JP2011528037A - 金属キレート化剤としてのデスアザデスフェリチオシンポリエーテル類似体の新規の塩及び多形体 - Google Patents

金属キレート化剤としてのデスアザデスフェリチオシンポリエーテル類似体の新規の塩及び多形体 Download PDF

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JP2011528037A
JP2011528037A JP2011518838A JP2011518838A JP2011528037A JP 2011528037 A JP2011528037 A JP 2011528037A JP 2011518838 A JP2011518838 A JP 2011518838A JP 2011518838 A JP2011518838 A JP 2011518838A JP 2011528037 A JP2011528037 A JP 2011528037A
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salt
solid composition
polymorph
magnesium
dadft
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JP2011528037A5 (enExample
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エイミー・イー・タッパー
ヒュー・ワイ・リーンホフ
ステファン・ディ・ペアレント
パトリシア・アンドレ
ジェイソン・エイ・ハンコ
フアミン・ジャン
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FerroKin BioScience Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Animal Behavior & Ethology (AREA)
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  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2011518838A 2008-07-14 2009-07-14 金属キレート化剤としてのデスアザデスフェリチオシンポリエーテル類似体の新規の塩及び多形体 Pending JP2011528037A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8057208P 2008-07-14 2008-07-14
US61/080,572 2008-07-14
US15257209P 2009-02-13 2009-02-13
US61/152,572 2009-02-13
PCT/US2009/050532 WO2010009120A2 (en) 2008-07-14 2009-07-14 Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents

Publications (2)

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JP2011528037A true JP2011528037A (ja) 2011-11-10
JP2011528037A5 JP2011528037A5 (enExample) 2012-08-30

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JP2011518838A Pending JP2011528037A (ja) 2008-07-14 2009-07-14 金属キレート化剤としてのデスアザデスフェリチオシンポリエーテル類似体の新規の塩及び多形体

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US (4) US8063227B2 (enExample)
EP (1) EP2303853A4 (enExample)
JP (1) JP2011528037A (enExample)
KR (1) KR20110039347A (enExample)
CN (2) CN102149700A (enExample)
AU (1) AU2009271074B2 (enExample)
CA (1) CA2728636A1 (enExample)
IL (2) IL210294A (enExample)
MX (1) MX2011000486A (enExample)
MY (1) MY163516A (enExample)
NZ (2) NZ590302A (enExample)
WO (1) WO2010009120A2 (enExample)
ZA (1) ZA201100311B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015500294A (ja) * 2011-12-09 2015-01-05 フェロキン バイオサイエンシーズ， インコーポレイテッド 金属過剰症を治療する経口製剤
JP2017500295A (ja) * 2013-11-22 2017-01-05 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． デスフェリチオシン類似体およびその使用
JP2017507158A (ja) * 2014-03-06 2017-03-16 ピーティーシー セラピューティクス， インコーポレイテッド 薬学的組成物、および１，２，４−オキサジアゾール安息香酸の塩
JP2018515475A (ja) * 2015-04-27 2018-06-14 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． 代謝的にプログラムされた金属キレーターおよびその使用
US11931346B2 (en) 2011-12-16 2024-03-19 University Of Florida Research Foundation, Incorporated Uses of 4′-desferrithiocin analogs

