JP2011521957A5 - - Google Patents
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- Publication number
- JP2011521957A5 JP2011521957A5 JP2011511775A JP2011511775A JP2011521957A5 JP 2011521957 A5 JP2011521957 A5 JP 2011521957A5 JP 2011511775 A JP2011511775 A JP 2011511775A JP 2011511775 A JP2011511775 A JP 2011511775A JP 2011521957 A5 JP2011521957 A5 JP 2011521957A5
- Authority
- JP
- Japan
- Prior art keywords
- emulsion
- alkyl
- group
- nhc
- preservative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000839 emulsion Substances 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 24
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 239000003755 preservative agent Substances 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
- 229940124597 therapeutic agent Drugs 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- 239000011734 sodium Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
- 229920002907 Guar gum Polymers 0.000 claims description 6
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 6
- 150000001450 anions Chemical class 0.000 claims description 6
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 6
- 150000001768 cations Chemical class 0.000 claims description 6
- 229920006184 cellulose methylcellulose Polymers 0.000 claims description 6
- 239000003974 emollient agent Substances 0.000 claims description 6
- 239000000665 guar gum Substances 0.000 claims description 6
- 235000010417 guar gum Nutrition 0.000 claims description 6
- 229960002154 guar gum Drugs 0.000 claims description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- 230000000087 stabilizing effect Effects 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 239000003995 emulsifying agent Substances 0.000 claims description 4
- 125000005843 halogen group Chemical group 0.000 claims description 4
- 239000003002 pH adjusting agent Substances 0.000 claims description 4
- 229910052700 potassium Inorganic materials 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 231100000344 non-irritating Toxicity 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- 229910001413 alkali metal ion Inorganic materials 0.000 claims description 2
- 239000003899 bactericide agent Substances 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 239000000417 fungicide Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims 15
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims 6
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims 6
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 claims 6
- -1 polyquaternium-1 Chemical compound 0.000 claims 6
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 claims 3
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims 3
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 3
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 3
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 3
- 239000004155 Chlorine dioxide Substances 0.000 claims 3
- 229920002413 Polyhexanide Polymers 0.000 claims 3
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 claims 3
- 229950010221 alexidine Drugs 0.000 claims 3
- 229960002233 benzalkonium bromide Drugs 0.000 claims 3
- 229960000686 benzalkonium chloride Drugs 0.000 claims 3
- 229960001950 benzethonium chloride Drugs 0.000 claims 3
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims 3
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims 3
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 3
- 229960002798 cetrimide Drugs 0.000 claims 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims 3
- 229960003260 chlorhexidine Drugs 0.000 claims 3
- 235000019398 chlorine dioxide Nutrition 0.000 claims 3
- 229960004926 chlorobutanol Drugs 0.000 claims 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 3
