JP2011528706A5 - - Google Patents
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- Publication number
- JP2011528706A5 JP2011528706A5 JP2011519228A JP2011519228A JP2011528706A5 JP 2011528706 A5 JP2011528706 A5 JP 2011528706A5 JP 2011519228 A JP2011519228 A JP 2011519228A JP 2011519228 A JP2011519228 A JP 2011519228A JP 2011528706 A5 JP2011528706 A5 JP 2011528706A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- cor
- alkyl group
- nhcor
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0813339A GB0813339D0 (en) | 2008-07-21 | 2008-07-21 | Novel reagents and method for conjugating biological molecules |
| GB0813339.9 | 2008-07-21 | ||
| GB0905762A GB0905762D0 (en) | 2009-04-02 | 2009-04-02 | Novel reagents and method for conjugating biological molecules |
| GB0905762.1 | 2009-04-02 | ||
| PCT/GB2009/001764 WO2010010324A1 (en) | 2008-07-21 | 2009-07-17 | Novel reagents and method for conjugating biological molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011180530A Division JP5626655B2 (ja) | 2008-07-21 | 2011-08-22 | 生体分子を接合するための新規な試薬及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528706A JP2011528706A (ja) | 2011-11-24 |
| JP2011528706A5 true JP2011528706A5 (OSRAM) | 2014-06-26 |
| JP5622117B2 JP5622117B2 (ja) | 2014-11-12 |
Family
ID=41226122
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519228A Expired - Fee Related JP5622117B2 (ja) | 2008-07-21 | 2009-07-17 | 生体分子を接合するための新規な試薬及び方法 |
| JP2011180530A Expired - Fee Related JP5626655B2 (ja) | 2008-07-21 | 2011-08-22 | 生体分子を接合するための新規な試薬及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011180530A Expired - Fee Related JP5626655B2 (ja) | 2008-07-21 | 2011-08-22 | 生体分子を接合するための新規な試薬及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8969626B2 (OSRAM) |
| EP (2) | EP2326349B1 (OSRAM) |
| JP (2) | JP5622117B2 (OSRAM) |
| KR (1) | KR101763559B1 (OSRAM) |
| CN (1) | CN102099058B (OSRAM) |
| AU (1) | AU2009275358C1 (OSRAM) |
| DK (2) | DK2326349T3 (OSRAM) |
| ES (2) | ES2560807T3 (OSRAM) |
| PL (1) | PL2326349T3 (OSRAM) |
| WO (1) | WO2010010324A1 (OSRAM) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| CN101557830B (zh) | 2006-12-15 | 2016-06-08 | 巴克斯特国际公司 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
| US8969626B2 (en) * | 2008-07-21 | 2015-03-03 | Polytherics Limited | Reagents and method for conjugating biological molecules |
| EP2403538B1 (en) | 2009-03-04 | 2017-10-04 | Polytherics Limited | Conjugated proteins and peptides |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| CA2769244A1 (en) | 2009-07-27 | 2011-02-03 | Lipoxen Technologies Limited | Glycopolysialylation of non-blood coagulation proteins |
| CN104530182A (zh) | 2009-07-27 | 2015-04-22 | 利普森技术有限公司 | 非凝血蛋白的糖基多唾液酸化 |
| RU2595442C2 (ru) | 2009-07-27 | 2016-08-27 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| GB201007357D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| BR112013006861A2 (pt) * | 2010-09-21 | 2019-07-02 | Cristal Delivery B V | ligante para ser utilizado em um sistema de liberação de fármaco, composto compreendendo um ligante, uso de um composto, sistema de liberação controlada e método para preparar um sistema de liberação controlada |
