CA2728636A1 - Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents - Google Patents
Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents Download PDFInfo
- Publication number
- CA2728636A1 CA2728636A1 CA2728636A CA2728636A CA2728636A1 CA 2728636 A1 CA2728636 A1 CA 2728636A1 CA 2728636 A CA2728636 A CA 2728636A CA 2728636 A CA2728636 A CA 2728636A CA 2728636 A1 CA2728636 A1 CA 2728636A1
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- Prior art keywords
- recited
- polymorph
- solid composition
- added
- salt
- Prior art date
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- 239000002184 metal Substances 0.000 title claims abstract description 26
- 239000002738 chelating agent Substances 0.000 title abstract description 17
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Public Health (AREA)
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- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8057208P | 2008-07-14 | 2008-07-14 | |
| US61/080,572 | 2008-07-14 | ||
| US15257209P | 2009-02-13 | 2009-02-13 | |
| US61/152,572 | 2009-02-13 | ||
| PCT/US2009/050532 WO2010009120A2 (en) | 2008-07-14 | 2009-07-14 | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2728636A1 true CA2728636A1 (en) | 2010-01-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CA2728636A Abandoned CA2728636A1 (en) | 2008-07-14 | 2009-07-14 | Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
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| US (4) | US8063227B2 (enExample) |
| EP (1) | EP2303853A4 (enExample) |
| JP (1) | JP2011528037A (enExample) |
| KR (1) | KR20110039347A (enExample) |
| CN (2) | CN102149700A (enExample) |
| AU (1) | AU2009271074B2 (enExample) |
| CA (1) | CA2728636A1 (enExample) |
| IL (2) | IL210294A (enExample) |
| MX (1) | MX2011000486A (enExample) |
| MY (1) | MY163516A (enExample) |
| NZ (2) | NZ605452A (enExample) |
| WO (1) | WO2010009120A2 (enExample) |
| ZA (1) | ZA201100311B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10010535B2 (en) | 2013-11-22 | 2018-07-03 | University Of Florida Research Foundation, Incorporated | Desferrithiocin analogs and uses thereof |
| US10570104B2 (en) | 2015-04-27 | 2020-02-25 | University Of Florida Research Foundation, Incorporated | Metabolically programmed metal chelators and uses thereof |
| US11931346B2 (en) | 2011-12-16 | 2024-03-19 | University Of Florida Research Foundation, Incorporated | Uses of 4′-desferrithiocin analogs |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003270473A1 (en) | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| BRPI0610644B8 (pt) | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
| US8324397B2 (en) | 2007-03-15 | 2012-12-04 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues |
| MY163516A (en) | 2008-07-14 | 2017-09-15 | Ferrokin Biosciences Inc | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| BR112012001761A2 (pt) * | 2009-07-27 | 2017-05-09 | Ferrokin Bioscience Inc | composto de formula i, composto farmacêutica e método de tratamento de uma condição mediada por metal em um indivduo |
| US20130053387A1 (en) * | 2010-05-04 | 2013-02-28 | FerroKin BioScience, Inc. | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
| AU2012347595A1 (en) * | 2011-12-09 | 2014-06-26 | Ferrokin Biosciences, Inc. | Oral formulations for treating metal overload |
| EP2928469A4 (en) * | 2012-12-07 | 2016-11-02 | Ferrokin Biosciences Inc | POLYMORPHIC FORMS OF DESAZADESFERRITHIOCIN ANALOGS |
| AU2014228308A1 (en) * | 2013-03-15 | 2015-08-27 | Ferrokin Biosciences, Inc. | Polymorph forms of desazadesferrithiocin analogs |
| KR102497273B1 (ko) * | 2014-03-06 | 2023-02-07 | 피티씨 테라퓨틱스, 인크. | 1,2,4-옥사디아졸 벤조산의 약학 조성물 및 염 |
| US10446309B2 (en) | 2016-04-20 | 2019-10-15 | Vishay Dale Electronics, Llc | Shielded inductor and method of manufacturing |
| CN107119083A (zh) * | 2017-04-28 | 2017-09-01 | 江苏梦得新材料科技有限公司 | 一种生物酶法制备聚二硫二丙烷磺酸钠的方法 |
| CN107174917A (zh) * | 2017-05-01 | 2017-09-19 | 蒋里军 | 粘土矿物治霾方法及其摩天大楼治霾烟囱 |
| CN108264892A (zh) * | 2017-12-21 | 2018-07-10 | 东北农业大学 | 一种用于释放地下油质材料的表面活性剂的组合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6083966A (en) * | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
