JP2011527684A5 - - Google Patents
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- Publication number
- JP2011527684A5 JP2011527684A5 JP2011517496A JP2011517496A JP2011527684A5 JP 2011527684 A5 JP2011527684 A5 JP 2011527684A5 JP 2011517496 A JP2011517496 A JP 2011517496A JP 2011517496 A JP2011517496 A JP 2011517496A JP 2011527684 A5 JP2011527684 A5 JP 2011527684A5
- Authority
- JP
- Japan
- Prior art keywords
- tetrahydro
- triazole
- diamine
- ethano
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 1,4-ethano-8- Phenyl-1,2,3,4-tetrahydro-1,5-naphthyridin-6-yl Chemical group 0.000 claims description 35
- 150000001875 compounds Chemical class 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 19
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- NALGRIOLHUTJGF-UHFFFAOYSA-N 3-N-[5-amino-1-(3-phenyl-1,6-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-5-yl)-1,2,4-triazol-3-yl]-5,6,7,8-tetrahydroquinoline-3,6-diamine Chemical compound C1=C2CC(N)CCC2=NC=C1NC(=N1)N=C(N)N1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 NALGRIOLHUTJGF-UHFFFAOYSA-N 0.000 claims description 2
- OYKRCBXJLAUWRI-UHFFFAOYSA-N C1=C2CC(NC(=O)CN(C)C)CCC2=NC=C1NC(=N1)N=C(N)N1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 Chemical compound C1=C2CC(NC(=O)CN(C)C)CCC2=NC=C1NC(=N1)N=C(N)N1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 OYKRCBXJLAUWRI-UHFFFAOYSA-N 0.000 claims description 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 9
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- QXAMGWKESXGGNV-UHFFFAOYSA-N 7-(diethylamino)-1-benzopyran-2-one Chemical compound C1=CC(=O)OC2=CC(N(CC)CC)=CC=C21 QXAMGWKESXGGNV-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- YDKLOLUTIIBXKR-UHFFFAOYSA-N 1-(6-chloro-4,5-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl)-3-N-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1,2,4-triazole-3,5-diamine Chemical compound N=1N(C=2C=3C4CCC(CC4)C=3C(Cl)=NN=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 YDKLOLUTIIBXKR-UHFFFAOYSA-N 0.000 claims 1
- GYLLFNNZHFQJHW-ZLPCBKJTSA-N 1-(6-chloro-4,5-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl)-3-N-[6-[(3S)-4-(cyclopropylmethyl)-3-methylpiperazin-1-yl]pyridin-3-yl]-1,2,4-triazole-3,5-diamine Chemical compound C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(Cl)=NN=3)=CC=2)CCN1CC1CC1 GYLLFNNZHFQJHW-ZLPCBKJTSA-N 0.000 claims 1
- MNUXODSDJVGUMZ-UHFFFAOYSA-N 1-[6-(1,3-benzodioxol-5-yl)-4,5-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl]-3-N-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1,2,4-triazole-3,5-diamine Chemical compound N=1N(C=2C=3C4CCC(CC4)C=3C(C=3C=C4OCOC4=CC=3)=NN=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 MNUXODSDJVGUMZ-UHFFFAOYSA-N 0.000 claims 1
- XIMFQRBXOBKICL-UHFFFAOYSA-N 1-[6-(2-chlorophenyl)-4,5-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl]-3-N-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1,2,4-triazole-3,5-diamine Chemical compound N=1N(C=2C=3C4CCC(CC4)C=3C(C=3C(=CC=CC=3)Cl)=NN=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 XIMFQRBXOBKICL-UHFFFAOYSA-N 0.000 claims 1
- PJZULLWNMANBEA-UHFFFAOYSA-N 3-N-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1-(3-phenyl-1,4,6-triazatricyclo[6.2.2.02,7]dodeca-2,4,6-trien-5-yl)-1,2,4-triazole-3,5-diamine Chemical compound N=1N(C=2N=C(C=3N4CCC(CC4)C=3N=2)C=2C=CC=CC=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 PJZULLWNMANBEA-UHFFFAOYSA-N 0.000 claims 1