| BR112013015898A2 (pt) | 2010-12-22 | 2018-06-26 | Baxter International Inc. | derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada. |
| CA2836478A1 (en) * | 2011-05-27 | 2012-12-06 | Baxter International Inc. | Therapeutic protein conjugated to water-soluble polymers via reduced cysteine sulfhydryl group |
| JP5841768B2 (ja) * | 2011-08-05 | 2016-01-13 | 花王株式会社 | 脂肪蓄積抑制剤 |
| AP2014008049A0 (en) | 2012-04-16 | 2014-11-30 | Cantab Biopharmaceuticals Patents Ltd | Optimised subcuraneous therapeutic agents |
| GB201210770D0 (en) * | 2012-06-18 | 2012-08-01 | Polytherics Ltd | Novel conjugation reagents |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
| CA2902872A1 (en) | 2013-03-15 | 2014-09-18 | Regeneron Pharmaceuticals, Inc. | Biologically active molecules, conjugates thereof, and therapeutic uses |
| AU2014228489B2 (en) | 2013-03-15 | 2018-11-15 | Zymeworks Bc Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| MX373528B (es) | 2013-08-26 | 2020-04-21 | Regeneron Pharma | Composiciones farmacéuticas que contienen diasterómeros macrólidos, métodos para su síntesis y usos terapéuticos. |
| KR102384740B1 (ko) | 2013-12-27 | 2022-04-07 | 자임워크스 인코포레이티드 | 약물 접합체를 위한 설폰아마이드-함유 연결 시스템 |
| HRP20191335T1 (hr) | 2014-03-11 | 2019-10-18 | Regeneron Pharmaceuticals, Inc. | Anti-egfrviii antitijela i njihove primjene |
| RS62860B1 (sr) | 2014-09-17 | 2022-02-28 | Zymeworks Inc | Citotoksična i antimitotička jedinjenja, i postupci upotrebe istih |
| JP2017534612A (ja) | 2014-10-14 | 2017-11-24 | ポリセリックス・リミテッド | Ｐｅｇの部分を含めた脱離基を含む試薬を用いるペプチド又はタンパク質のコンジュゲーションのための方法 |
| BR112017020149A8 (pt) | 2015-03-27 | 2023-05-02 | Regeneron Pharma | Derivados de maitansinoide, conjugados dos mesmos e métodos de uso |
| CN107849131A (zh) | 2015-07-06 | 2018-03-27 | 瑞泽恩制药公司 | 多特异性抗原结合分子及其用途 |
| MA43416A (fr) | 2015-12-11 | 2018-10-17 | Regeneron Pharma | Méthodes pour ralentir ou empêcher la croissance de tumeurs résistantes au blocage de l'egfr et/ou d'erbb3 |
| EA039072B9 (ru) | 2016-01-25 | 2022-02-04 | Регенерон Фармасьютикалз, Инк. | Производные майтанзиноида, их конъюгаты и способы применения |
| CN109153711B (zh) * | 2016-03-01 | 2022-04-26 | 伊利诺伊大学理事会 | 具有降低的l-谷氨酰胺酶活性和增强的稳定性的l-天冬酰胺酶变体和融合蛋白 |
| EP3448891A1 (en) | 2016-04-28 | 2019-03-06 | Regeneron Pharmaceuticals, Inc. | Methods of making multispecific antigen-binding molecules |
| EP3478324A1 (en) | 2016-07-01 | 2019-05-08 | GlaxoSmithKline Intellectual Property (No.2) Limited | Antibody-drug conjugates and therapeutic methods using the same |
| EP4273172A3 (en) | 2016-09-23 | 2024-02-28 | Regeneron Pharmaceuticals, Inc. | Bi specific anti-muc16-cd3 antibodies and anti-muc16 drug conjugates |
| MX2019003325A (es) | 2016-09-23 | 2019-08-05 | Regeneron Pharma | Anticuerpos anti-steap2, conjugados anticuerpo-farmaco, y moleculas de fijacion al antigeno biespecificas que se fijan a steap2 y cd3, y usos de estos. |
| MX394528B (es) | 2016-11-08 | 2025-03-24 | Regeneron Pharma | Esteroides y conjugados de proteinas de los mismos. |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
