JP2011526244A5 - - Google Patents
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- JP2011526244A5 JP2011526244A5 JP2011501003A JP2011501003A JP2011526244A5 JP 2011526244 A5 JP2011526244 A5 JP 2011526244A5 JP 2011501003 A JP2011501003 A JP 2011501003A JP 2011501003 A JP2011501003 A JP 2011501003A JP 2011526244 A5 JP2011526244 A5 JP 2011526244A5
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- 102100030173 Muellerian-inhibiting factor Human genes 0.000 claims 47
- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 239000000178 monomer Substances 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 239000013638 trimer Substances 0.000 claims 12
- 229940044551 receptor antagonist Drugs 0.000 claims 9
- 239000002464 receptor antagonist Substances 0.000 claims 9
- 208000002223 abdominal aortic aneurysm Diseases 0.000 claims 8
- 208000007474 aortic aneurysm Diseases 0.000 claims 8
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 6
- 108090000288 Glycoproteins Proteins 0.000 claims 6
- 102000003886 Glycoproteins Human genes 0.000 claims 6
- 206010028851 Necrosis Diseases 0.000 claims 6
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- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 4
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- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims 4
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 201000004624 Dermatitis Diseases 0.000 claims 4
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 4
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 4
- 101100001347 Mus musculus Akt1s1 gene Proteins 0.000 claims 4
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- 208000002552 acute disseminated encephalomyelitis Diseases 0.000 claims 4
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- KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 claims 3
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 3
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 3
- 102100037637 Cholesteryl ester transfer protein Human genes 0.000 claims 3
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- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 3
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 claims 3
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- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 claims 3
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 3
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 3
- 201000009906 Meningitis Diseases 0.000 claims 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 3
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- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 2
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- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 201000009273 Endometriosis Diseases 0.000 claims 2
- 206010058838 Enterocolitis infectious Diseases 0.000 claims 2
- 208000001640 Fibromyalgia Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
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- 208000015023 Graves' disease Diseases 0.000 claims 2
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 2
- 208000001204 Hashimoto Disease Diseases 0.000 claims 2
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 2
- 208000007514 Herpes zoster Diseases 0.000 claims 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 2
- 208000004852 Lung Injury Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 2
- 208000009433 Moyamoya Disease Diseases 0.000 claims 2
- 208000009525 Myocarditis Diseases 0.000 claims 2
- 208000000592 Nasal Polyps Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 208000035539 Ovarian infection Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010034277 Pemphigoid Diseases 0.000 claims 2
- 201000011152 Pemphigus Diseases 0.000 claims 2
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 206010038910 Retinitis Diseases 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
