JP2011528555A - 高齢の動物の生活の質を向上させるための方法 - Google Patents

高齢の動物の生活の質を向上させるための方法 Download PDF

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JP2011528555A
JP2011528555A JP2011518956A JP2011518956A JP2011528555A JP 2011528555 A JP2011528555 A JP 2011528555A JP 2011518956 A JP2011518956 A JP 2011518956A JP 2011518956 A JP2011518956 A JP 2011518956A JP 2011528555 A JP2011528555 A JP 2011528555A
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ヤムカ,ライアン・マイケル
フリーセン,キム・ジーン
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ヒルズ・ペット・ニュートリシャン・インコーポレーテッド
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/142Amino acids; Derivatives thereof
    • A23K20/147Polymeric derivatives, e.g. peptides or proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/158Fatty acids; Fats; Products containing oils or fats
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/20Feeding-stuffs specially adapted for particular animals for horses
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/40Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Birds (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
JP2011518956A 2008-07-18 2009-07-20 高齢の動物の生活の質を向上させるための方法 Pending JP2011528555A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/176,331 2008-07-18
US12/176,331 US8252742B2 (en) 2004-12-30 2008-07-18 Methods for enhancing the quality of life of a senior animal
PCT/US2009/051114 WO2010009458A1 (en) 2008-07-18 2009-07-20 Methods for enhancing the quality of life of a senior animal

Related Child Applications (1)

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JP2014255730A Division JP6178302B2 (ja) 2008-07-18 2014-12-18 高齢の動物の生活の質を向上させるための方法

Publications (2)

Publication Number Publication Date
JP2011528555A true JP2011528555A (ja) 2011-11-24
JP2011528555A5 JP2011528555A5 (https=) 2012-08-30

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JP2011518956A Pending JP2011528555A (ja) 2008-07-18 2009-07-20 高齢の動物の生活の質を向上させるための方法
JP2014255730A Active JP6178302B2 (ja) 2008-07-18 2014-12-18 高齢の動物の生活の質を向上させるための方法

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Country Status (10)

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US (3) US8252742B2 (https=)
EP (2) EP2315533A1 (https=)
JP (2) JP2011528555A (https=)
CN (2) CN102186359B (https=)
AU (1) AU2009270702B2 (https=)
BR (1) BRPI0915979A8 (https=)
CA (1) CA2731069C (https=)
RU (1) RU2513698C2 (https=)
WO (1) WO2010009458A1 (https=)
ZA (1) ZA201101282B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017159741A1 (ja) * 2016-03-16 2017-09-21 味の素株式会社 行動体力向上剤

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005322887B2 (en) * 2004-12-30 2010-03-11 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
US8252742B2 (en) 2004-12-30 2012-08-28 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
JP2013528800A (ja) * 2010-05-12 2013-07-11 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド ネコの炎症を診断、抑制および予防し、炎症状態を緩和するための方法
CN102884434B (zh) * 2010-05-12 2015-08-19 希尔氏宠物营养品公司 用于诊断、控制和预防犬科动物炎症及减轻犬科动物炎性病况的方法
WO2012087486A1 (en) * 2010-12-20 2012-06-28 Hill's Pet Nutrition, Inc. Pet food compositions for inducing a satiety response
WO2012141316A1 (ja) 2011-04-13 2012-10-18 味の素株式会社 栄養組成物
US20130059028A1 (en) * 2011-09-01 2013-03-07 Julie Marie Foy Compositions and Methods for Providing a Life-Stage-Appropriate Animal Diet
MX369318B (es) 2013-11-12 2019-11-05 Hills Pet Nutrition Inc Mejorar el nivel de hidratacion en un gato.
WO2015188198A2 (en) * 2014-06-06 2015-12-10 Berg Llc Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta
CN104026404B (zh) * 2014-06-10 2016-02-24 贵州省台江县禹洋农业发展有限公司 一种老年期犬粮
AU2016219070B2 (en) 2015-02-13 2020-06-11 Mars, Incorporated Pet food feeding system
CN104982668B (zh) * 2015-07-21 2016-08-17 广州市优百特饲料科技有限公司 一种功能性脂肪粉及其制备方法
GB201522304D0 (en) * 2015-12-17 2016-02-03 Mars Inc Food product for reducing muscle breakdown
BR112018076320B1 (pt) * 2016-12-15 2023-03-07 Société des Produits Nestlé S.A. Composição alimentícia para animais de estimação, seu uso, e método não-terapêutico para aumentar a absorção de aminoácidos em um canino
MX383445B (es) 2016-12-27 2025-03-13 Hills Pet Nutrition Inc Star Composiciones alimenticias para mascotas.
US20180245747A1 (en) * 2017-02-28 2018-08-30 Abl Ip Holding Llc Autonomous electronics platform for light fixtures with integral thermal management
CN107184598A (zh) * 2017-04-28 2017-09-22 深圳市众康动保科技有限公司 一种宠物用心脏病复方片剂
GB201721627D0 (en) 2017-12-21 2018-02-07 Mars Inc Pet food product
EP4586824A1 (en) * 2022-09-14 2025-07-23 Société des Produits Nestlé S.A. Compositions and methods utilizing southern ocean mackerel oil for providing health benefits in an animal
WO2024069273A1 (en) * 2022-09-30 2024-04-04 Societe Des Produits Nestle Sa Methods for providing health benefits in animals