| KR20250008984A (ko) | 2017-05-18 | 2025-01-16 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| EP3635009A1 (en) | 2017-06-07 | 2020-04-15 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for internalizing enzymes |
| SG11202004151YA (en) | 2017-11-07 | 2020-06-29 | Regeneron Pharma | Hydrophilic linkers for antibody drug conjugates |
| CA3086926A1 (en) | 2018-01-08 | 2019-07-11 | Regeneron Pharmaceuticals, Inc. | Steroids and antibody-conjugates thereof |
| MX2020011487A (es) | 2018-04-30 | 2020-12-07 | Regeneron Pharma | Anticuerpos y moleculas biespecificas de union al antigeno que se unen a her2 y/o aplp2, conjugados y usos de estos. |
| SG11202010909RA (en) | 2018-05-09 | 2020-12-30 | Regeneron Pharma | Anti-msr1 antibodies and methods of use thereof |
| EP3793591A1 (en) | 2018-05-17 | 2021-03-24 | Regeneron Pharmaceuticals, Inc. | Anti-cd63 antibodies, conjugates, and uses thereof |
| AU2019403404B2 (en) | 2018-12-21 | 2025-05-29 | Regeneron Pharmaceuticals, Inc. | Rifamycin analogs and antibody-drug conjugates thereof |
| CN113727757A (zh) | 2019-02-21 | 2021-11-30 | 瑞泽恩制药公司 | 使用结合met的抗-met抗体和双特异性抗原结合分子治疗眼癌的方法 |
| WO2021055350A1 (en) | 2019-09-16 | 2021-03-25 | Regeneron Pharmaceuticals, Inc. | Radiolabeled met binding proteins for immuno-pet imaging |
| US11814428B2 (en) | 2019-09-19 | 2023-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-PTCRA antibody-drug conjugates and uses thereof |
| CA3166619A1 (en) | 2020-02-28 | 2021-09-02 | Julian Andreev | Bispecific antigen binding molecules that bind her2, and methods of use thereof |
| CA3179154A1 (en) | 2020-04-16 | 2021-10-21 | Regeneron Pharmaceuticals, Inc. | Diels-alder conjugation methods |
| BR112023000489A2 (pt) | 2020-07-13 | 2023-03-28 | Regeneron Pharma | Análogos de camptotecina conjugados a um resíduo de glutamina em uma proteína, e seu uso |
| AU2021339892A1 (en) | 2020-09-14 | 2023-04-27 | Regeneron Pharmaceuticals, Inc. | Antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof |
| CA3190569A1 (en) | 2020-10-22 | 2022-04-28 | Christopher Daly | Anti-fgfr2 antibodies and methods of use thereof |
| CN113461929B (zh) * | 2021-07-13 | 2023-04-21 | 浙江倍合德制药有限公司 | 一种tpgs系列产品的精制提纯方法 |
| JP2025502147A (ja) | 2022-01-12 | 2025-01-24 | リジェネロン ファーマシューティカルズ，インク． | タンパク質中のグルタミン残基にコンジュゲートしたカンプトテシンアナログおよびその使用 |
| EP4489855A1 (en) | 2022-03-11 | 2025-01-15 | Regeneron Pharmaceuticals, Inc. | Anti-glp1r antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof |
| AU2023310999A1 (en) | 2022-07-21 | 2025-01-23 | Firefly Bio, Inc. | Glucocorticoid receptor agonists and conjugates thereof |
| AU2023407365A1 (en) | 2022-12-21 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Prodrugs of topoisomerase i inhibitor for adc conjugations and methods of use thereof |
| WO2024229105A1 (en) | 2023-05-02 | 2024-11-07 | Regeneron Pharmaceuticals, Inc. | Anti-human m-cadherin (cdh15) antibodies, conjugates, and uses thereof for delivery of genetic payloads to muscle cells |
| WO2025014533A1 (en) | 2023-07-10 | 2025-01-16 | Regeneron Pharmaceuticals, Inc. | Anti-human cacng1 antibody-drug conjugates and uses thereof |
