ES2399319T3 - Triazoles sustituidos con heteroarilos bicíclicos que contienen puentes útiles como inhibidores de AXL - Google Patents
Triazoles sustituidos con heteroarilos bicíclicos que contienen puentes útiles como inhibidores de AXL Download PDFInfo
- Publication number
- ES2399319T3 ES2399319T3 ES09790063T ES09790063T ES2399319T3 ES 2399319 T3 ES2399319 T3 ES 2399319T3 ES 09790063 T ES09790063 T ES 09790063T ES 09790063 T ES09790063 T ES 09790063T ES 2399319 T3 ES2399319 T3 ES 2399319T3
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- Prior art keywords
- tetrahydro
- ethane
- diamine
- triazol
- compound
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7939808P | 2008-07-09 | 2008-07-09 | |
| US79398P | 2008-07-09 | ||
| PCT/US2009/049627 WO2010005879A1 (en) | 2008-07-09 | 2009-07-02 | Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2399319T3 true ES2399319T3 (es) | 2013-03-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ES09790063T Active ES2399319T3 (es) | 2008-07-09 | 2009-07-02 | Triazoles sustituidos con heteroarilos bicíclicos que contienen puentes útiles como inhibidores de AXL |
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| Country | Link |
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| US (4) | US8431594B2 (OSRAM) |
| EP (1) | EP2328888B1 (OSRAM) |
| JP (1) | JP5613156B2 (OSRAM) |
| CA (1) | CA2730251C (OSRAM) |
| CY (1) | CY1113642T1 (OSRAM) |
| DK (1) | DK2328888T3 (OSRAM) |
| ES (1) | ES2399319T3 (OSRAM) |
| HR (1) | HRP20130045T1 (OSRAM) |
| PL (1) | PL2328888T3 (OSRAM) |
| PT (1) | PT2328888E (OSRAM) |
| SI (1) | SI2328888T1 (OSRAM) |
| WO (1) | WO2010005879A1 (OSRAM) |
Families Citing this family (33)
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| WO2007030680A2 (en) * | 2005-09-07 | 2007-03-15 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as axl inhibitors |
| EP2114954B1 (en) | 2006-12-29 | 2013-02-13 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| US9650391B2 (en) * | 2006-12-29 | 2017-05-16 | Rigel Pharmaceuticals Inc. | N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as Axl inhibitors |
| ES2656496T3 (es) | 2006-12-29 | 2018-02-27 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos útiles como inhibidores de AXL |
| ME01832B (me) | 2006-12-29 | 2014-12-20 | Rigel Pharmaceuticals Inc | Policiklični heteroaril supstituisani triazoli koji su korisni kao axl inhibitori |
| US8012965B2 (en) | 2006-12-29 | 2011-09-06 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| EP2205592B1 (en) * | 2007-10-26 | 2013-05-08 | Rigel Pharmaceuticals, Inc. | Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| MX2010008926A (es) | 2008-02-15 | 2011-02-23 | Rigel Pharmaceuticals Inc | Compuestos de pirimidin-2-amina y su uso como inhibidores de jak cinasas. |
| SI2328888T1 (sl) * | 2008-07-09 | 2013-03-29 | Rigel Pharmaceuticals, Inc. | Premoščeni biciklični heteroaril substituirani triazoli, uporabni kot inhibitorji Axl |
| JP5592884B2 (ja) | 2008-07-09 | 2014-09-17 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｘｌ阻害剤として有用な多環式ヘテロアリール置換トリアゾール |
| JP4644273B2 (ja) * | 2008-07-15 | 2011-03-02 | 本田技研工業株式会社 | 車両周辺監視装置 |
| WO2010083465A1 (en) | 2009-01-16 | 2010-07-22 | Rigel Pharmaceuticals, Inc. | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
| US8797966B2 (en) | 2011-09-23 | 2014-08-05 | Ofinno Technologies, Llc | Channel state information transmission |
| US8848673B2 (en) | 2011-12-19 | 2014-09-30 | Ofinno Technologies, Llc | Beam information exchange between base stations |
| NZ627586A (en) | 2012-01-31 | 2016-08-26 | Daiichi Sankyo Co Ltd | Pyridone derivatives |
| CA2879542A1 (en) | 2012-07-25 | 2014-01-30 | Salk Institute For Biological Studies | Regulating the interaction between tam ligands and lipid membranes with exposed phosphatidylserine |
