JP2011529503A5 - - Google Patents
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- JP2011529503A5 JP2011529503A5 JP2011521235A JP2011521235A JP2011529503A5 JP 2011529503 A5 JP2011529503 A5 JP 2011529503A5 JP 2011521235 A JP2011521235 A JP 2011521235A JP 2011521235 A JP2011521235 A JP 2011521235A JP 2011529503 A5 JP2011529503 A5 JP 2011529503A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- compound
- alcohol
- cis
- double bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8417208P | 2008-07-28 | 2008-07-28 | |
| US61/084,172 | 2008-07-28 | ||
| PCT/US2009/051927 WO2010014585A1 (en) | 2008-07-28 | 2009-07-28 | Pkc-activating compounds for the treatment of neurodegenerative diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014182597A Division JP2015042643A (ja) | 2008-07-28 | 2014-09-08 | 神経変性疾患の治療のためのpkc活性化化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529503A JP2011529503A (ja) | 2011-12-08 |
| JP2011529503A5 true JP2011529503A5 (https=) | 2012-09-13 |
| JP5653917B2 JP5653917B2 (ja) | 2015-01-14 |
Family
ID=41136734
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011521235A Expired - Fee Related JP5653917B2 (ja) | 2008-07-28 | 2009-07-28 | 神経変性疾患の治療のためのpkc活性化化合物 |
| JP2014182597A Pending JP2015042643A (ja) | 2008-07-28 | 2014-09-08 | 神経変性疾患の治療のためのpkc活性化化合物 |
| JP2016051212A Expired - Fee Related JP6449186B2 (ja) | 2008-07-28 | 2016-03-15 | 神経変性疾患の治療のためのpkc活性化化合物 |
| JP2018111869A Pending JP2018168170A (ja) | 2008-07-28 | 2018-06-12 | 神経変性疾患の治療のためのpkc活性化化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014182597A Pending JP2015042643A (ja) | 2008-07-28 | 2014-09-08 | 神経変性疾患の治療のためのpkc活性化化合物 |
| JP2016051212A Expired - Fee Related JP6449186B2 (ja) | 2008-07-28 | 2016-03-15 | 神経変性疾患の治療のためのpkc活性化化合物 |
| JP2018111869A Pending JP2018168170A (ja) | 2008-07-28 | 2018-06-12 | 神経変性疾患の治療のためのpkc活性化化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (7) | US8163800B2 (https=) |
| EP (3) | EP3586839A1 (https=) |
| JP (4) | JP5653917B2 (https=) |
| CA (2) | CA2731171C (https=) |
| ES (1) | ES2683021T3 (https=) |
| WO (1) | WO2010014585A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090030055A1 (en) * | 2002-07-02 | 2009-01-29 | Thomas Nelson | PKC activation as a means for enhancing sAPPALPHA secretion and improving cognition using bryostatin type compounds |
| CA2731171C (en) | 2008-07-28 | 2016-10-18 | Blanchette Rockefeller Neurosciences Institute | Pkc-activating compounds for the treatment of neurodegenerative diseases |
| US10052299B2 (en) | 2009-10-30 | 2018-08-21 | Retrotope, Inc. | Alleviating oxidative stress disorders with PUFA derivatives |
| US20140038186A1 (en) * | 2010-02-22 | 2014-02-06 | Tapan Kumar Khan | Alzheimer's disease-specific alterations of protein kinase c epsilon (pkc-epsilon) protein levels |
| US20120027687A1 (en) | 2010-07-08 | 2012-02-02 | Alkon Daniel L | Fatty acid protein kinase c activators and anticoagulant for the treatment of stroke |
| EP2605773A1 (en) | 2010-08-19 | 2013-06-26 | Blanchette Rockefeller Neurosciences, Institute | Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators |
| WO2012148930A2 (en) | 2011-04-26 | 2012-11-01 | Retrotope, Inc. | Oxidative retinal diseases |
| JP6106157B2 (ja) | 2011-04-26 | 2017-03-29 | レトロトップ、 インコーポレイテッドRetrotope, Inc. | 神経変性障害および筋疾患に関与するpufa |
| JP6145087B2 (ja) * | 2011-04-26 | 2017-06-07 | レトロトップ、 インコーポレイテッドRetrotope, Inc. | Pufa酸化関与障害 |
| KR102112087B1 (ko) | 2011-04-26 | 2020-05-18 | 레트로토프 인코포레이티드 | 에너지 프로세싱 손상 장애 및 미토콘드리아 결함 |
| EP2764120B1 (en) | 2011-10-05 | 2020-06-10 | Blanchette Rockefeller Neurosciences, Institute | Stimulus-elicited genomic profile markers of a neurodegenerative condition |