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003529347A (ja) * 2000-01-25 2003-10-07 ジュヴェノン インコーポレイテッド 高齢ペット用の栄養補給食品
JP2004519241A (ja) * 2001-03-09 2004-07-02 ソシエテ デ プロデユイ ネツスル ソシエテ アノニム 高齢化に伴う生理的障害を改善し寿命を延ばす組成物
WO2006074089A2 (en) * 2004-12-30 2006-07-13 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
WO2007062325A1 (en) * 2005-11-18 2007-05-31 Hill's Pet Nutrition, Inc. Methods for reducing the amount of proinflammatory substance in animal tissue or body fluid
WO2007088046A2 (en) * 2006-02-01 2007-08-09 Nestec S.A. Nutritional system and methods for increasing longevity
JP2007524402A (ja) * 2003-07-03 2007-08-30 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド コンパニオン動物における精神活動の加齢劣化を減少させる組成物及び方法
WO2008018043A2 (en) * 2006-08-09 2008-02-14 The Iams Company Methods of improving bone health and muscle health
JP2008511332A (ja) * 2004-08-30 2008-04-17 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド ゲノムベースのダイエットデザイン
JP2008519838A (ja) * 2004-11-09 2008-06-12 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 遺伝子調節のための酸化防止剤の使用
JP2008521819A (ja) * 2004-11-24 2008-06-26 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 動物における免疫応答を増大させる方法

