JP2016044150A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic containing astaxanthin and being excellent in the stability of the astaxanthin.SOLUTION: The invention provides a cosmetic containing astaxanthin, oryzanol, alcohol, and water. The content of the alcohol to the total amount of the cosmetic is 0.1-40 mass%, the content of the water to the total amount of the cosmetic is 60-98 mass%, and the total content of the alcohol and water to the total amount of the cosmetic is 60.1 mass% or more to less than 100 mass%.SELECTED DRAWING: None

Description

  The present invention relates to a cosmetic.

Astaxanthin, a kind of carotenoid, is known to have functions such as an antioxidant effect, an anti-inflammatory effect, a skin aging preventive effect, a stain or wrinkle formation preventive effect, and is applied to various compositions such as foods and cosmetics. Has been.
However, astaxanthin has a problem of improving the storage stability of the compound itself, and it involves a difficulty in formulating it stably in cosmetics. In particular, it may be visually confirmed that the bright red color of astaxanthin fades due to a decrease in stability.
Various proposals have been made for improving the stability of a composition containing the antioxidant components astaxanthin, lycopene, coenzyme Q10, etc. For example, in an oily composition containing lycopene and oryzanol, the thermal stability of lycopene Has been reported to improve (see, for example, Patent Document 1).
In addition, a whitening supplement using an oil-phase-containing capsule containing reduced coenzyme Q and rice oil has been proposed (see, for example, Patent Document 2).
Furthermore, a skin external preparation containing a carotenoid-containing oily component and resveratrol has been proposed for the purpose of inhibiting the degradation of carotenoids (see, for example, Patent Document 3).

JP 2012-184221 A JP 2006-70016 A JP2013-216650A

However, in patent document 1, only thermal stability is evaluated in an oil-based composition, and the aqueous composition is not examined. Patent Document 2 also examines a supplement containing an oil phase that is effective for whitening by oral ingestion, and does not consider an aqueous composition.
In Patent Document 3, resveratrol itself used in combination with carotenoids is not sufficiently stable and may be colored over time, and the effect of suppressing discoloration is not sufficient.

  An object of the present invention is to provide a cosmetic containing astaxanthin and having excellent astaxanthin stability.

The present invention is as follows.
[1] A cosmetic containing astaxanthin, oryzanol, alcohol, and water, the content of alcohol with respect to the total amount of cosmetic is 0.1% by mass to 40% by mass, and the content of water with respect to the total amount of cosmetic is 60 Cosmetics which are mass%-98 mass%, and the total content of alcohol and water with respect to cosmetics whole quantity is 60.1 mass% or more and less than 100 mass%.
[2] The alcohol is at least one alcohol selected from the group consisting of ethanol, 1,2-pentanediol, octoxyglycerin, propylene glycol, butylene glycol, glycerin, and diglycerin. Cosmetics.

[3] The makeup according to [1] or [2], wherein the alcohol includes at least one alcohol selected from the group consisting of ethanol, propylene glycol, butylene glycol, 1,2-pentanediol, and octoxyglycerin. Fee.
[4] The content of at least one alcohol selected from the group consisting of ethanol, propylene glycol, butylene glycol, 1,2-pentanediol, and octoxyglycerin is 1% by mass or more and 20% by mass with respect to the total amount of the cosmetic. Cosmetics as described in [3] which are the mass% or less.
[5] The cosmetic according to [1] or [2], wherein the alcohol includes at least one alcohol selected from the group consisting of glycerin and diglycerin.
[6] The cosmetic according to [5], wherein the content of at least one alcohol selected from the group consisting of glycerin and diglycerin is 1% by mass or more and 15% by mass or less based on the total amount of the cosmetic.
[7] The method according to any one of [1] to [6], further comprising at least one compound selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene phytosterol, and polyoxyethylene cholesterol. Cosmetics.

  ADVANTAGE OF THE INVENTION According to this invention, the cosmetics which contain astaxanthin and were excellent in the stability of astaxanthin can be provided.

The cosmetic of the present invention is a cosmetic containing astaxanthin, oryzanol, alcohol, and water, and the content of alcohol relative to the total amount of the cosmetic is 0.1% by mass to 40% by mass, and the content of water Is 60 mass% or more and 98 mass% or less, and the total content of alcohol and water is 60.1 mass% or more and less than 100 mass%.
In the cosmetic of the present invention, by containing oryzanol, the stability of astaxanthin is improved in a cosmetic having a high content of alcohol and water. For this reason, the cosmetic of the present invention is a cosmetic that can be expected to have various functions such as high antioxidant activity of astaxanthin while having a refreshing feeling of use, and the fading of the cosmetic caused by the decomposition of astaxanthin Is sufficiently suppressed.

The operation of the present invention is not clear, but is considered as follows.
Oryzanol is known to contain a substance in which several triterpene alcohols are ester-bonded to ferulic acid, and itself has an ultraviolet absorbing ability. When astaxanthin and oryzanol coexist in an aqueous medium containing alcohol and water, when active species that cause decomposition of astaxanthin are generated in the aqueous medium by applying energy such as heat and light, the active species is It is presumed that degradation of astaxanthin is suppressed as a result of degradation of ester bonds in the ferulic acid skeleton of oryzanol, which is more reactive. In addition, since the decomposition product of oryzanol itself functions as a stable antioxidant, the stability of astaxanthin is not impaired. However, the operation of the present invention is not limited to the above description.

In the present specification, a numerical range indicated using “to” indicates a range including the numerical values described before and after “to” as the minimum value and the maximum value, respectively.
Further, in the present specification, the amount of each component in the composition is the total amount of the plurality of substances present in the composition unless there is a specific indication when there are a plurality of substances corresponding to each component in the composition. Means.
Hereinafter, embodiments of the present invention will be described more specifically.

[Astaxanthin]

Astaxanthin encompasses at least one of derivatives such as astaxanthin and esters of astaxanthin. In the present invention, astaxanthin and derivatives of astaxanthin are collectively referred to as “astaxanthin” unless otherwise specified.
Astaxanthin may be contained in the cosmetic of the present invention as an astaxanthin-containing oil separated or extracted from a natural product containing astaxanthin. Astaxanthin may be a purified product obtained by appropriately purifying astaxanthin separated or extracted from natural products as necessary, or may be a synthetic product.

Astaxanthin may be a natural product containing astaxanthin such as plants, algae, crustaceans and bacteria. In addition, any astaxanthin obtained according to a conventional method can be used.
Examples of natural astaxanthin include red yeast faffia, hematococcus algae, marine bacteria, and krill. Examples of astaxanthin that can be used in the present invention include natural products containing astaxanthin and extracts from cultures of natural products containing astaxanthin. Among them, astaxanthin that can be used in the present invention, astaxanthin extracted from Haematococcus algae and a pigment derived from krill are particularly preferable from the viewpoint of quality or productivity. Hereinafter, astaxanthin extracted from Haematococcus alga is also referred to as Haematococcus alga extract.

  As astaxanthin, a commercially available Haematococcus alga extract or krill extract may be used. Examples of Haematococcus alga extract include ASTOTS-S, ASTOTS-ST, ASTOTS-2.5 O, ASTOTS-5 O, ASTOTS-10 O, etc. (trade name) of Takeda Paper Instruments Co., Ltd., Fuji Chemical It can be obtained as Asteril (registered trademark) oil 50F, Asteryl (registered trademark) oil 5F, manufactured by Kogyo Co., Ltd., BioAstin (registered trademark) SCE7, manufactured by Toyo Enzyme Chemical Co., Ltd., or the like. As a krill extract, Astax ST (trade name) manufactured by Itano Frozen Co., Ltd. can be obtained.

