid-2-isostearate, L-ascorbic acid-6-palmitate, L-ascorbic acid-6 isopalmitate, L-ascorbic acid-6-stearate, L-ascorbic acid -6-isostearate, L-ascorbic acid-2,6-dipalmitate, L-ascorbic acid-2,6-diisopalmitate, L-ascorbic acid-2,6-distearate, L-ascorbic acid-2, 6-Diisostearate, L-ascorbic acid-2-glucose Do-6-palmitate, L-ascorbic acid-2-glucoside-6-isopalmitate, L-ascorbic acid-2-glucoside-6-stearate, L-ascorbic acid-2-glucoside-6-isostearate, L- Ascorbic acid-2-glucoside-6-tocopheryl, L-ascorbic acid-2-sulfuric acid-6-palmitate, L-ascorbic acid-2-sulfuric acid-6-isopalmitate, L-ascorbic acid-2-sulfuric acid-6-stearate L-ascorbic acid-2-sulfate-6-isostearate, L-ascorbic acid-2-sulfate-6-tocopheryl, L-ascorbic acid-2-maleic acid-6-palmitate, L-ascorbic acid-2- Maleic acid-6-isopalmitate, L-ascorbic acid-2-maleic acid-6-stearate, L- Scorbic acid-2-maleic acid-6-isostearate, L-ascorbic acid-2-maleic acid-6-tocopheryl, L-ascorbic acid-2-phosphate-6-palmitate, L-ascorbic acid-2-phosphorus Acid-6-isopalmitate, L-ascorbic acid-2-phosphate-6-stearate, L-ascorbic acid-2-phosphate-6-isostearate, L-ascorbic acid-2-phosphate-6-tocopheryl , Palmitoyl 2-0-L-ascorbic acid, isopalmitoyl 2-0-L-ascorbic acid phosphate, stearyl 2-0-L-ascorbic acid phosphate, isostearyl 2-0-L-ascorbic acid phosphate, tocopheryl 2-0-L-ascorbic acid phosphate, retinoyl 2-0-L-ascorbic acid phosphate, tocopheryl phosphate, tocotrie Norophosphate, tocopheryl glucoside, tocopheryl sulfate, tocopheryl dimethyl glycine, retinoyl phosphate, retinoyl glucoside, retinoyl sulfate, retinoyl dimethyl glycine The composition of the fat-soluble mixture is as follows. Carbon powder 5% and α-tocopherol 1% each were mixed, and palmitic acid was added as a residue to make 100% and kneaded well to obtain a uniform conductive particle-dispersed fat-soluble mixture.

Formula B
2% behenyl alcohol and 0.5% stearic acid

Water balance

  The gel of formulation A was heated to 80 ° C., and the formulation B solution dissolved by heating to 80 ° C. was added, and the mixture was homogenized by stirring at 5000 rpm for 5 minutes with a homomixer. Further, the arginine aqueous solution of Formulation C was added with stirring, the mixture was cooled with paddle stirring, the stirring was stopped at 40 ° C. or less, and the mixture was allowed to stand to prepare the emulsion composition of the present invention. It was 2915 nm when the average particle diameter of the emulsion composition was measured.

  This emulsified composition is used for pigmentation treatment and wrinkle removal medicines, pharmaceutical raw materials, cosmetics, cosmetic raw materials, foods, food additives, external preparations, ion introduction compositions, vibration introduction compositions, electromagnetic wave introduction compositions. , Composition for heat introduction, composition for electrolysis, functional food, whitening as anti-aging agent, improvement of pigmentation, treatment of acne, improvement of wrinkles, improvement of rough skin, improvement of oily skin, improvement of dry skin, Twice a day for 178 men and women, including placebo who suffers from pore reduction, scar treatment, red face treatment, hair loss treatment, hair growth promotion, burn treatment, skin sterilization, skin mite killing, skin texture improvement (5CC at a time) was applied to the affected area and applied externally for 60 days. The lesion was clearly improved after 3 months compared to the beginning of use. In addition, about the ion introducing device, the vibration introducing device, the electromagnetic wave introducing device, the heat introducing device, and the electrolytic introducing device, commercially available products were used.

  In addition, when this emulsified particle is added at 0.5% concentration as an antioxidant component of feed, feed additives, antioxidants, and antioxidants, the respective oxidation is suppressed, discoloration and odor generation are suppressed, and the quality of the product is reduced. It was confirmed that the lifetime can be extended by about twice and an excellent antioxidant effect can be exhibited.