| AT500490A1 (de) * | 2001-10-16 | 2006-01-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte |
| WO2004017959A2 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
| US20060069134A1 (en) * | 2002-10-01 | 2006-03-30 | Kaneka Corporation | Process for producing optically active alpha-substituted cysteine or salt thereof, intermediate therefor, and process for producing the same |
| AU2003270473A1 (en) | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| CA2538159A1 (en) | 2003-09-09 | 2005-03-17 | University Of Florida Research Foundation, Inc. | Polyamine-metal chelator conjugates |
| BRPI0610644B8 (pt) * | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
| US20080138440A1 (en) * | 2006-11-29 | 2008-06-12 | Cormedix Inc. | Methods of diagnosing and alleviating gadolinium toxicity |
| JP2010512398A (ja) | 2006-12-12 | 2010-04-22 | ユニバーシティ オブ フロリダ | デスフェリチオシン類縁体アクチニド除染剤 |
| US8324397B2 (en) | 2007-03-15 | 2012-12-04 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues |
| MY163516A (en) * | 2008-07-14 | 2017-09-15 | Ferrokin Biosciences Inc | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
| BR112012001761A2 (pt) * | 2009-07-27 | 2017-05-09 | Ferrokin Bioscience Inc | composto de formula i, composto farmacêutica e método de tratamento de uma condição mediada por metal em um indivduo |
| JP5925679B2 (ja) | 2009-08-25 | 2016-05-25 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイティド | デスフェリチオシンポリエーテル類似体およびその使用 |
| US20130053387A1 (en) * | 2010-05-04 | 2013-02-28 | FerroKin BioScience, Inc. | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
-
2009
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- 2009-07-14 CN CN201310322314.9A patent/CN103435569B/zh not_active Expired - Fee Related
- 2009-07-14 CA CA2728636A patent/CA2728636A1/en not_active Abandoned
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2010
- 2010-12-27 IL IL210294A patent/IL210294A/en not_active IP Right Cessation
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2011
- 2011-01-12 ZA ZA2011/00311A patent/ZA201100311B/en unknown
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- 2011-08-04 US US13/198,287 patent/US8710087B2/en not_active Expired - Fee Related
- 2011-10-06 US US13/267,285 patent/US8846731B2/en not_active Expired - Fee Related
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2014
- 2014-03-17 IL IL231558A patent/IL231558A0/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11931346B2 (en) | 2011-12-16 | 2024-03-19 | University Of Florida Research Foundation, Incorporated | Uses of 4′-desferrithiocin analogs |
| US10010535B2 (en) | 2013-11-22 | 2018-07-03 | University Of Florida Research Foundation, Incorporated | Desferrithiocin analogs and uses thereof |
| US10570104B2 (en) | 2015-04-27 | 2020-02-25 | University Of Florida Research Foundation, Incorporated | Metabolically programmed metal chelators and uses thereof |
Also Published As
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| IL210294A0 (en) | 2011-03-31 |
| US20110160257A1 (en) | 2011-06-30 |
| US8710087B2 (en) | 2014-04-29 |
| AU2009271074B2 (en) | 2014-10-30 |
| CN103435569A (zh) | 2013-12-11 |
| EP2303853A2 (en) | 2011-04-06 |
| MY163516A (en) | 2017-09-15 |
| MX2011000486A (es) | 2011-08-03 |
| US20120202857A1 (en) | 2012-08-09 |
| US8063227B2 (en) | 2011-11-22 |
| KR20110039347A (ko) | 2011-04-15 |
| CN103435569B (zh) | 2015-08-19 |
| ZA201100311B (en) | 2011-12-28 |
| AU2009271074A1 (en) | 2010-01-21 |
| CN102149700A (zh) | 2011-08-10 |
| WO2010009120A8 (en) | 2011-02-24 |
| US8829197B2 (en) | 2014-09-09 |
| IL210294A (en) | 2014-04-30 |
| NZ605452A (en) | 2014-05-30 |
| IL231558A0 (en) | 2014-04-30 |
| US8846731B2 (en) | 2014-09-30 |
| NZ590302A (en) | 2013-02-22 |
| EP2303853A4 (en) | 2011-08-10 |
| WO2010009120A3 (en) | 2010-04-22 |
| US20120270911A1 (en) | 2012-10-25 |
| US20100137383A1 (en) | 2010-06-03 |
| JP2011528037A (ja) | 2011-11-10 |
| WO2010009120A2 (en) | 2010-01-21 |
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| FZDE | Discontinued |
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