  The content of astaxanthin in the Haematococcus alga extract or krill extract that can be used in the present invention as a pure pigment content is preferably 0.001% by mass to 50% by mass from the viewpoint of handling during cosmetic production. More preferably, it is 0.01 mass%-25 mass%.

  Astaxanthin is contained in the cosmetic of the present invention as a method of dissolving in alcohol such as ethanol and contained in cosmetic, a method of solubilizing with a solubilizer or the like and incorporating into cosmetic, astaxanthin can be dissolved Examples of the method include a method in which astaxanthin is dissolved in oil to prepare an oil phase, and then the cosmetic composition contains a dispersion composition in which an oil phase containing astaxanthin and an aqueous phase are combined and dispersed.

  The content of astaxanthin in the cosmetic is preferably 0.000001% by mass to 0.01% by mass, more preferably 0.00001% by mass to 0.0075% by mass from the viewpoint of obtaining the effect expected for the inclusion of astaxanthin. Preferably, 0.0001% by mass to 0.005% by mass is more preferable. When it is 0.000001% by mass or more, there is a tendency that an effect of removing active oxygen and the like can be sufficiently obtained, and when it is 0.01% by mass or less, the appearance at the time of use becomes good.

[Oryzanol]
The cosmetic of the present invention contains oryzanol. Oryzanol is a component that is abundant in rice bran oil and rice germ oil. Oryzanol is not a single component but a mixture of compounds in which several triterpene alcohols are ester-linked to ferulic acid.
There is no restriction | limiting in particular about the origin of the oryzanol which can be used for the cosmetics of this invention. For example, it may be a compound obtained by extraction and purification from rice seed coat, rice bran oil, rice germ oil or the like, or a compound obtained entirely or partially by synthesis.
Furthermore, the compound represented by Structural Formula (1) shown below and at least one compound selected from the compound represented by Structural Formula (2), a compound derived from a natural product, or a synthesized compound are included. Oryzanol can also be used in the cosmetic of the present invention.

In Structural Formula (1) and Structural Formula (2), R ³ and R ⁴ are each independently an alkyl group having a linear or branched chain having 1 to 10 carbon atoms, or a linear chain having 1 to 10 carbon atoms. Represents an alkenyl group having a shape or a branched chain, and the alkyl group and the alkenyl group may have at least one substituent selected from the group consisting of an oxoalkyl group having 1 to 3 carbon atoms and an OH group. .

As the oryzanol used in the cosmetic of the present invention, γ-oryzanol derived from natural products is a suitable example.
Hereinafter, oryzanol that can be used in the cosmetic of the present invention will be described in detail.

(Ferulic acid triterpene alcohol ester)
Oryzanols that can be used in the present invention include ferulic acid triterpene alcohol esters.
Ferulic acid triterpene alcohol ester has a structure in which ferulic acid is ester-bonded to triterpene alcohol.
The ferulic acid triterpene alcohol ester can be applied to the present invention as long as it is a compound having at least one of a triterpene skeleton and a sterol skeleton as an alcohol moiety ester-bonded to ferulic acid. In addition, since oryzanol obtained from plant extracts such as rice contains a plurality of ferulic acid triterpene alcohol esters having different structures, when using oryzanol derived from plants, multiple types having different triterpene alcohol sites are used. Of ferulic acid triterpene alcohol ester.
In the ferulic acid triterpene alcohol ester, typical examples of the triterpene alcohol compound that forms an ester bond with ferulic acid are shown below.

As a typical compound which comprises oryzanol, the compound formed by ester-linking the above-mentioned triterpene alcohol compound with ferulic acid is mentioned.
Moreover, the at least 1 sort (s) of compound selected from the group which consists of a compound represented by the above-mentioned structural formula (1) and a compound represented by structural formula (2) is mentioned.
Oryzanol may be a derivative in which the compound having these structures further has a substituent. As used herein, “oryzanol” includes derivatives of oryzanol.

A commercially available product may be used as oryzanol.
A representative example of commercially available ferulic acid triterpene alcohol ester is γ-oryzanol. γ-Oryzanol is a component extracted and separated from rice bran oil and rice germ oil for the first time by Tsuchiya et al. in 1954, and the component is a mixture in which the alcohol part is composed of various phytosterols and triterpenes.

As typical compounds constituting γ-oryzanol, β-sitosterol ferulic acid ester, 2,4-methylenecycloartanol ferulic acid ester, cycloartenol ferulic acid ester, campesterol ferulic acid ester, stigmasterol ferulic acid ester And cyclobranol ferulic acid ester.
The name oryzanol was given as a generic name for nutritional and other effects on animals, but now the name of oryzanol is used only for ferulic acid esters extracted from rice-derived materials such as rice bran and rice germ. ing.
As a commercial item, it is often provided as γ-oryzanol. As typical oryzanols in the market, γ-oryzanol (trade name: Tsukino Food Industry), γ-oryzanol (trade name: Oriza Oily), γ-oryzanol C, OK sterol, OK triterpene (all trade names) : Okayasu Shoten Co., Ltd.). Any of the aforementioned commercially available oryzanols is preferably used as oryzanol in the cosmetic of the present invention.

  The content of oryzanol in the cosmetic of the present invention is preferably 0.0001% by mass to 1% by mass with respect to the total amount of the cosmetic from the viewpoint that the stability of astaxanthin is further improved. It is more preferable that it is mass%-0.5 mass%.

The cosmetic of the present invention is an aqueous cosmetic that contains 60% by mass of alcohol and water. Examples of a method for preparing a stable cosmetic by adding oryzanol to the cosmetic of the present invention, which is an aqueous cosmetic, include the following methods.
A method in which oryzanol is previously mixed with an organic solvent capable of dissolving oryzanol and contained in the cosmetic, a method in which a mixture obtained by kneading oryzanol and a specific solubilizer capable of dissolving oryzanol is contained in the cosmetic, oryzanol in advance An aqueous solution in which oryzanol is dissolved in a mixed solvent of an organic solvent that can solubilize water and water, and a method of containing this aqueous solution in cosmetics, and an oryzanol-containing dispersion composition containing oryzanol in the oil phase are prepared. And a method of incorporating the oryzanol-containing dispersion composition into the cosmetic.
Among these, from the viewpoint of further enhancing the stability improvement effect of astaxanthin, a mixture obtained by kneading oryzanol and a solubilizer, an aqueous solution obtained by dissolving oryzanol in a mixed solvent of an organic solvent and water, and an oryzanol-containing dispersion composition Preferably, oryzanol is contained in the cosmetic in an embodiment selected from the group consisting of:

[alcohol]
The cosmetics of this invention contain 0.1 mass% or more and 40 mass% or less alcohol with respect to cosmetics whole quantity. The content of the alcohol in the total amount of the cosmetic is preferably 1.0% by mass or more and 30% by mass or less, and more preferably 3.0% by mass or more and 20% by mass or less.
The cosmetic may contain only one kind of alcohol, and may contain two or more kinds according to the purpose.

  The alcohol that can be used in the present invention can be used without particular limitation depending on the purpose as long as it is an alcohol that can be used in cosmetics. The alcohol may be a monohydric alcohol or a polyhydric alcohol. Especially, at least 1 sort (s) of alcohol chosen from C1-C5 monovalent | monohydric lower alcohol and C3-C12 polyhydric alcohol is preferable.

