JP2011521940A5 - - Google Patents

Download PDF

Info

Publication number
JP2011521940A5
JP2011521940A5 JP2011511102A JP2011511102A JP2011521940A5 JP 2011521940 A5 JP2011521940 A5 JP 2011521940A5 JP 2011511102 A JP2011511102 A JP 2011511102A JP 2011511102 A JP2011511102 A JP 2011511102A JP 2011521940 A5 JP2011521940 A5 JP 2011521940A5
Authority
JP
Japan
Prior art keywords
composition
group
cas
exendin
obesity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011511102A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011521940A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2009/005659 external-priority patent/WO2009144555A1/en
Publication of JP2011521940A publication Critical patent/JP2011521940A/ja
Publication of JP2011521940A5 publication Critical patent/JP2011521940A5/ja
Withdrawn legal-status Critical Current

Links

JP2011511102A 2008-05-28 2009-05-18 ピラゾロスピロケトンアセチルCoAカルボキシラーゼ阻害剤 Withdrawn JP2011521940A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5665208P 2008-05-28 2008-05-28
US61/056,652 2008-05-28
US5868908P 2008-06-04 2008-06-04
US61/058,689 2008-06-04
US17111209P 2009-04-21 2009-04-21
US61/171,112 2009-04-21
PCT/IB2009/005659 WO2009144555A1 (en) 2008-05-28 2009-05-18 Pyrazolospiroketone acetyl-coa carboxylase inhibitors

Publications (2)

Publication Number Publication Date
JP2011521940A JP2011521940A (ja) 2011-07-28
JP2011521940A5 true JP2011521940A5 (enExample) 2012-07-05

Family

ID=40974463

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011511102A Withdrawn JP2011521940A (ja) 2008-05-28 2009-05-18 ピラゾロスピロケトンアセチルCoAカルボキシラーゼ阻害剤

Country Status (5)

