|
WO2010118238A2
(en)
*
|
2009-04-08 |
2010-10-14 |
Surmodics, Inc. |
Controlled release devices and methods for delivery of nucleic acids
|
|
JP5695035B2
(ja)
|
2009-06-03 |
2015-04-01 |
フォーサイト・ビジョン5・インコーポレイテッドForsight Vision5,Inc. |
前眼部薬物供給
|
|
AU2011208374B2
(en)
*
|
2010-01-19 |
2016-09-08 |
Polypid Ltd. |
Sustained-release nucleic acid matrix compositions
|
|
EP2734261B1
(en)
|
2011-07-18 |
2018-02-21 |
Mor-Research Applications Ltd. |
A device for adjusting the intraocular pressure
|
|
ES2912370T3
(es)
|
2011-09-14 |
2022-05-25 |
Forsight Vision5 Inc |
Aparato para inserción ocular
|
|
US9006199B2
(en)
|
2011-11-14 |
2015-04-14 |
Silenseed Ltd. |
Methods and compositions for treating prostate cancer
|
|
US20130122096A1
(en)
|
2011-11-14 |
2013-05-16 |
Silenseed Ltd. |
Compositions for drug delivery and methods of manufacturing and using same
|
|
WO2013086419A1
(en)
*
|
2011-12-09 |
2013-06-13 |
California Institute Of Technology |
Polymer scaffolds and their use in the treatment of vision loss
|
|
CN102525935A
(zh)
*
|
2012-01-18 |
2012-07-04 |
上海交通大学医学院 |
一种纳米药物载体脑内递送方法
|
|
US8889642B2
(en)
|
2012-04-19 |
2014-11-18 |
Silenseed Ltd. |
Methods and compositions for RNAi-based cancer treatment
|
|
NL2009145C2
(en)
*
|
2012-07-06 |
2014-01-07 |
Xeltis B V |
Implant.
|
|
CN102861341B
(zh)
*
|
2012-09-29 |
2015-06-17 |
张建祥 |
一种能高效负载核酸类药物的复合纳米载体及其制备方法
|
|
CN104884006B
(zh)
|
2012-10-26 |
2017-12-15 |
弗赛特影像5股份有限公司 |
用于持续释放药物到眼睛的眼科系统
|
|
WO2014076703A1
(en)
*
|
2012-11-14 |
2014-05-22 |
Silenseed Ltd. |
Methods and compositions for treating cancer
|
|
KR20150105956A
(ko)
|
2012-12-12 |
2015-09-18 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작 및 치료적 적용을 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화
|
|
US10102441B2
(en)
*
|
2013-02-07 |
2018-10-16 |
Vanderbilt University |
Methods for automatic segmentation of inner ear anatomy in post-implantation CT and applications of same
|
|
US9784730B2
(en)
|
2013-03-21 |
2017-10-10 |
University Of Washington Through Its Center For Commercialization |
Nanoparticle for targeting brain tumors and delivery of O6-benzylguanine
|
|
CN107823721B
(zh)
*
|
2013-05-02 |
2021-01-29 |
德国凯德诺有限责任公司 |
球囊表面涂层
|
|
CN107995927B
(zh)
|
2013-06-17 |
2021-07-30 |
布罗德研究所有限公司 |
用于肝靶向和治疗的crispr-cas系统、载体和组合物的递送与用途
|
|
JP6738729B2
(ja)
|
2013-06-17 |
2020-08-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
分裂終了細胞の疾患および障害をターゲティングおよびモデリングするための系、方法および組成物の送達、エンジニアリングおよび最適化
|
|
CA2915795C
(en)
|
2013-06-17 |
2021-07-13 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
|
CN103394128A
(zh)
*
|
2013-08-02 |
2013-11-20 |
苏州市马尔泰新材料有限公司 |
一种含有川芎的模具材料
|
|
CN103394127A
(zh)
*
|
2013-08-02 |
2013-11-20 |
苏州市马尔泰新材料有限公司 |
一种含有中西医药的阴道模具材料
|
|
BR112016013201B1
(pt)
|
2013-12-12 |
2023-01-31 |
The Broad Institute, Inc. |
Uso de uma composição compreendendo um sistema crispr-cas no tratamento de uma doença genética ocular
|
|
SG10201804973TA
(en)
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Compositions and Methods of Use of Crispr-Cas Systems in Nucleotide Repeat Disorders
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
EP3540051B1
(en)
|
2013-12-12 |
2022-08-17 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hsv and viral diseases and disorders.