- 229960004867 hexetidine Drugs 0.000 claims 3
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims 3
- 229910052753 mercury Inorganic materials 0.000 claims 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 3
- 229940067107 phenylethyl alcohol Drugs 0.000 claims 3
- 235000010241 potassium sorbate Nutrition 0.000 claims 3
- 239000004302 potassium sorbate Substances 0.000 claims 3
- 229940069338 potassium sorbate Drugs 0.000 claims 3
- 235000010199 sorbic acid Nutrition 0.000 claims 3
- 239000004334 sorbic acid Substances 0.000 claims 3
- 229940075582 sorbic acid Drugs 0.000 claims 3
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims 3
- 229940033663 thimerosal Drugs 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5667508P | 2008-05-28 | 2008-05-28 | |
| US61/056,675 | 2008-05-28 | ||
| PCT/US2009/045282 WO2009154978A2 (en) | 2008-05-28 | 2009-05-27 | Self-preserved emulsions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011521957A JP2011521957A (ja) | 2011-07-28 |
| JP2011521957A5 true JP2011521957A5 (https=) | 2012-06-28 |
Family
ID=41203940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511775A Pending JP2011521957A (ja) | 2008-05-28 | 2009-05-27 | 自己防腐エマルジョン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090298956A1 (https=) |
| EP (1) | EP2278953B1 (https=) |
| JP (1) | JP2011521957A (https=) |
| KR (2) | KR20110010788A (https=) |
| AU (1) | AU2009260572B2 (https=) |
| BR (1) | BRPI0912302A2 (https=) |
| CA (1) | CA2725523C (https=) |
| ES (1) | ES2586283T3 (https=) |
| WO (1) | WO2009154978A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004017477D1 (de) * | 2004-11-09 | 2008-12-11 | Novagali Pharma Sa | Öl-in-Wasser-Emulsion mit niedriger Konzentration des kationischen Mittels und positivem Zetapotential |
| EP2228058A1 (en) | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
| EP2389939A1 (en) | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
| JP5673278B2 (ja) * | 2011-03-24 | 2015-02-18 | 日油株式会社 | ホスホリルコリン類似構造を有する化合物および化粧料 |
| JP5782847B2 (ja) * | 2011-06-13 | 2015-09-24 | 日油株式会社 | ホスホリルコリン類似構造を有する化合物および化粧料 |
| JP5782846B2 (ja) * | 2011-06-13 | 2015-09-24 | 日油株式会社 | ホスホリルコリン類似構造を有する化合物および化粧料 |
| PL2887923T3 (pl) * | 2012-08-24 | 2023-08-14 | Sun Pharmaceutical Industries Limited | Preparat okulistyczny polioksylipidu lub polioksylowego kwasu tłuszczowego i leczenie chorób oczu |
| EP3373976B1 (en) | 2015-11-10 | 2024-01-03 | Sun Pharmaceutical Industries Limited | Topical formulations and uses thereof |
| US10918694B2 (en) | 2016-02-29 | 2021-02-16 | Sun Pharma Global Fze | Topical cyclosporine-containing formulations and uses thereof |
| ITUA20162425A1 (it) * | 2016-04-08 | 2017-10-08 | Medivis S R L | Composizione oftalmica che comprende PVP-I |
| CN108201526A (zh) * | 2018-03-13 | 2018-06-26 | 云南云龙制药股份有限公司 | 一种治疗鼻炎的凝胶及其制备方法和应用 |
| US20230093908A1 (en) * | 2019-08-18 | 2023-03-30 | IVIEW Therapeutics (Zhuhai) Co., Ltd. | In-situ Gel Containing Cyclosporine Micelles as Sustained Ophthalmic Drug Delivery System |
| AR124568A1 (es) * | 2021-01-16 | 2023-04-12 | Godrej Industries Ltd | Agentes antifúngicos, mezcla de los mismos y composiciones de limpieza para el cuidado personal que los contienen |
| CN115463088A (zh) * | 2021-06-11 | 2022-12-13 | 温士顿医药股份有限公司 | 含前列腺素衍生物的眼用纳米乳剂组合物 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3608073A (en) * | 1968-07-16 | 1971-09-21 | Barnes Hind Pharm Inc | Emulsion of pilocarpine for ophthalmic use |
| US4215064A (en) * | 1978-11-30 | 1980-07-29 | Johnson & Johnson | Phosphobetaines |
| US4503002A (en) * | 1978-11-30 | 1985-03-05 | Mona Industries, Inc. | Phosphate quaternary compounds |
