CN102365087A - 改善认知功能和降低心率的方法 - Google Patents
改善认知功能和降低心率的方法 Download PDFInfo
- Publication number
- CN102365087A CN102365087A CN2010800157224A CN201080015722A CN102365087A CN 102365087 A CN102365087 A CN 102365087A CN 2010800157224 A CN2010800157224 A CN 2010800157224A CN 201080015722 A CN201080015722 A CN 201080015722A CN 102365087 A CN102365087 A CN 102365087A
- Authority
- CN
- China
- Prior art keywords
- dha
- acid
- less
- tfa
- still less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810349154.XA CN108324706A (zh) | 2009-02-02 | 2010-02-02 | 改善认知功能和降低心率的方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14931009P | 2009-02-02 | 2009-02-02 | |
| US61/149,310 | 2009-02-02 | ||
| US18354809P | 2009-06-02 | 2009-06-02 | |
| US61/183,548 | 2009-06-02 | ||
| PCT/US2010/022952 WO2010088700A1 (en) | 2009-02-02 | 2010-02-02 | Methods for improving cognitive function and decreasing heart rate |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810349154.XA Division CN108324706A (zh) | 2009-02-02 | 2010-02-02 | 改善认知功能和降低心率的方法 |
| CN201410152946.XA Division CN104042600A (zh) | 2009-02-02 | 2010-02-02 | 改善认知功能和降低心率的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102365087A true CN102365087A (zh) | 2012-02-29 |
Family
ID=42041547
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800157224A Pending CN102365087A (zh) | 2009-02-02 | 2010-02-02 | 改善认知功能和降低心率的方法 |
| CN201810349154.XA Pending CN108324706A (zh) | 2009-02-02 | 2010-02-02 | 改善认知功能和降低心率的方法 |
| CN201410152946.XA Pending CN104042600A (zh) | 2009-02-02 | 2010-02-02 | 改善认知功能和降低心率的方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810349154.XA Pending CN108324706A (zh) | 2009-02-02 | 2010-02-02 | 改善认知功能和降低心率的方法 |
| CN201410152946.XA Pending CN104042600A (zh) | 2009-02-02 | 2010-02-02 | 改善认知功能和降低心率的方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20100203123A1 (https=) |
| EP (2) | EP2391361A1 (https=) |
| JP (5) | JP2012516852A (https=) |
| CN (3) | CN102365087A (https=) |
| AU (2) | AU2016201382A1 (https=) |
| CA (1) | CA2751275A1 (https=) |
| HK (1) | HK1202243A1 (https=) |
| WO (1) | WO2010088700A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| US20110177061A1 (en) * | 2009-07-10 | 2011-07-21 | Martek Biosciences Corporation | Methods of treating and preventing neurological disorders using docosahexaenoic acid |
| CN103732223A (zh) * | 2011-05-19 | 2014-04-16 | 加利福尼亚大学董事会 | 用于认知能力下降的医疗食品 |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
| US20130084272A1 (en) * | 2011-09-29 | 2013-04-04 | Philippe Perrin | Compositions, kits and methods for nutritional supplementation with twelve carbon chain fatty acids and twelve carbon chain acylglycerols |
| CA2903599A1 (en) * | 2013-03-15 | 2014-09-18 | Genspera, Inc. | Methods for making cancer compositions |
| KR102416853B1 (ko) | 2013-12-20 | 2022-07-05 | 마라 리뉴어블즈 코퍼레이션 | 미생물로부터 오일을 회수하는 방법 |
| TR201503136A2 (tr) * | 2015-03-16 | 2016-09-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Dronedaron ve esansiyel yağ asitlerinin farmasötik kompozisyonları. |
| US10851395B2 (en) | 2016-06-10 | 2020-12-01 | MARA Renewables Corporation | Method of making lipids with improved cold flow properties |
| EP3559206B1 (en) | 2016-12-22 | 2025-12-03 | Mara Renewables Corporation | Methods for producing biomass rich in dha, palmitic acid and protein using a eukaryotic microorganism |
| JP7101087B2 (ja) * | 2018-09-05 | 2022-07-14 | 株式会社 伊藤園 | 軽度認知障害に対する緑茶成分の有効性評価方法 |
| FR3092968B1 (fr) * | 2019-02-22 | 2021-05-21 | Microphyt | Complement alimentaire |
| CN114555074A (zh) * | 2019-08-08 | 2022-05-27 | 斯威本科技大学 | 长链多不饱和脂肪酸的用途 |