Examples of monovalent lower alcohols include ethanol and isopropanol.
Examples of the polyhydric alcohol include dihydric alcohols such as propylene glycol, 1,3-butylene glycol, 1,3-propanediol, 1,2-pentanediol, diethylene glycol, dipropylene glycol, and octoxyglycerin (hereinafter referred to as diol). Trivalent alcohols such as glycerin and 1,2,6-hexanetriol; tetrahydric alcohols such as diglycerin and pentaerythritol; pentahydric alcohols such as xylitol; hexavalent alcohols such as sorbitol and mannitol; Examples thereof include polyhydric alcohol polymers such as propylene glycol, triethylene glycol and polyethylene glycol.
Moreover, sugar alcohols, such as pentaerythritol, xylitol, sorbitol, mannitol, etc. are mentioned as alcohol suitable for cosmetics irrespective of a valence.

  Among them, the alcohol used in the cosmetic of the present invention is selected from the group consisting of ethanol, 1,2-pentanediol, octoxyglycerin, propylene glycol, butylene glycol, glycerin, diglycerin, diethylene glycol, and dipropylene glycol. Preferred is at least one alcohol. Further, from the viewpoint of good solubility of astaxanthin and oryzanol, ethanol, 1,3-butylene glycol, 1,2-pentanediol, and octoxyglycerol are propylene glycol, glycerol, and Dipropylene glycol is more preferred.

The alcohol contained in the cosmetic can be selected in consideration of the solubility of oryzanol.
For example, oryzanol can be dissolved in alcohol that can dissolve poorly soluble oryzanol and contained in cosmetics.
As the monovalent alcohol capable of dissolving oryzanol, ethanol is preferably mentioned.
Examples of the polyhydric alcohol capable of dissolving oryzanol preferably include diols such as propylene glycol, 1,3-propanediol, 1,3-butylene glycol, 1,2-pentanediol, octoxyglycerin, From the viewpoint of suitability for use in cosmetics, 1,3-butylene glycol, 1,2-pentanediol, and octoxyglycerin are more preferable.
When the alcohol capable of dissolving the aforementioned oryzanol is included, the oryzanol can be uniformly contained in the cosmetic of the present invention containing a large amount of alcohol and water.
When the cosmetic of the present invention uses an alcohol capable of dissolving oryzanol, the content of the alcohol capable of dissolving oryzanol is 1.0% by mass or more and 20% by mass or less based on the total amount of the cosmetic. Preferably there is.

The alcohol contained in the cosmetic can be selected in consideration of familiarity with the skin and imparting moisture retention. In this case, a polyhydric alcohol is preferable as the alcohol.
Examples of the polyhydric alcohol to be contained in the cosmetic include glycerin, diglycerin, propylene glycol, diethylene glycol, dipropylene glycol and the like. Among these, from the viewpoint of improving moisture retention, the group consisting of glycerin and diglycerin. More preferred are at least one alcohol selected.
Glycerin, diglycerin, diethylene glycol, dipropylene glycol, and the like have a low function of dissolving oryzanol as compared with the alcohol that can dissolve oryzanol described above. Therefore, when polyhydric alcohol or the like having a lower function of dissolving oryzanol is used in the cosmetic, as described in detail below, oryzanol is kneaded with a compound capable of dissolving oryzanol into the cosmetic. It is preferable to take the method of making it contain, the method of making cosmetics contain as a dispersion composition which contains an oryzanol in an oil phase.
When the cosmetic of the present invention uses a polyhydric alcohol with good moisture retention, the content of the polyhydric alcohol is preferably 1.0% by mass or more and 15% by mass or less with respect to the total amount of the cosmetic.

[water]
The cosmetic of the present invention contains 60% by mass or more and 98% by mass or less of water with respect to the total amount of the cosmetic. The water content can be appropriately adjusted within the above range depending on the purpose of use of the cosmetic and the feeling of use. The water content is preferably 70% by mass or more and 97% by mass or less, and more preferably 80% by mass or more and 95% by mass or less with respect to the total amount of the cosmetic.
Moreover, the total amount of alcohol and water is 60.1% by mass or more and less than 100% by mass, and preferably 70% by mass or more and 98% by mass or less with respect to the total amount of the cosmetic.
As the water used in the cosmetic of the present invention, it is preferable to use purified water, distilled water, ion-exchanged water, pure water, milli-Q water which is ultrapure water, or the like from the viewpoint of few impurities.

[Other ingredients]
In addition to astaxanthin, oryzanol, alcohol, and water, the cosmetics of the present invention are additives that are usually used in the fields of foods, cosmetics, etc., as necessary, in addition to the above components, as long as the effects of the present invention are not impaired Components (sometimes referred to as other components) may be appropriately contained depending on the form.
Other components can be contained in the cosmetic of the present invention as an oil-soluble or water-soluble additive component depending on the characteristics.

  Since oryzanol is hardly soluble in water, in order to contain oryzanol in the cosmetics of the present invention, as described above, a method of dissolving oryzanol in an alcohol capable of dissolving oryzanol is included in the cosmetics. In addition, it is possible to employ a method in which oryzanol can be dissolved and kneaded with at least one of the compounds shown below, and the resulting mixture is contained in the cosmetic.

(At least one compound selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene phytosterol, and polyoxyethylene cholesterol)
The cosmetic of the present invention can contain at least one compound selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene phytosterol, and polyoxyethylene cholesterol.
As at least one compound selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene phytosterol, and polyoxyethylene cholesterol, oxyethylene (EO) as a hydrophilic group and phytosteryl group as a hydrophobic group, Examples thereof include compounds having a sterol group such as a cholesteryl group in the molecule, and hardened castor oil having oxyethylene (EO) as a hydrophilic group. Among them, polyoxyethylene hardened castor oil, polyoxyethylene phytosterol, and Although at least 1 type of compound selected from the group which consists of polyoxyethylene cholesterol is illustrated preferably, it is not specifically limited.

Polyoxyethylene hydrogenated castor oil is a hardened castor oil derivative having 20 to 100 ethylene oxide units (hereinafter sometimes referred to as POE), for example, POE (40) hardened castor oil, POE (60) hardened castor oil. Oil, POE (100) hydrogenated castor oil, and the like. In addition, the numerical value in () written together with POE indicates the number of POEs included in the molecule. The following description is also the same.
As the polyoxyethylene hydrogenated castor oil, commercially available products may be used. Examples of commercially available products include Nikkor (registered trademark) HCO (Nikko Chemicals Co., Ltd.), EMALEX (registered trademark) HC (Nihon Emulsion Co., Ltd.). And UNIOX (registered trademark) HC (NOF).

Polyoxyethylene phytosterol is a phytosterol derivative having 10 to 50 ethylene oxide units, and examples thereof include POE (10) phytosterol, POE (20) phytosterol, and POE (30) phytosterol.
Commercial products such as Nikkor (registered trademark) BPS (Nikko Chemicals Co., Ltd.) can also be used. For example, NIKKOL (registered trademark) series BPS-5, BPS-10, BPS-20, BPS-30 (Nikko Chemicals Co., Ltd.) can be mentioned. Further, POE phytostanyl ether which is a hydrogenated sterol of polyoxyethylene phytosterol can be used.
As a commercially available product of hydrogenated sterol of polyoxyethylene phytosterol, Nikkor (registered trademark) BPSH-25 (Nikko Chemicals Co., Ltd.) can be mentioned.
As polyoxyethylene cholesterol ether, EMALEX (registered trademark) series CS-5, CS-10, CS-15, CS-20, CS-24, CS-30 (above, trade name: Nippon Emulsion Co., Ltd.) Is mentioned.

The content of at least one compound selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene phytosterol, and polyoxyethylene cholesterol is based on the oryzanol content from the viewpoint of improving the solubility of oryzanol. The mass ratio is preferably 1.0-fold to 20-fold, more preferably 1.5-fold to 15-fold, and even more preferably 2.0-fold to 12-fold. .
The content of at least one compound selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene phytosterol, and polyoxyethylene cholesterol is 0.05% by mass to 1.0% with respect to the total amount of the cosmetic. It is preferable that it is mass%.

