JP2012012417A5 - - Google Patents
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- Publication number
- JP2012012417A5 JP2012012417A5 JP2011227135A JP2011227135A JP2012012417A5 JP 2012012417 A5 JP2012012417 A5 JP 2012012417A5 JP 2011227135 A JP2011227135 A JP 2011227135A JP 2011227135 A JP2011227135 A JP 2011227135A JP 2012012417 A5 JP2012012417 A5 JP 2012012417A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- independently
- occurrence
- optionally substituted
- nrco
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 5
- 125000001118 alkylidene group Chemical group 0.000 claims 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Chemical group 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 229910052717 sulfur Chemical group 0.000 claims 3
- 239000011593 sulfur Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 0 *c1c(-c2c[n]c3c2c(*)c(*)cn3)nc(*)[s]1 Chemical compound *c1c(-c2c[n]c3c2c(*)c(*)cn3)nc(*)[s]1 0.000 description 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58438304P | 2004-06-30 | 2004-06-30 | |
| US60/584,383 | 2004-06-30 | ||
| US58472104P | 2004-07-01 | 2004-07-01 | |
| US60/584,721 | 2004-07-01 | ||
| USPCT/US05/11358 | 2005-04-04 | ||
| US11/098,751 | 2005-04-04 | ||
| PCT/US2005/011358 WO2005103050A2 (en) | 2004-04-02 | 2005-04-04 | Azaindoles useful as inhibitors of rock and other protein kinases |
| US11/098,751 US7514448B2 (en) | 2004-04-02 | 2005-04-04 | Azaindoles useful as inhibitors of rock and other protein kinases |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519460A Division JP5122280B2 (ja) | 2004-06-30 | 2005-06-29 | タンパク質キナーゼのインヒビターとして有用なアザインドール |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013001760A Division JP2013064015A (ja) | 2004-06-30 | 2013-01-09 | タンパク質キナーゼのインヒビターとして有用なアザインドール |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012012417A JP2012012417A (ja) | 2012-01-19 |
| JP2012012417A5 true JP2012012417A5 (enExample) | 2013-02-28 |
Family
ID=37801682
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519460A Expired - Fee Related JP5122280B2 (ja) | 2004-06-30 | 2005-06-29 | タンパク質キナーゼのインヒビターとして有用なアザインドール |
| JP2011227135A Pending JP2012012417A (ja) | 2004-06-30 | 2011-10-14 | タンパク質キナーゼのインヒビターとして有用なアザインドール |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519460A Expired - Fee Related JP5122280B2 (ja) | 2004-06-30 | 2005-06-29 | タンパク質キナーゼのインヒビターとして有用なアザインドール |
Country Status (4)
| Country | Link |
|---|---|
| JP (2) | JP5122280B2 (enExample) |
| IL (1) | IL180303A0 (enExample) |
| MX (1) | MX2007000092A (enExample) |
| NO (1) | NO20070502L (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007000092A (es) * | 2004-06-30 | 2007-03-07 | Vertex Pharma | Azaindoles utiles como inhibidores de proteinas cinasas. |
| US7410988B2 (en) * | 2004-08-13 | 2008-08-12 | Genentech, Inc. | 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| DE102008038221A1 (de) * | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | 7-Azaindolderivate |
| DE102009058280A1 (de) * | 2009-12-14 | 2011-06-16 | Merck Patent Gmbh | Thiazolderivate |
| KR101851810B1 (ko) | 2010-04-16 | 2018-04-26 | 에이씨 이뮨 에스.에이. | 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 신규 화합물 |
| WO2011163527A1 (en) * | 2010-06-23 | 2011-12-29 | Vertex Pharmaceuticals Incorporated | Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase |
| DE102011105469A1 (de) * | 2011-06-24 | 2012-12-27 | Merck Patent Gmbh | 7-Azaindolderivate |
| CN104603118B (zh) * | 2012-05-31 | 2017-10-03 | 菲尼克斯药品股份公司 | 作为孤儿核受体RORγ调节物的经甲酰胺或磺酰胺取代的噻唑及相关衍生物 |
| SG11201605072VA (en) * | 2014-02-04 | 2016-08-30 | Taiho Pharmaceutical Co Ltd | Azaindole derivative |
| EP4225741A4 (en) * | 2020-10-05 | 2024-10-30 | Enliven Inc. | 7-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES |
| WO2023110843A1 (en) * | 2021-12-15 | 2023-06-22 | Almirall, S.A. | Heterobicyclic derivatives as itk inhibitors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265403B1 (en) * | 1999-01-20 | 2001-07-24 | Merck & Co., Inc. | Angiogenesis inhibitors |
| CA2397661C (en) * | 2000-03-01 | 2012-01-03 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
| SE0202463D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
| MXPA06011328A (es) * | 2004-04-02 | 2006-12-15 | Vertex Pharma | Azaindoles utiles como inhibidotes de roca y otras proteinas cinasas. |
| MX2007000092A (es) * | 2004-06-30 | 2007-03-07 | Vertex Pharma | Azaindoles utiles como inhibidores de proteinas cinasas. |
-
2005
- 2005-06-29 MX MX2007000092A patent/MX2007000092A/es active IP Right Grant
- 2005-06-29 JP JP2007519460A patent/JP5122280B2/ja not_active Expired - Fee Related
-
2006
- 2006-12-25 IL IL180303A patent/IL180303A0/en unknown
-
2007
- 2007-01-26 NO NO20070502A patent/NO20070502L/no not_active Application Discontinuation
-
2011
- 2011-10-14 JP JP2011227135A patent/JP2012012417A/ja active Pending
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