| CA2929188C (en) | 2013-11-20 | 2022-08-09 | Signalchem Lifesciences Corp. | Quinazoline derivatives as tam family kinase inhibitors |
| US10233176B2 (en) | 2013-11-27 | 2019-03-19 | Signalchem Lifesciences Corporation | Aminopyridine derivatives as TAM family kinase inhibitors |
| CA2946538A1 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| TWI723572B (zh) | 2014-07-07 | 2021-04-01 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| WO2017027717A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Bicyclic fused pyrimidine compounds as tam inhibitors |
| WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
| US20190099413A1 (en) | 2016-02-26 | 2019-04-04 | Ono Pharmaceutical Co., Ltd. | Drug for cancer therapy characterized in that axl inhibitor and immune checkpoint inhibitor are administered in combination |
| EP3436461B1 (en) | 2016-03-28 | 2023-11-01 | Incyte Corporation | Pyrrolotriazine compounds as tam inhibitors |
| EP3673907A4 (en) | 2017-08-23 | 2020-08-19 | ONO Pharmaceutical Co., Ltd. | CANCER TREATMENT PHARMACEUTICAL INCLUDING AX1 INHIBITOR AS AN EFFECTIVE INGREDIENT |
| MY208007A (en) | 2017-09-27 | 2025-04-04 | Incyte Corp | Salts of pyrrolotriazine derivatives useful as tam inhibitors |
| JP7223998B2 (ja) | 2017-10-13 | 2023-02-17 | 小野薬品工業株式会社 | Ａｘｌ阻害剤を有効成分として含む固形がん治療剤 |
| AR117600A1 (es) | 2018-06-29 | 2021-08-18 | Incyte Corp | Formulaciones de un inhibidor de axl / mer |
| KR20210142154A (ko) | 2019-03-21 | 2021-11-24 | 옹쎄오 | 암 치료를 위한 키나제 억제제와 조합된 dbait 분자 |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| EP4114401A1 (en) | 2020-03-06 | 2023-01-11 | Incyte Corporation | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
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| GB1403866A (en) * | 1971-12-06 | 1975-08-28 | Wyeth John & Brother Ltd | Derivatives of 3-amino-1,2,4-triazoles |
| WO1995003286A1 (en) | 1993-07-23 | 1995-02-02 | The Green Cross Corporation | Triazole derivative and pharmaceutical use thereof |
| GB9918180D0 (en) | 1999-08-02 | 1999-10-06 | Smithkline Beecham Plc | Novel compositions |
| CA2432870A1 (en) | 2000-12-22 | 2002-07-25 | Ronghui Lin | Substituted triazole diamine derivatives as kinase inhibitors |
| DE10123586A1 (de) | 2001-05-08 | 2002-11-28 | Schering Ag | 3,5-Diamino-1,2,4-triazole als Kinase Inhibitoren |
| TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
| EP1504047B1 (en) | 2002-05-03 | 2007-12-12 | Janssen Pharmaceutica N.V. | Polymeric microemulsions |
| CA2501719C (en) * | 2002-08-06 | 2013-02-05 | Toray Industries, Inc. | Remedy or preventive for kidney disease and method of diagnosing kidney disease |
| WO2004039955A2 (en) | 2002-10-29 | 2004-05-13 | Rigel Pharmaceuticals, Inc. | Modulators of angiogenesis and tumorigenesis |
| TWI335913B (en) | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
| AR045731A1 (es) | 2003-08-06 | 2005-11-09 | Vertex Pharma | Compuestos de aminotriazol utiles como inhibidores de quinasas de proteinas |
| US20060100259A1 (en) | 2004-02-11 | 2006-05-11 | Palmer David C | Process for the preparation of substituted triazole compounds |
| NZ580450A (en) | 2004-09-17 | 2011-06-30 | Vertex Pharma | Diaminotriazole Compounds Useful as Protein Kinase Inhibitors |
| CA2584752A1 (en) | 2004-10-21 | 2006-05-04 | Vertex Pharmaceuticals Incorporated | Triazoles useful as inhibitors of protein kinases |
| US20060166936A1 (en) | 2004-10-29 | 2006-07-27 | Hayley Binch | Diaminotriazole compounds useful as inhibitors of protein kinases |
| WO2007030680A2 (en) * | 2005-09-07 | 2007-03-15 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as axl inhibitors |