(Oil component)
The cosmetic of the present invention can contain one or more oily components selected from oily components other than astaxanthin and oryzanol depending on the purpose.
As an example of the oily component that can be used in the cosmetic of the present invention, any oily component that exhibits a useful effect when used in cosmetics can be used.
In terms of chemical structure, oily components such as fats and oils, hydrocarbons, waxes, ester compounds, higher fatty acids, higher alcohols, polymer compounds, oil-soluble dyes, oil-soluble proteins and the like can be mentioned.

In addition, oil-soluble functional substances contained in animals and plants, such as terpenoids, alkaloids, polyphenols, and various vegetable oils, animal oils, and the like, which are mixtures thereof, can also be used in the cosmetics of the present invention.
Examples of oil components include fats and oils such as coconut oil, olive oil, corn oil and jojoba oil, higher fatty acids such as stearic acid, oleic acid, palmitic acid, myristic acid and lauric acid, behenyl alcohol, stearyl alcohol, cetanol, isostearyl alcohol , Oleyl alcohol, decanol, dodecanol, tetradecanol, hexyldecanol, higher alcohols such as 2-octyldodecanol, 2-decyltetradecanol, sterols such as cholesterol and phytosterol, ethylhexyl palmitate, isopropyl myristate, myristine Ester compounds such as octyldodecyl acid, N-lauroyl-L-glutamic acid di (phytosteryl 2-octyldodecyl), squalane, squalene, hydrogenated polydecene, hydrogenated polyisobute And hydrocarbons.

Further, as functional oily components, β-carotene, zeaxanthin, lycopene, lutein and other astaxanthin carotenoids, tocopherol, tocotrienol and other vitamin E, coenzyme Q10 and other ubiquinones, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) Ω-3 oils and fats such as linolenic acid can also be included.
Furthermore, it is preferable to contain a triterpene as an oily component having a function.
Among the triterpenes, pentacyclic triterpenes having a carboxylic acid or a carboxylic acid derivative are particularly preferable. These are mainly obtained from plant extracts. Examples of this include Asian acid, Madecasso acid contained in Rhizoma extract, Ursolic acid, oleanolic acid, betulinic acid contained in rosemary extract, oleanolic acid contained in perilla leaf extract, ursolic acid, tormentic acid, licorice extract And glycyrrhetinic acid. In addition to acid-type triterpenes containing these carboxylic acids, glycoside-type forms (referred to as heterosides) bonded to sugars can also be included.
It is also preferable to include Centella asiatica (Tubusa extract) in which the acid type triterpene asiatic acid and madecassoic acid and the glycoside asiaticoside and madecassoside are appropriately mixed.
In addition, as an oil component having a moisturizing function, active ceramides such as ceramide I, ceramide II, ceramide III, ceramide V and ceramide VI, glycosphingolipids such as glucosylceramide and galactosylceramide, sphingomyelin and pseudoceramide are also preferably included. Can do.

When the oil component is contained, it is preferable to use a mixture of the oil component and oryzanol in advance.
The content of the oily component used in the cosmetic of the present invention is appropriately selected according to the purpose, and is preferably 0.1 to 100 times by mass with respect to the total content of oryzanol. 5 to 50 times the amount is more preferable.

(Other additives)
Other additives further include, for example, one or more components selected from preservatives, antioxidants, colorants, thickeners, or pH adjusters. Moreover, a fragrance | flavor, an antibacterial agent, a moisturizer, a ultraviolet absorber, an active oxygen removal agent, an antimicrobial agent, a hair restorer, an anti-inflammatory agent, a whitening agent, a mineral, an amino acid, etc. can be used.
Hereinafter, although the example of another additive is given, the component which can be contained in this invention is not limited to the compound as described below.

In the cosmetic of the present invention, oryzanol is considered to function as a stabilizer for astaxanthin.
Thus, oryzanol not only exhibits effectiveness as a functional component, but also suppresses degradation of astaxanthin by light or heat over time, contributing to stability improvement. For this reason, even when astaxanthin is contained in a transparent cosmetic, discoloration due to decomposition of astaxanthin is suppressed over a long period of time, and a good appearance is maintained.
Moreover, since the ratio of the alcohol and water which occupies for the cosmetics whole quantity exceeds 60 mass%, the cosmetics of this invention become cosmetics which have a refreshing touch, containing astaxanthin and oryzanol.

[Method of manufacturing cosmetics]
The manufacturing method of the cosmetics of this invention is not specifically limited, It can manufacture according to a well-known method.
Examples of the method applied when astaxanthin and oryzanol are contained in the cosmetic of the present invention include the following methods.
For example, a method of dissolving at least one selected from astaxanthin and oryzanol in an alcohol capable of dissolving at least one selected from astaxanthin and oryzanol to be contained in a cosmetic (hereinafter referred to as a first method), astaxanthin And at least one selected from oryzanol and a solubilizing agent capable of dissolving at least one selected from astaxanthin and oryzanol and kneaded in cosmetics (hereinafter referred to as the second method), astaxanthin and oryzanol in advance A dispersion composition containing at least one selected from the group consisting of: a method of containing in cosmetics (hereinafter referred to as the third method), at least one selected from astaxanthin and oryzanol dissolved in the oil component Dispersed, a method to be contained in cosmetics (hereinafter, referred to as the fourth method), and the like.
A plurality of the first to fourth methods described above may be combined. In the first to fourth methods, astaxanthin and oryzanol may be contained in the cosmetic by different methods, or may be contained in the cosmetic by the same method.
Hereinafter, although the preferable example of the manufacturing method of the cosmetics of this invention is demonstrated more concretely, the manufacturing method of the cosmetics of this invention is not limited to the following description.

(First method: a method in which at least one selected from astaxanthin and oryzanol is dissolved in alcohol and contained in cosmetics)
The first method is a method in which astaxanthin and oryzanol are dissolved in alcohol, respectively, so that they are uniformly mixed in the cosmetic of the present invention containing a mixture of alcohol and water.
As an example of a cosmetic production method to which the first method is applied, astaxanthin and an alcohol capable of dissolving astaxanthin are mixed to prepare an astaxanthin-containing liquid, and the obtained astaxanthin-containing liquid is Preparing an astaxanthin-containing aqueous solution by dissolving in a mixed solvent of water and ethanol, preparing an oryzanol-containing liquid containing oryzanol and an alcohol capable of dissolving oryzanol, and an astaxanthin-containing aqueous solution The manufacturing method of cosmetics including mixing a solution and an oryzanol containing liquid is mentioned.

  For example, the content in the case of using an alcohol for the purpose of dissolving oryzanol in the alcohol is appropriately selected according to the purpose, but is more preferably 1% by mass to 30% by mass with respect to the total amount of the cosmetic. More preferably, it is 20 mass%-20 mass%.

(Second method: a method in which at least one selected from astaxanthin and oryzanol is kneaded with a solubilizing agent capable of solubilizing astaxanthin and oryzanol and contained in cosmetics)
The second method is a method in which at least one selected from astaxanthin and oryzanol and a solubilizer compatible with astaxanthin and oryzanol are kneaded and dissolved in a mixture of alcohol and water as a base material for cosmetics. . Further, when kneading, astaxanthin and oryzanol may be kneaded simultaneously with the solubilizer or may be kneaded individually. Further, when kneading, as long as the stability and solubility are not affected, they may be kneaded simultaneously with other additives other than astaxanthin and oryzanol.