Family Cites Families (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2980716A (en) * 1954-06-11 1961-04-18 Research Corp Method for preparing 6, 8-dihalooctanoic esters
US3202414A (en) 1962-01-15 1965-08-24 Gen Motors Corp Vehicle door actuator
US3202514A (en) * 1963-07-15 1965-08-24 Gen Foods Corp Animal food and method of making the same
US6090414A (en) * 1970-05-20 2000-07-18 Life Science Labs, Inc. Method and composition to reduce cancer incidence
US3946123A (en) * 1975-03-10 1976-03-23 Star-Kist Foods, Inc. Canned pet food
US4053647A (en) 1975-12-12 1977-10-11 Samuel Prussin Pet food product and process of producing such
JPS5519090Y2 (https=) 1976-06-14 1980-05-06
AU524005B2 (en) 1978-07-05 1982-08-26 Jerky Treats Inc. Meat containing animal biscuit or kibble
US4247562A (en) * 1978-12-21 1981-01-27 The Quaker Oats Company Moist pet food with blood chunks and a fluid gravy system
JPS57132849A (en) 1981-02-12 1982-08-17 Sanwa Kagaku Kenkyusho:Kk Preparation of aseptic health feed
JPS57132849U (https=) 1981-02-14 1982-08-19
US5004624A (en) * 1983-03-14 1991-04-02 Star-Kist Foods, Inc. Semi-moist pet food having free gravy and process for preparation thereof
AU601992B2 (en) * 1986-06-21 1990-09-27 Dainippon Ink And Chemicals Inc. Isoliquiritigenin for the treatment of kidney and liver diseases
US5030458A (en) * 1989-11-27 1991-07-09 Shug Austin L Method for preventing diet-induced carnitine deficiency in domesticated dogs and cats
US4997672A (en) * 1987-03-10 1991-03-05 Virginia Commonwealth University Salt taste enhancer
DE58902094D1 (de) * 1988-01-28 1992-10-01 Koeltringer Peter Kombinationspraeparat zur behandlung von nervenzell-und nervenfasererkrankungen und verletzungen.
US6977167B2 (en) * 1988-09-07 2005-12-20 Martek Biosciences Corporation Mixtures of omega-3 and omega-6 highly unsaturated fatty acids from euryhaline microorganisms
US4997671A (en) * 1988-09-09 1991-03-05 Nabisco Brands, Inc. Chewy dog snacks
US5114704A (en) * 1989-05-30 1992-05-19 Nabisco Brands, Inc. Raw hide having a coating containing an inorganic pyrophosphate
PT95826B (pt) * 1989-11-09 1997-11-28 Asta Medica Ag Processo para a preparacao de composicoes farmaceuticas contendo como ingrediente activo acido r-alfa-liponico ou acido s-alfa-liponico
US6746678B1 (en) * 1991-02-22 2004-06-08 Howard K. Shapiro Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments
US5419283A (en) * 1992-04-08 1995-05-30 Ciuffo Gatto S.R.L. Animal chew toy of starch material and degradable ethylene copolymer
US5569670A (en) 1992-06-05 1996-10-29 Asta Medica Aktiengesellschaft Combination medications containing alpha-lipoic acid and related
US5624896A (en) * 1992-06-09 1997-04-29 Neorx Corporation Clearing agents useful in pretargeting methods
US5292538A (en) * 1992-07-22 1994-03-08 Metagenics, Inc. Improved sustained energy and anabolic composition and method of making
DE4235912C2 (de) 1992-10-23 2002-12-05 Viatris Gmbh Verfahren zur Herstellung kristalliner Thioctsäure und deren Verwendung
JP3347381B2 (ja) * 1993-01-27 2002-11-20 協和醗酵工業株式会社 ペットフード
US5532010A (en) * 1993-05-28 1996-07-02 Nabisco, Inc. Coated canine biscuits and preparation process
US5339771A (en) * 1993-09-15 1994-08-23 Axelrod Herbert R Animal chew toy containing animal meal
CA2176709A1 (en) * 1993-11-15 1995-05-26 Howard R. Higley Method of treating renal disease by administering igf-i and igfbp-3
CA2147109A1 (en) 1994-04-18 1995-10-19 Gregory A. Reinhart Pet food product containing omega-6 and omega-3 fatty acids and process for reducing inflammatory skin responses
US7105607B2 (en) * 1994-04-19 2006-09-12 Applied Elastomerics, Inc. Tear resistant gels, composites, and articles
US6458767B1 (en) 1994-05-04 2002-10-01 The Uab Research Foundation Use of peptides inhibitory for thrombospondin dependent TGF-β activation in the treatment of kidney disease
DE4427079C2 (de) * 1994-07-30 2002-12-19 Viatris Gmbh Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure
US5976548A (en) 1994-11-08 1999-11-02 Viva America Marketing, Inc. Nutritional supplement composition and use