- ZSBRPSXTBIZVCN-UHFFFAOYSA-N 3-N-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1-(6-pyridin-4-yl-4,5-diazatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-3-yl)-1,2,4-triazole-3,5-diamine Chemical compound N=1N(C=2C=3C4CCC(CC4)C=3C(C=3C=CN=CC=3)=NN=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 ZSBRPSXTBIZVCN-UHFFFAOYSA-N 0.000 claims 1
- NLTFNEOTIGWQDZ-UHFFFAOYSA-N 3-[3-fluoro-4-(4-pyrrolidin-1-ylpiperidin-1-yl)phenyl]-1,2-dihydro-1,2,4-triazole-3,5-diamine Chemical compound N1NC(N)=NC1(N)C(C=C1F)=CC=C1N1CCC(N2CCCC2)CC1 NLTFNEOTIGWQDZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- PDOYLWPVRHKQTC-KPQWGBOZSA-N C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C(=CC=CC=4)Cl)=NN=3)=CC=2)CCN1CC1CC1 Chemical compound C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C(=CC=CC=4)Cl)=NN=3)=CC=2)CCN1CC1CC1 PDOYLWPVRHKQTC-KPQWGBOZSA-N 0.000 claims 1
- HFHFWMOYBXDKQX-KHRZNOOSSA-N C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C=C(C)C=CC=4)=NN=3)=CC=2)CCN1CC1CC1 Chemical compound C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C=C(C)C=CC=4)=NN=3)=CC=2)CCN1CC1CC1 HFHFWMOYBXDKQX-KHRZNOOSSA-N 0.000 claims 1
- SEFCNRFOIXDHSG-RBKXMNCYSA-N C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C=CC=CC=4)=NN=3)=CC=2)CCN1CC1CC1 Chemical compound C([C@@H]1C)N(C=2N=CC(NC3=NN(C(N)=N3)C=3C=4C5CCC(CC5)C=4C(C=4C=CC=CC=4)=NN=3)=CC=2)CCN1CC1CC1 SEFCNRFOIXDHSG-RBKXMNCYSA-N 0.000 claims 1
- AXVJAULMQQDJGJ-UHFFFAOYSA-N C1=C2CN(C(=O)CN(C)C)CCC2=NC=C1NC(=N1)N=C(N)N1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 Chemical compound C1=C2CN(C(=O)CN(C)C)CCC2=NC=C1NC(=N1)N=C(N)N1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 AXVJAULMQQDJGJ-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- LJKHWOQADJHEBF-UHFFFAOYSA-N N=1N(C=2N=C3C4CCN(CC4)C3=C(C=3C=C(C=CC=3)C(F)(F)F)C=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 Chemical compound N=1N(C=2N=C3C4CCN(CC4)C3=C(C=3C=C(C=CC=3)C(F)(F)F)C=2)C(N)=NC=1NC(C=C1F)=CC=C1N(CC1)CCC1N1CCCC1 LJKHWOQADJHEBF-UHFFFAOYSA-N 0.000 claims 1
- QFTYPWAATNYFCG-UHFFFAOYSA-N N=1N(C=2N=C3C4CCN(CC4)C3=C(C=3C=CC=CC=3)C=2)C(N)=NC=1NC(C=C1C2)=CN=C1CCC2NC1CCCC1 Chemical compound N=1N(C=2N=C3C4CCN(CC4)C3=C(C=3C=CC=CC=3)C=2)C(N)=NC=1NC(C=C1C2)=CN=C1CCC2NC1CCCC1 QFTYPWAATNYFCG-UHFFFAOYSA-N 0.000 claims 1
- TXEZJWJTNHDBKW-UHFFFAOYSA-N NC1=NC(NC=2C=C3CNCCC3=NC=2)=NN1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 Chemical compound NC1=NC(NC=2C=C3CNCCC3=NC=2)=NN1C(N=C1C2CCN(CC2)C1=1)=CC=1C1=CC=CC=C1 TXEZJWJTNHDBKW-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000004321 azepin-2-yl group Chemical group [H]N1C([H])=C([H])C([H])=C([H])C([H])=C1* 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 125000004914 dipropylamino group Chemical group C(CC)N(CCC)* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000006316 iso-butyl amino group Chemical group [H]N(*)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- HUUBMTMJIQHAEN-UHFFFAOYSA-N triazole-1,4-diamine Chemical compound NC1=CN(N)N=N1 HUUBMTMJIQHAEN-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7939808P | 2008-07-09 | 2008-07-09 | |
| US61/079,398 | 2008-07-09 | ||
