|
US3674836A
(en)
|
1968-05-21 |
1972-07-04 |
Parke Davis & Co |
2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
|
|
US4027009A
(en)
|
1973-06-11 |
1977-05-31 |
Merck & Co., Inc. |
Compositions and methods for depressing blood serum cholesterol
|
|
JPS5612114B2
(cg-RX-API-DMAC7.html)
|
1974-06-07 |
1981-03-18 |
|
|
|
JPS5432794A
(en)
|
1977-08-18 |
1979-03-10 |
Omron Tateisi Electronics Co |
Manufacturing method of terminal rack
|
|
NO154918C
(no)
|
1977-08-27 |
1987-01-14 |
Bayer Ag |
Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
|
|
US4231938A
(en)
|
1979-06-15 |
1980-11-04 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
|
DE2951135A1
(de)
|
1979-12-19 |
1981-06-25 |
Hoechst Ag, 6230 Frankfurt |
Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
|
|
MX7065E
(es)
|
1980-06-06 |
1987-04-10 |
Sankyo Co |
Un procedimiento microbiologico para preparar derivados de ml-236b
|
|
US4450171A
(en)
|
1980-08-05 |
1984-05-22 |
Merck & Co., Inc. |
Antihypercholesterolemic compounds
|
|
US4448784A
(en)
|
1982-04-12 |
1984-05-15 |
Hoechst-Roussel Pharmaceuticals, Inc. |
1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof
|
|
US5354772A
(en)
|
1982-11-22 |
1994-10-11 |
Sandoz Pharm. Corp. |
Indole analogs of mevalonolactone and derivatives thereof
|
|
US4499289A
(en)
|
1982-12-03 |
1985-02-12 |
G. D. Searle & Co. |
Octahydronapthalenes
|
|
CA1327360C
(en)
|
1983-11-14 |
1994-03-01 |
William F. Hoffman |
Oxo-analogs of mevinolin-like antihypercholesterolemic agents
|
|
US4613610A
(en)
|
1984-06-22 |
1986-09-23 |
Sandoz Pharmaceuticals Corp. |
Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
|
|
US4686237A
(en)
|
1984-07-24 |
1987-08-11 |
Sandoz Pharmaceuticals Corp. |
Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof
|
|
US4647576A
(en)
|
1984-09-24 |
1987-03-03 |
Warner-Lambert Company |
Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
|
|
ATE60571T1
(de)
|
1984-12-04 |
1991-02-15 |
Sandoz Ag |
Inden-analoga von mevalonolakton und ihre derivate.
|
|
AU598775B2
(en)
|
1985-10-25 |
1990-07-05 |
Sandoz Ag |
Heterocyclic analogs of mevalonolactone
|
|
DE3543999A1
(de)
|
1985-12-13 |
1987-06-19 |
Bayer Ag |
Hochreine acarbose
|
|
FR2596393B1
(fr)
|
1986-04-01 |
1988-06-03 |
Sanofi Sa |
Derives de l'acide hydroxy-3 dihydroxyoxophosphorio-4 butanoique, leur procede de preparation, leur application comme medicament et les compositions les renfermant
|
|
US4681893A
(en)
|
1986-05-30 |
1987-07-21 |
Warner-Lambert Company |
Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
|
|
HU205125B
(en)
|
1987-05-22 |
1992-03-30 |
Squibb & Sons Inc |
Process for producing phosphorous compounds and pharmaceutical compositions comprising same
|
|
US4759923A
(en)
|
1987-06-25 |
1988-07-26 |
Hercules Incorporated |
Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
|
|
JP2569746B2
(ja)
|
1987-08-20 |
1997-01-08 |
日産化学工業株式会社 |
キノリン系メバロノラクトン類
|
|
US4924024A
(en)
|
1988-01-11 |
1990-05-08 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing squalene synthetase inhibitors, new intermediates and method
|
|
US4871721A
(en)
|
1988-01-11 |
1989-10-03 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing squalene synthetase inhibitors
|
|
NO177005C
(no)
|
1988-01-20 |
1995-07-05 |
Bayer Ag |
Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
|
|
US5506219A
(en)
|
1988-08-29 |
1996-04-09 |
E. R. Squibb & Sons, Inc. |
Pyridine anchors for HMG-CoA reductase inhibitors
|
|
US5753675A
(en)
|
1989-03-03 |
1998-05-19 |
Novartis Pharmaceuticals Corporation |
Quinoline analogs of mevalonolactone and derivatives thereof
|