| CA2855932A1 (en) | 2011-11-13 | 2013-05-16 | Blanchette Rockefeller Neurosciences Institute | Pkc activators and combinations thereof |
| EP2780316B1 (en) * | 2011-11-13 | 2020-04-15 | Blanchette Rockefeller Neurosciences Institute | Esters of dcpla and methods of treatment using the same |
| EP2957285B1 (en) * | 2013-02-15 | 2018-01-10 | Nishizaki Bioinformation Research Institute | Phospholipid compound containing unsaturated fatty acid derivative having cyclopropane ring |
| JP2016516201A (ja) * | 2013-03-15 | 2016-06-02 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 神経保護性pkc活性化因子を特定する方法 |
| US9962357B2 (en) | 2013-10-18 | 2018-05-08 | West Virginia University | Halogenated esters of cyclopropanated unsaturated fatty acids for use in the treatment of neurodegenerative diseases |
| MX2016013680A (es) | 2014-04-18 | 2017-07-05 | Neurotrope Bioscience Inc | Métodos y composiciones para el tratamiento de trastornos por el almacenamiento de lípidos. |
| US9413754B2 (en) | 2014-12-23 | 2016-08-09 | Airwatch Llc | Authenticator device facilitating file security |
| US20180217163A1 (en) | 2015-05-11 | 2018-08-02 | Daniel L. Alkon | Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele |
| WO2017053659A1 (en) | 2015-09-23 | 2017-03-30 | Khan Tapan K | Methods for survival and rejuvenation of dermal fibroblasts using pkc activators |
| US20180311209A1 (en) | 2015-10-08 | 2018-11-01 | Cognitive Research Enterprises, Inc. | Dosing regimens of pkc activators |
| EP3950649A1 (en) | 2015-11-23 | 2022-02-09 | Retrotope, Inc. | Site-specific isotopic labeling of 1, 4-diene systems |
| JP6912072B2 (ja) * | 2016-12-14 | 2021-07-28 | 国立大学法人山口大学 | 前頭側頭型認知症の予防又は治療用医薬 |
| WO2018187647A1 (en) | 2017-04-06 | 2018-10-11 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of neurological diseases, disorders, or conditions |
| EP3793543A1 (en) * | 2018-05-18 | 2021-03-24 | Neurotrope Bioscience, Inc. | Methods and compositions for treatment of alzheimer's disease |
| WO2020118282A1 (en) * | 2018-12-07 | 2020-06-11 | The Johns Hopkins University | Methods, compositions and kits for treating multiple sclerosis and other disorders |
| IL295783B2 (en) | 2020-02-21 | 2026-03-01 | Retrotope Inc | Processes for isotopic alteration of polyunsaturated fatty acids and their derivatives |
| US20220133687A1 (en) * | 2020-11-02 | 2022-05-05 | Synaptogenix, Inc. | Methods of treating and preventing neurodegenerative diseases with hgf activating compounds |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
| WO2022170232A1 (en) * | 2021-02-08 | 2022-08-11 | Synaptogenix, Inc. | Treatment of multiple sclerosis using pkc activators |
| WO2022170226A1 (en) * | 2021-02-08 | 2022-08-11 | Synaptogenix, Inc. | Treatment of optic nerve inflammation using pkc activators |
| US20250345400A1 (en) * | 2022-05-18 | 2025-11-13 | Virginia Commonwealth University | Methods for treatment of cognitive impairment in cirrhosis patients |
| WO2025056602A1 (en) | 2023-09-11 | 2025-03-20 | Elastin Biosciences Ltd. | Pharmaceutical compositions and use thereof in treatment of conditions and diseases related to elastin deficiency and/or aging |
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| US6080784A (en) | 1986-06-11 | 2000-06-27 | Procyon Pharmaceuticals, Inc. | Protein kinase C modulators N |
| US5385915A (en) | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
| US5242932A (en) | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