|
|
US20170056526A1
(en)
*
|
2014-02-26 |
2017-03-02 |
Ethris Gmbh |
Compositions for gastrointestinal administration of rna
|
|
CN104027848B
(zh)
*
|
2014-06-24 |
2015-10-14 |
中国人民解放军第四军医大学 |
一种用于牙周组织的生物支架材料及其制备方法
|
|
US10006030B2
(en)
|
2014-07-14 |
2018-06-26 |
Silenseed Ltd. |
RNA interference compositions targeting heat shock protein 90 and methods of use thereof
|
|
EP3180426B1
(en)
|
2014-08-17 |
2019-12-25 |
The Broad Institute, Inc. |
Genome editing using cas9 nickases
|
|
CN106573133B
(zh)
|
2014-08-19 |
2020-03-03 |
加利福尼亚大学董事会 |
用于局部药物递送的植入物及其使用方法
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
US11033659B2
(en)
|
2014-09-29 |
2021-06-15 |
Board Of Regents Of The University Of Nebraska |
Nanofiber structures and methods of synthesis and use thereof
|
|
MX379450B
(es)
*
|
2014-10-23 |
2025-03-11 |
Singh Biotechnology Llc |
Anticuerpos de un solo dominio dirigidos contra antígenos intracelulares
|
|
US20180072815A1
(en)
|
2014-10-23 |
2018-03-15 |
Singh Biotechnology, Llc |
Single Domain Antibodies Directed Against Intracellular Antigens
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
EP3234192B1
(en)
|
2014-12-19 |
2021-07-14 |
The Broad Institute, Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
EP3237615B2
(en)
|
2014-12-24 |
2023-07-26 |
The Broad Institute, Inc. |
Crispr having or associated with destabilization domains
|
|
WO2016168141A1
(en)
|
2015-04-13 |
2016-10-20 |
Forsight Vision5, Inc. |
Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
|
|
CA3012631A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
AU2016279062A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
CN109536474A
(zh)
|
2015-06-18 |
2019-03-29 |
布罗德研究所有限公司 |
降低脱靶效应的crispr酶突变
|
|
US11214800B2
(en)
|
2015-08-18 |
2022-01-04 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
WO2017069958A2
(en)
|
2015-10-09 |
2017-04-27 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
KR102761827B1
(ko)
|
2015-10-22 |
2025-02-03 |
더 브로드 인스티튜트, 인코퍼레이티드 |
타입 vi-b crispr 효소 및 시스템
|
|
EP3368687B1
(en)
|
2015-10-27 |
2021-09-29 |
The Broad Institute, Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
EP3368689B1
(en)
|
2015-10-28 |
2020-06-17 |
The Broad Institute, Inc. |
Composition for modulating immune responses by use of immune cell gene signature
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
EP3389735B1
(en)
|
2015-12-19 |
2022-03-23 |
Cardiac Pacemakers, Inc. |
Biologically inert coating for implantable medical devices
|
|
WO2017127473A1
(en)
*
|
2016-01-19 |
2017-07-27 |
The University Of North Carolina At Chapel Hill |
Methods and compositions using rna interference for inhibition of kras
|
|
US11180759B2
(en)
|
2016-01-19 |
2021-11-23 |
The University Of North Carolina At Chapel Hill |
Methods and compositions using RNA interference and antisense oligonucleotides for inhibition of KRAS
|
|
WO2017189308A1
(en)
|
2016-04-19 |
2017-11-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
KR102424476B1
(ko)
|
2016-04-19 |
2022-07-25 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신규한 crispr 효소 및 시스템
|
|
US11286478B2
(en)
|
2016-04-19 |
2022-03-29 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
|
US12031235B2
(en)
|
2016-04-28 |
2024-07-09 |
Amogreentech Co., Ltd. |
Nanofiber composite membrane for guided bone regeneration, and manufacturing method therefor
|
|
WO2017218787A1
(en)
|
2016-06-16 |
2017-12-21 |
Cardiac Pacemakers, Inc. |
Hydrophilization and antifouling of enhanced metal surfaces
|
|
JP7267013B2
(ja)
|
2016-06-17 |
2023-05-01 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
Vi型crisprオルソログ及び系
|
|
US20210222164A1
(en)
|
2016-06-29 |
2021-07-22 |
The Broad Institute, Inc. |
Crispr-cas systems having destabilization domain
|
|
WO2018017929A1
(en)
*
|
2016-07-21 |
2018-01-25 |
Board Of Regents Of The University Of Nebraska |