|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
|
US5177080A
(en)
|
1990-12-14 |
1993-01-05 |
Bayer Aktiengesellschaft |
Substituted pyridyl-dihydroxy-heptenoic acid and its salts
|
|
JP2648897B2
(ja)
|
1991-07-01 |
1997-09-03 |
塩野義製薬株式会社 |
ピリミジン誘導体
|
|
DE4129603A1
(de)
|
1991-09-06 |
1993-03-11 |
Thomae Gmbh Dr K |
Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
|
|
GB9209628D0
(en)
|
1992-05-05 |
1992-06-17 |
Smithkline Beecham Plc |
Compounds
|
|
US5470845A
(en)
|
1992-10-28 |
1995-11-28 |
Bristol-Myers Squibb Company |
Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia
|
|
LT3300B
(en)
|
1992-12-23 |
1995-06-26 |
Schering Corp |
Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor
|
|
US5594016A
(en)
|
1992-12-28 |
1997-01-14 |
Mitsubishi Chemical Corporation |
Naphthalene derivatives
|
|
US5662934A
(en)
|
1993-01-05 |
1997-09-02 |
Najarian; Thomas |
Compositions and methods for lowering cholesterol while maintaining antioxidant levels
|
|
DK0680320T3
(da)
|
1993-01-19 |
1999-10-25 |
Warner Lambert Co |
Stabilt oralt CI-981-præparat og fremgangsmåde til fremstilling deraf
|
|
US5801170A
(en)
|
1993-12-07 |
1998-09-01 |
Smithkline Beecham Plc |
Heterocyclic biphenylylamides useful as 5HT1D antagonists
|
|
US5776983A
(en)
|
1993-12-21 |
1998-07-07 |
Bristol-Myers Squibb Company |
Catecholamine surrogates useful as β3 agonists
|
|
US5488064A
(en)
|
1994-05-02 |
1996-01-30 |
Bristol-Myers Squibb Company |
Benzo 1,3 dioxole derivatives
|
|
US5385929A
(en)
|
1994-05-04 |
1995-01-31 |
Warner-Lambert Company |
[(Hydroxyphenylamino) carbonyl] pyrroles
|
|
US5612359A
(en)
|
1994-08-26 |
1997-03-18 |
Bristol-Myers Squibb Company |
Substituted biphenyl isoxazole sulfonamides
|
|
US5491134A
(en)
|
1994-09-16 |
1996-02-13 |
Bristol-Myers Squibb Company |
Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
|
|
US5541204A
(en)
|
1994-12-02 |
1996-07-30 |
Bristol-Myers Squibb Company |
Aryloxypropanolamine β 3 adrenergic agonists
|
|
US5698527A
(en)
|
1995-08-08 |
1997-12-16 |
Merck & Co., Inc. |
Steroidal glycosides as antihyperlipidemic agents
|
|
WO1997021993A2
(en)
|
1995-12-13 |
1997-06-19 |
The Regents Of The University Of California |
Nuclear receptor ligands and ligand binding domains
|
|
IL117702A0
(en)
|
1996-03-28 |
1996-07-23 |
Tel Aviv Medical Center Resear |
Drug for hyperlipoproteinemia
|
|
US5770615A
(en)
|
1996-04-04 |
1998-06-23 |
Bristol-Myers Squibb Company |
Catecholamine surrogates useful as β3 agonists
|
|
DE19622222A1
(de)
|
1996-06-03 |
1997-12-04 |
Hoechst Ag |
Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikament zur Normalisierung der Serumlipide
|
|
AU2401697A
(en)
|
1996-06-20 |
1998-01-07 |
Pfizer Inc. |
4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors
|
|
HRP970330B1
(en)
|
1996-07-08 |
2004-06-30 |
Bayer Ag |
Cycloalkano pyridines
|
|
DE19653645A1
(de)
|
1996-12-20 |
1998-06-25 |
Hoechst Ag |
Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
|
|
DE19653647A1
(de)
|
1996-12-20 |
1998-06-25 |
Hoechst Ag |
Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
|
|
US6482821B2
(en)
|
1996-12-20 |
2002-11-19 |
Hoechst Aktiengellschaft |
Vitronectin receptor antagonists, their preparation and their use
|
|
TW536540B
(en)
|
1997-01-30 |
2003-06-11 |
Bristol Myers Squibb Co |
Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
|
|
CN1255043A
(zh)
|
1997-05-08 |
2000-05-31 |
英国阿格里沃有限公司 |
杀真菌剂
|
|
GB9713739D0
(en)
|
1997-06-27 |
1997-09-03 |
Karobio Ab |
Thyroid receptor ligands
|
|
MXPA00003546A
(es)
|
1997-10-08 |
2002-08-06 |
Sankyo Co |
Compuesto heterociclico fusionado sustituido.