| PCT/US2009/049627 WO2010005879A1 (en) | 2008-07-09 | 2009-07-02 | Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011527684A JP2011527684A (ja) | 2011-11-04 |
| JP2011527684A5 true JP2011527684A5 (OSRAM) | 2014-08-21 |
| JP5613156B2 JP5613156B2 (ja) | 2014-10-22 |
Family
ID=41026400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517496A Expired - Fee Related JP5613156B2 (ja) | 2008-07-09 | 2009-07-02 | Ａｘｌ阻害剤として有用な架橋二環ヘテロアリール置換トリアゾール |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US8431594B2 (OSRAM) |
| EP (1) | EP2328888B1 (OSRAM) |
| JP (1) | JP5613156B2 (OSRAM) |
| CA (1) | CA2730251C (OSRAM) |
| CY (1) | CY1113642T1 (OSRAM) |
| DK (1) | DK2328888T3 (OSRAM) |
| ES (1) | ES2399319T3 (OSRAM) |
| HR (1) | HRP20130045T1 (OSRAM) |
| PL (1) | PL2328888T3 (OSRAM) |
| PT (1) | PT2328888E (OSRAM) |
| SI (1) | SI2328888T1 (OSRAM) |
| WO (1) | WO2010005879A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007030680A2 (en) * | 2005-09-07 | 2007-03-15 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as axl inhibitors |
| EP2484679B1 (en) * | 2006-12-29 | 2016-09-28 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituted triazoles and n5-heteroaryl substitued triazoles useful as axl inhibitors |
| PT2114955E (pt) | 2006-12-29 | 2013-04-18 | Rigel Pharmaceuticals Inc | Triazoles substituídos com arilo bicíclico em ponte ou heteroarilo bicíclico em ponte úteis como inibidores de axl |
| CA2710051C (en) | 2006-12-29 | 2017-05-16 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as axl inhibitors |
| ES2460894T3 (es) | 2006-12-29 | 2014-05-14 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con heteroarilo policíclico útiles como inhibidores de Axl |
| US7872000B2 (en) | 2006-12-29 | 2011-01-18 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as Axl inhibitors |
| SI2205592T1 (sl) * | 2007-10-26 | 2013-09-30 | Rigel Pharmaceuticals, Inc. | Triazoli substituirani s policikličnim arilom in triazoli substituirani s policikličnim heteroarilom uporabni kot Axl inhibitorji |
| AU2009214440B2 (en) | 2008-02-15 | 2014-09-25 | Rigel Pharmaceuticals, Inc. | Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases |
| WO2010005876A2 (en) | 2008-07-09 | 2010-01-14 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| PT2328888E (pt) * | 2008-07-09 | 2013-01-29 | Rigel Pharmaceuticals Inc | Triazóis bicíclicos em ponte substituídos com heteroarilos úteis como inibidores axl |
| JP4644273B2 (ja) * | 2008-07-15 | 2011-03-02 | 本田技研工業株式会社 | 車両周辺監視装置 |
| US8546433B2 (en) | 2009-01-16 | 2013-10-01 | Rigel Pharmaceuticals, Inc. | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
| US8797966B2 (en) | 2011-09-23 | 2014-08-05 | Ofinno Technologies, Llc | Channel state information transmission |
| US8879496B2 (en) | 2011-12-19 | 2014-11-04 | Ofinno Technologies, Llc | Beamforming codeword exchange between base stations |
| AU2013216006B2 (en) | 2012-01-31 | 2017-06-08 | Daiichi Sankyo Company, Limited | Pyridone derivatives |
| EP2877211A4 (en) | 2012-07-25 | 2016-02-10 | Salk Inst For Biological Studi | CONTROL OF INTERACTION BETWEEN TAM LIGANDS AND LIPID MEMBRANES WITH EXPOSED PHOSPHATIDYL SERININE |
| CA2929188C (en) | 2013-11-20 | 2022-08-09 | Signalchem Lifesciences Corp. | Quinazoline derivatives as tam family kinase inhibitors |
| MX373365B (es) * | 2013-11-27 | 2020-05-26 | Signalchem Lifesciences Corp | Derivados de aminopiridina como inhibidores de cinasas de la familia de tyro3, axl y mer (tam). |
