JP2015143248A5 - - Google Patents
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- Publication number
- JP2015143248A5 JP2015143248A5 JP2015057637A JP2015057637A JP2015143248A5 JP 2015143248 A5 JP2015143248 A5 JP 2015143248A5 JP 2015057637 A JP2015057637 A JP 2015057637A JP 2015057637 A JP2015057637 A JP 2015057637A JP 2015143248 A5 JP2015143248 A5 JP 2015143248A5
- Authority
- JP
- Japan
- Prior art keywords
- unit dose
- dha
- pharmaceutical composition
- composition
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 26
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 15
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims 10
- 229930195729 fatty acid Natural products 0.000 claims 10
- 239000000194 fatty acid Substances 0.000 claims 10
- 150000004665 fatty acids Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims 8
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims 4
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 4
- ITNKVODZACVXDS-YNUSHXQLSA-N ethyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate Chemical compound CCOC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC ITNKVODZACVXDS-YNUSHXQLSA-N 0.000 claims 3
- -1 DHA ester Chemical class 0.000 claims 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 2
- 235000021342 arachidonic acid Nutrition 0.000 claims 2
- 229940114079 arachidonic acid Drugs 0.000 claims 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 claims 1
- 230000007000 age related cognitive decline Effects 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 1
- VCDLWFYODNTQOT-UHFFFAOYSA-N docosahexaenoic acid methyl ester Natural products CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OC VCDLWFYODNTQOT-UHFFFAOYSA-N 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14931009P | 2009-02-02 | 2009-02-02 | |
| US61/149,310 | 2009-02-02 | ||
| US18354809P | 2009-06-02 | 2009-06-02 | |
| US61/183,548 | 2009-06-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548414A Division JP2012516852A (ja) | 2009-02-02 | 2010-02-02 | 認知機能改善および心拍数低下のための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018073345A Division JP2018104477A (ja) | 2009-02-02 | 2018-04-05 | 認知機能改善および心拍数低下のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015143248A JP2015143248A (ja) | 2015-08-06 |
| JP2015143248A5 true JP2015143248A5 (https=) | 2015-12-24 |
Family
ID=42041547
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548414A Withdrawn JP2012516852A (ja) | 2009-02-02 | 2010-02-02 | 認知機能改善および心拍数低下のための方法 |
| JP2015057637A Pending JP2015143248A (ja) | 2009-02-02 | 2015-03-20 | 認知機能改善および心拍数低下のための方法 |
| JP2018073345A Pending JP2018104477A (ja) | 2009-02-02 | 2018-04-05 | 認知機能改善および心拍数低下のための方法 |
| JP2019238726A Pending JP2020050675A (ja) | 2009-02-02 | 2019-12-27 | 認知機能改善および心拍数低下のための方法 |
| JP2022023007A Withdrawn JP2022059063A (ja) | 2009-02-02 | 2022-02-17 | 認知機能改善および心拍数低下のための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548414A Withdrawn JP2012516852A (ja) | 2009-02-02 | 2010-02-02 | 認知機能改善および心拍数低下のための方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018073345A Pending JP2018104477A (ja) | 2009-02-02 | 2018-04-05 | 認知機能改善および心拍数低下のための方法 |
| JP2019238726A Pending JP2020050675A (ja) | 2009-02-02 | 2019-12-27 | 認知機能改善および心拍数低下のための方法 |
| JP2022023007A Withdrawn JP2022059063A (ja) | 2009-02-02 | 2022-02-17 | 認知機能改善および心拍数低下のための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20100203123A1 (https=) |
| EP (2) | EP2391361A1 (https=) |
| JP (5) | JP2012516852A (https=) |
| CN (3) | CN102365087A (https=) |
| AU (2) | AU2016201382A1 (https=) |
| CA (1) | CA2751275A1 (https=) |
| HK (1) | HK1202243A1 (https=) |