| WO2008045978A1 (en) * | 2006-10-10 | 2008-04-17 | Rigel Pharmaceuticals, Inc. | Pinane-substituted pyrimidinediamine derivatives useful as axl inhibitors |
| WO2008080134A2 (en) * | 2006-12-22 | 2008-07-03 | Rigel Pharmaceuticals, Inc. | 4-amin0-2- (hetero) arylamino-5- (hetero) arylthiazoles useful as axl inhibitors |
| ME01832B (me) * | 2006-12-29 | 2014-12-20 | Rigel Pharmaceuticals Inc | Policiklični heteroaril supstituisani triazoli koji su korisni kao axl inhibitori |
| US8012965B2 (en) * | 2006-12-29 | 2011-09-06 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| ES2656496T3 (es) * | 2006-12-29 | 2018-02-27 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos útiles como inhibidores de AXL |
| US9650391B2 (en) * | 2006-12-29 | 2017-05-16 | Rigel Pharmaceuticals Inc. | N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as Axl inhibitors |
| EP2114954B1 (en) * | 2006-12-29 | 2013-02-13 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| JP2010529990A (ja) | 2007-06-15 | 2010-09-02 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤およびそれを使用するための方法 |
| EP2205592B1 (en) * | 2007-10-26 | 2013-05-08 | Rigel Pharmaceuticals, Inc. | Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| MX2010008926A (es) | 2008-02-15 | 2011-02-23 | Rigel Pharmaceuticals Inc | Compuestos de pirimidin-2-amina y su uso como inhibidores de jak cinasas. |
| JP5592884B2 (ja) | 2008-07-09 | 2014-09-17 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｘｌ阻害剤として有用な多環式ヘテロアリール置換トリアゾール |
| SI2328888T1 (sl) * | 2008-07-09 | 2013-03-29 | Rigel Pharmaceuticals, Inc. | Premoščeni biciklični heteroaril substituirani triazoli, uporabni kot inhibitorji Axl |
| WO2010083465A1 (en) * | 2009-01-16 | 2010-07-22 | Rigel Pharmaceuticals, Inc. | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
-
2009
- 2009-07-02 SI SI200930487T patent/SI2328888T1/sl unknown
- 2009-07-02 CA CA2730251A patent/CA2730251C/en active Active
- 2009-07-02 ES ES09790063T patent/ES2399319T3/es active Active
- 2009-07-02 WO PCT/US2009/049627 patent/WO2010005879A1/en not_active Ceased
- 2009-07-02 EP EP20090790063 patent/EP2328888B1/en active Active
- 2009-07-02 HR HRP20130045AT patent/HRP20130045T1/hr unknown
- 2009-07-02 JP JP2011517496A patent/JP5613156B2/ja not_active Expired - Fee Related
- 2009-07-02 US US13/002,488 patent/US8431594B2/en active Active
- 2009-07-02 PT PT09790063T patent/PT2328888E/pt unknown
- 2009-07-02 DK DK09790063T patent/DK2328888T3/da active
- 2009-07-02 PL PL09790063T patent/PL2328888T3/pl unknown
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2012
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2013
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2014
- 2014-01-08 US US14/150,401 patent/US8933080B2/en active Active
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2015
- 2015-01-09 US US14/593,981 patent/US9206161B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1158638A1 (en) | 2012-07-20 |
| EP2328888B1 (en) | 2012-11-07 |
| WO2010005879A1 (en) | 2010-01-14 |
| US8658669B2 (en) | 2014-02-25 |
| JP5613156B2 (ja) | 2014-10-22 |
| CA2730251A1 (en) | 2010-01-14 |
| PL2328888T3 (pl) | 2013-04-30 |
| JP2011527684A (ja) | 2011-11-04 |
| CY1113642T1 (el) | 2016-06-22 |
| US20150126514A1 (en) | 2015-05-07 |
| DK2328888T3 (da) | 2013-02-11 |
| CA2730251C (en) | 2016-08-09 |
| SI2328888T1 (sl) | 2013-03-29 |
| PT2328888E (pt) | 2013-01-29 |
| US20110105512A1 (en) | 2011-05-05 |
| US8431594B2 (en) | 2013-04-30 |
| US20140128400A1 (en) | 2014-05-08 |
| US9206161B2 (en) | 2015-12-08 |
| US20130018051A1 (en) | 2013-01-17 |
| EP2328888A1 (en) | 2011-06-08 |
| HRP20130045T1 (hr) | 2013-02-28 |
| US8933080B2 (en) | 2015-01-13 |
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