Examples of the solubilizer that is compatible with astaxanthin and oryzanol include at least one compound selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene phytosterol, and polyoxyethylene cholesterol.
At least one compound selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene phytosterol, and polyoxyethylene cholesterol is 1.0 to 20 times by mass with respect to the oryzanol content. The mixture is sufficiently mixed at 10 to 45 ° C. for 5 to 60 minutes using a stirrer or stirrer that can uniformly stir a mixture having a higher viscosity than liquid components such as water and alcohol. A mixture is obtained.
In the present invention, kneading means a premix for preparing a homogeneous mixture in advance in the absence of a solvent or in the presence of a slight solvent for viscosity adjustment.
When kneading astaxanthin, oryzanol and a solubilizer, astaxanthin or oryzanol may be previously dissolved in a solvent and kneaded with a solubilizer for the purpose of shortening the time for compatibility. Moreover, as the solvent at that time, it is preferable to use the alcohol described above, but it is not particularly limited.
By adding a premix composition (kneaded material) containing astaxanthin, oryzanol and solubilizer obtained by kneading to a cosmetic preparation solution containing other than astaxanthin and oryzanol, and thoroughly mixing at 10 ° C to 35 ° C. The cosmetic of the present invention can be obtained.
Also in the second method, the kneaded material containing oryzanol may be used in combination with an astaxanthin-containing aqueous solution or a dispersion composition containing astaxanthin. The astaxanthin-containing aqueous solution used or the dispersion composition containing astaxanthin can be prepared in the same manner as in the first method.

(Third method: a method in which a dispersion composition containing at least one selected from astaxanthin and oryzanol is prepared in advance and contained in cosmetics)
The third method includes preparing an astaxanthin-containing dispersion composition containing astaxanthin in the oil phase, and preparing an oryzanol-containing dispersion composition containing oryzanol. Thereafter, the astaxanthin-containing dispersion composition, oryzanol-containing dispersion composition, and an aqueous solvent containing water and alcohol can be mixed to obtain a cosmetic.

(Fourth method: a method in which at least one selected from astaxanthin and oryzanol is dissolved and dispersed in an oil component and contained in cosmetics)
A cosmetic preparation is classified into an oily component and an aqueous component. First, at least one of astaxanthin and oryzanol is dissolved in an oily component heated and dissolved at 70 ° C to 150 ° C to prepare a uniform oily solution. Then, the uniform suspension is prepared by mixing and stirring the oily solution and the aqueous solution in which the aqueous component is uniformly dissolved while heating to 40 ° C to 90 ° C. Include in cosmetics.

In the preparation of the dispersion composition, a general mixing means is also known, but a stirring means having a stronger shearing force, that is, a high-speed stirring method using a homomixer, a disper mixer, an ultramixer, etc., an ultrasonic homogenizer is used. It is preferable to prepare a dispersion composition by refining using a refining means such as an ultrasonic method to be used or a high pressure homogenizer method in which a high shearing force is applied with a high pressure homogenizer.
Examples of ultrasonic homogenizers include ultrasonic homogenizers US-600, US-1200T, RUS-1200T, MUS-1200T (above, trade names, Nippon Seiki Seisakusho Co., Ltd.), ultrasonic processors UIP2000, UIP-4000, UIP. -8000, UIP-16000 (above, trade name, Heelscher). These high-power ultrasonic irradiation devices are used at a frequency of 25 kHz or less, preferably 15 to 20 kHz.

Examples of high-pressure homogenizers include Microfluidizer (trade name: Microfluidics), Nanomizer (Yoshida Kikai Kogyo Co., Ltd.), Starburst (Sugino Machine Co., Ltd.), Gorin type homogenizer (APV), Lanier type Examples include a homogenizer (Ranie), a high-pressure homogenizer (Niro Soabi), a homogenizer (Sanwa Machinery Co., Ltd.), a high-pressure homogenizer (Izumi Food Machinery Co., Ltd.), and an ultra-high pressure homogenizer (squid company).
The operating pressure of the high-pressure homogenizer is 50 MPa or more, more preferably 150 MPa or more, from the viewpoint of miniaturization. In addition, the number of passes of the high-pressure treatment may be one, but in order to improve the uniformity of the entire liquid, it is preferably 2 times or more, more preferably 2 to 5 times. The temperature before the high-pressure dispersion treatment is preferably set to 20 ° C to 80 ° C, more preferably 40 ° C to 70 ° C. Immediately after the high-pressure dispersion treatment, it is preferable to quickly cool using a cooling means and lower the temperature to a predetermined temperature. Any commercially available heat exchanger can be used as the cooling device.

In the cosmetic of the present invention, when oryzanol is contained as a dispersion composition, the volume average particle diameter of the dispersed particles containing oryzanol is preferably 5 nm to 200 nm, more preferably 5 nm to 100 nm, and more preferably 5 nm. More preferably, it is ˜50 nm.
The volume average particle diameter determined by the dynamic light scattering method is applied to the particle diameter of the dispersed particles in the present invention from the particle diameter range and ease of measurement.

(Particle size measurement)
As a commercially available measuring device using dynamic light scattering, Nanotrac UPA (Nikkiso Co., Ltd.), dynamic light scattering type particle size distribution measuring device LB-550 (Horiba, Ltd.), a concentrated particle size analyzer FPAR-1000 (Otsuka Electronics Co., Ltd.) etc. are mentioned.
The volume average particle diameter of the dispersed particles in the present invention is a value measured using Nanotrac UPA (Nikkiso Co., Ltd.), and specifically, a value measured as follows is adopted.

  The particle diameter is measured by diluting the cosmetic of the present invention 10 times with pure water and measuring at room temperature. The volume average particle diameter is obtained when 1.333 (pure water) is used as the refractive index of the dispersion medium and the viscosity of pure water is used as the viscosity of the dispersion medium.

After preparing the cosmetic of the present invention, if necessary, a sterilization step can be performed.
The sterilization step may be performed at any stage in each step of preparing the cosmetic of the present invention. However, when the sterilization step is performed, it is preferably performed as soon as possible after stirring and mixing or dispersing.

(Sterilization method)
Examples of the sterilization method in the sterilization process include heating methods such as dry heat sterilization and steam sterilization, electron beam sterilization, sterilization using ionizing radiation, electromagnetic wave methods such as high-frequency sterilization, and gases such as ethylene oxide gas (EOG) sterilization. Examples thereof include sterilization, hydrogen peroxide low temperature plasma sterilization, chemical sterilization methods, chemical sterilization methods, and filtration sterilization methods such as separation and removal. In the production method of the present invention, heat sterilization (dry heat sterilization, steam sterilization) and filter sterilization are preferable.

  Hereinafter, the present invention will be described in detail with reference to examples. However, the present invention is not limited to the examples.

[Example 1, Comparative Examples 1 to 2]
[Preparation of cosmetics]
A cosmetic was prepared according to the formulation described in Table 1 below.
The astaxanthin content was 2.5 ppm and the 1,3-butylene glycol content was 3% by mass, added to a mixed solvent of water / ethanol = 7/3, and the resulting liquid was used as the base liquid. .
The obtained base solution was mixed with an oryzanol content of 0.01 mM (mmol / liter) and an 1,3-butylene glycol content of 3% by mass, and oryzanol was mixed with 1,3-butylene. A mixed solution dissolved in glycol was prepared.
Astaxanthin used ASTAZ ST-S (trade name: Takeda Paper Co., Ltd., Haematococcus alga extract). As the oryzanol, γ-oryzanol C (trade name, Okayasu Shoten Co., Ltd.) was used.
In Example 1, a mixed solution in which oryzanol was dissolved in 1,3-butylene glycol was added to a base solution containing astaxanthin and stirred to prepare a cosmetic.
In Comparative Example 1 and Comparative Example 2, ascorbic acid glucoside (AA2G, trade name, Hayashibara Co., Ltd .: described as “AA2G (antioxidant)” in Table 1) instead of oryzanol, magnesium ascorbate phosphate (APM, trade name, Wako Pure Chemical Industries, Ltd .: described in Table 1 as “APM (antioxidant)”) 0.01 mM and 1,3-butylene glycol in amounts of 3% by mass, respectively Then, a mixed liquid mixture was prepared, and the obtained liquid mixture was added to prepare a cosmetic.

