JP2011520959A5 - - Google Patents

Info

Publication number

JP2011520959A5

JP2011520959A5 JP2011510515A JP2011510515A JP2011520959A5 JP 2011520959 A5 JP2011520959 A5 JP 2011520959A5 JP 2011510515 A JP2011510515 A JP 2011510515A JP 2011510515 A JP2011510515 A JP 2011510515A JP 2011520959 A5 JP2011520959 A5 JP 2011520959A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

amino acid

pharmaceutical composition

acid residues

Prior art date

2009-05-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 229920001184 polypeptide Polymers 0.000 claims 17
• 108090000765 processed proteins & peptides Proteins 0.000 claims 17
• 102000004196 processed proteins & peptides Human genes 0.000 claims 17
• 125000000539 amino acid group Chemical group 0.000 claims 12
• 239000008194 pharmaceutical composition Substances 0.000 claims 11
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 235000018417 cysteine Nutrition 0.000 claims 4
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 4
• 229940125721 immunosuppressive agent Drugs 0.000 claims 4
• 239000003018 immunosuppressive agent Substances 0.000 claims 4
• RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 4
• 229960004866 mycophenolate mofetil Drugs 0.000 claims 4
• 229930105110 Cyclosporin A Natural products 0.000 claims 3
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 3
• 108010036949 Cyclosporine Proteins 0.000 claims 3
• 229960001265 ciclosporin Drugs 0.000 claims 3
• 230000028993 immune response Effects 0.000 claims 3
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 241000588724 Escherichia coli Species 0.000 claims 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
• 206010052779 Transplant rejections Diseases 0.000 claims 2
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
• 229960002930 sirolimus Drugs 0.000 claims 2
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
• 238000002054 transplantation Methods 0.000 claims 2
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
• 208000023328 Basedow disease Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 206010009900 Colitis ulcerative Diseases 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 208000015023 Graves' disease Diseases 0.000 claims 1
• 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 241000721454 Pemphigus Species 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
• 206010047115 Vasculitis Diseases 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 235000001014 amino acid Nutrition 0.000 claims 1
• 230000001363 autoimmune Effects 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 206010028417 myasthenia gravis Diseases 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 230000002207 retinal effect Effects 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
• 210000001745 uvea Anatomy 0.000 claims 1