Example: Emulsified composition 1 part by mass of a mixture of vitamin derivatives having the following composition was dissolved in 20 parts by mass of glycerin and stirred until uniform to prepare an emulsified composition.
Composition of Vitamin Derivative Mixture The following vitamin derivatives were mixed at 10 ppm each, and the remainder was mixed with Surfactin sodium to make 1 g.
Methyl L-ascorbate, ethyl L-ascorbate, propyl L-ascorbate, butyl L-ascorbate, pentyl L-ascorbate, L-ascorbic acid-2-palmitate, L-ascorbic acid-2-isopalmitate, L- Ascorbic acid-2-stearate, L-ascorbic acid-2-isostearate, L-ascorbic acid-6-palmitate, L-ascorbic acid-6 isopalmitate, L-ascorbic acid-6-stearate, L-ascorbic acid -6-isostearate, L-ascorbic acid-2,6-dipalmitate, L-ascorbic acid-2,6-diisopalmitate, L-ascorbic acid-2,6-distearate, L-ascorbic acid-2, 6-Diisostearate, L-ascorbic acid-2-glucose Do-6-palmitate, L-ascorbic acid-2-glucoside-6-isopalmitate, L-ascorbic acid-2-glucoside-6-stearate, L-ascorbic acid-2-glucoside-6-isostearate, L- Ascorbic acid-2-glucoside-6-tocopheryl, L-ascorbic acid-2-sulfuric acid-6-palmitate, L-ascorbic acid-2-sulfuric acid-6-isopalmitate, L-ascorbic acid-2-sulfuric acid-6-stearate L-ascorbic acid-2-sulfate-6-isostearate, L-ascorbic acid-2-sulfate-6-tocopheryl, L-ascorbic acid-2-maleic acid-6-palmitate, L-ascorbic acid-2- Maleic acid-6-isopalmitate, L-ascorbic acid-2-maleic acid-6-stearate, L- Scorbic acid-2-maleic acid-6-isostearate, L-ascorbic acid-2-maleic acid-6-tocopheryl, L-ascorbic acid-2-phosphate-6-palmitate, L-ascorbic acid-2-phosphate -6-isopalmitate, L-ascorbic acid-2-phosphate-6-stearate, L-ascorbic acid-2-phosphate-6-isostearate, L-ascorbic acid-2-phosphate-6-tocopheryl, Palmitoyl 2-0-L-ascorbic acid, isopalmitoyl 2-0-L-ascorbic acid phosphate, stearyl 2-0-L-ascorbic acid phosphate, isostearyl 2-0-L-ascorbic acid phosphate, tocopheryl 2 -0-L-ascorbic acid phosphate, retinoyl 2-0-L-ascorbic acid phosphate, tocopheryl phosphate, tocopheryl Glucoside, tocopheryl sulfate, retinoyl phosphate, retinoyl glucoside, retinoyl sulfate, retinoyl dimethylglycine

Example:
1 part by weight of squalane and 1 part by weight of VCIP were added to the composition described in the previous paragraph and stirred until uniform. This operation was repeated 4 times. Next, 4 parts by mass of squalane was added and stirred until uniform. This operation was repeated twice to obtain an emulsified composition of the present invention.

  According to the present invention, at least one simple substance of glycerin and / or liquid matrix or a composite thereof, one or more simple substances of an antioxidant substance having a surface tension reducing action dissolved or dispersed therein, or a composite thereof, and emulsification Dispersion of emulsified particles in water or a liquid solvent with a raw material composed of one or more of a fat-soluble or water-soluble substance contained in the particles or a composite thereof has good stability and good stability. The emulsion composition of the present invention is a pharmaceutical, a pharmaceutical raw material, a cosmetic, a cosmetic raw material, an external preparation, an ion introduction composition, a vibration introduction composition, an electromagnetic wave introduction composition, It can be widely applied to uses such as compositions for introducing heat, compositions for introducing electrolysis, foods, food additives, functional foods, feeds, feed additives, anti-aging agents, antioxidants, and antioxidants.

Claims (13)