| WO2025096921A1 (en) | 2023-11-03 | 2025-05-08 | Regeneron Pharmaceuticals, Inc. | Peptide acids as a glp1r agonist and antibody-drug conjugates thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US147443A (en) * | 1874-02-10 | Improvement in lamp-extinguishers | ||
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US5414135A (en) | 1991-12-30 | 1995-05-09 | Sterling Winthrop Inc. | Vinyl sulfone coupling of polyoxyalkylenes to proteins |
| US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| US5877224A (en) | 1995-07-28 | 1999-03-02 | Rutgers, The State University Of New Jersey | Polymeric drug formulations |
| GB9713979D0 (en) | 1997-07-03 | 1997-09-10 | Univ Nottingham | Method for attaching peg to macromolecules |
| US6958212B1 (en) * | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| US6828412B1 (en) | 1999-09-03 | 2004-12-07 | School Of Pharmacy, University Of London | Degradable polymers |
| AU7025600A (en) | 1999-09-08 | 2001-04-10 | School Of Pharmacy, University Of London, The | Uniform molecular weight polymers |
| KR101025143B1 (ko) | 2002-12-31 | 2011-04-01 | 넥타르 테라퓨틱스 | 가수분해상으로 안정한 말레이미드－종결 중합체 |
| JP4009721B2 (ja) * | 2003-05-23 | 2007-11-21 | 独立行政法人産業技術総合研究所 | イオン結合性ポリマー含有基板、該基板を含有する検出用センサー及び病原菌又は病原菌が生産する毒素の検出方法 |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| US20060147443A1 (en) | 2004-12-22 | 2006-07-06 | Kuros Biosurgery Ag | Synthetic biomaterials having incorporated therein bioactive factors through enzymatically degradable linkages |
| EP2209494B1 (en) | 2007-10-09 | 2016-07-20 | Polytherics Limited | Novel conjugated proteins and peptides |
| US8969626B2 (en) | 2008-07-21 | 2015-03-03 | Polytherics Limited | Reagents and method for conjugating biological molecules |
| EP2403538B1 (en) | 2009-03-04 | 2017-10-04 | Polytherics Limited | Conjugated proteins and peptides |
| GB0912485D0 (en) | 2009-07-17 | 2009-08-26 | Polytherics Ltd | Improved conjugation method |
-
2009
- 2009-07-17 US US13/055,455 patent/US8969626B2/en not_active Expired - Fee Related
- 2009-07-17 CN CN200980128495.3A patent/CN102099058B/zh not_active Expired - Fee Related
- 2009-07-17 ES ES11171786.4T patent/ES2560807T3/es active Active
- 2009-07-17 PL PL09784718T patent/PL2326349T3/pl unknown
- 2009-07-17 DK DK09784718.0T patent/DK2326349T3/en active
- 2009-07-17 KR KR1020117003833A patent/KR101763559B1/ko not_active Expired - Fee Related
- 2009-07-17 ES ES09784718.0T patent/ES2536882T3/es active Active
- 2009-07-17 EP EP09784718.0A patent/EP2326349B1/en not_active Not-in-force
- 2009-07-17 AU AU2009275358A patent/AU2009275358C1/en not_active Ceased
- 2009-07-17 WO PCT/GB2009/001764 patent/WO2010010324A1/en not_active Ceased
- 2009-07-17 JP JP2011519228A patent/JP5622117B2/ja not_active Expired - Fee Related
- 2009-07-17 DK DK11171786.4T patent/DK2374481T3/en active
- 2009-07-17 EP EP11171786.4A patent/EP2374481B1/en not_active Not-in-force
-
2011
- 2011-07-01 US US13/175,820 patent/US8618333B2/en not_active Expired - Fee Related
- 2011-08-22 JP JP2011180530A patent/JP5626655B2/ja not_active Expired - Fee Related
-
2013
- 2013-11-21 US US14/086,702 patent/US9896412B2/en not_active Expired - Fee Related
-
2015
- 2015-02-04 US US14/614,152 patent/US20150148544A1/en not_active Abandoned
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