JP2012031085A - 細胞賦活剤、毛包上皮系細胞増殖促進剤及び育毛剤 - Google Patents
細胞賦活剤、毛包上皮系細胞増殖促進剤及び育毛剤 Download PDFInfo
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- JP2012031085A JP2012031085A JP2010171045A JP2010171045A JP2012031085A JP 2012031085 A JP2012031085 A JP 2012031085A JP 2010171045 A JP2010171045 A JP 2010171045A JP 2010171045 A JP2010171045 A JP 2010171045A JP 2012031085 A JP2012031085 A JP 2012031085A
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- hair
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- hair follicle
- follicle epithelial
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Abstract
新規有効成分を含有する、毛乳頭細胞の毛包上皮系細胞への働きかけを強め、毛包上皮系細胞の増殖を促進することが可能な、細胞賦活剤、毛包上皮系細胞増殖促進剤及び育毛剤を提供すること。
【解決手段】
サトウモロコシ抽出物を有効成分として含有する、毛乳頭細胞が有する毛包上皮系細胞を増殖させる作用を増強するための細胞賦活剤。
【選択図】なし
Description
サトウモロコシ抽出物は、サトウモロコシ(砂糖蜀黍、学名:Sorghum bicolor Moench var. saccharatum Koern.)からの抽出される抽出成分を含有する抽出物である。
本実施形態に係る細胞賦活剤は、毛乳頭細胞が有する毛包上皮系細胞増殖作用を増強するための細胞賦活剤であって、サトウモロコシ抽出物を有効成分として含有する。
本実施形態に係る育毛剤は、サトウモロコシ抽出物を有効成分として含有する。
サトウモロコシ茎汁6.0質量%、水94.0質量%からなる組成液を調製し、これを10倍希釈することにより、サトウモロコシ抽出物含有液を得た。得られたサトウモロコシ抽出物含有液を、さらに10倍、20倍、100倍に希釈して試験サンプル1〜3とし、これらの試験サンプルについて下記のとおり毛包上皮系細胞増殖試験I及びIIを行った。なお、試験I及びIIは、各々の試験サンプルについて2回ずつ行った。試験Iにて測定された吸光度は、表1に示すとおりであり、試験IIにて測定された吸光度は、表2に示すとおりであった。なお、表1及び表2には、2回の試験で測定された吸光度の相加平均値を示す。
まず、ヒト上皮角化細胞(以下、「HEK」(Human Epidermal Keratinocytes)と称する。)を、TOYOBO社製Keratinocyte Growth Medium Kitにて、T75フラスコで培養した。また、ヒト頭皮毛乳頭細胞(以下、「HFDPC」(Human Follicle Dermal Papilla Cell)と称する。)についても、HEKと同時期に必要な細胞数となるよう、TOYOBO社製毛乳頭細胞増殖培地にて、T75コラーゲンTypeIコーティングフラスコにて、37℃、CO2雰囲気下、インキュベータ内で培養した。
HEK及びHFDPCの共存培養下における、HEK単一の増殖率を確認するため、インサート培養によって細胞培養を行った。なお、インサート培養は、培地を共有しつつも、両細胞が混合しないように隔てられている培養方法であって、公知の培養方法である。
実施例1における試験サンプル1〜3にかえて、西洋オトギリソウ乾燥エキス(セントジョーンズワート)の水溶液を、濃度0.1質量%、0.05質量%、0.01質量%となるように調製し、試験サンプル4〜6とした。これらの試験サンプル4〜6について、上記のとおり毛包上皮系細胞増殖試験Iを行った。なお、試験Iは、各々の試験サンプルについて2回ずつ行った。試験Iにて測定された吸光度は、表1に示すとおりであった。なお、表1には、2回の試験で測定された吸光度の相加平均値を示す。
上記の毛包上皮系細胞増殖試験I及びIIにおいて、試験サンプルを添加しなかった場合の吸光度を、比較例2とした。このとき試験Iにて測定された吸光度は、表1に示すとおりであり、試験IIにて測定された吸光度は、表2に示すとおりであった。
Claims (3)
- サトウモロコシ抽出物を有効成分として含有する、
毛乳頭細胞が有する毛包上皮系細胞を増殖させる作用を増強するための細胞賦活剤。 - サトウモロコシ抽出物を有効成分として含有する、毛包上皮系細胞増殖促進剤。
- サトウモロコシ抽出物を有効成分として含有する、育毛剤。
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JP2013170167A (ja) * | 2012-02-22 | 2013-09-02 | Yoshikatsu Taya | 育毛剤ゆめ |
CN111712227A (zh) * | 2017-12-14 | 2020-09-25 | 绿十字生命健康有限公司 | 用于缓解特应性皮炎、脱发和创伤或者减少皮肤皱纹的化妆品组合物和药物组合物 |
JP2021506969A (ja) * | 2017-12-14 | 2021-02-22 | グリーン・クロス・ウェルビーイング・コーポレイションGreen Cross Wellbeing Corporation | アトピー性皮膚炎、脱毛、傷または皮膚しわ改善用化粧料組成物および薬学組成物 |
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