|
|
NZ508118A
(en)
|
1998-07-06 |
2003-07-25 |
Bristol Myers Squibb Co |
Heteroaryl substituted biphenyl sulfonamides useful as dual angiotensin endothelin receptor antogonists
|
|
AU5612199A
(en)
|
1998-09-10 |
2000-04-03 |
Forbes Medi-Tech Inc. |
Compositions comprising one or more phytosterols, phytostanols or mixtures of both and one or more alpha, beta, delta, or gamma tocotrienols or derivatives thereof and use of the compositions in treating or preventing cardiovascular disease, its underlying conditions and other
|
|
US6147089A
(en)
|
1998-09-17 |
2000-11-14 |
Pfizer Inc. |
Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
|
|
WO2000030665A1
(en)
|
1998-11-25 |
2000-06-02 |
Nutri Pharma Asa |
Composition comprising soy protein, dietary fibres and a phytoestrogen compound and use thereof in the prevention and/or treatment of cardiovascular diseases
|
|
US6462091B1
(en)
|
1998-12-23 |
2002-10-08 |
G.D. Searle & Co. |
Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
|
|
GB9828442D0
(en)
|
1998-12-24 |
1999-02-17 |
Karobio Ab |
Novel thyroid receptor ligands and method II
|
|
AU776785B2
(en)
|
1999-02-24 |
2004-09-23 |
Johns Hopkins University, The |
Compositions and methods for modulating serum cholesterol
|
|
AU5031200A
(en)
|
1999-05-28 |
2000-12-18 |
Vertex Pharmaceuticals Incorporated |
Method for preparing 5-substituted oxazoles
|
|
US6414002B1
(en)
|
1999-09-22 |
2002-07-02 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
|
|
IL153645A0
(en)
|
2000-07-31 |
2003-07-06 |
Smithkline Beecham Plc |
Carboxamide compounds and their use as antagonists of a human 11cby receptor
|
|
WO2002101146A1
(fr)
|
2001-05-11 |
2002-12-19 |
Arina Nakayama |
Papier lumineux et son procede de production et d'utilisation
|
|
GB0124627D0
(en)
|
2001-10-15 |
2001-12-05 |
Smithkline Beecham Plc |
Novel compounds
|
|
BR0213521A
(pt)
|
2001-10-25 |
2004-10-19 |
Takeda Chemical Industries Ltd |
Composto, composição farmacêutica, agente farmacêutico, uso do composto, e, métodos para antagonizar um receptor de hormÈnio que concentra melanina em um mamìfero, para prevenir ou tratar uma doença causada por um hormÈnio que concentra melanina em um mamìfero, para prevenir ou tratar a obesidade em um mamìfero, para suprimir a entrada de alimento em um mamìfero, para prevenir ou tratar a depressão em um mamìfero, para prevenir ou tratar a ansiedade em um mamìfero e para produzir o composto
|
|
MXPA05006568A
(es)
|
2002-12-20 |
2005-09-22 |
Pharmacia Corp |
Compuestos de pirazol aciclico para la inhibicion de proteina cinasa-2 activada por proteina cinasa activada por mitogenos.
|
|
EP1618112A1
(en)
|
2003-04-11 |
2006-01-25 |
SmithKline Beecham Corporation |
Heterocyclic mchr1 antagonists
|
|
JP2006193426A
(ja)
|
2003-09-05 |
2006-07-27 |
Sankyo Co Ltd |
置換された縮環ピリミジン−4(3h)−オン化合物
|
|
AU2004285913A1
(en)
|
2003-10-23 |
2005-05-12 |
Glaxo Group Limited |
3-(4-aminophenyl) thienopyrimid-4-one derivatives as MCH R1 antagonists for the treatment of obesity, diabetes, depression and anxiety
|
|
US20050176738A1
(en)
|
2003-11-07 |
2005-08-11 |
Neurocrine Biosciences, Inc. |
Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
|
|
US20050256124A1
(en)
|
2004-04-15 |
2005-11-17 |
Neurocrine Biosciences, Inc. |
Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
|
|
RU2266906C1
(ru)
|
2004-04-29 |
2005-12-27 |
Общество с ограниченной ответственностью "Исследовательский Институт Химического Разнообразия" (ООО "Исследовательский Институт Химического Разнообразия") |
Анелированные карбамоилазагетероциклы, способы их получения (варианты), фармацевтическая композиция, фокусированная библиотека
|
|
US7745447B2
(en)
|
2005-10-26 |
2010-06-29 |
Bristol-Myers Squibb Company |
Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists
|
|
AR056155A1
(es)
|
2005-10-26 |
2007-09-19 |
Bristol Myers Squibb Co |
Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica
|
|
US7553836B2
(en)
|
2006-02-06 |
2009-06-30 |
Bristol-Myers Squibb Company |
Melanin concentrating hormone receptor-1 antagonists
|