| WO (1) | WO2010088700A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| US20110177061A1 (en) * | 2009-07-10 | 2011-07-21 | Martek Biosciences Corporation | Methods of treating and preventing neurological disorders using docosahexaenoic acid |
| CN103732223A (zh) * | 2011-05-19 | 2014-04-16 | 加利福尼亚大学董事会 | 用于认知能力下降的医疗食品 |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
| US20130084272A1 (en) * | 2011-09-29 | 2013-04-04 | Philippe Perrin | Compositions, kits and methods for nutritional supplementation with twelve carbon chain fatty acids and twelve carbon chain acylglycerols |
| CA2903599A1 (en) * | 2013-03-15 | 2014-09-18 | Genspera, Inc. | Methods for making cancer compositions |
| KR102416853B1 (ko) | 2013-12-20 | 2022-07-05 | 마라 리뉴어블즈 코퍼레이션 | 미생물로부터 오일을 회수하는 방법 |
| TR201503136A2 (tr) * | 2015-03-16 | 2016-09-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Dronedaron ve esansiyel yağ asitlerinin farmasötik kompozisyonları. |
| US10851395B2 (en) | 2016-06-10 | 2020-12-01 | MARA Renewables Corporation | Method of making lipids with improved cold flow properties |
| EP3559206B1 (en) | 2016-12-22 | 2025-12-03 | Mara Renewables Corporation | Methods for producing biomass rich in dha, palmitic acid and protein using a eukaryotic microorganism |
| JP7101087B2 (ja) * | 2018-09-05 | 2022-07-14 | 株式会社 伊藤園 | 軽度認知障害に対する緑茶成分の有効性評価方法 |
| FR3092968B1 (fr) * | 2019-02-22 | 2021-05-21 | Microphyt | Complement alimentaire |
| CN114555074A (zh) * | 2019-08-08 | 2022-05-27 | 斯威本科技大学 | 长链多不饱和脂肪酸的用途 |
| KR20220163979A (ko) | 2020-04-03 | 2022-12-12 | 마라 리뉴어블즈 코퍼레이션 | 높은 수준의 오메가-3 지방산을 갖는 미생물 오일 |
| DE102020115238A1 (de) * | 2020-06-09 | 2021-12-09 | Pm-International Ag | Nahrungsergänzungsmittel und Nahrungsmittel |
| EP4176448A1 (en) * | 2020-07-02 | 2023-05-10 | Pear Therapeutics (US), Inc. | Systems, methods, and devices for generating and administering digital therapeutic placebos and shams |
| CA3204546A1 (en) * | 2021-01-15 | 2022-07-21 | Cambridge Cognition Limited | Methods and systems of identifying individuals for perioperative neurocognitive disorder and/or post-viral cognitive impairment |
| EP4637824A1 (en) * | 2023-01-18 | 2025-10-29 | Bioventures, Llc | Method of preventing and treating alzheimer's disease and related dementias with drugs inhibiting the interaction between 14-3-3g protein and hexokinase-1 protein |
| JP2025079778A (ja) * | 2023-11-10 | 2025-05-22 | ダイドーグループホールディングス株式会社 | 生理機能改善用の組成物 |
| WO2025100476A1 (ja) * | 2023-11-10 | 2025-05-15 | 国立大学法人京都大学 | 生理機能改善用の組成物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5407957A (en) | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
| US20050027004A1 (en) * | 1993-06-09 | 2005-02-03 | Martek Biosciences Corporation | Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions |
| CA2164291C (en) * | 1993-06-09 | 2007-10-30 | David John Kyle | Methods and pharmaceutical compositions useful for treating neurological disorders |
| US5928696A (en) | 1994-08-16 | 1999-07-27 | Dr. Frische Gmbh | Process for extracting native products which are not water-soluble from native substance mixtures by centrifugal force |
| AU5346296A (en) * | 1995-04-17 | 1996-11-07 | Japan As Represented By Director-General Of Agency Of Industrial Science And Technology | Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fa tty acids by using the microorganisms |
| JP3985035B2 (ja) * | 1995-09-14 | 2007-10-03 | 独立行政法人産業技術総合研究所 | （ｎ−６）系ドコサペンタエン酸含有油脂ならびに該油脂の製造方法および用途 |
| WO2000050547A1 (en) | 1999-02-26 | 2000-08-31 | Monsanto Company | Process for separating a triglyceride comprising a docosahexaenoic acid residue from a mixture of triglycerides |
| AU2001232786A1 (en) | 2000-01-11 | 2001-07-24 | Monsanto Company | Process for making an enriched mixture of polyunsaturated fatty acid esters |
