JP2011529085A5 - - Google Patents
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- Publication number
- JP2011529085A5 JP2011529085A5 JP2011520237A JP2011520237A JP2011529085A5 JP 2011529085 A5 JP2011529085 A5 JP 2011529085A5 JP 2011520237 A JP2011520237 A JP 2011520237A JP 2011520237 A JP2011520237 A JP 2011520237A JP 2011529085 A5 JP2011529085 A5 JP 2011529085A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- group
- nrr
- alkyl
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims description 38
- 125000000217 alkyl group Chemical group 0.000 claims description 34
- 229910052799 carbon Inorganic materials 0.000 claims description 18
- 239000003112 inhibitor Substances 0.000 claims description 18
- 125000005415 substituted alkoxy group Chemical group 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
- 239000000651 prodrug Substances 0.000 claims description 14
- 229940002612 prodrug Drugs 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 14
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 12
- 125000004104 aryloxy group Chemical group 0.000 claims description 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 12
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 12
- 150000001412 amines Chemical class 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 10
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 125000000623 heterocyclic group Chemical group 0.000 claims description 8
- -1 nitro, hydroxy Chemical group 0.000 claims description 8
- 125000003003 spiro group Chemical group 0.000 claims description 8
- 102100034343 Integrase Human genes 0.000 claims description 6
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 239000002777 nucleoside Substances 0.000 claims description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000003107 substituted aryl group Chemical group 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 3
- 229910052757 nitrogen Chemical group 0.000 claims description 3
- XNDAUZRSIAEAAR-HNNXBMFYSA-N (4s)-5-amino-4-[3-[4-(5-methylthiophen-2-yl)phenyl]propanoylamino]-5-oxopentanoic acid Chemical compound S1C(C)=CC=C1C1=CC=C(CCC(=O)N[C@@H](CCC(O)=O)C(N)=O)C=C1 XNDAUZRSIAEAAR-HNNXBMFYSA-N 0.000 claims description 2
- ADDJDJQFPKUMAF-SFHVURJKSA-N (4s)-5-amino-5-oxo-4-[[4-(4-phenylthiophen-2-yl)benzoyl]amino]pentanoic acid Chemical compound C1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N)=CC=C1C1=CC(C=2C=CC=CC=2)=CS1 ADDJDJQFPKUMAF-SFHVURJKSA-N 0.000 claims description 2
- PSUIUGOBEHETNS-UHFFFAOYSA-N 1-carbamimidoyl-1-nitrosoguanidine Chemical compound NC(=N)N(N=O)C(N)=N PSUIUGOBEHETNS-UHFFFAOYSA-N 0.000 claims description 2
- 101001023866 Arabidopsis thaliana Mannosyl-oligosaccharide glucosidase GCS1 Proteins 0.000 claims description 2
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims description 2
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims description 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims description 2
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 claims description 2
- 229940099797 HIV integrase inhibitor Drugs 0.000 claims description 2
- 229940122440 HIV protease inhibitor Drugs 0.000 claims description 2
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims description 2
- 102000014150 Interferons Human genes 0.000 claims description 2
- 108010050904 Interferons Proteins 0.000 claims description 2
- 108010007843 NADH oxidase Proteins 0.000 claims description 2
- 229940087098 Oxidase inhibitor Drugs 0.000 claims description 2
- 229940123066 Polymerase inhibitor Drugs 0.000 claims description 2
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims description 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical class N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 2
- 101800001838 Serine protease/helicase NS3 Proteins 0.000 claims description 2
- 125000004450 alkenylene group Chemical group 0.000 claims description 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 claims description 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 2
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims description 2
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims description 2
- 125000004414 alkyl thio group Chemical group 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- 125000005530 alkylenedioxy group Chemical group 0.000 claims description 2
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims description 2
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims description 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims description 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 2