| US4209449A (en) * | 1978-11-30 | 1980-06-24 | Mona Industries | Phosphate quaternary compounds |
| US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| MX9206219A (es) * | 1991-10-28 | 1994-01-31 | Mona Industries Inc | Composiciones antimicrobianas de fosfolipidos |
| US5286719A (en) * | 1991-10-28 | 1994-02-15 | Mona Industries, Inc. | Phospholipid virucidal compositions |
| US5648348A (en) * | 1991-10-28 | 1997-07-15 | Mona Industries, Inc. | Phospholipid antimicrobial compositions |
| US5505953A (en) * | 1992-05-06 | 1996-04-09 | Alcon Laboratories, Inc. | Use of borate-polyol complexes in ophthalmic compositions |
| AU7319394A (en) * | 1993-07-01 | 1995-01-24 | Allergan, Inc. | Contact lens cleaning solution based on quaternary ammonium phosphate esters |
| EP0708646A1 (en) * | 1994-05-06 | 1996-05-01 | Alcon Laboratories, Inc. | Use of vitamin e tocopheryl derivatives in ophthalmic compositions |
| ES2094688B1 (es) * | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
| US5827835A (en) * | 1994-08-30 | 1998-10-27 | Alcon Laboratories, Inc. | Thermally-gelling emulsions |
| US5874469A (en) * | 1996-01-05 | 1999-02-23 | Alcon Laboratories, Inc. | Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs |
| PT877600E (pt) * | 1996-08-09 | 2004-02-27 | Alcon Mfg Ltd | Sistemas conservantes para composicoes farmaceuticas contendo ciclodextrinas |
| EP1020194A4 (en) * | 1997-10-01 | 2003-05-21 | Wakamoto Pharma Co Ltd | AQUEOUS TYPE EMULSION COMPOSITIONS |
| US6120758A (en) * | 1998-07-16 | 2000-09-19 | Shaklee Corporation | Preservative system for topically applied products |
| DK1124535T3 (da) * | 1998-10-27 | 2003-01-06 | Alcon Lab Inc | Konserverende system til topisk indgivelige farmaceutiske præparater indeholdende en fedtsyre/aminosyresæbe |
| US6750250B1 (en) * | 2001-07-12 | 2004-06-15 | Alcon, Inc. | 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders |
| US6451775B1 (en) * | 2001-08-29 | 2002-09-17 | Colonial Chemical Inc. | Castor amidopropyl dimethyl phospholipids as emulsifiers |
| US6585961B1 (en) * | 2001-11-30 | 2003-07-01 | Richard F. Stockel | Antimicrobial compositions |
| WO2003086332A1 (en) * | 2002-04-11 | 2003-10-23 | Dvm Pharmaceuticals, Inc. | Antimicrobial wash and carrier solutions, and uses thereof |
| US20060141059A1 (en) * | 2004-12-27 | 2006-06-29 | Alcon, Inc. | Self-preserved ophthalmic pharmaceutical compositions containing tobramycin |
| US20070297990A1 (en) * | 2006-06-27 | 2007-12-27 | Shah Mandar V | Self-preserving composition |
| US20080026013A1 (en) * | 2006-07-28 | 2008-01-31 | Laura Rabinovich-Guilatt | Compositions containing quaternary ammonium compounds |
| WO2008035246A2 (en) * | 2006-07-28 | 2008-03-27 | Novagali Pharma Sa | Compositions containing quaternary ammonium compounds |
| TW200904485A (en) * | 2007-05-18 | 2009-02-01 | Alcon Res Ltd | Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions |
-
2009
- 2009-05-27 EP EP09767290.1A patent/EP2278953B1/en not_active Not-in-force
- 2009-05-27 ES ES09767290.1T patent/ES2586283T3/es active Active
- 2009-05-27 BR BRPI0912302A patent/BRPI0912302A2/pt not_active IP Right Cessation
- 2009-05-27 KR KR1020107028352A patent/KR20110010788A/ko not_active Ceased
- 2009-05-27 US US12/472,880 patent/US20090298956A1/en not_active Abandoned
- 2009-05-27 WO PCT/US2009/045282 patent/WO2009154978A2/en not_active Ceased
- 2009-05-27 AU AU2009260572A patent/AU2009260572B2/en not_active Ceased
- 2009-05-27 JP JP2011511775A patent/JP2011521957A/ja active Pending
- 2009-05-27 KR KR1020167029032A patent/KR20160123400A/ko not_active Ceased
- 2009-05-27 CA CA2725523A patent/CA2725523C/en not_active Expired - Fee Related
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