(Evaluation of dark heat stability)
The cosmetics of Example 1 and Comparative Examples 1 and 2 were filled in a glass container shielded with aluminum foil, stored at 70 ° C. for 3 days, a dark heat test was performed, and dark heat stability was evaluated.
First, the absorbance at 483 nm of each cosmetic immediately after preparation was measured with a spectrophotometer U-3310 manufactured by Hitachi, Ltd. using an ultraviolet-visible absorption spectrum and a 1 cm optical path length. After storage at 70 ° C. for 3 days, the same measurement was performed, and the residual rate (%) in which astaxanthin was not decomposed was measured from the change rate (%) before and after storage in the absorption of astaxanthin. The results are shown in Table 1 below.
When the residual ratio of astaxanthin was 80% or more, it was judged to be a level having no practical problem.

  From the results in Table 1, it was found that the cosmetic of Example 1 was superior to the cosmetics of Comparative Example 1 and Comparative Example 2 containing a known antioxidant due to the dark heat stability of astaxanthin.

[Example 2, Comparative Examples 3 to 5]
A cosmetic was prepared in the same manner as in Example 1 according to the formulation described in Table 2 below. Further, in place of oryzanol, ascorbic acid glucoside (AA2G, trade name, Hayashibara Co., Ltd .: described as “AA2G (antioxidant)” in Table 2), magnesium ascorbate phosphate (APM, trade name, Japanese) Kojun Pharmaceutical Co., Ltd .: described in Table 2 as “APM (antioxidant)”, t-butylmethoxydibenzoylmethane (Wako Pure Chemical Industries, Ltd., UV absorber: in Table 2) A mixture was prepared by adding 0.01 mM and 1,3-butylene glycol in amounts of “t-butylmethoxydibenzoylmethane (UV absorber)” to 3% by mass, respectively. The obtained mixture was added to a base solution containing astaxanthin to prepare cosmetics of Comparative Examples 3 to 5.

(Evaluation of light stability)
1.5 ml of each of the cosmetics of Example 2 and Comparative Examples 3 to 5 was added to one hole of a 24-well plate, and 5 UV-irradiation lamps 8W365nm lamps were used at DNA-FIX Donafix (Ato Co., Ltd.). Used to irradiate with ultraviolet rays. Irradiation was performed for 30 minutes, 1 hour, and 2 hours. Absorbance at a wavelength of 490 nm before and after UV irradiation was measured with a plate reader (ARVO MX: trade name, PerkinElmer).
In each cosmetic, prepare a control solution that does not contain astaxanthin, contains oryzanol, ascorbic acid glucoside, magnesium ascorbate phosphate, and t-butylmethoxydibenzoylmethane. The absorbance at a wavelength of 490 nm before and after was measured.
Astaxanthin measurement method: Calculation was performed according to the following formula to obtain a residual amount (%) of astaxanthin. The results are also shown in Table 2 below.

Astaxanthin remaining amount (%) =
[(Absorbance in cosmetics after UV irradiation)-(absorbance of control solution not containing astaxanthin after UV irradiation)] / [(absorbance in cosmetics before UV irradiation)-(control containing no astaxanthin before UV irradiation) Absorbance of liquid))
In this test, 365 nm ultraviolet light was irradiated at about 1.78 mW / cm ^{2, and the} illuminance was measured by Illuminating Society Journal 82 (11) (1998) pp. According to 877-884, it is a severe test corresponding to the amount of UV exposure for 6 days in the day (8 hours / day of exposure). In the test, if the residual ratio of astaxanthin was 40% or more, changes in appearance such as fading in general use could not be visually confirmed, and it was judged that there was no practical problem.

From the results of Table 2, it can be seen that the cosmetic of Example 2 is superior in light stability to the cosmetics of Comparative Examples 3 to 5 containing a known antioxidant and ultraviolet absorber.
From the above results, it was confirmed that the cosmetics of the examples were excellent in dark heat stability and light stability, and oryzanol contributed to the stabilization of astaxanthin.

[Example 3-1 and Example 3-2]
[Lotion]
A lotion having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
Astaxanthin (derived from ASTATTS-ST Haematococcus algae) 2.5ppm
γ-oryzanol (γ-oryzanol C: trade name, Okayasu Co., Ltd.) 10ppm
Ethanol (alcohol) 10.0
1,3-butylene glycol (alcohol) 5.0
Methylparaben (Platingence-M: Ueno Pharmaceutical) 0.1
Phenoxyethanol 0.3
Hydrolyzed collagen 0.5
Purified water remaining

Except that the skin lotion of Example 3-1 was prepared and the temperature was changed to 50 ° C., the dark heat stability was evaluated in the same manner as in Example 1. Precipitation occurred after 3 months of storage. It was confirmed.
Although the above dark heat stability evaluation results are at a level where there is no practical problem, for the purpose of improving the stability, the formulation of the lotion of Example 3-1 was formulated with POE (20) phytosterol ether (BPS- No. 20, trade name, Nikko Chemicals Co., Ltd.) was added in an amount of 0.3% by mass, and the content of purified water was reduced by 0.3% by mass to prepare a cosmetic of Example 3-2.
In preparing the cosmetic of Example 3-2, oryzanol was previously dissolved in 1 ml of ethanol and kneaded and dissolved with POE (20) phytosterol ether, which is a solubilizing agent, to prepare a premix composition. The cosmetic of Example 3-2 was produced by mixing the obtained premix composition and cosmetic preparations other than oryzanol at a temperature of 20 ° C. to 30 ° C. for 30 minutes.
About the cosmetics of Example 3-2, when dark heat stability evaluation was performed like Example 3-1, it turned out that generation | occurrence | production of precipitation is suppressed also after three months progress. From this, it was found that the addition of POE (20) phytosterol ether capable of solubilizing oryzanol further improves the temporal stability of the cosmetic.

[Example 4]
A lotion having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
γ-oryzanol 0.05
Haematococcus alga extract (containing 20% by weight of astaxanthin) 0.01
1,3-butylene glycol (alcohol) 4.0
Ethanol (alcohol) 2.0
Dipropylene glycol (alcohol) 4.0
Arbutin 2.0
Dipotassium glycyrrhizinate 1.0
Polyoxyethylene methyl glucoside 1.0
Polyethylene glycol 1.0
Polyoxyethylene hydrogenated castor oil (60 EO) 0.2
Phenoxyethanol 0.3
Glycerin mono-2-ethylhexyl ether 0.2
Citric acid Appropriate amount Sodium hydroxide Appropriate amount N-acetyl-L-hydroxyproline 1.0
Water-soluble collagen 1.0
Hydrolyzed collagen 1.0
Seaweed extract (1) 1.0
Sucrose fatty acid ester 0.5
Phospholipid 0.2
Polyglyceryl monooleate 0.2
Phosphoric acid-L-ascorbyl magnesium 1.0
Sodium hyaluronate 0.2
Water remaining

[Example 5]
<Preparation of an astaxanthin-containing emulsion composition>
The following components were dissolved for 1 hour while heating at 70 ° C. to obtain an aqueous phase composition A.
Sucrose stearate (HLB = 16) 33.0 g
Decaglyceryl monooleate (HLB = 12) 67.0 g
Glycerin (alcohol) 450.0g
300.0g of pure water

The following components were dissolved for 1 hour while heating at 70 ° C. to obtain an oil phase composition A.
Krill extract 15.0g
Mixed tocopherol (RIKEN vitamin, RIKEN E oil 800) 32.0g
Medium-chain fatty acid glyceride (Kao, Coconut MT) 93.0g
Lecithin (RIKEN Vitamin, Recion P, derived from soybean) 10.0 g

The aqueous phase composition A obtained above was stirred with a homogenizer (model name: HP93, SMT Co., Ltd.) while maintaining the temperature at 70 ° C. (10000 rpm), and the oil phase composition A was added to the aqueous phase composition A. Thus, a preliminary emulsion was obtained.
Subsequently, the obtained preliminary emulsified product was cooled to about 40 ° C., and high-pressure emulsification was performed using an optimizer HJP-25005 (Sugino Machine Co., Ltd.) at a pressure of 200 MPa. After high-pressure emulsification, the mixture was filtered through a microfilter having an average pore diameter of 1 μm to prepare an astaxanthin-containing emulsion composition (astaxanthin content: 0.3% by mass).