- 125000005110 aryl thio group Chemical group 0.000 claims description 2
- 125000005164 aryl thioalkyl group Chemical group 0.000 claims description 2
- 125000005242 carbamoyl alkyl group Chemical group 0.000 claims description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000003623 enhancer Substances 0.000 claims description 2
- 229940124784 gp41 inhibitor Drugs 0.000 claims description 2
- 125000004994 halo alkoxy alkyl group Chemical group 0.000 claims description 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 2
- 125000001188 haloalkyl group Chemical group 0.000 claims description 2
- 125000004475 heteroaralkyl group Chemical group 0.000 claims description 2
- 125000001072 heteroaryl group Chemical group 0.000 claims description 2
- 125000005326 heteroaryloxy alkyl group Chemical group 0.000 claims description 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 2
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims description 2
- 125000005368 heteroarylthio group Chemical group 0.000 claims description 2
- 239000003084 hiv integrase inhibitor Substances 0.000 claims description 2
- 239000004030 hiv protease inhibitor Substances 0.000 claims description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 2
- 229940079322 interferon Drugs 0.000 claims description 2
- 230000009545 invasion Effects 0.000 claims description 2
- 238000013160 medical therapy Methods 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 125000004043 oxo group Chemical group O=* 0.000 claims description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 2
- 125000004426 substituted alkynyl group Chemical group 0.000 claims description 2
- 125000000464 thioxo group Chemical group S=* 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 2
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8385508P | 2008-07-25 | 2008-07-25 | |
| US61/083,855 | 2008-07-25 | ||
| US14768109P | 2009-01-27 | 2009-01-27 | |
| US61/147,681 | 2009-01-27 | ||
| US22011009P | 2009-06-24 | 2009-06-24 | |
| US61/220,110 | 2009-06-24 | ||
| PCT/US2009/051741 WO2010011959A1 (en) | 2008-07-25 | 2009-07-24 | Antiviral compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011529085A JP2011529085A (ja) | 2011-12-01 |
| JP2011529085A5 true JP2011529085A5 (enExample) | 2012-09-06 |
Family
ID=41211919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520237A Withdrawn JP2011529085A (ja) | 2008-07-25 | 2009-07-24 | 抗ウイルス化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7998950B2 (enExample) |
| EP (1) | EP2321319B1 (enExample) |
| JP (1) | JP2011529085A (enExample) |
| AR (1) | AR072534A1 (enExample) |
| AT (1) | ATE549335T1 (enExample) |
| AU (1) | AU2009273844A1 (enExample) |
| TW (1) | TW201016698A (enExample) |
| WO (1) | WO2010011959A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110223131A1 (en) | 2010-02-24 | 2011-09-15 | Gilead Sciences, Inc. | Antiviral compounds |
| JP2014034523A (ja) * | 2012-08-07 | 2014-02-24 | Manac Inc | モノまたはジハロゲノピリジルアミン類の製造方法 |
| JP7381190B2 (ja) | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | Ｎ４－ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| CN104628650A (zh) * | 2015-02-02 | 2015-05-20 | 西安近代化学研究所 | 1-(3-氨丙基)-2-甲基咪唑的制备方法 |
| KR102626210B1 (ko) | 2017-12-07 | 2024-01-18 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
| JP2024536868A (ja) | 2021-09-27 | 2024-10-08 | ヤンセン ファーマシューティカ エヌ．ベー． | ベンズイミダゾール及びアザベンズイミダゾールｉｌ－１７阻害剤化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR056918A1 (es) | 2005-01-10 | 2007-11-07 | Tibotec Pharm Ltd | 2-oxo-3-ciano-1,6a-diaza-tetrahidro-fluorantenos 1,5,6-sustituidos, proceso de preparacion del compuesto y composicion farmaceutica |
| JP2009503083A (ja) | 2005-08-04 | 2009-01-29 | スミスクライン ビーチャム コーポレーション | Ｈｉｖインテグラーゼ阻害薬 |
| GB0707708D0 (en) | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
| EP2005995A1 (en) | 2007-06-22 | 2008-12-24 | Glaxo Group Limited | Heterocyclic compounds for the treatment of tuberculosis |
-
2009
- 2009-07-24 AT AT09790816T patent/ATE549335T1/de active
- 2009-07-24 EP EP09790816A patent/EP2321319B1/en not_active Not-in-force
- 2009-07-24 JP JP2011520237A patent/JP2011529085A/ja not_active Withdrawn
- 2009-07-24 US US12/509,250 patent/US7998950B2/en not_active Expired - Fee Related
- 2009-07-24 WO PCT/US2009/051741 patent/WO2010011959A1/en not_active Ceased
- 2009-07-24 AR ARP090102836A patent/AR072534A1/es unknown
- 2009-07-24 AU AU2009273844A patent/AU2009273844A1/en not_active Abandoned
- 2009-07-24 TW TW098125063A patent/TW201016698A/zh unknown