| KR20220163979A (ko) | 2020-04-03 | 2022-12-12 | 마라 리뉴어블즈 코퍼레이션 | 높은 수준의 오메가-3 지방산을 갖는 미생물 오일 |
| DE102020115238A1 (de) * | 2020-06-09 | 2021-12-09 | Pm-International Ag | Nahrungsergänzungsmittel und Nahrungsmittel |
| EP4176448A1 (en) * | 2020-07-02 | 2023-05-10 | Pear Therapeutics (US), Inc. | Systems, methods, and devices for generating and administering digital therapeutic placebos and shams |
| CA3204546A1 (en) * | 2021-01-15 | 2022-07-21 | Cambridge Cognition Limited | Methods and systems of identifying individuals for perioperative neurocognitive disorder and/or post-viral cognitive impairment |
| EP4637824A1 (en) * | 2023-01-18 | 2025-10-29 | Bioventures, Llc | Method of preventing and treating alzheimer's disease and related dementias with drugs inhibiting the interaction between 14-3-3g protein and hexokinase-1 protein |
| JP2025079778A (ja) * | 2023-11-10 | 2025-05-22 | ダイドーグループホールディングス株式会社 | 生理機能改善用の組成物 |
| WO2025100476A1 (ja) * | 2023-11-10 | 2025-05-15 | 国立大学法人京都大学 | 生理機能改善用の組成物 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5407957A (en) | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
| US20050027004A1 (en) * | 1993-06-09 | 2005-02-03 | Martek Biosciences Corporation | Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions |
| CA2164291C (en) * | 1993-06-09 | 2007-10-30 | David John Kyle | Methods and pharmaceutical compositions useful for treating neurological disorders |
| US5928696A (en) | 1994-08-16 | 1999-07-27 | Dr. Frische Gmbh | Process for extracting native products which are not water-soluble from native substance mixtures by centrifugal force |
| AU5346296A (en) * | 1995-04-17 | 1996-11-07 | Japan As Represented By Director-General Of Agency Of Industrial Science And Technology | Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fa tty acids by using the microorganisms |
| JP3985035B2 (ja) * | 1995-09-14 | 2007-10-03 | 独立行政法人産業技術総合研究所 | (n−6)系ドコサペンタエン酸含有油脂ならびに該油脂の製造方法および用途 |
| WO2000050547A1 (en) | 1999-02-26 | 2000-08-31 | Monsanto Company | Process for separating a triglyceride comprising a docosahexaenoic acid residue from a mixture of triglycerides |
| AU2001232786A1 (en) | 2000-01-11 | 2001-07-24 | Monsanto Company | Process for making an enriched mixture of polyunsaturated fatty acid esters |
| RU2336307C2 (ru) | 2000-01-19 | 2008-10-20 | Мартек Биосайнсис Корпорейшн | Способ получения липидов (варианты) и липиды, полученные этим способом |
| EP1272048B1 (en) | 2000-04-12 | 2008-05-21 | Westfalia Separator GmbH | Method for the fractionation of oil and polar lipid-containing native raw materials |
| CA2446059C (en) | 2001-05-14 | 2010-03-23 | Dsm Ip Assets B.V. | Production and use of a polar lipid-rich fraction containing stearidonic acid and gamma linolenic acid from plant seeds and microbes |
| AU2002309856B2 (en) | 2001-05-14 | 2008-10-23 | Dsm Ip Assets B.V. | Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsaturated fatty acids from microbes, genetically modified plant seeds and marine organisms |
| AU2002320251A1 (en) * | 2001-07-05 | 2003-01-21 | Vital Basics, Inc. | Compositions for improving mental performance |
| WO2003092628A2 (en) | 2002-05-03 | 2003-11-13 | Martek Biosciences Corporation | High-quality lipids and methods for producing by enzymatic liberation from biomass |
| US20090054523A1 (en) * | 2005-01-24 | 2009-02-26 | Morten Bryhn | Use of a Fatty Acid Composition Containing DHA for the Production of a Medical Product or a Food Stuff for the Treatment of Amyloidos-Related Diseases |