US5599835A (en) * 1994-11-23 1997-02-04 Fischer; Frederick B. Use of DL-lipoic acid as a medical food in the treatment of diabetes mellitus
US5730988A (en) * 1995-04-20 1998-03-24 Lynntech, Inc. Nutritional supplements for improving glucose metabolism
US6184227B1 (en) * 1995-07-21 2001-02-06 Savvipharm Inc. Salts of aminoimidazole carboxamide useful in the prevention and treatment of liver diseases
FR2738741B1 (fr) * 1995-09-19 1997-12-05 Oreal Composition pour la teinture des fibres keratiniques, contenant un antagoniste de substance p
JP3798464B2 (ja) * 1996-04-09 2006-07-19 株式会社海洋バイオテクノロジー研究所 新規微細藻類及びそれを用いた高度不飽和脂肪酸の製造方法
CA2208392C (en) * 1996-06-21 2002-09-03 University Of Guelph Method for enriching docosahexaenoic acid in expressed milk of dairy cattle
US5977162A (en) 1996-09-16 1999-11-02 Seidman; Michael D. Therapeutic treatment for auditory function
CA2269806C (en) * 1996-10-28 2006-01-24 Bernhard H. Van Lengerich Embedding and encapsulation of controlled release particles
US5976568A (en) 1997-02-21 1999-11-02 Medical Doctors' Research Institute, Inc. Modular system of dietary supplement compositions for optimizing health benefits and methods
US6080788A (en) * 1997-03-27 2000-06-27 Sole; Michael J. Composition for improvement of cellular nutrition and mitochondrial energetics
US6232346B1 (en) * 1997-03-27 2001-05-15 Michael J. Sole Composition for improvement of cellular nutrition and mitochondrial energetics
US6133323A (en) 1997-04-09 2000-10-17 The Iams Company Process for enhancing immune response in animals using β-carotene as a dietary supplement
US5851573A (en) 1997-04-29 1998-12-22 The Iams Company Pet food composition for large breed puppies and method for promoting proper skeletal growth
US6264994B1 (en) * 1997-05-15 2001-07-24 University Of Washington Compositions for treating alzheimer's disease and other amyloidoses
US5883083A (en) * 1997-06-09 1999-03-16 Harlmen, Inc. Dietary supplement for alleviating behavioral problems in canines and reducing seizures in canines and felines
US5916912A (en) * 1997-06-16 1999-06-29 The Regents Of The University Of California Dietary composition for enhancing metabolism and alleviating oxidative stress
DE19726519A1 (de) 1997-06-23 1998-12-24 Asta Medica Ag Verfahren zur Herstellung trockener Thioctsäure
EP0891719A1 (en) 1997-07-14 1999-01-20 N.V. Nutricia Nutritional composition containing methionine
US6039952A (en) 1997-10-22 2000-03-21 The Iams Company Composition and method for improving clinical signs in animals with renal disease
GB9722361D0 (en) 1997-10-24 1997-12-17 Pharma Nord Uk Ltd Pharmaceutical formulation for treating liver disorders
US6365623B1 (en) * 1997-11-17 2002-04-02 Nicholas V. Perricone Treatment of acne using lipoic acid
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
DE19810336A1 (de) 1998-03-11 1999-09-23 Asta Medica Ag Alpha-Liponsäure mit neuartiger Modifikation
US6117477A (en) * 1998-03-18 2000-09-12 Kal Kan Foods, Inc. Multicomponent food product and methods of making and using the same
US6306430B1 (en) * 1998-04-16 2001-10-23 The Iams Company Process for decreasing adiposity using vitamin a as a dietary supplement
RU2131677C1 (ru) 1998-05-05 1999-06-20 Научно-производственная фирма "Аквазинэль" Кормовая добавка "биовитос"
US6492325B1 (en) 1998-05-22 2002-12-10 Boys Town National Research Hospital Use of α1β1 integrin receptor inhibitors and TGF-β1 inhibitors in the treatment of kidney disease
US6197340B1 (en) * 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
JP2000014392A (ja) * 1998-07-07 2000-01-18 Ikeda Shokken Kk 高度不飽和脂肪酸含有グリセリドの製造方法
DE19834608A1 (de) * 1998-07-31 2000-02-03 Basf Ag Kristallmodifikation der Liponsäure
US6136339A (en) 1998-08-21 2000-10-24 Gardiner; Paul T. Food supplements and methods comprising lipoic acid and creatine
IT1302307B1 (it) * 1998-09-01 2000-09-05 Sigma Tau Healthscience Spa Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil
ES2203245T3 (es) 1998-09-02 2004-04-01 Heska Corporation Metodo y composicion para proteger un carnivoro obligado de una enfermedad de metabolismo anormal de carbohidratos.