An emulsion composition in which a part or all of the emulsion film is composed of an antioxidant substance having a surface tension reducing action,
The antioxidant is L-ascorbic acid-2-glucoside-6-palmitate, L-ascorbic acid-2-glucoside-6-isopalmitate, L-ascorbic acid-2-glucoside-6-stearate, L-ascorbic acid 2-glucoside-6-isostearate, L-ascorbic acid-2-glucoside-6-tocopheryl, L-ascorbic acid-2-sulfuric acid-6-palmitate, L-ascorbic acid-2-sulfuric acid-6-isopalmitate, L-ascorbic acid-2-sulfate-6-stearate, L-ascorbic acid-2-sulfate-6-isostearate, L-ascorbic acid-2-sulfate-6-tocopheryl, L-ascorbic acid-2-malein Acid-6-palmitate, L-ascorbic acid-2-maleic acid-6-isopalmitate, L-asco Binic acid-2-maleic acid-6-stearate, L-ascorbic acid-2-maleic acid-6-isostearate, L-ascorbic acid-2-maleic acid-6-tocopheryl, tocopheryl 2-0-L- One or more selected from the group consisting of ascorbic acid phosphate, retinoyl 2-0-L-ascorbic acid phosphate, tocopheryl glucoside, tocopheryl sulfate, retinoyl phosphate, retinoyl glucoside, retinoyl sulfate and retinoyl dimethylglycine, or Salt,
One or more selected from the group consisting of glycerin, diglycerin, polyglycerin, ethanol, propanol, isopropanol, propylene glycol, polyethylene glycol, 1,3-butanediol and behenyl alcohol;
L-ascorbic acid tetrahexyldecanoic acid, retinol, retinoic acid, retinol palmitate, retinoic acid palmitate, retinoic acid isopalmitate, retinoic acid stearate, retinol stearate, astaxanthin, lutein, lycopene, β-carotene, α-carotene, α-tocopherol, β One or more selected from the group consisting of tocopherol, γ-tocopherol, ubiquinone, coenzyme A, tocotrienol, pycnogenol, pigment and magnetic powder;
Mineral oil, liquid paraffin, squalane, squalene, isopropyl palmitate, isopropyl myristate, isooctyl myristate, isotridecyl myristate, octadecyl myristate, octyldodecyl myristate, isostearyl cholesteryl ester, 2-ethylhexanoic acid triglyceride, 2-ethyl Cetyl hexanoate, sunflower oil, olive oil, jojoba oil, camellia oil, grape seed oil, avocado oil, macadamia nut oil, almond oil, rice germ oil, clove oil, orange oil, spruce oil, octamethyltrisiloxane, decamethyltetra Siloxane, methylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, methylcyclopolysiloxane Sun, methylpolysiloxane cyclosiloxane emulsion composition stabilized which encloses the one or more selected from the group consisting of methylphenyl polysiloxane and palmitic acid, a.   An emulsified composition in which emulsified particles comprising the emulsified composition according to claim 1 are dispersed in one or more of water and / or a liquid solvent or a composite thereof.   The emulsified composition according to claim 1 or 2, wherein the emulsified film is a multilayer molecular film.   The emulsified composition according to claim 2, wherein the concentration of the antioxidant substance having an effect of lowering the surface tension of the emulsified membrane is more than 10% (W / W) different from the concentration in the adjacent membrane solvent.   The emulsion composition according to claim 1, wherein an antioxidant substance or a substance that is easily denatured and decomposed by any of light, heat, oxygen, and free radicals is included in the emulsion composition.   The emulsified composition according to claim 1, wherein a fat-soluble substance or a water-soluble substance is encapsulated in the emulsified composition.   A solid containing the emulsified composition according to claim 1.   The emulsified composition according to claim 1, comprising a surfactant and / or an antioxidant other than an antioxidant having a surface tension lowering effect in the emulsion membrane constituent.   The emulsified composition according to claim 1, wherein the average emulsified particle diameter is in the range of 100 µm to 1 nm.   Applications of the emulsified composition are pharmaceuticals, pharmaceutical raw materials, cosmetics, cosmetic raw materials, external preparations, ion introduction compositions, vibration introduction compositions, electromagnetic wave introduction compositions, heat introduction compositions, electrolytic introduction compositions, foods , Food additives, functional foods, feed, feed additives, anti-aging agents, antioxidants, antioxidants, antibacterial agents, antiviral agents, paints, liquid crystal displays, toners, ink jet inks, inkjet printed circuit boards, The emulsified composition according to claim 1 selected from photosensitive particles for photographic film.   Claimed by mixing or penetrating or introducing the emulsified composition according to claim 1 into another substance by one or more simple methods or mixing methods selected from ion introduction, vibration introduction, electromagnetic wave introduction, heat introduction, and electrolysis introduction. A method for enhancing the effect of the use according to Item 10.   The method for producing an emulsified composition according to any one of claims 1 to 3, which is impact resistant and subjected to shear deformation at a shear rate of at least 15 / s and has an average particle size of less than 1000 nm dispersed in water and an aqueous solvent.   Shear deformation is performed using at least one dispersion device selected from the group consisting of static mixers, jet dispersers, microporous filters, membrane filters, escuttleders, microfluidizers, and Manton-Gaulin homogenizer nozzles. A method for producing the emulsion composition according to claim 12.