| RU2336307C2 (ru) | 2000-01-19 | 2008-10-20 | Мартек Биосайнсис Корпорейшн | Способ получения липидов (варианты) и липиды, полученные этим способом |
| EP1272048B1 (en) | 2000-04-12 | 2008-05-21 | Westfalia Separator GmbH | Method for the fractionation of oil and polar lipid-containing native raw materials |
| CA2446059C (en) | 2001-05-14 | 2010-03-23 | Dsm Ip Assets B.V. | Production and use of a polar lipid-rich fraction containing stearidonic acid and gamma linolenic acid from plant seeds and microbes |
| AU2002309856B2 (en) | 2001-05-14 | 2008-10-23 | Dsm Ip Assets B.V. | Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsaturated fatty acids from microbes, genetically modified plant seeds and marine organisms |
| AU2002320251A1 (en) * | 2001-07-05 | 2003-01-21 | Vital Basics, Inc. | Compositions for improving mental performance |
| WO2003092628A2 (en) | 2002-05-03 | 2003-11-13 | Martek Biosciences Corporation | High-quality lipids and methods for producing by enzymatic liberation from biomass |
| US20090054523A1 (en) * | 2005-01-24 | 2009-02-26 | Morten Bryhn | Use of a Fatty Acid Composition Containing DHA for the Production of a Medical Product or a Food Stuff for the Treatment of Amyloidos-Related Diseases |
| US8324276B2 (en) * | 2005-01-24 | 2012-12-04 | Pronova Biopharma Norge As | Fatty acid composition for treatment of alzheimer's disease and cognitive dysfunction |
| WO2006116755A2 (en) * | 2005-04-28 | 2006-11-02 | Trustees Of Tufts College | Synergitic effects of docosahexaenoic acid (dha) and carotenoid absorption of cognitive function |
| EP1888081B1 (en) * | 2005-05-23 | 2016-12-28 | Massachusetts Institute of Technology | Compositions containing pufa and methods of use thereof |
| BRPI0613358A8 (pt) * | 2005-07-08 | 2017-12-26 | Dsm Ip Assets Bv | ácidos de gordura poli - insaturada para o tratamento da demência e condições relacionadas à pré-demência |
| WO2009002145A1 (en) * | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Lipid composition for improving function of brain functioning |
| JP2010532418A (ja) | 2007-06-29 | 2010-10-07 | マーテック バイオサイエンシーズ コーポレーション | 多価不飽和脂肪酸のエステルの製造方法および精製方法 |
| US20110177061A1 (en) * | 2009-07-10 | 2011-07-21 | Martek Biosciences Corporation | Methods of treating and preventing neurological disorders using docosahexaenoic acid |
-
2010
- 2010-02-02 CA CA2751275A patent/CA2751275A1/en not_active Abandoned
- 2010-02-02 CN CN2010800157224A patent/CN102365087A/zh active Pending
- 2010-02-02 JP JP2011548414A patent/JP2012516852A/ja not_active Withdrawn
- 2010-02-02 EP EP10703592A patent/EP2391361A1/en not_active Withdrawn
- 2010-02-02 CN CN201810349154.XA patent/CN108324706A/zh active Pending
- 2010-02-02 CN CN201410152946.XA patent/CN104042600A/zh active Pending
- 2010-02-02 EP EP15162676.9A patent/EP2939671A1/en not_active Withdrawn
- 2010-02-02 US US12/699,009 patent/US20100203123A1/en not_active Abandoned
- 2010-02-02 WO PCT/US2010/022952 patent/WO2010088700A1/en not_active Ceased
-
2012
- 2012-12-13 US US13/713,980 patent/US20130172412A1/en not_active Abandoned
-
2015
- 2015-03-17 HK HK15102730.4A patent/HK1202243A1/xx unknown
- 2015-03-20 JP JP2015057637A patent/JP2015143248A/ja active Pending
-
2016
- 2016-03-03 AU AU2016201382A patent/AU2016201382A1/en not_active Abandoned
-
2017
- 2017-10-10 AU AU2017245327A patent/AU2017245327A1/en not_active Abandoned
-
2018
- 2018-04-05 JP JP2018073345A patent/JP2018104477A/ja active Pending
-
2019
- 2019-12-27 JP JP2019238726A patent/JP2020050675A/ja active Pending
-
2022
- 2022-02-17 JP JP2022023007A patent/JP2022059063A/ja not_active Withdrawn
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