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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AU2003270473A1 (en) 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
ES2732625T3 (es) 2005-04-04 2019-11-25 Univ Florida Análogos de poliéter de desferritiocina
CN104003955A (zh) 2007-03-15 2014-08-27 佛罗里达大学研究基金公司 去铁硫辛聚醚类似物
CN102149700A (zh) 2008-07-14 2011-08-10 法罗肯生物科学公司 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物
BR112012001761A2 (pt) * 2009-07-27 2017-05-09 Ferrokin Bioscience Inc composto de formula i, composto farmacêutica e método de tratamento de uma condição mediada por metal em um indivduo
EP2566854A4 (en) * 2010-05-04 2013-11-06 Shire Llc DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS
WO2014089482A1 (en) * 2012-12-07 2014-06-12 Ferrokin Biosciences, Inc. Polymorph forms of desazadesferrithiocin analogs
HK1220194A1 (zh) * 2013-03-15 2017-04-28 Ferrokin Biosciences, Inc. 去氮杂去铁硫代霉素(desazadesferrithiocin)类似物的多晶型形式
US10446309B2 (en) 2016-04-20 2019-10-15 Vishay Dale Electronics, Llc Shielded inductor and method of manufacturing
CN107119083A (zh) * 2017-04-28 2017-09-01 江苏梦得新材料科技有限公司 一种生物酶法制备聚二硫二丙烷磺酸钠的方法
CN107174917A (zh) * 2017-05-01 2017-09-19 蒋里军 粘土矿物治霾方法及其摩天大楼治霾烟囱
CN108264892A (zh) * 2017-12-21 2018-07-10 东北农业大学 一种用于释放地下油质材料的表面活性剂的组合物

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JP2008536833A (ja) * 2005-04-04 2008-09-11 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイティド デフェリチオシンポリエーテル類似体

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AU2003270473A1 (en) 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
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CN102149700A (zh) 2008-07-14 2011-08-10 法罗肯生物科学公司 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物
BR112012001761A2 (pt) 2009-07-27 2017-05-09 Ferrokin Bioscience Inc composto de formula i, composto farmacêutica e método de tratamento de uma condição mediada por metal em um indivduo
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015500294A (ja) * 2011-12-09 2015-01-05 フェロキン バイオサイエンシーズ， インコーポレイテッド 金属過剰症を治療する経口製剤
US11931346B2 (en) 2011-12-16 2024-03-19 University Of Florida Research Foundation, Incorporated Uses of 4′-desferrithiocin analogs
JP2017500295A (ja) * 2013-11-22 2017-01-05 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． デスフェリチオシン類似体およびその使用
JP2017507158A (ja) * 2014-03-06 2017-03-16 ピーティーシー セラピューティクス， インコーポレイテッド 薬学的組成物、および１，２，４−オキサジアゾール安息香酸の塩
JP2020045354A (ja) * 2014-03-06 2020-03-26 ピーティーシー セラピューティクス， インコーポレイテッド 薬学的組成物、および１，２，４−オキサジアゾール安息香酸の塩
JP7335795B2 (ja) 2014-03-06 2023-08-30 ピーティーシー セラピューティクス， インコーポレイテッド 薬学的組成物、および１，２，４－オキサジアゾール安息香酸の塩
JP2018515475A (ja) * 2015-04-27 2018-06-14 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． 代謝的にプログラムされた金属キレーターおよびその使用
US10570104B2 (en) 2015-04-27 2020-02-25 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof

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WO2010009120A3 (en) 2010-04-22
US20100137383A1 (en) 2010-06-03
US8846731B2 (en) 2014-09-30
IL231558A0 (en) 2014-04-30
MX2011000486A (es) 2011-08-03
US20110160257A1 (en) 2011-06-30
WO2010009120A8 (en) 2011-02-24
KR20110039347A (ko) 2011-04-15
AU2009271074B2 (en) 2014-10-30
IL210294A (en) 2014-04-30
NZ605452A (en) 2014-05-30
ZA201100311B (en) 2011-12-28
CN103435569B (zh) 2015-08-19
MY163516A (en) 2017-09-15
US8063227B2 (en) 2011-11-22
US8710087B2 (en) 2014-04-29
US8829197B2 (en) 2014-09-09
EP2303853A2 (en) 2011-04-06
CN102149700A (zh) 2011-08-10
CN103435569A (zh) 2013-12-11
IL210294A0 (en) 2011-03-31
US20120202857A1 (en) 2012-08-09
CA2728636A1 (en) 2010-01-21
WO2010009120A2 (en) 2010-01-21
US20120270911A1 (en) 2012-10-25
EP2303853A4 (en) 2011-08-10
AU2009271074A1 (en) 2010-01-21
NZ590302A (en) 2013-02-22

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