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- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000001106 Takayasu Arteritis Diseases 0.000 claims 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 2
- 206010069363 Traumatic lung injury Diseases 0.000 claims 2
- 241000223109 Trypanosoma cruzi Species 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 206010047642 Vitiligo Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
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- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
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- 239000003972 antineoplastic antibiotic Substances 0.000 claims 2
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- 230000001363 autoimmune Effects 0.000 claims 2
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- 208000000594 bullous pemphigoid Diseases 0.000 claims 2
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- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000003146 cystitis Diseases 0.000 claims 2
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- 206010014599 encephalitis Diseases 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 208000007565 gingivitis Diseases 0.000 claims 2
- 206010020718 hyperplasia Diseases 0.000 claims 2
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- 210000000265 leukocyte Anatomy 0.000 claims 2
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- 201000000980 schizophrenia Diseases 0.000 claims 2
- 230000036303 septic shock Effects 0.000 claims 2
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- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 claims 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 claims 1
- 206010036774 Proctitis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 208000037824 growth disorder Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3838108P | 2008-03-20 | 2008-03-20 | |
| US61/038,381 | 2008-03-20 | ||
| US3937108P | 2008-03-25 | 2008-03-25 | |
| US61/039,371 | 2008-03-25 | ||
| US4580708P | 2008-04-17 | 2008-04-17 | |
| US61/045,807 | 2008-04-17 | ||
| US12109508P | 2008-12-09 | 2008-12-09 | |
| US61/121,095 | 2008-12-09 | ||
| PCT/US2009/037887 WO2009117710A2 (en) | 2008-03-20 | 2009-03-20 | Methods of treating inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011526244A JP2011526244A (ja) | 2011-10-06 |
| JP2011526244A5 true JP2011526244A5 (https=) | 2011-11-24 |
Family
ID=41091567
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501003A Pending JP2011526244A (ja) | 2008-03-20 | 2009-03-20 | 炎症の処置方法 |
| JP2011501000A Pending JP2011515416A (ja) | 2008-03-20 | 2009-03-20 | 抗ｍｉｆ抗体を用いる処置方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501000A Pending JP2011515416A (ja) | 2008-03-20 | 2009-03-20 | 抗ｍｉｆ抗体を用いる処置方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20110044988A1 (https=) |
| EP (2) | EP2252318A4 (https=) |
| JP (2) | JP2011526244A (https=) |
| KR (1) | KR20110014141A (https=) |
| CN (2) | CN102088993A (https=) |
| AU (2) | AU2009225389A1 (https=) |
| BR (1) | BRPI0910259A2 (https=) |
| CA (2) | CA2717071A1 (https=) |
| CO (1) | CO6300848A2 (https=) |
| EA (1) | EA201001529A1 (https=) |
| IL (1) | IL207752A0 (https=) |
| MX (1) | MX2010010198A (https=) |
| NZ (1) | NZ588033A (https=) |
| WO (2) | WO2009117710A2 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102088993A (zh) * | 2008-03-20 | 2011-06-08 | 卡罗勒斯治疗公司 | 炎症的治疗方法 |
| US20110070184A1 (en) * | 2008-03-24 | 2011-03-24 | Carolus Therpeutics, Inc. | Methods and compositions for treating atherosclerosis and related condidtions |
| US20100183598A1 (en) * | 2008-11-12 | 2010-07-22 | Carolus Therapeutics, Inc. | Methods of treating cardiovascular disorders |
| AU2010298249A1 (en) * | 2009-09-23 | 2012-04-19 | Carolus Therapeutics, Inc. | Methods of treating inflammation |