FR2786100B1 (fr) 1998-11-24 2002-03-01 Aventis Laboratoire Nouvelle application therapeutique de la nicergoline
CA2356174A1 (en) * 1998-12-21 2000-06-29 Monash University Kidney disease detection and treatment
US20040029175A1 (en) * 1998-12-21 2004-02-12 Comper Wayne D. Method for kidney disease detection
AUPP784398A0 (en) * 1998-12-21 1999-01-21 Monash University Kidney disease detection and treatment
US6284786B1 (en) * 1999-02-16 2001-09-04 The Center For The Improvement Of Human Functioning, Int'l., Inc. Treatment of cancer using lipoic acid in combination with ascorbic acid
US6238708B1 (en) 1999-02-23 2001-05-29 The Iams Company Composition and process for controlling glucose metabolism in companion animals by dietary starch
AUPP887399A0 (en) 1999-02-24 1999-03-25 Bartlett Grain Pty Ltd Animal feed formulae for the nutritional enrichment of foodstuffs
PT1033364E (pt) * 1999-03-01 2005-07-29 Pfizer Prod Inc Ciano com acidos oxamicos e derivados como ligandos de receptores de tiroide
IT1306130B1 (it) 1999-04-16 2001-05-30 Sigma Tau Healthscience Spa Composizione comprendente una carnitina e glutatione, atta adaumentare l'assorbimento del glutatione sinergizzandone gli effetti.
EP1179984B2 (en) 1999-05-27 2011-10-05 The Iams Company Process for manufacturing a product for enhancing immune response in companion animal using a combination of antioxidants
US6365211B1 (en) * 1999-06-18 2002-04-02 The Procter & Gamble Co. Cooking aid with reduced foaming
JP4098927B2 (ja) * 1999-08-03 2008-06-11 花王株式会社 油脂組成物
AU7828200A (en) 1999-09-23 2001-04-24 Juvenon Corporation Nutritional supplement for increased energy and stamina
US6426362B1 (en) * 1999-10-08 2002-07-30 Galileo Laboratories, Inc. Formulations of tocopherols and methods of making and using them
HK1050135A1 (zh) * 1999-11-02 2003-06-13 Depomed, Inc. 用於促进将药物给予胃的饭後模式药理学诱导
JP2003513039A (ja) * 1999-11-03 2003-04-08 ジュヴェノン インコーポレイテッド 良性の健忘症を治療する方法
NL1013817C2 (nl) * 1999-12-10 2001-06-12 Stork Mps Bv Coagulatieoplossing voor het laten coaguleren van een collageen.
US6379727B1 (en) * 1999-12-29 2002-04-30 John F. Addy Flavoring system for pet foods
US20030060503A1 (en) * 2000-01-25 2003-03-27 Juvenon, Inc. Nutritional supplements for mature pets
CZ20022927A3 (cs) * 2000-02-01 2003-06-18 Muscletech Research And Development Inc. Doplňky stravy založené na alfa-lipoové kyselině pro zvýšení čisté svalové hmoty a síly
EG22407A (en) * 2000-02-17 2003-01-29 Iams Company Method for improving bone modeling and chondrocyte functioning in growing canines
PE20011109A1 (es) * 2000-03-22 2001-11-27 Nestle Sa Alimento para mascotas dentalmente beneficioso y su metodo de fabricacion
JP4487376B2 (ja) * 2000-03-31 2010-06-23 味の素株式会社 腎疾患治療剤
EP1155627A1 (en) 2000-05-18 2001-11-21 Belovo Eggs & Egg Products Eggs with balanced lipid composition
US6436463B1 (en) * 2000-06-26 2002-08-20 Hill's Pet Nutrition, Inc. Pet food composition and method
WO2002013624A1 (en) 2000-08-10 2002-02-21 Renessen Llc Products comprising corn oil and corn meal obtained from high oil corn
US6592863B2 (en) 2000-08-22 2003-07-15 Nestec S.A. Nutritional composition
CA2424570A1 (en) * 2000-09-07 2002-03-14 University Of Maryland Biotechnology Institute Use of arachidonic acid for enhanced culturing of fish larvae and broodstock
US6784159B2 (en) * 2000-09-29 2004-08-31 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture Triterpene saponins from soybeans for treating kidney disease
US6277842B1 (en) * 2000-10-17 2001-08-21 James Alexander Carthron Dietary supplemental method for fat and weight reduction
US20020052402A1 (en) * 2000-10-31 2002-05-02 Colgate-Palmolive Company Composition and method
US20020115710A1 (en) * 2000-10-31 2002-08-22 Zicker Steven Curtis Composition and method
US8592479B2 (en) * 2000-10-31 2013-11-26 Hill's Pet Nutrition, Inc. Antioxidant-containing food composition for use in enhancing antiviral immunity in companion animals