Country Link
US (1) US20110009443A1 (enExample)
EP (1) EP2297164A1 (enExample)
JP (1) JP2011521940A (enExample)
CA (1) CA2724603A1 (enExample)
WO (1) WO2009144555A1 (enExample)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5435592B2 (ja) 2008-05-28 2014-03-05 ファイザー・インク ピラゾロスピロケトンアセチルCoAカルボキシラーゼ阻害剤
UA102336C2 (uk) * 2009-11-10 2013-06-25 Пфайзер Інк. N1-ПІРАЗОЛСПІРОКЕТОНИ ЯК ІНГІБІТОРИ АЦЕТИЛ-СоА-КАРБОКСИЛАЗ
ES2557895T3 (es) 2010-03-19 2016-01-29 Pfizer Inc Derivados de 2,3-dihidro-1H-inden-1-il-2,7-diazaespiro[3.6]nonano y su uso como antagonistas o agonistas inversos del receptor de grelina
US9006450B2 (en) * 2010-07-01 2015-04-14 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof
DK2621493T3 (en) 2010-09-30 2016-10-24 Pfizer N1 PYRAZOLOSPIROKETON-ACETYL-CoA carboxylase INHIBITORS
CN103189377B (zh) * 2010-10-29 2015-02-25 辉瑞大药厂 N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂
EA022375B1 (ru) 2011-04-22 2015-12-30 Пфайзер Инк. ПРОИЗВОДНЫЕ ПИРАЗОЛОСПИРОКЕТОНОВ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ АЦЕТИЛ-КоА-КАРБОКСИЛАЗ
JP2014520879A (ja) 2011-07-15 2014-08-25 ファイザー・インク Gpr119調節因子
RU2013157388A (ru) 2011-07-22 2015-08-27 Пфайзер Инк. Хинолинильные модуляторы глюкагонового рецептора
WO2013030713A1 (en) 2011-08-31 2013-03-07 Pfizer Inc. Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
AU2012335220B2 (en) 2011-11-11 2017-06-01 Pfizer Inc. 2-thiopyrimidinones
AU2013245353A1 (en) 2012-04-06 2014-09-25 Pfizer Inc. Diacylglycerol acyltransferase 2 inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
WO2013164730A1 (en) 2012-05-04 2013-11-07 Pfizer Inc. Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin- 2 -amine compounds as inhibitors of app, bace1 and bace 2.
JP2015529239A (ja) 2012-09-20 2015-10-05 ファイザー・インク アルキル置換ヘキサヒドロピラノ[3,4−d][1,3]チアジン−2−アミン化合物
CA2893256A1 (en) 2012-12-11 2014-06-19 Pfizer Inc. Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
CA2893333C (en) 2012-12-19 2017-10-24 Pfizer Inc. Carbocyclic-and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
WO2014125394A1 (en) 2013-02-13 2014-08-21 Pfizer Inc. HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
MX2016002479A (es) 2013-09-12 2016-05-31 Pfizer Uso de inhibidores de acetil-coa carboxilasa para tratar acne vulgaris.
ES2665153T3 (es) 2013-10-09 2018-04-24 Pfizer Inc. Antagonistas del receptor EP3 de prostaglandina
CU24395B1 (es) 2014-03-17 2019-04-04 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
PL3536685T3 (pl) 2014-04-04 2022-05-16 Pfizer Inc. Bicykliczne skondensowane związki heteroarylowe lub arylowe i ich zastosowanie jako inhibitory IRAK4
JP6111002B1 (ja) 2014-04-10 2017-04-05 ファイザー・インク 2−アミノ−6−メチル−4,4a,5,6−テトラヒドロピラノ[3,4−d][1,3]チアジン−8a(8H)−イル−1,3−チアゾール−4−イルアミド
EP3194367B1 (en) * 2014-09-17 2021-08-18 Boehringer Ingelheim International GmbH Tetrahydroisoquinoline derivatives and pharmaceutical compositions useful for the treatment of obesity and diabetes
WO2016092413A1 (en) 2014-12-10 2016-06-16 Pfizer Inc. Indole and indazole compounds that activate ampk
EP3237401B1 (en) 2014-12-22 2019-03-06 Pfizer Inc Antagonists of prostaglandin ep3 receptor
SG11201708407TA (en) 2015-05-05 2017-11-29 Pfizer 2-thiopyrimidinones
WO2016193844A1 (en) 2015-05-29 2016-12-08 Pfizer Inc. Novel heterocyclic compounds as inhibitors of vanin-1 enzyme
DK3310784T3 (da) 2015-06-17 2020-11-09 Pfizer Tricykliske forbindelser og deres anvendelse som phosphodiesterasehæmmere
WO2016203335A1 (en) 2015-06-18 2016-12-22 Pfizer Inc. Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
US20180230127A1 (en) 2015-08-13 2018-08-16 Pfizer Inc. Bicyclic-Fused Heteroaryl Or Aryl Compounds
HRP20210472T1 (hr) 2015-08-27 2021-05-14 Pfizer Inc. Biciklički kondenzirani heteroarilni ili arilni spojevi kao modulatori irak4
WO2017037567A1 (en) 2015-09-03 2017-03-09 Pfizer Inc. Regulators of frataxin
WO2017051303A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
EP3353174A1 (en) 2015-09-24 2018-08-01 Pfizer Inc N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl]amides useful as bace inhibitors
JP2018531923A (ja) 2015-09-24 2018-11-01 ファイザー・インク N−[2−(2−アミノ−6,6−二置換−4,4a,5,6−テトラヒドロピラノ[3,4−d][1,3]チアジン−8a(8H)−イル)−1,3−チアゾール−4−イル]アミド
TN2018000198A1 (en) 2015-12-29 2019-10-04 Pfizer Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
AU2017252015A1 (en) 2016-04-19 2018-11-08 Ureka Sarl Peptide-oligourea foldamer compounds and methods of their use
US10906888B2 (en) 2016-07-14 2021-02-02 Pfizer Inc. Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
WO2019133445A1 (en) 2017-12-28 2019-07-04 Inception Ibd, Inc. Aminothiazoles as inhibitors of vanin-1
JP7161605B2 (ja) 2018-08-31 2022-10-26 ファイザー・インク Nash/nafldおよび関連疾患の治療のための組合せ
WO2020102575A1 (en) 2018-11-16 2020-05-22 Inception Ibd, Inc. Heterocyclic aminothiazoles and uses thereof
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors
CA3140972C (en) 2019-05-20 2024-06-18 Pfizer Inc. Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
CN110922372A (zh) * 2019-11-04 2020-03-27 天津大学 达格列净的氨基酸共晶物及其制备方法
PT4097099T (pt) 2020-02-07 2024-07-19 Gasherbrum Bio Inc Agonistas heterocíclicos de glp-1
WO2021219019A1 (en) 2020-04-29 2021-11-04 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
KR20230013126A (ko) * 2020-05-21 2023-01-26 시오노기 앤드 컴파니, 리미티드 지방성 간질환의 치료용 의약
EP4490155A1 (en) 2022-03-09 2025-01-15 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
US20250250269A1 (en) 2022-04-14 2025-08-07 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2024118524A1 (en) 2022-11-28 2024-06-06 Cerevel Therapeutics, Llc Azaindole compounds and their use as phosphodiesterase inhibitors
CN121002014A (zh) 2022-12-15 2025-11-21 加舒布鲁姆生物公司 具有glp-1激动剂活性的化合物的盐和固体形式

