JP2011521979A5 - - Google Patents
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- Publication number
- JP2011521979A5 JP2011521979A5 JP2011511948A JP2011511948A JP2011521979A5 JP 2011521979 A5 JP2011521979 A5 JP 2011521979A5 JP 2011511948 A JP2011511948 A JP 2011511948A JP 2011511948 A JP2011511948 A JP 2011511948A JP 2011521979 A5 JP2011521979 A5 JP 2011521979A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridine
- hydroxymethyl
- methyl
- hydroxy
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13087408P | 2008-06-04 | 2008-06-04 | |
| US61/130,874 | 2008-06-06 | ||
| PCT/CA2009/000787 WO2009146555A1 (en) | 2008-06-04 | 2009-06-04 | Hiv integrase inhibitors from pyridoxine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521979A JP2011521979A (ja) | 2011-07-28 |
| JP2011521979A5 true JP2011521979A5 (https=) | 2012-01-05 |
| JP5514810B2 JP5514810B2 (ja) | 2014-06-04 |
Family
ID=41397686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511948A Expired - Fee Related JP5514810B2 (ja) | 2008-06-04 | 2009-06-04 | ピリドキシンに由来するｈｉｖインテグラーゼ阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8742123B2 (https=) |
| EP (1) | EP2300433A4 (https=) |
| JP (1) | JP5514810B2 (https=) |
| CN (1) | CN102112447B (https=) |
| AU (1) | AU2009253812A1 (https=) |
| CA (1) | CA2726742A1 (https=) |
| RU (1) | RU2010153656A (https=) |
| WO (1) | WO2009146555A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8410300B2 (en) * | 2006-09-21 | 2013-04-02 | Taimed Biologics, Inc. | Protease inhibitors |
| KR20090117950A (ko) | 2007-03-08 | 2009-11-16 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절자 및 그것의 사용 방법 |
| EP2337563B1 (en) * | 2008-09-08 | 2014-04-09 | The Board of Trustees of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| KR20110082180A (ko) | 2008-10-28 | 2011-07-18 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 알데히드 탈수소효소의 조절자 및 그것의 사용방법 |
| US8283366B2 (en) | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
| WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| ES2643403T3 (es) | 2011-12-28 | 2017-11-22 | Global Blood Therapeutics, Inc. | Compuestos de benzaldehído sustituidos y métodos para su uso en el aumento de la oxigenación tisular |
| HK1203412A1 (en) | 2011-12-28 | 2015-10-30 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| JP6410790B2 (ja) | 2013-03-14 | 2018-10-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ミトコンドリアアルデヒドデヒドロゲナーゼ−２調節因子およびその使用方法 |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| MX379235B (es) | 2013-03-15 | 2025-03-11 | Global Blood Therapeutics Inc | Compuestos y sus usos para modular la hemoglobina. |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2014150258A1 (en) | 2013-03-15 | 2014-09-25 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| CN105073728A (zh) | 2013-03-15 | 2015-11-18 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| CN114181195A (zh) | 2014-02-07 | 2022-03-15 | 全球血液疗法股份有限公司 | 一种化合物的结晶多晶型物 |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| SG11201804647TA (en) | 2015-12-04 | 2018-06-28 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
| TWI773657B (zh) | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物 |
| TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| CN108203439B (zh) * | 2016-12-20 | 2020-04-14 | 四川大学 | 苯乙烯吡啶类化合物、其制备方法和用途 |
| RU2641309C1 (ru) * | 2017-07-24 | 2018-01-17 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Антисептическое лекарственное средство |
| EP3687538B1 (en) * | 2017-10-30 | 2024-04-17 | Montreal Heart Institute | Methods of treating elevated plasma cholesterol |
| US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
| ES2949871T3 (es) * | 2019-04-11 | 2023-10-03 | Janssen Pharmaceutica Nv | Anillos de piridina que contienen derivados como inhibidores de MALT1 |
| WO2020237374A1 (en) * | 2019-05-28 | 2020-12-03 | Montreal Heart Institute | Picolinic acid derivatives and use thereof for treating diseases associated with elevated cholesterol |
| CN113116890B (zh) * | 2021-04-25 | 2022-06-03 | 西南大学 | 5-Pyridoxolactone用于制备抑制家蚕核型多角体病毒的药物中的应用 |
| CN117343006B (zh) * | 2023-10-08 | 2024-07-09 | 河南科技大学 | 一种arb-272572的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6107291A (en) | 1997-12-19 | 2000-08-22 | Amgen Inc. | Azepine or larger medium ring derivatives and methods of use |
| DK1004578T3 (da) | 1998-11-05 | 2004-06-28 | Pfizer Prod Inc | 5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater |
| PA8586801A1 (es) * | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
| DE602004004665T2 (de) | 2003-08-20 | 2008-01-03 | Pharmacyclics, Inc., Sunnyvale | Acetylenderivate als inhibitoren von histondeacetylase |
| WO2005103003A2 (en) * | 2004-04-26 | 2005-11-03 | Pfizer Inc. | Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors |
| US8114886B2 (en) * | 2005-04-08 | 2012-02-14 | Daiichi Sankyo Company, Limited | Pyridylmethylsulfone derivative |
-
2009
- 2009-06-04 AU AU2009253812A patent/AU2009253812A1/en not_active Abandoned
- 2009-06-04 CN CN2009801304571A patent/CN102112447B/zh not_active Expired - Fee Related
- 2009-06-04 EP EP09757017A patent/EP2300433A4/en not_active Withdrawn
- 2009-06-04 WO PCT/CA2009/000787 patent/WO2009146555A1/en not_active Ceased
- 2009-06-04 JP JP2011511948A patent/JP5514810B2/ja not_active Expired - Fee Related
- 2009-06-04 RU RU2010153656/04A patent/RU2010153656A/ru unknown
- 2009-06-04 US US12/995,890 patent/US8742123B2/en not_active Expired - Fee Related
- 2009-06-04 CA CA2726742A patent/CA2726742A1/en not_active Abandoned
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