US20090156658A1 (en) * 2000-10-31 2009-06-18 Hill's Pet Nutrition, Inc. Antioxidant-Containing Food Composition For Use In Inhibiting Histamine Pathways In Companion Animals
US8669282B2 (en) * 2000-10-31 2014-03-11 Hill's Pet Nutrition, Inc. Companion animal compositions including lipoic acid and methods of use thereof
US20020076470A1 (en) * 2000-10-31 2002-06-20 Colgate-Palmolive Company Composition and method
US20020076469A1 (en) * 2000-10-31 2002-06-20 Colgate-Palmolive Company Composition and method
DE60039726D1 (de) * 2000-12-29 2008-09-11 Martin Francis Gannon Tiernahrungsmittelzusammensetzung
US7001610B2 (en) 2001-04-23 2006-02-21 Omeganutrel Inc. Food supplement and use thereof for elevating levels of essential fatty acids in livestock and products therefrom
AU2002303744B2 (en) * 2001-05-14 2008-04-17 Dsm Ip Assets B.V. A method of improving the flavor, tenderness and overall consumer acceptability of poultry meat
US6596762B2 (en) * 2001-05-17 2003-07-22 The Regents Of The University Of Colorado Antioxidant compositions and use for treatment of hepatic steatosis and steatohepatitis
US6596768B2 (en) * 2001-05-22 2003-07-22 Church & Dwight Co., Inc. Unsaturated lipid-enriched feedstock for ruminants
US6902739B2 (en) * 2001-07-23 2005-06-07 Nutracea Methods for treating joint inflammation, pain, and loss of mobility
GB0119052D0 (en) * 2001-08-03 2001-09-26 Mars Uk Ltd Foodstuff
US6923960B2 (en) * 2001-10-03 2005-08-02 Vsl Pharmaceuticals Inc. Antioxidant combination composition and use thereof
GB0129864D0 (en) 2001-12-13 2002-02-06 Danisco Animal feed
US20030190343A1 (en) * 2002-03-05 2003-10-09 Pfizer Inc. Palatable pharmaceutical compositions for companion animals
ES2355890T3 (es) 2002-04-05 2011-04-01 Societe des Produits Nestlé S.A. Composiciones y métodos para promocionar la asimilación de lípidos en los animales domésticos.
US20030194478A1 (en) 2002-04-12 2003-10-16 Davenport Gary Mitchell Dietary methods for canine performance enhancement
US6733793B2 (en) 2002-06-04 2004-05-11 Metaproteomics, Llc Oral composition with insulin-like activities and methods of use
US6572899B1 (en) * 2002-07-03 2003-06-03 Vitacost.Com, Inc. Memory loss treatment formulation
EP1544281B1 (en) 2002-08-07 2016-10-05 Kao Corporation Fat composition
JP2004141130A (ja) 2002-08-28 2004-05-20 Mars Inc 特定の犬種に専用のドッグフード
US6974841B1 (en) 2002-09-27 2005-12-13 Rapisarda Family Irrevocable Trust Pet anti-aging wellness supplement
EP2384750A1 (en) 2002-09-27 2011-11-09 Martek Biosciences Corporation Improved Glycemic Control for Prediabetes and/or Diabetes Type II using Docohexaenoic Acid
US8841344B2 (en) * 2002-10-03 2014-09-23 Hill's Pet Nutrition, Inc. Method of using omega-3 fatty acids
JP3813585B2 (ja) * 2003-01-23 2006-08-23 花王株式会社 ジグリセリドの製造方法
RU2221456C1 (ru) 2003-03-11 2004-01-20 Общество с ограниченной ответственностью "Арсентех" Биологически активное вещество, биологически активная добавка к пище, фармацевтический препарат, биологически активная добавка для кормления животных, ветеринарный препарат, удобрение, активатор микробиологических процессов, пероральное питание, парфюмерно-косметическое средство, гигиеническое средство, молочный продукт, кондитерское изделие, хлебобулочное изделие, масло-жировой продукт, соус, алкогольный напиток, безалкогольный напиток, рыбный продукт, мясной продукт, макаронные изделия, жевательная резинка, пиво
CA2525560A1 (en) * 2003-05-13 2004-11-25 The Regents Of The University Of Colorado Diagnostic and therapeutic treatments related to mitochondrial disorders
US7202270B2 (en) * 2003-06-20 2007-04-10 Sami Labs Limited Convenient stable non-hygroscopic crystalline solid forms of racemic and chiral LA-plus salts: process for their manufacture and uses
US8633247B2 (en) * 2003-08-11 2014-01-21 Hill's Pet Nutrition, Inc. Method for decreasing cartilage damage in dogs
JP4699901B2 (ja) 2003-09-02 2011-06-15 ジェレックスインターナショナル株式会社 体脂肪代謝機能と燃焼エネルギーの活用機能とを備えているダイエット用添加物質
US7078064B2 (en) * 2003-12-03 2006-07-18 George Zabrecky Compositions and methods useful for treating and preventing chronic liver disease, chronic HCV infection and non-alcoholic steatohepatitis
