JP2011519919A - 不斉水素化のための触媒的プロセス - Google Patents
不斉水素化のための触媒的プロセス Download PDFInfo
- Publication number
- JP2011519919A JP2011519919A JP2011508434A JP2011508434A JP2011519919A JP 2011519919 A JP2011519919 A JP 2011519919A JP 2011508434 A JP2011508434 A JP 2011508434A JP 2011508434 A JP2011508434 A JP 2011508434A JP 2011519919 A JP2011519919 A JP 2011519919A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- thione
- dihydroimidazol
- aminoethyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XESORRKVRNORPM-SSDOTTSWSA-N N[C@H](C1)COc(c(F)c2)c1cc2F Chemical compound N[C@H](C1)COc(c(F)c2)c1cc2F XESORRKVRNORPM-SSDOTTSWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5075408P | 2008-05-06 | 2008-05-06 | |
| US61/050,754 | 2008-05-06 | ||
| PCT/PT2009/000025 WO2009136803A2 (en) | 2008-05-06 | 2009-05-06 | Process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011519919A true JP2011519919A (ja) | 2011-07-14 |
| JP2011519919A5 JP2011519919A5 (https=) | 2012-12-06 |
Family
ID=40933790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508434A Pending JP2011519919A (ja) | 2008-05-06 | 2009-05-06 | 不斉水素化のための触媒的プロセス |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8710239B2 (https=) |
| EP (1) | EP2303855B1 (https=) |
| JP (1) | JP2011519919A (https=) |
| AR (1) | AR071632A1 (https=) |
| CA (1) | CA2723411A1 (https=) |
| ES (1) | ES2531458T3 (https=) |
| PT (1) | PT2303855E (https=) |
| WO (1) | WO2009136803A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR071632A1 (es) | 2008-05-06 | 2010-06-30 | Bial Portela & Ca Sa | Proceso catalitico para hidrogenacion asimetrica en la sintesis de inhibidores de la dopamina-beta-hidroxilasa" |
| WO2014077715A1 (en) * | 2012-11-14 | 2014-05-22 | BIAL - PORTELA & Cª, S.A. | 1,3-dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7125904B2 (en) | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
| KR20090091326A (ko) | 2006-12-12 | 2009-08-27 | 바이알 - 포르텔라 앤드 씨에이 에스에이 | 촉매적 비대칭 수소화 방법 |
| AR071632A1 (es) | 2008-05-06 | 2010-06-30 | Bial Portela & Ca Sa | Proceso catalitico para hidrogenacion asimetrica en la sintesis de inhibidores de la dopamina-beta-hidroxilasa" |
-
2009
- 2009-05-05 AR ARP090101613A patent/AR071632A1/es unknown
- 2009-05-06 JP JP2011508434A patent/JP2011519919A/ja active Pending
- 2009-05-06 PT PT09742906T patent/PT2303855E/pt unknown
- 2009-05-06 WO PCT/PT2009/000025 patent/WO2009136803A2/en not_active Ceased
- 2009-05-06 EP EP09742906.2A patent/EP2303855B1/en not_active Not-in-force
- 2009-05-06 CA CA2723411A patent/CA2723411A1/en not_active Abandoned
- 2009-05-06 ES ES09742906.2T patent/ES2531458T3/es active Active
- 2009-05-06 US US12/990,918 patent/US8710239B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20110237803A1 (en) | 2011-09-29 |
| EP2303855A2 (en) | 2011-04-06 |
| US8710239B2 (en) | 2014-04-29 |
| PT2303855E (pt) | 2015-03-11 |
| ES2531458T3 (es) | 2015-03-16 |
| EP2303855B1 (en) | 2014-12-31 |
| WO2009136803A3 (en) | 2010-07-22 |
| WO2009136803A2 (en) | 2009-11-12 |
| CA2723411A1 (en) | 2009-11-12 |
| AR071632A1 (es) | 2010-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120502 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120502 |
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| A072 | Dismissal of procedure [no reply to invitation to correct request for examination] |
Free format text: JAPANESE INTERMEDIATE CODE: A073 Effective date: 20121016 |