| EP3125920B1 (en) | 2014-04-04 | 2020-12-23 | Del Mar Pharmaceuticals | Dianhydrogalactitol, diacetyldianhydrogalactitol or dibromodulcitol to treat non-small-cell carcinoma of the lung and ovarian cancer |
| TWI723572B (zh) | 2014-07-07 | 2021-04-01 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
| WO2016183071A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Hetero-tricyclic compounds and their use for the treatment of cancer |
| US9708333B2 (en) | 2015-08-12 | 2017-07-18 | Incyte Corporation | Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors |
| US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
| US20190099413A1 (en) | 2016-02-26 | 2019-04-04 | Ono Pharmaceutical Co., Ltd. | Drug for cancer therapy characterized in that axl inhibitor and immune checkpoint inhibitor are administered in combination |
| TWI753892B (zh) | 2016-03-28 | 2022-02-01 | 美商英塞特公司 | 作為ｔａｍ抑制劑之吡咯并三嗪化合物 |
| EP3673907A4 (en) | 2017-08-23 | 2020-08-19 | ONO Pharmaceutical Co., Ltd. | CANCER TREATMENT PHARMACEUTICAL INCLUDING AX1 INHIBITOR AS AN EFFECTIVE INGREDIENT |
| MA50655B1 (fr) | 2017-09-27 | 2021-11-30 | Incyte Corp | Sels de dérivés de pyrrolotriazine utiles en tant qu'inhibiteurs de tam |
| JP7223998B2 (ja) | 2017-10-13 | 2023-02-17 | 小野薬品工業株式会社 | Ａｘｌ阻害剤を有効成分として含む固形がん治療剤 |
| MD3813800T2 (ro) | 2018-06-29 | 2025-10-31 | Incyte Corp | Formulări de inhibitor al AXL/MER |
| JP2022526713A (ja) | 2019-03-21 | 2022-05-26 | オンクセオ | がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子 |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN115697343A (zh) | 2020-03-06 | 2023-02-03 | 因赛特公司 | 包含axl/mer和pd-1/pd-l1抑制剂的组合疗法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1403866A (en) * | 1971-12-06 | 1975-08-28 | Wyeth John & Brother Ltd | Derivatives of 3-amino-1,2,4-triazoles |
| EP0710654A4 (en) | 1993-07-23 | 1996-08-28 | Green Cross Corp | TRIAZOLE DERIVATIVE AND ITS PHARMACEUTICAL USE |
| GB9918180D0 (en) | 1999-08-02 | 1999-10-06 | Smithkline Beecham Plc | Novel compositions |
| CN100357278C (zh) | 2000-12-22 | 2007-12-26 | 奥索-麦克尼尔药品公司 | 作为激酶抑制剂的取代的三唑二胺衍生物 |
| DE10123586A1 (de) * | 2001-05-08 | 2002-11-28 | Schering Ag | 3,5-Diamino-1,2,4-triazole als Kinase Inhibitoren |
| TWI335221B (en) | 2001-09-27 | 2011-01-01 | Alcon Inc | Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma |
| CN1290893C (zh) | 2002-05-03 | 2006-12-20 | 詹森药业有限公司 | 聚合物微乳状液 |
| WO2004017997A1 (ja) | 2002-08-06 | 2004-03-04 | Toray Industries, Inc. | 腎疾患治療又は予防剤及び腎疾患の診断方法 |
| WO2004039955A2 (en) | 2002-10-29 | 2004-05-13 | Rigel Pharmaceuticals, Inc. | Modulators of angiogenesis and tumorigenesis |
| AR042052A1 (es) * | 2002-11-15 | 2005-06-08 | Vertex Pharma | Diaminotriazoles utiles como inhibidores de proteinquinasas |
| WO2005013982A1 (en) | 2003-08-06 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Aminotriazole compounds useful as inhibitors of protein kinases |
| MXPA06009193A (es) | 2004-02-11 | 2007-01-26 | Johnson & Johnson | Procedimiento para la preparacion de compuestos triazol sustituidos. |
| JP5116092B2 (ja) | 2004-09-17 | 2013-01-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼの阻害剤として有用なジアミノトリアゾール化合物 |
| AU2005299816B2 (en) | 2004-10-21 | 2011-09-01 | Vertex Pharmaceuticals Incorporated | Triazoles useful as inhibitors of protein kinases |