| DK0618968T3 (da) | 1991-12-06 | 2000-04-10 | Max Planck Gesellschaft | Midler til diagnostisering og behandling af Alzheimer's sygdom |
| US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| JPH06279311A (ja) | 1993-03-26 | 1994-10-04 | Sagami Chem Res Center | プロテインキナーゼcアイソザイムの活性化剤 |
| US6107050A (en) | 1993-05-03 | 2000-08-22 | The United States Of America As Represented By The Department Of Health And Human Services | Diagnostic test for alzheimers disease |
| US5976816A (en) | 1993-05-03 | 1999-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | Cell tests for alzheimer's disease |
| US20030108956A1 (en) | 1993-05-03 | 2003-06-12 | Alkon Daniel L. | Cell tests for Alzheimer's disease |
| US7625697B2 (en) | 1994-06-17 | 2009-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for constructing subarrays and subarrays made thereby |
| US5863902A (en) | 1995-01-06 | 1999-01-26 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
| US6303567B1 (en) | 1995-03-14 | 2001-10-16 | Praecis Pharmaceuticals, Inc . | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
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| US6277826B1 (en) | 1996-08-27 | 2001-08-21 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| AU2316797A (en) | 1996-02-29 | 1997-09-16 | Mount Sinai Hospital Corporation | Shc proteins |
| JPH1090263A (ja) | 1996-07-25 | 1998-04-10 | Mclean Hospital Corp:The | アルツハイマー病の診断のためのerk−1およびerk−2の利用 |
| WO2000020867A1 (en) | 1998-10-01 | 2000-04-13 | Alexey Vladimirovich Titievsky | A novel ret-independent signaling pathway for gdnf |
| WO2000070099A2 (en) | 1999-05-19 | 2000-11-23 | Mitokor | Differential gene expression in specific regions of the brain in neurodegenerative diseases |
| WO2001027624A2 (en) | 1999-10-08 | 2001-04-19 | Superarray, Inc. | Compositions and methods for detecting protein modification and enzymatic activity |
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| US6869772B2 (en) | 2000-03-10 | 2005-03-22 | Washington University | Method for labeling individual cells |
| DE60124080T2 (de) | 2000-03-23 | 2007-03-01 | Elan Pharmaceuticals, Inc., San Francisco | Verbindungen und verfahren zur behandlung der alzheimerschen krankheit |
| US6495540B2 (en) | 2000-03-28 | 2002-12-17 | Bristol - Myers Squibb Pharma Company | Lactams as inhibitors of A-β protein production |
| EP1268434A1 (en) | 2000-04-03 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Cyclic lactams as inhibitors of a-beta protein production |
| WO2001077086A1 (en) | 2000-04-11 | 2001-10-18 | Dupont Pharmaceuticals Company | SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| JP2004502664A (ja) | 2000-06-30 | 2004-01-29 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病処置用化合物 |
| WO2002010768A2 (en) | 2000-07-31 | 2002-02-07 | The Regents Of The University Of California | Model for alzheimer's disease and other neurodegenerative diseases |
| JP2004517892A (ja) | 2000-12-13 | 2004-06-17 | ワイス | β−アミロイド産生の複素環スルホンアミド阻害剤 |
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| JP2004517619A (ja) | 2000-12-21 | 2004-06-17 | ノバルティス アクチエンゲゼルシャフト | インターロイキン−1関連遺伝子およびタンパク質 |
| WO2002063005A2 (en) | 2001-02-06 | 2002-08-15 | Incyte Genomics, Inc. | Lipid-associated molecules |
| AU2002254029A1 (en) | 2001-02-27 | 2002-09-12 | Daniel L. Alkon | Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation |
| JP4024554B2 (ja) | 2001-02-27 | 2007-12-19 | 松下電器産業株式会社 | 燃料電池発電システム |
| US6874208B2 (en) | 2001-03-14 | 2005-04-05 | Autoliv Asp, Inc. | Anchoring attachment apparatus |