ITMI20040069A1 (it) * 2004-01-21 2004-04-21 Tiberio Bruzzese Uso di composizioni di acidi grassi n-3 ad elevata concentrazione per il trattamento di disturbi del sistema nervoso centrale
AU2005232392B2 (en) 2004-04-16 2011-01-06 Société des Produits Nestlé S.A. Method and compositions for reducing oxidative stress in an animal
US20050266051A1 (en) 2004-05-27 2005-12-01 The Procter & Gamble Company Pet food compositions and methods
US20060002985A1 (en) * 2004-07-02 2006-01-05 Zicker Steven C Compositions and methods for decreasing age-related deterioration in mental activities in companion animals
EP1817058B1 (en) * 2004-11-24 2015-09-02 Hill's Pet Nutrition, Inc. Composition for use in improving liver clearance of xenobiotic substances in an animal
US20090176864A1 (en) * 2004-11-24 2009-07-09 Hill's Pet Nutrition, Inc. Methods For Improving Hepatic and Immune Function In An Animal
US8168161B2 (en) 2004-12-22 2012-05-01 Hill's Pet Nutrition, Inc. Method to promote oral health in companion animals
US8647660B2 (en) * 2004-12-29 2014-02-11 Hill's Pet Nutrition, Inc. Combination of limited nutrients and enhanced dietary antioxidants to impart improved kidney health
CA2592389C (en) * 2004-12-29 2013-05-14 Hill's Pet Nutrition, Inc. Methods for inhibiting a decline in learning and/or memory in animals
US7700139B2 (en) * 2004-12-30 2010-04-20 Commonwealth Scientific And Industrial Research Organization Method and means for improving bowel health
US8252742B2 (en) 2004-12-30 2012-08-28 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
RU2403800C2 (ru) * 2004-12-30 2010-11-20 Хилл`С Пет Ньютришн, Инк. Композиция для кошачьего потребления
JP5240757B2 (ja) * 2005-02-22 2013-07-17 持田製薬株式会社 神経再生促進剤
WO2006117668A1 (en) * 2005-05-04 2006-11-09 Pronova Biopharma Norge As Fatty acid analogues, i.e. dha derivatives for uses as a medicament
EP1896077B1 (en) 2005-06-29 2012-08-15 Hill's Pet Nutrition, Inc. Methods and compositions for the prevention and treatment of inflammatory disease
BRPI0613000A2 (pt) * 2005-07-14 2012-12-04 Hills Pet Nutrition Inc método para aumentar a longevidade de um animal, artigo de fabricação, kit, e, meio de comunicação de informação acerca de ou instruções para a administração a um animal velho de uma composição
CN101287460B (zh) * 2005-08-17 2012-04-25 希尔氏宠物营养品公司 预防和治疗肾病的组合物
WO2007035752A2 (en) * 2005-09-20 2007-03-29 J.R. Simplot Company Low acrylamide foods
RU2400105C2 (ru) * 2005-11-10 2010-09-27 Хилл`С Пет Ньютришн, Инк. Композиции и способы улучшения состояния кожного покрова и шерстного покрова
ZA200805905B (en) * 2005-12-16 2009-10-28 Nutricia Nv Use of soluble dietary fibres against muscle wasting
NZ569068A (en) * 2005-12-20 2011-11-25 Cenestra Llc Omega 3 fatty acid formulations of EPA and DHA
US9265745B2 (en) * 2005-12-21 2016-02-23 Brudy Technology S.L. Use of DHA, EPA or DHA-derived EPA for treating a pathology associated with cellular oxidative damage
FR2903860B1 (fr) * 2006-07-21 2010-12-31 Royal Canin Sa Aliment sec pour reduire l'appetit des chiens
US7282225B1 (en) 2006-09-27 2007-10-16 Occular Technologies, Inc. Composition and methods for improving retinal health
US20110130360A1 (en) * 2006-10-20 2011-06-02 Dow Global Technologies Inc. Preventing or reducing oxidative stress or oxidative cell injury
US20080299286A1 (en) 2007-06-04 2008-12-04 David B Josephson Palatability enhancing compositions and foods for pets, and methods regarding the same
CA2691691C (en) 2007-06-20 2013-09-24 Seth J. Baum Compositions and methods of treating chronic kidney disease
US20080317884A1 (en) 2007-06-22 2008-12-25 Jewell Dennis E Enhancing Disease Resistance In An Animal
WO2009067530A1 (en) * 2007-11-20 2009-05-28 Albion International Inc. Increased protein or energy digestion resulting from inclusion of metal amino acid chelates in animal feed
EP2224930B1 (en) 2008-01-04 2016-06-15 Nestec S.A. Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing congnitive and related functions
CN102170792A (zh) * 2008-07-18 2011-08-31 希尔氏宠物营养品公司 提高老龄动物生活质量的方法