  The obtained astaxanthin emulsion composition was diluted to 1% by mass with MilliQ water, and the particle size of the dispersed particles was measured using a particle size analyzer FPAR-1000 (Otsuka Electronics Co., Ltd.). It was.

  Even if the above krill extract is replaced with product name: Astax-ST Marine Daio Co., Ltd. or product name: ASTOTS-S Takeda Paper Co., Ltd. (Hematococcus alga extract), an equivalent emulsion composition is obtained. Can do.

<Preparation of aqueous dispersion composition containing communis extract>
The following components were mixed and dissolved with heating using a paddle at 70 ° C. for 30 minutes to obtain a suspension A.
Glycerin 67.0g
28.0g of pure water
Lecithin (SLP-White (trade name); Sakai Oil Co., Ltd.) 450.0 g
TECA ^{* 1} 1.0g
* 1: TECA (trade name) (a mixture containing asiatic acid, madecacinic acid, and asiaticoside, Bayer Healthcare, a 5-cyclic triterpene)

  The suspension A obtained above is passed through an ultrahigh pressure disperser (model name: Starburst Mini, Sugino Machine Co., Ltd.) 5 times at a pressure of 200 MPa while maintaining the temperature at 60 ° C. To prepare an aqueous dispersion composition containing communis extract.

  The resulting aquatic extract-containing aqueous dispersion composition is diluted 10-fold with milli-Q water, and dispersed particles are obtained using a dynamic light scattering particle size analyzer (trade name: Nanotrac UPA (Nikkiso Co., Ltd.)). The particle size of was measured to be 19 nm.

<Preparation of oryzanol dispersion composition>
γ-oryzanol (γ-oryzanol C: trade name, Okayasu Co., Ltd.) 1.0 g
POE (20) phytosterol ether 3.0 g
1,3-butylene glycol (alcohol) 16.0 g

The above three components are mixed and heated and dissolved at a temperature of 70 ° C. to 150 ° C. to prepare a uniform oily solution. The obtained oily solution was added to an aqueous phase containing the following two components heated to 40 ° C. to 90 ° C. with stirring to obtain a suspension.
Lecithin (SLP White: Sakai Oil) 4.0g
Glycerin (alcohol) 46.0g
Purified water Upto100g
The obtained suspension was subjected to a dispersion treatment at a temperature of 20 ° C. or more and 80 ° C. or less under a pressure of 100 MPa or more to obtain an oryzanol dispersion composition.
As a commercially available measuring apparatus using dynamic light scattering, Nanotrac UPA (Nikkiso Co., Ltd.) was used for measurement as follows.
The dispersion composition is diluted 10 times with pure water and measured at room temperature (25 ° C.). It was 9.3 nm when it calculated | required as a volume average particle diameter when using 1.333 (pure water) as a dispersion medium refractive index and the viscosity of a pure water as a viscosity of a dispersion medium.

<Preparation of Stearyl Glycyrrhetinate Dispersion Composition>
The following components were dissolved for 1 hour while heating at 70 ° C. to obtain an aqueous phase composition.
Decaglyceryl monooleate (HLB = 12) 18.9 g
Glycerin 35.0g
Pure water remaining upto 100.0g

Moreover, the following component was melt | dissolved for 1 hour, heating at 70 degreeC, and the oil phase composition was obtained.
Stearyl glycyrrhetinate 3.33g
3.33 g tocopherol acetate
Tocopherol 10.77 g
Tri (caprylic / capric) glyceryl 6.0g
Purified lecithin (derived from soybean) 4.2g

  While maintaining the aqueous phase composition in a stirred state, the oil phase composition was added and then dispersed for 4 minutes using a high-pressure homogenizer to obtain a preliminary dispersion.

Subsequently, the obtained pre-dispersion was cooled to about 60 ° C., and the optimizer HJP-250 was used.
No. 05 (manufactured by Sugino Machine Co., Ltd.) was used for high-pressure dispersion at a pressure of 245 MPa to obtain a dispersion composition.
Thereafter, the obtained dispersion composition was filtered through a microfilter having an average pore diameter of 1 μm and sterilized by heating at 80 ° C. for 30 minutes to prepare a glycyrrhetic acid derivative (stearyl glycyrrhetic acid stearyl dispersion containing stearyl glycyrrhetinate).

A serum having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
Astaxanthin-containing emulsion composition (containing 0.3% by weight of astaxanthin) 0.5
Oryzanol dispersion composition (containing 1% by weight of oryzanol) 0.05
Dipropylene glycol (alcohol) 4.0
Glycerin (alcohol) 5.0
Diglycerin (alcohol) 2.0
1,2-pentanediol (alcohol) 2.0
Polyoxyethylene hydrogenated castor oil (60 EO) 0.2
Phosphoric acid-L-ascorbyl magnesium 2.0
Dipotassium glycyrrhizinate 1.0
Phenoxyethanol 0.5
Methyl paraoxybenzoate 0.1
Alkali Neges Relatus B-16 Polymer 0.05
Citric acid appropriate amount Sodium citrate appropriate amount N-acetyl-L-hydroxyproline 1.0
Water-soluble collagen 1.0
Hydrolyzed collagen 1.0
Yeast extract 1.0
A camellia extract-containing aqueous dispersion composition (containing 1% by weight of a camellia extract) 0.05
Stearyl glycyrrhetinate dispersion composition (containing 1.0% by mass of stearyl glycyrrhetinate) 0.5
Polyglyceryl monooleate 0.2
Water remaining

[Example 5]
A cream having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
γ-oryzanol 0.5
Haematococcus alga extract (containing 20% by weight of astaxanthin) 0.1
Arbutin 2.0
1,2-pentanediol (alcohol) 3.0
1,3-butylene glycol (alcohol) 3.0
Dipropylene glycol (alcohol) 7.0
Concentrated glycerin (alcohol) 5.0
Polyethylene glycol 6000 1.0
Sodium hyaluronate 0.5
Trimethylglycine 0.5
Xanthan gum 0.5
Acrylic acid / alkyl methacrylate copolymer 0.7
Squalane 0.5
Shea fat 1.0
Sara honey bee 1.0
Behenyl alcohol 1.0
Glyceryl monostearate 2.0
Polyoxyethylene glyceryl isostearate 1.0
Tocopherol 0.5
Water-soluble collagen 1.0
Hydrolyzed collagen solution (from fish) 1.0
N-acetyl-L-hydroxyproline 1.0
Camellia extract 0.2
Sucrose fatty acid ester 0.1
Phospholipid 0.1
Polyglyceryl monooleate 0.1
Sodium citrate appropriate amount phenoxyethanol 0.3
Purified water remaining