| US20060166936A1 (en) | 2004-10-29 | 2006-07-27 | Hayley Binch | Diaminotriazole compounds useful as inhibitors of protein kinases |
| WO2007030680A2 (en) * | 2005-09-07 | 2007-03-15 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as axl inhibitors |
| WO2008045978A1 (en) * | 2006-10-10 | 2008-04-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors |
| WO2008080134A2 (en) * | 2006-12-22 | 2008-07-03 | Rigel Pharmaceuticals, Inc. | 4-amin0-2- (hetero) arylamino-5- (hetero) arylthiazoles useful as axl inhibitors |
| US7872000B2 (en) * | 2006-12-29 | 2011-01-18 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as Axl inhibitors |
| EP2484679B1 (en) * | 2006-12-29 | 2016-09-28 | Rigel Pharmaceuticals, Inc. | N3-heteroaryl substituted triazoles and n5-heteroaryl substitued triazoles useful as axl inhibitors |
| PT2114955E (pt) | 2006-12-29 | 2013-04-18 | Rigel Pharmaceuticals Inc | Triazoles substituídos com arilo bicíclico em ponte ou heteroarilo bicíclico em ponte úteis como inibidores de axl |
| CA2710051C (en) * | 2006-12-29 | 2017-05-16 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as axl inhibitors |
| ES2460894T3 (es) * | 2006-12-29 | 2014-05-14 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con heteroarilo policíclico útiles como inhibidores de Axl |
| CA2690653A1 (en) | 2007-06-15 | 2008-12-24 | Irm Llc | Protein kinase inhibitors and methods for using thereof |
| SI2205592T1 (sl) * | 2007-10-26 | 2013-09-30 | Rigel Pharmaceuticals, Inc. | Triazoli substituirani s policikličnim arilom in triazoli substituirani s policikličnim heteroarilom uporabni kot Axl inhibitorji |
| AU2009214440B2 (en) | 2008-02-15 | 2014-09-25 | Rigel Pharmaceuticals, Inc. | Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases |
| PT2328888E (pt) * | 2008-07-09 | 2013-01-29 | Rigel Pharmaceuticals Inc | Triazóis bicíclicos em ponte substituídos com heteroarilos úteis como inibidores axl |
| WO2010005876A2 (en) | 2008-07-09 | 2010-01-14 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| US8546433B2 (en) * | 2009-01-16 | 2013-10-01 | Rigel Pharmaceuticals, Inc. | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
-
2009
- 2009-07-02 PT PT09790063T patent/PT2328888E/pt unknown
- 2009-07-02 HR HRP20130045AT patent/HRP20130045T1/hr unknown
- 2009-07-02 CA CA2730251A patent/CA2730251C/en active Active
- 2009-07-02 US US13/002,488 patent/US8431594B2/en active Active
- 2009-07-02 ES ES09790063T patent/ES2399319T3/es active Active
- 2009-07-02 JP JP2011517496A patent/JP5613156B2/ja not_active Expired - Fee Related
- 2009-07-02 SI SI200930487T patent/SI2328888T1/sl unknown
- 2009-07-02 PL PL09790063T patent/PL2328888T3/pl unknown
- 2009-07-02 DK DK09790063T patent/DK2328888T3/da active
- 2009-07-02 EP EP20090790063 patent/EP2328888B1/en active Active
- 2009-07-02 WO PCT/US2009/049627 patent/WO2010005879A1/en not_active Ceased
-
2012
- 2012-09-14 US US13/620,010 patent/US8658669B2/en active Active
-
2013
- 2013-02-06 CY CY20131100109T patent/CY1113642T1/el unknown
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2014
- 2014-01-08 US US14/150,401 patent/US8933080B2/en active Active
-
2015
- 2015-01-09 US US14/593,981 patent/US9206161B2/en active Active
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