Ring and tubular structures and methods of synthesis and use thereof
|
|
WO2018031692A1
(en)
|
2016-08-09 |
2018-02-15 |
Cardiac Pacemakers, Inc. |
Functionalized peg for implantable medical devices
|
|
WO2018035387A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
US11352647B2
(en)
|
2016-08-17 |
2022-06-07 |
The Broad Institute, Inc. |
Crispr enzymes and systems
|
|
WO2018049025A2
(en)
|
2016-09-07 |
2018-03-15 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
AU2017335828B2
(en)
|
2016-09-28 |
2023-07-13 |
Board Of Regents Of The University Of Nebraska |
Nanofiber structures and methods of use thereof
|
|
US12447213B2
(en)
|
2016-10-07 |
2025-10-21 |
The Broad Institute, Inc. |
Modulation of novel immune checkpoint targets
|
|
WO2018088719A1
(ko)
*
|
2016-11-09 |
2018-05-17 |
주식회사 삼양바이오팜 |
Kras를 표적으로 하는 핵산 함유 약제학적 조성물 및 그 제조방법
|
|
EP4361261A3
(en)
|
2017-03-15 |
2024-07-10 |
The Broad Institute Inc. |
Novel cas13b orthologues crispr enzymes and systems
|
|
CN110799645B
(zh)
|
2017-04-12 |
2024-08-02 |
博德研究所 |
新型vi型crispr直系同源物和系统
|
|
WO2018204777A2
(en)
|
2017-05-05 |
2018-11-08 |
The Broad Institute, Inc. |
Methods for identification and modification of lncrna associated with target genotypes and phenotypes
|
|
JP2020520961A
(ja)
|
2017-05-24 |
2020-07-16 |
サイレンシード リミテッド |
がん免疫療法のための組成物及び方法
|
|
WO2018227078A1
(en)
|
2017-06-09 |
2018-12-13 |
Board Of Regents Of The University Of Nebraska |
Nanofiber structures and methods of use thereof
|
|
CN110168093B
(zh)
*
|
2017-09-12 |
2023-08-15 |
中科蓝华(广州)生物医药技术有限公司 |
一种转染细胞内寄生虫的试剂盒及其应用
|
|
AU2018335389B2
(en)
|
2017-09-19 |
2023-11-02 |
Board Of Regents Of The University Of Nebraska |
Nanofiber structures and methods of use thereof
|
|
EP3684456A4
(en)
*
|
2017-09-22 |
2021-06-16 |
Cochlear Limited |
DISTRIBUTION OF BIOACTIVE INGREDIENT
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
WO2019094983A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway
|
|
US10968257B2
(en)
|
2018-04-03 |
2021-04-06 |
The Broad Institute, Inc. |
Target recognition motifs and uses thereof
|
|
CA3103983A1
(en)
|
2018-06-19 |
2019-12-26 |
Biontech Us Inc. |
Neoantigens and uses thereof
|
|
WO2020041380A1
(en)
|
2018-08-20 |
2020-02-27 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
|
WO2020124072A1
(en)
|
2018-12-14 |
2020-06-18 |
Board Of Regents Of The University Of Nebraska |
Nanofiber structures and methods of manufacture and use thereof
|
|
WO2020191102A1
(en)
|
2019-03-18 |
2020-09-24 |
The Broad Institute, Inc. |
Type vii crispr proteins and systems
|
|
JP2022532420A
(ja)
|
2019-05-17 |
2022-07-14 |
サイレンシード リミテッド |
神経周囲浸潤及び疼痛を軽減するための組成物及び方法
|
|
JP7295559B2
(ja)
*
|
2019-06-03 |
2023-06-21 |
国立大学法人 奈良先端科学技術大学院大学 |
キトサン系複合体組成物及びキトサン系複合体の製造方法
|
|
US11173291B2
(en)
|
2020-03-20 |
2021-11-16 |
The Regents Of The University Of California |
Implantable drug delivery devices for localized drug delivery
|
|
US11344526B2
(en)
|
2020-03-20 |
2022-05-31 |
The Regents Of The University Of California |
Implantable drug delivery devices for localized drug delivery
|
|
US11338119B2
(en)
|
2020-03-20 |
2022-05-24 |
The Regents Of The University Of California |
Implantable drug delivery devices for localized drug delivery
|
|
US20240016731A1
(en)
*
|
2020-09-28 |
2024-01-18 |
The Regents Of The University Of California |
Drug Implants Containing Apalutamide and Methods of Use Thereof
|
|
IT202100021779A1
(it)
|
2021-08-11 |
2023-02-11 |
Plasfer S R L |
Piastrine trasfettate con sirna e loro usi terapeutici
|
|
TR2021017752A2
(tr)
|
2021-11-15 |
2021-12-21 |
S D Ue Idari Ve Maliis Dai Bas Genelsekreterlik |
Transdermal- i̇laç salim özelli̇kli̇ yeni̇li̇kçi̇ nanoli̇fli̇ medi̇kal teksti̇l malzemesi̇ üreti̇m yöntemi̇
|
|
CN114381421B
(zh)
*
|
2022-02-09 |
2023-08-15 |
河北医科大学 |
溶菌酶诱导的小鼠血管平滑肌细胞炎症模型及其建立方法和应用
|