| US8324276B2 (en) * | 2005-01-24 | 2012-12-04 | Pronova Biopharma Norge As | Fatty acid composition for treatment of alzheimer's disease and cognitive dysfunction |
| WO2006116755A2 (en) * | 2005-04-28 | 2006-11-02 | Trustees Of Tufts College | Synergitic effects of docosahexaenoic acid (dha) and carotenoid absorption of cognitive function |
| EP1888081B1 (en) * | 2005-05-23 | 2016-12-28 | Massachusetts Institute of Technology | Compositions containing pufa and methods of use thereof |
| BRPI0613358A8 (pt) * | 2005-07-08 | 2017-12-26 | Dsm Ip Assets Bv | ácidos de gordura poli - insaturada para o tratamento da demência e condições relacionadas à pré-demência |
| WO2009002145A1 (en) * | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Lipid composition for improving function of brain functioning |
| JP2010532418A (ja) | 2007-06-29 | 2010-10-07 | マーテック バイオサイエンシーズ コーポレーション | 多価不飽和脂肪酸のエステルの製造方法および精製方法 |
| US20110177061A1 (en) * | 2009-07-10 | 2011-07-21 | Martek Biosciences Corporation | Methods of treating and preventing neurological disorders using docosahexaenoic acid |
-
2010
- 2010-02-02 CA CA2751275A patent/CA2751275A1/en not_active Abandoned
- 2010-02-02 CN CN2010800157224A patent/CN102365087A/zh active Pending
- 2010-02-02 JP JP2011548414A patent/JP2012516852A/ja not_active Withdrawn
- 2010-02-02 EP EP10703592A patent/EP2391361A1/en not_active Withdrawn
- 2010-02-02 CN CN201810349154.XA patent/CN108324706A/zh active Pending
- 2010-02-02 CN CN201410152946.XA patent/CN104042600A/zh active Pending
- 2010-02-02 EP EP15162676.9A patent/EP2939671A1/en not_active Withdrawn
- 2010-02-02 US US12/699,009 patent/US20100203123A1/en not_active Abandoned
- 2010-02-02 WO PCT/US2010/022952 patent/WO2010088700A1/en not_active Ceased
-
2012
- 2012-12-13 US US13/713,980 patent/US20130172412A1/en not_active Abandoned
-
2015
- 2015-03-17 HK HK15102730.4A patent/HK1202243A1/xx unknown
- 2015-03-20 JP JP2015057637A patent/JP2015143248A/ja active Pending
-
2016
- 2016-03-03 AU AU2016201382A patent/AU2016201382A1/en not_active Abandoned
-
2017
- 2017-10-10 AU AU2017245327A patent/AU2017245327A1/en not_active Abandoned
-
2018
- 2018-04-05 JP JP2018073345A patent/JP2018104477A/ja active Pending
-
2019
- 2019-12-27 JP JP2019238726A patent/JP2020050675A/ja active Pending
-
2022
- 2022-02-17 JP JP2022023007A patent/JP2022059063A/ja not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| TREVOR A. MORI ET AL: "Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans", 《HYPERTENSION》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2939671A1 (en) | 2015-11-04 |
| US20100203123A1 (en) | 2010-08-12 |
| EP2391361A1 (en) | 2011-12-07 |
| AU2016201382A1 (en) | 2016-03-24 |
| JP2020050675A (ja) | 2020-04-02 |
| CN104042600A (zh) | 2014-09-17 |
| CN108324706A (zh) | 2018-07-27 |
| JP2015143248A (ja) | 2015-08-06 |
| CA2751275A1 (en) | 2010-08-05 |
| US20130172412A1 (en) | 2013-07-04 |
| AU2010207929A1 (en) | 2011-09-22 |
| JP2012516852A (ja) | 2012-07-26 |
| HK1202243A1 (en) | 2015-09-25 |
| JP2018104477A (ja) | 2018-07-05 |
| JP2022059063A (ja) | 2022-04-12 |
| AU2017245327A1 (en) | 2017-11-02 |
| WO2010088700A1 (en) | 2010-08-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: DISIMAN INTELLECTUAL PROPERTY ASSETS B.V. Free format text: FORMER OWNER: MARTEK BIOSCIENCES CORP. Effective date: 20130220 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20130220 Address after: Holland Heerlen Applicant after: Disiman Intellectual Property Assets B.V. Address before: American Maryland Applicant before: Martek Biosciences Corp. |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120229 |