| BR0210721A (pt) | 2001-06-27 | 2004-07-20 | Elan Pharm Inc | Composto, sal ou éster farmaceuticamente aceitável, método para fabricar um composto, e, método para tratar um paciente que tem, ou para evitar que o paciente adquira uma doença ou condição |
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| WO2004083241A2 (en) | 2003-03-19 | 2004-09-30 | Takeda Pharmaceutical Company Limited | Btc-interacting proteins and use thereof |
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| CA2582270A1 (en) | 2004-11-15 | 2006-05-26 | Blanchette Rockefeller Neurosciences Institute | Abnormalities of phosphatase 2a (pp2a) for diagnosis and treatment of alzheimer's disease |
| WO2007019080A2 (en) | 2005-08-03 | 2007-02-15 | Merck & Co., Inc. | Tricyclic beta-secretase inhibitors for the treatment of alzheimer's disease |
| WO2007044094A1 (en) | 2005-10-11 | 2007-04-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
| EP1934618B1 (en) | 2005-10-11 | 2009-05-13 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio-alzheimer's disease-specific molecular biomarkers (adsmb) |
| US20090029873A1 (en) | 2005-10-11 | 2009-01-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb) |
| WO2007043998A1 (en) | 2005-10-11 | 2007-04-19 | Blanchette Rockefeller Neurosciences Institute | Alzheimer’s disease-specific alterations of the erk1/erk2 phosphorylation ratio |
| US7595167B2 (en) | 2005-10-11 | 2009-09-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio |
| CN101478912A (zh) | 2006-06-21 | 2009-07-08 | 莱克西克医疗技术有限公司 | 评估痴呆与痴呆型紊乱 |
| JP2008143819A (ja) * | 2006-12-08 | 2008-06-26 | Tomoyuki Nishizaki | 酸化ストレス誘導細胞死の抑制剤 |
| EP3332797A3 (en) | 2007-02-09 | 2018-08-01 | Blanchette Rockefeller Neurosciences Institute | Therapeutic effects of bryostatins, bryologs and other related substances on head trauma-induced memory impairment and brain injury |
| US20100209914A1 (en) | 2007-05-25 | 2010-08-19 | Ore Pharmaceuticals , Inc. | Methods, systems, and kits for evaluating multiple sclerosis |
| EP2767541A1 (en) * | 2008-03-03 | 2014-08-20 | Rxbio, Inc. | LPA receptor agonists and antagonists |
| CA2731171C (en) | 2008-07-28 | 2016-10-18 | Blanchette Rockefeller Neurosciences Institute | Pkc-activating compounds for the treatment of neurodegenerative diseases |
-
2009
- 2009-07-28 CA CA2731171A patent/CA2731171C/en not_active Expired - Fee Related
- 2009-07-28 US US12/510,681 patent/US8163800B2/en active Active
- 2009-07-28 JP JP2011521235A patent/JP5653917B2/ja not_active Expired - Fee Related
- 2009-07-28 EP EP19189948.3A patent/EP3586839A1/en not_active Withdrawn
- 2009-07-28 ES ES09790874.3T patent/ES2683021T3/es active Active
- 2009-07-28 EP EP18172435.2A patent/EP3403650A3/en not_active Withdrawn
- 2009-07-28 WO PCT/US2009/051927 patent/WO2010014585A1/en not_active Ceased
- 2009-07-28 EP EP09790874.3A patent/EP2328572B1/en not_active Not-in-force
- 2009-07-28 CA CA2941035A patent/CA2941035A1/en not_active Abandoned
-
2012
- 2012-02-21 US US13/401,459 patent/US9119825B2/en active Active
-
2014
- 2014-09-08 JP JP2014182597A patent/JP2015042643A/ja active Pending
-
2015
- 2015-07-20 US US14/803,762 patent/US10323011B2/en active Active
-
2016
- 2016-03-15 JP JP2016051212A patent/JP6449186B2/ja not_active Expired - Fee Related
-
2018
- 2018-06-12 JP JP2018111869A patent/JP2018168170A/ja active Pending
-
2019
- 2019-05-01 US US16/400,132 patent/US10696644B2/en active Active
-
2020
- 2020-06-17 US US16/903,551 patent/US11390596B2/en active Active
-
2022
- 2022-07-06 US US17/858,204 patent/US11820745B2/en active Active
-
2023
- 2023-10-02 US US18/375,745 patent/US20240025870A1/en not_active Abandoned
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