| EP2308485A1 (en) * | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| EP2308484A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| WO2012125680A1 (en) | 2011-03-16 | 2012-09-20 | Novartis Ag | Methods of treating vasculitis using an il-17 binding molecule |
| US9133164B2 (en) * | 2011-04-13 | 2015-09-15 | Innov88 Llc | MIF inhibitors and their uses |
| TWI407964B (zh) * | 2011-05-10 | 2013-09-11 | Univ Fu Jen Catholic | 干擾性核糖核酸用於治療或減緩疼痛之用途 |
| EP2723380B1 (en) | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| US10596233B2 (en) | 2011-06-30 | 2020-03-24 | Dignity Health | Use of pertussis toxin as a therapeutic agent |
| US9801921B2 (en) | 2011-06-30 | 2017-10-31 | Dignity Health | Use of pertussis toxin as a therapeutic agent |
| US9238689B2 (en) | 2011-07-15 | 2016-01-19 | Morpho Sys AG | Antibodies that are cross-reactive for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT) |
| CN102357249A (zh) * | 2011-10-26 | 2012-02-22 | 广州赫尔氏药物开发有限公司 | 能够抑制耐药性结核杆菌的药物 |
| ES2656292T3 (es) | 2012-05-01 | 2018-02-26 | Translatum Medicus Inc. | Métodos de tratamiento y diagnóstico de enfermedades oculares que causan ceguera |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| US10561676B2 (en) * | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| WO2015051330A1 (en) | 2013-10-03 | 2015-04-09 | Oregon Health & Science University | RECOMBINANT POLYPEPTIDES COMPRISING MHC CLASS II α1 DOMAINS |
| CN114478773A (zh) * | 2015-01-09 | 2022-05-13 | 阿达尔塔有限公司 | Cxcr4结合分子 |
| TW201718851A (zh) * | 2015-09-18 | 2017-06-01 | 通用醫院公司 | 具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途 |
| WO2017106332A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| CN109069426B (zh) * | 2015-12-14 | 2021-10-29 | X4 制药有限公司 | 治疗癌症的方法 |
| CN109152780B (zh) | 2016-03-11 | 2021-10-01 | 阿迪亚生命科学公司 | 用于治疗结晶性关节病症的cxcr-2抑制剂 |
| KR102645432B1 (ko) * | 2016-03-28 | 2024-03-11 | (주)아모레퍼시픽 | 피부 세포 분화 촉진용 조성물 및 피부 세포 분화 촉진 물질의 스크리닝 방법 |
| US11337969B2 (en) | 2016-04-08 | 2022-05-24 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| EP3445402A4 (en) * | 2016-04-21 | 2019-12-11 | The Board Of Regents Of The University Of Texas System | METHOD AND COMPOSITIONS FOR DETECTING ANEURYSMS |
| KR102379464B1 (ko) | 2016-06-20 | 2022-03-29 | 키맵 리미티드 | 항-pd-l1 항체 |
| CN109640988A (zh) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
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| US11291641B2 (en) * | 2016-10-03 | 2022-04-05 | The Children's Medical Center Corporation | Prevention and treatment of diabetic nephropathy |
| CN108355133A (zh) * | 2017-01-26 | 2018-08-03 | 中国医学科学院阜外医院 | 靶向cxcr7的药物组合物和方法 |
| US11767564B2 (en) * | 2017-10-27 | 2023-09-26 | Board Of Regents, The University Of Texas System | Use of SDHA as a prognostic marker and therapeutic target in uveal melanoma |
| CN107964045B (zh) * | 2017-12-18 | 2021-04-23 | 南京医科大学 | 一种人鼠嵌合抗CXCR2全分子IgG及其应用 |
| BR112020020930A2 (pt) | 2018-04-11 | 2021-03-02 | Ohio State Innovation Foundation | composição de liberação de fármaco, método para tratar um distúrbio oftalmológico e kit |
| US11679146B2 (en) | 2018-06-05 | 2023-06-20 | Anji Pharmaceuticals Inc. | Compositions and methods for treating pancreatitis |
| EP3802595A1 (en) * | 2018-06-07 | 2021-04-14 | OncoOne Research & Development GmbH | Anti-oxmif/anti-cd3 antibody for cancer treatment |
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| EP4237002A4 (en) * | 2020-10-28 | 2025-02-12 | University Health Network | METHODS OF TREATING SPONDYLOARTHRITIS OR SYMPTOMS THEREOF |
| WO2022203308A1 (ko) * | 2021-03-22 | 2022-09-29 | 클립스비엔씨 주식회사 | 신규한 재조합 마이코박테리움 스메그마티스 균주 및 이의 용도 |
| JP2024516548A (ja) | 2021-04-08 | 2024-04-16 | ジョスリン ダイアビーティス センター インコーポレイテッド | 腎機能低下の診断及び予測の方法 |
| KR102561554B1 (ko) * | 2021-04-14 | 2023-07-28 | 부산대학교 산학협력단 | 치주질환 진단용 바이오마커 조성물, 치주질환 치료 효용성 평가용 바이오마커 조성물 및 이를 이용한 진단키트 |
| WO2023150294A2 (en) * | 2022-02-04 | 2023-08-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods of detecting and treating cerebral aneurysms |