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE509023T1 (de) * 2005-07-19 2011-05-15 Merck Sharp & Dohme Spirochromanon-derivate als acetyl-koenzym-a- carboxylase-hemmer
WO2008065508A1 (en) * 2006-11-29 2008-06-05 Pfizer Products Inc. Spiroketone acetyl-coa carboxylase inhibitors

Similar Documents

Publication Publication Date Title
JP2011521939A5 (enExample)
JP2013509393A5 (enExample)
TWI918593B (zh) Glp1r激動劑的治療用途
NZ595024A (en) Benzofuranyl derivatives used as glucokinase inhibitors
RU2523552C2 (ru) Лекарственное средство, включающее совместное применение или комбинацию ингибитора dpp-iv и другого лекарственного средства для лечения диабета
JP2017160212A5 (enExample)
TW536401B (en) A pharmaceutical composition of N,N-bis(phenylcarbamoylmethyl)dimethylammomum chloride and derivatives for the treatment of pain
RU2014134409A (ru) Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
ME02016B (me) Derivati dioksabiciklo[3.2.1]oktan-2,3,4-triola
JP2008520544A5 (ja) 癌関連疲労の治療または予防のための医薬の製造への使用方法
CN107106873A (zh) 用于治疗非酒精性脂肪肝病的acc抑制剂组合治疗
JP2009508955A5 (enExample)
FI3539540T3 (fi) Sglt2:n estäjä 1-kloori-4-(beta-d-glukopyranos-1-yyli)-2-[4-((s)-tetrahydrofuran-3-yylioksi)bentsyyli]bentseeni yhdessä insuliinin kanssa käytettäväksi menetelmässä hypoglykemiariskin vähentämiseksi
CN110693868A (zh) 双胍组合物和治疗代谢性病症的方法
JP2005523946A5 (enExample)
JP2013522194A5 (enExample)
RU2019114952A (ru) Способы лечения рака желудочно-кишечного тракта с применением комбинационных видов терапии, содержащих липосомальный иринотекан и оксалиплатин
CN101137368A (zh) 治疗糖尿病的罗氟司特
JP2002507571A (ja) アントラサイクリン誘導体とカンプトテシン誘導体の相乗組合せを含有する抗腫瘍組成物
RU2009134137A (ru) Нейрогенные соединения
WO2007081974A2 (en) Viral hepatitis treatment
JP2022529312A5 (enExample)
JP2020536121A5 (enExample)
JP2008505139A (ja) 悪心および嘔吐の処置における置換2−チオ−3,5−ジシアノ−4−フェニル−6−アミノピリジン類の使用
TW202308620A (zh) 包括gpr40促進劑以及sglt-2抑制物之醫藥組成物及其製備方法