[Example 6]
An emulsion having the following composition was prepared by using the following oil phase component and aqueous phase component as an emulsion composition in the same manner as in Example 5 (total amount: 100% by mass).
[Composition] [Content (% by mass)]
(A) Oil phase component Hematococcus alga extract (containing 0.3% by mass of astaxanthin) 0.2
Squalane 8.0
Jojoba oil 7.0
Cetyl alcohol 1.5
(B) Water phase component Oryzanol dispersion composition (containing 1% by mass of oryzanol) 0.5
1,3-butylene glycol (alcohol) 1.0
Glycerin (alcohol) 2.0
1,2-pentanediol (alcohol) 3.0
Glycerol monostearate 2.0
Polyoxyethylene cetyl ether 3.0
Polyoxyethylene soorbitan monooleate 2.0
Sucrose stearate 0.1
Polyglyceryl oleate-10 0.1
Polyglyceryl stearate-2 0.1
Phenoxyethanol 0.2
Collagen 1.0
Camellia extract 0.5
Arbutin 0.3
Dipotassium glycyrrhizinate 0.2
Sodium citrate 0.3
POE (20) phytosterol ether (BPS-20: trade name, Nikko Chemicals Co., Ltd.) 0.3
Perfume Trace Purified water Remaining

[Example 7]
A jelly-like serum having the following composition was prepared by a conventional method. (Total amount 100 mass%).
[Composition] [Content (% by mass)]
Oryzanol dispersion composition (containing 1% by weight of oryzanol) 0.05
Haematococcus alga extract (containing 0.3% by weight of astaxanthin) 0.05
Astaxanthin-containing emulsion composition 0.2
Ceramide III, VI mixture 1.0
Hydrolyzed collagen 1.0
Acetylhydroxyproline 1.0
Octoxyglycerin (alcohol) 0.1
Oleic acid 0.5
1,3-butylene glycol (alcohol) 1.0
Glycerin (alcohol) 2.0
Sucrose 0.1
Polyglyceryl oleate-10 0.1
Polyglyceryl stearate-2 0.1
Phenoxyethanol 0.2
Collagen 1.0
Sodium citrate 1.0
(PEG-240 / decyltetradeceth-20 / HDI) copolymer 0.3
Damask rose flower oil Trace fragrance Trace purified water Remaining

  The cosmetics of each of the examples described above all had a good feeling of use, and even when stored for a long period of time, no change in appearance such as fading was observed, and the cosmetics were excellent in stability.

[Example 6 ]
A cream having the following composition was prepared by a conventional method (total amount: 100% by mass).
[Composition] [Content (% by mass)]
γ-oryzanol 0.5
Haematococcus alga extract (containing 20% by weight of astaxanthin) 0.1
Arbutin 2.0
1,2-pentanediol (alcohol) 3.0
1,3-butylene glycol (alcohol) 3.0
Dipropylene glycol (alcohol) 7.0
Concentrated glycerin (alcohol) 5.0
Polyethylene glycol 6000 1.0
Sodium hyaluronate 0.5
Trimethylglycine 0.5
Xanthan gum 0.5
Acrylic acid / alkyl methacrylate copolymer 0.7
Squalane 0.5
Shea fat 1.0
Sara honey bee 1.0
Behenyl alcohol 1.0
Glyceryl monostearate 2.0
Polyoxyethylene glyceryl isostearate 1.0
Tocopherol 0.5
Water-soluble collagen 1.0
Hydrolyzed collagen solution (from fish) 1.0
N-acetyl-L-hydroxyproline 1.0
Camellia extract 0.2
Sucrose fatty acid ester 0.1
Phospholipid 0.1
Polyglyceryl monooleate 0.1
Sodium citrate appropriate amount phenoxyethanol 0.3
Purified water remaining

[Example 7 ]
An emulsion having the following composition was prepared by using the following oil phase component and aqueous phase component as an emulsion composition in the same manner as in Example 5 (total amount: 100% by mass).
[Composition] [Content (% by mass)]
(A) Oil phase component Hematococcus alga extract (containing 0.3% by mass of astaxanthin) 0.2
Squalane 8.0
Jojoba oil 7.0
Cetyl alcohol 1.5
(B) Water phase component Oryzanol dispersion composition (containing 1% by mass of oryzanol) 0.5
1,3-butylene glycol (alcohol) 1.0
Glycerin (alcohol) 2.0
1,2-pentanediol (alcohol) 3.0
Glycerol monostearate 2.0
Polyoxyethylene cetyl ether 3.0
Polyoxyethylene soorbitan monooleate 2.0
Sucrose stearate 0.1
Polyglyceryl oleate-10 0.1
Polyglyceryl stearate-2 0.1
Phenoxyethanol 0.2
Collagen 1.0
Camellia extract 0.5
Arbutin 0.3
Dipotassium glycyrrhizinate 0.2
Sodium citrate 0.3
POE (20) phytosterol ether (BPS-20: trade name, Nikko Chemicals Co., Ltd.) 0.3
Perfume Trace Purified water Remaining

[Example 8 ]
A jelly-like serum having the following composition was prepared by a conventional method. (Total amount 100 mass%).
[Composition] [Content (% by mass)]
Oryzanol dispersion composition (containing 1% by weight of oryzanol) 0.05
Haematococcus alga extract (containing 0.3% by weight of astaxanthin) 0.05
Astaxanthin-containing emulsion composition 0.2
Ceramide III, VI mixture 1.0
Hydrolyzed collagen 1.0
Acetylhydroxyproline 1.0
Octoxyglycerin (alcohol) 0.1
Oleic acid 0.5
1,3-butylene glycol (alcohol) 1.0
Glycerin (alcohol) 2.0
Sucrose 0.1
Polyglyceryl oleate-10 0.1
Polyglyceryl stearate-2 0.1
Phenoxyethanol 0.2
Collagen 1.0
Sodium citrate 1.0
(PEG-240 / decyltetradeceth-20 / HDI) copolymer 0.3
Damask rose flower oil Trace fragrance Trace purified water Remaining

Claims (7)

A cosmetic containing astaxanthin, oryzanol, alcohol, and water;
The alcohol content with respect to the total amount of the cosmetic is 0.1% by mass or more and 40% by mass or less, the content of water with respect to the total amount of the cosmetic is 60% by mass or more and 98% by mass or less, and the alcohol with respect to the total amount of the cosmetic Cosmetics whose total content with water is 60.1 mass% or more and less than 100 mass%.   The alcohol comprises at least one alcohol selected from the group consisting of ethanol, 1,2-pentanediol, octoxyglycerin, propylene glycol, butylene glycol, glycerin, diglycerin, and dipropylene glycol. Cosmetics.   The cosmetic according to claim 1 or 2, wherein the alcohol comprises at least one alcohol selected from the group consisting of ethanol, propylene glycol, butylene glycol, 1,2-pentanediol, and octoxyglycerin.   The content of at least one alcohol selected from the group consisting of ethanol, propylene glycol, butylene glycol, 1,2-pentanediol, and octoxyglycerin is 1% by mass or more and 20% by mass or less based on the total amount of the cosmetic. The cosmetic according to claim 3.   The cosmetic according to claim 1 or 2, wherein the alcohol comprises at least one alcohol selected from the group consisting of glycerin and diglycerin.   The cosmetic according to claim 5, wherein the content of at least one alcohol selected from the group consisting of glycerin and diglycerin is 1% by mass or more and 15% by mass or less based on the total amount of the cosmetic.   The cosmetic according to any one of claims 1 to 6, further comprising at least one compound selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene phytosterol, and polyoxyethylene cholesterol.