| WO2025171411A1 (en) * | 2024-02-09 | 2025-08-14 | Herophilus, Inc. | Compositions and methods related to modulating macrophage migration inhibitory factor (mif)-cd74 signaling and related treatments for neuroinflammatory conditions |
| CN121714692A (zh) * | 2026-02-26 | 2026-03-24 | 华中科技大学同济医学院附属协和医院 | Cxcl14抑制剂在制备用于预防或治疗患者腹主动脉瘤的药物中的应用 |
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| DE69435303D1 (de) * | 1993-05-17 | 2010-09-02 | Cytokine Pharmasciences Inc | Er behandlung von krankheiten bei denen eine cytok |
| US6645493B1 (en) * | 1993-05-17 | 2003-11-11 | The Picower Institute For Medical Research | Composition containing anti-MIF antibody |
| US20070072861A1 (en) * | 2000-03-27 | 2007-03-29 | Barbara Roniker | Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders |
| BR0206986A (pt) * | 2001-01-12 | 2005-11-01 | Cytokine Pharmasciences Inc | Métodos e composições para modular a regulação da resposta a citotóxica do linfócito por fator inibitório de migração de macrófago |
| JP2003226653A (ja) * | 2001-11-30 | 2003-08-12 | Jun Nishihira | 多発性硬化症治療剤 |
| WO2003047622A1 (fr) * | 2001-11-30 | 2003-06-12 | Jun Nishihira | Remedes pour la sclerose en plaques |
| US6656168B2 (en) * | 2001-12-18 | 2003-12-02 | Kimberly-Clark Worldwide, Inc. | Feminine care product with discrete areas of a skin wellness additive |
| WO2003072753A2 (en) * | 2002-02-27 | 2003-09-04 | Emory University | Multimeric binding complexes |
| KR101017732B1 (ko) * | 2002-03-01 | 2011-02-28 | 이뮤노메딕스, 인코오포레이티드 | 내재화 항-ｃｄ74 항체 및 그 이용방법 |
| WO2004049095A2 (en) * | 2002-11-25 | 2004-06-10 | Jallal Messadek | Betaine and salicylic acid compositions |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| US20050202010A1 (en) * | 2003-08-29 | 2005-09-15 | Giroir Brett P. | Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor |
| US7897349B2 (en) * | 2003-12-30 | 2011-03-01 | The United States Of America As Represented By The Department Of Veterans Affairs | Macrophage migration inhibitory factor (MIF) as marker for urological inflammatory disease |
| US20060257466A1 (en) * | 2005-04-06 | 2006-11-16 | Kim Perry M | Administration of macrophage targeted formulations of compounds which modulate cholesterol-metabolizing enzymes for treatment of atherosclerosis |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| JPWO2007138961A1 (ja) * | 2006-05-29 | 2009-10-08 | レドックス・バイオサイエンス株式会社 | マクロファージ遊走阻止因子阻害剤 |
| CN102088993A (zh) * | 2008-03-20 | 2011-06-08 | 卡罗勒斯治疗公司 | 炎症的治疗方法 |
| US20110070184A1 (en) * | 2008-03-24 | 2011-03-24 | Carolus Therpeutics, Inc. | Methods and compositions for treating atherosclerosis and related condidtions |
| US20100183598A1 (en) * | 2008-11-12 | 2010-07-22 | Carolus Therapeutics, Inc. | Methods of treating cardiovascular disorders |
| US20110256130A1 (en) * | 2008-12-01 | 2011-10-20 | Joshua Robert Schultz | Methods of treating inflammatory disorders |
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- 2009-03-20 KR KR1020107023480A patent/KR20110014141A/ko not_active Withdrawn
- 2009-03-20 EP EP09721240A patent/EP2252318A4/en not_active Withdrawn
- 2009-03-20 JP JP2011501003A patent/JP2011526244A/ja active Pending
- 2009-03-20 CA CA2717071A patent/CA2717071A1/en not_active Abandoned
- 2009-03-20 EA EA201001529A patent/EA201001529A1/ru unknown
- 2009-03-20 MX MX2010010198A patent/MX2010010198A/es active IP Right Grant
- 2009-03-20 US US12/918,968 patent/US20110044988A1/en not_active Abandoned
- 2009-03-20 WO PCT/US2009/037887 patent/WO2009117710A2/en not_active Ceased
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- 2009-03-20 BR BRPI0910259A patent/BRPI0910259A2/pt not_active IP Right Cessation
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- 2009-03-20 JP JP2011501000A patent/JP2011515416A/ja active Pending
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