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003529347A (ja) * 2000-01-25 2003-10-07 ジュヴェノン インコーポレイテッド 高齢ペット用の栄養補給食品
JP2004519241A (ja) * 2001-03-09 2004-07-02 ソシエテ デ プロデユイ ネツスル ソシエテ アノニム 高齢化に伴う生理的障害を改善し寿命を延ばす組成物
JP2007524402A (ja) * 2003-07-03 2007-08-30 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド コンパニオン動物における精神活動の加齢劣化を減少させる組成物及び方法
JP2008511332A (ja) * 2004-08-30 2008-04-17 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド ゲノムベースのダイエットデザイン
JP2008519838A (ja) * 2004-11-09 2008-06-12 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 遺伝子調節のための酸化防止剤の使用
JP2008521819A (ja) * 2004-11-24 2008-06-26 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 動物における免疫応答を増大させる方法
WO2006074089A2 (en) * 2004-12-30 2006-07-13 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
WO2007062325A1 (en) * 2005-11-18 2007-05-31 Hill's Pet Nutrition, Inc. Methods for reducing the amount of proinflammatory substance in animal tissue or body fluid
JP2009519899A (ja) * 2005-11-18 2009-05-21 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 動物の組織または体液中の炎症性物質の量を減少させるための方法
WO2007088046A2 (en) * 2006-02-01 2007-08-09 Nestec S.A. Nutritional system and methods for increasing longevity
JP2009536148A (ja) * 2006-02-01 2009-10-08 ネステク ソシエテ アノニム 寿命を伸長するための栄養システム及び方法
WO2008018043A2 (en) * 2006-08-09 2008-02-14 The Iams Company Methods of improving bone health and muscle health

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017159741A1 (ja) * 2016-03-16 2017-09-21 味の素株式会社 行動体力向上剤
JPWO2017159741A1 (ja) * 2016-03-16 2019-01-31 味の素株式会社 行動体力向上剤

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